Weight Loss Studies and Clinical Trials

by Team PCT on August 10, 2010

Shedding excess weight can be an extremely arduous task, especially if you use conventional methods. Diets rarely yield long-term weight loss. In her book The Psychology of Ideal Body Image as an Oppressive Force in the Lives of Women, Barbara Cohen, Ph.D. argues that 95% of diets fail. With two-thirds of Americans either overweight (defined as a body-mass index (BMI) of 25 or higher) or obese (a 30-plus BMI), there is clearly a need to stop this epidemic.

Ongoing research can provide promising solutions. Government agencies, universities, hospitals, and corporations are frequently enrolling patients in studies designed to test the effectiveness of new drugs, procedures and medical devices on weight loss management. Moreover, some studies will even provide an economic incentive for you to lose weight.

Finding the trial that’s right for you.

Paidclinicaltrials.org is an excellent resource for starting your clinical trial search. It lists federally and privately supported clinical trials conducted in the U.S. and around the world. There are more than 1100 studies in obesity and/or weight loss which are actively recruiting to date.

In fact, more than 400 of these clinical trials are evaluating new treatments strategies such as drugs, behavioral modifications, devices, procedures, surgeries, and diets for their effectiveness in helping patients lose weight. To find clinical trials specific to weight loss management or obesity which are currently looking for patients, click here.

You can also tailor the search to your specific needs. For example, you can limit the search to clinical trials actively enrolling adults (18-65) in your state. You might initially be overwhelmed by the medical jargon used to describe each of the trials.

Don’t be discouraged. Every trial description has the contact information for a health care professional involved in the study who can provide you with a clear understanding of the trial. They will explain the main purpose of the trial, how long they expect it to last, where it will be conducted, and what treatments will be used. Below, you’ll find a list of just some of the drugs, procedures, or devices which are currently being investigated for use in weight loss management.


List of Treatments based on Drugs List of Treatment Procedures or Devices
Growth Hormone Lacroscopic adjustable gastric band
Orlistat Gastric bypass
Exenatide Intragastric ballon
Zonisamide Transcranial Direct Current Stimulation
Sibutramine List of Treatment Devices
Liraglutide Boussignac TM CPAP
Vitamin D Venturi Face Mask


Before participating in a clinical trial
Before considering participating in a clinical trial you should talk about it with your primary health care provider. Your physician knows you and your medical history best, which makes them an excellent source for evaluating whether a trial might be beneficial. He or she can also help you identify key questions and concerns specific to your health needs that might be important to discuss with the study coordinator prior to participation.

For example, if you have a preexisting heart condition your physician could offer advice about your risks and benefits of participating in weight loss management clinical trials. You should also alert a family member or loved one to your decision to participate and someone along for support and to hear the responses to the questions regarding your participation.

According to clinicaltrials.gov, some helpful questions to ask while visiting the physician conducting the trials include:

•How will this affect my daily life?
•How will I be safety be monitored?
•Are there any risks involved?
•What happens if I am harmed by the trial?
•What are the alternative treatments besides the one being tested in the trial?
•Do I have to pay for any part of the trial?
•Can I opt to remain on this treatment, even after termination of the trial?

Benefits and risks associated with participating in a clinical trial
Not only will you gain access to treatments before they are widely available, but in some cases, trials will provide the treatment at no cost. Sometimes participants are also compensated financially for their time and travel. Moreover, during the trial you will have regular monitoring by the doctors and other health care professionals involved in the study.

Along with these benefits are also risks. There may be unpleasant, serious, or even life-threatening side effects to an experimental treatment. Not all of the adverse drug reactions are known since some of the treatments, procedures, indications for the experimental drugs are relatively new. Also, the effectiveness of these new weight loss therapies may be unknown. Not every patient receives the active agent. For example, you could be randomly assigned to the placebo group instead of the active drug group.

Weight loss drugs and procedures are designed to be a tool to help patients overcome the disease. There isn’t a ‘one pill’ treatment that treats obesity and rapidly provides weight loss. Many health care providers agree that permanent lifestyle changes in diet and exercise are necessary regardless of whether you choose to enroll in a clinical trial. If you are struggling with weight loss, make sure you avail yourself of all your options before deciding the best plan for you.

{ 32 comments… read them below or add one }

gloria thompson August 10, 2010 at 10:38 pm

I been struggling for years with my weight. I need help. Can you help me? I would like to participate in your weight loss program. Thank you.

Shirley Young August 11, 2010 at 9:08 pm

I am very interested in weight loss clinical trials around the area of Bloomington, IN.
Shirley Young

debra solomon August 11, 2010 at 9:52 pm

I am a 53 yr old female 5’1 185lbs and am willing to try ANYTHING !

I live in Silver Creek, Ga. which is a suburb of Rome, Ga.

I cannot pay for any treatment, though.

Thank you very much.

Debra Solomon

maria zygman August 12, 2010 at 1:55 am

i would like to participe in the studie for weight loss ….send me information,, about the clinics. thanks
bonita spring florida 34135

Kathy Hill August 12, 2010 at 2:01 pm

I am interested in participating in your weightloss clinical trial studies in Georgia. I am not sure this is the correct method for sign-up and if not please inform me how to sign up.

trina Pot September 19, 2010 at 4:18 am

I need to lose weight. Ihave been trying for 20 years i am now 41 years old.

Nikki Martin September 23, 2010 at 10:26 pm

Hi I’m a 36yr old over weight female residing in Augusta Ga.I’m interested in being a part of a weight loss clinical trial.

Susie Needham October 12, 2010 at 2:02 am

Are you looking for the token fatty in Canada? – Here I am.
Desperately seeking weight loss and maintenance sanity. I am 48, been married 28 years and I feel like the president of the dieters failure club. I have tried several diets, pills (1 was prescription), potions, followed Canada’s food guide, and exercised. I have cried myself to sleep at the disappointment I feel for myself when a product doesn’t work, or only temporarily works. Please help me save myself, my dignity, my self respect and get me back on the fit for life road to health and happiness.
Thank you for your time and response.

Ana October 21, 2010 at 2:30 am

When will you have a weight loss study I would like to join please let me know Ilive in Miami Dade,Florida Thank You

cherylyn bindie October 22, 2010 at 6:56 pm

Definitely interested in more information regarding weight loss trials. In Honolulu, HI—–for a few more months then to Pa.

Melinda Mccoy October 29, 2010 at 1:49 pm

I am a 50 year old woman who is Morbidly Obese according to the American health.
I am 5’5″ and i weigh 265. Can someone please help me..
Thank you.
Melinda,in Houston, Tx

laura lee August 24, 2012 at 6:34 pm

i been struggling with m weight for a while and since having my 2 kids, i have seemed to put on extra, ive tried most diets and even doctors have rescribed orlistat to which i think does not work, i have a vsd to which putting weight on can put pressure on my heart, so i feel i would benefi from taking part in your trials

Melanie Brace September 19, 2012 at 6:36 pm

I would love to find out about weight loss studies as I have been struggling for
years with my weight. I Live in Wimberley, Tx . Are there any studies close by ?

denise kugler October 3, 2012 at 4:38 am

I am interested in a weight loss clinical trial in las vegas, nevada.

Marilyn Benson October 3, 2012 at 2:49 pm

I do not want to play around. I want to try the diet drug they used on rats. I have not heard anything about this in awhile now. But, it was 100% successful. One of the results was, the rats were very lean but need some fat. I want to try this.

I am 59 years old, approximately 5’5″, 264 pounds. I have just started Pure Green Coffee Bean Extract-2 weeks now. I saw on Dr. Oz where a trial was done and in 12 weeks, people lost 17 pounds. I am also looking at detoxing my liver.

I want to lose my middle, arms, hips, and thighs. I want to lose about 100 pounds.

Korri October 3, 2012 at 3:14 pm

I need help and I am broke. I can lose weight but for some reason no matter how many sit-ups I do my stomach goes no where. Some type of surgery is what I would like to try, just can’t afford it.

Lawrence curry October 7, 2012 at 6:15 pm

I am 60 years old and overweight and very much interested in a weight loss clinical studies program in the Ann Arbor, MI area.

Lawrence curry October 7, 2012 at 6:16 pm

Sounds interesting and I am very much interested in a clinical studies weight in the Ann Arbor, Mi area.

LUCY D October 20, 2012 at 8:17 pm

I am very interested in taking part in this trial, do any take place in england?

Team PCT October 23, 2012 at 4:43 pm

Hi Lucy,
All of our clinical trials can be accessed by visiting our main page; you can then search by country and state or by the condition you are interested in by clicking on the search tabs on the left.For example, you would search for clinical trials under the tab of United Kingdom, and then if you want to narrow the results, you can choose from one of the cities listed.

shelia blakeney October 24, 2012 at 1:30 am

i think that i would like to try it.

Regina October 26, 2012 at 3:45 pm

After i had my first son it took me two years just to loose up to about 20 pounds which for my hight i was still considered over weight. Now that i have had my second son it seems much harder. Going to the gym for several months straight and not realy seeing much progress. I have finally lost some weight this year but im still considered atleast 60 or 70 pounds over weight for being only 4″11. Ive tried everything and have thrown so much money out the window. Can you please help me so im not so tired and more and have more energy to go out an play with my children.

peggy November 1, 2012 at 8:40 pm

I am interested in this trial but it would have to be in nashville tennessee area

Team PCT November 2, 2012 at 6:59 pm

Hi Peggy,

You can search for clinical trials in your area by clicking on the “clinical trial locations” tab for the United States, and then enter your state and a list of trials will pull up.

david smyre December 6, 2012 at 12:20 am

I would like to sign up for some of your clinical experiments, what do I have to do to get started?

Jennifer December 6, 2012 at 1:16 am

I’m interested in this weight loss clinical

Team PCT December 6, 2012 at 4:14 pm

Thanks for your comment David. You can search for clinical trials by clicking on the ‘search by category’ tab and entering the keyword “weight loss.” You can also search by clicking on the ‘search by location’ tab and entering your country and state. Good luck!

oralia Castillo January 10, 2013 at 4:18 am

I like it I would like to help .if I could get more information..

Team PCT January 11, 2013 at 11:02 pm

Thank you for your comment on our site! To search for weight loss clinical trials in your area, go to our home page and click on the tab “search by medical conditions.” This will pull up all clinical trials, then click on your country, and then on your state to see a list of current trials. Good luck :)

Elisa Hernandez January 18, 2013 at 12:10 am

I’m Interested In This Weight Loss Clinic, And Am Willing To Try ANYTHING! It Would Also Be Helpful If I Could Get More Information On This.

mary February 21, 2013 at 9:22 pm

I Have 5 kids and i can not lose belly fat, need help asap

Team PCT February 28, 2013 at 3:50 pm

Hi Mary,
Thanks for stopping by. There are ongoing clinical trials pertaining to weight loss and diet, obesity, etc. You can search for these on our home page by clicking on the ‘search by condition’ tab and entering those keywords. Or, you can search for trials by your country and state. Good luck!

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