Paid Clinical Trials for Healthy Volunteers in the United States

Paid Clinical Trials and Focus Groups by Category

All Categories ... Healthy Participants » ... United States

Pharmacodynamic Study to Compare Acute Effects of Dihydroergotamine Mesylate (DHE) on Pulmonary Arterial Pressure

Condition: Healthy
Interventions: Drug: MAP0004; Drug: IV Placebo; Drug: Placebo Inhaler; Drug: DHE 45
Sponsor: MAP Pharmaceuticals, Inc.
Not yet recruiting - verified March 2010
Multiple Dose Safety Study of SRX246 Capsules in Healthy Volunteers

Condition: Healthy
Intervention: Drug: SRX246
Sponsor: Azevan Pharmaceuticals
Not yet recruiting - verified March 2010
Pharmacokinetic Study in Patients With Chronic Kidney Disease and Healthy Volunteers

Condition: Kidney Disease
Intervention:
Sponsor: University of California, San Francisco
Recruiting - verified February 2010
Cardiovascular Radiologic and Metabolic Assessment in HIV: An Investigation of Pathophysiology

Conditions: HIV; Cardiovascular Disease
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified February 2010
Effect of Sodium Thiosulfate on Urine Chemistries of Hypercalciuric Stone Formers

Condition: Kidney Stones
Intervention: Drug: Sodium thiosulfate
Sponsor: VA New York Harbor Healthcare System
Recruiting - verified March 2010
An Open-Label, Randomized Phase I Study in Healthy Adults of the Safety and Immunogenicity of Prime-Boost Intervals With Monovalent Influenza Subunit Virion (H5N1) Vaccine, A/Indonesia/05/2005 (Sanofi Pasteur, Inc.) Administered Alone or Following Re...

Condition: Influenza A Virus, H5N1 Subtype
Interventions: Biological: VRC-AVIDNA036-00-VP; Biological: Monovalent Influenza Subunit Virion (Inactive H5N1) Vaccine
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified February 2010
Cytology Study of Cells From Patients With Low Back Pain

Condition: Back Pain
Intervention:
Sponsor: Texas Tech University Health Sciences Center
Recruiting - verified March 2010
Study of Cells From Spinal Cavity of Patients With Low Back Pain

Condition: Low Back Pain
Intervention:
Sponsor: Texas Tech University Health Sciences Center
Recruiting - verified March 2010
Mothers' Thoughts About What Their Children Eat

Condition: Healthy Volunteers
Intervention:
Sponsor: National Human Genome Research Institute (NHGRI)
Recruiting - verified February 2010
Top-Down Attentional Control of Visual-Processing

Conditions: Focal Brain Lesion; Focal Lesions; fMRI
Intervention:
Sponsor: National Institute of Mental Health (NIMH)
Recruiting - verified November 2009
Heart Biomarker Evaluation in Apnea Treatment

Conditions: Cardiovascular Disease; Obstructive Sleep Apnea; Coronary Artery Disease
Interventions: Other: Healthy Lifestyles and Sleep Education plus PAP; Other: Healthy Lifestyles and Sleep Education plus Supplemental Oxygen; Other: Healthy Lifestyles and Sleep Education
Sponsors: University Hospitals of Cleveland; Case Western Reserve University; Partners HealthCare; Johns Hopkins University; VA Boston Healthcare System
Recruiting - verified March 2010
Sustiva Levels With Use of a Gel Capsule

Condition: HIV
Interventions: Drug: Efavirenz; Drug: Over-encapsulated efavirenz
Sponsor: University of Minnesota - Clinical and Translational Science Institute
Recruiting - verified March 2010
Enhancing Cognitive Function and Reintegration in Iraq and Afghanistan Veterans With Post Traumatic Stress Disorder (PTSD) Using Computer-Based Cognitive Training

Condition: Cognitive Impairment
Intervention: Other: Brain Fitness Program by Posit Science
Sponsors: San Francisco Veterans Administration Medical Center; Department of Defense
Not yet recruiting - verified March 2010
Healthy Homes/Healthy Kids_5-9

Conditions: Obesity; Injury
Interventions: Behavioral: Healthy Eating/Physical Activity; Behavioral: Safety/Injury Prevention
Sponsors: HealthPartners Research Foundation; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); University of Washington; University of Minnesota School of Public Health
Not yet recruiting - verified March 2010
Rebif Advanced Magnetic Resonance Imaging (MRI) and Immunology Pilot Trial

Condition: Multiple Sclerosis
Intervention: Drug: Rebif
Sponsor: EMD Serono
Not yet recruiting - verified March 2010
Diagnosis of Intestinal Motility by Image Analysis Using Capsule Endoscopy

Condition: Intestinal Abnormalities
Intervention: Device: PillCam SB2
Sponsor: Given Imaging Ltd.
Recruiting - verified March 2010
Healthy and Renal Impairment Study of Colcrys (Colchicine, USP)

Condition: Pharmacokinetics
Interventions: Drug: colchicine 0.6 mg; Drug: colchicine 0.6 mg; Drug: colchicine; Drug: colchicine; Drug: colchicine
Sponsor: Mutual Pharmaceutical Company, Inc.
Recruiting - verified March 2010
Collection of Human Samples to Study Hairy Cell and Other Leukemias and to Develop Recombinant Immunotoxins for Cancer Treatment

Conditions: Hairy Cell Leukemia (HCL); Chronic Lymphocytic Leukemia (CLL); Non-Hodgkins Lymphoma (NHL); Cutaneous T Cell Lymphoma (CTCL); Adult T Cell Lymphoma (ATL)
Intervention:
Sponsor: National Cancer Institute (NCI)
Recruiting - verified January 2010
Sample Collection Registry for Quality Control of Biological and Environmental Specimens and Assay Development and Testing

Condition: Biospecimen
Intervention:
Sponsor: National Institute of Environmental Health Sciences (NIEHS)
Recruiting - verified January 2010
Recurrent Low Back Pain:Linking Mechanisms to Outcomes

Condition: Low Back Pain, Mechanical
Intervention: Other: Core Stabilization
Sponsors: Drexel University; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified March 2010
Using Diffuse Noxious Inhibitory Control (DNIC) to Predict Acupuncture Therapy Outcome: A Pilot Study

Condition: Pain
Intervention: Other: Acupuncture
Sponsors: University of Washington; Bastyr University
Recruiting - verified March 2010
Efficacy of Systane Ultra to Stabilize the Tear Film in Dry Eye Subjects

Condition: Dry Eye
Intervention: Drug: Systane Ultra Lubricant Eye Drops
Sponsor: Alcon Research
Not yet recruiting - verified March 2010
Physical, Functional and Neural Effects of Two Lower Extremity Exercise Protocols in Children With Cerebral Palsy

Conditions: Cerebral Palsy; Children; Adolescents
Intervention: Behavioral: Physical Exercise
Sponsor: National Institutes of Health Clinical Center (CC)
Recruiting - verified January 2010
Effectiveness of Pedialink CEASE Module

Condition: Tobacco Use
Intervention: Other: Exposure to practice that has been trained in Pedialink CEASE
Sponsors: Massachusetts General Hospital; Flight Attendant Medical Research Institute
Recruiting - verified March 2010
Evaluation of the Safety and Immune Response to an Investigational Dengue Type 1 Vaccine

Condition: Dengue Virus
Interventions: Biological: Investigational Vaccine for DEN1; Other: Placebo injection
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified January 2010
Genotype Stratified Pharmacokinetic Study of Montelukast

Condition: Asthma
Intervention: Drug: 10 mg tablet of montelukast (Singulair)
Sponsors: Nemours Children's Clinic; Merck Investigator Initiated Studies Program
Recruiting - verified March 2010
Use of Topical Lidocaine to Reduce Pain in Patients With Diabetic Neuropathy

Condition: Diabetic Peripheral Neuropathy
Interventions: Other: Skin biopsy; Other: Skin biopsy
Sponsors: Albany Medical College; Endo Pharmaceuticals
Recruiting - verified March 2010
Clinical Outcome Comparison Between Medial and Lateral Offset Reverse Shoulder Arthroplasty

Conditions: Rotator Cuff Tear; Proximal Humerus Fractures; Malunions; Chronic Proximal Humerus Dislocations
Intervention:
Sponsor: Loma Linda University
Not yet recruiting - verified March 2010
OTIS Autoimmune Diseases in Pregnancy Project

Conditions: Crohn's Disease; Rheumatoid Arthritis
Intervention:
Sponsors: University of California, San Diego; Organization of Teratology Information Specialists (OTIS); Abbott
Recruiting - verified March 2010
Cellular and Humoral Immune Response to Primary and Secondary Immunization With Subvirion H5N1 Vaccines

Condition: Influenza
Intervention: Biological: Inactivated Influenza A/H5N1/Indonesia/05/05 (clade 2)
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting - verified February 2010
Biomarkers of Metabolic Syndrome and Prediabetes

Conditions: Metabolic Syndrome; Diabetes; Prediabetes; Hypertension
Intervention:
Sponsor: West Virginia School of Osteopathic Medicine
Recruiting - verified March 2010
Use of Fiber-optic Probe for Non-invasive Diagnosis of Melanoma and Assessment of Impact of Ultraviolet (UV) Exposure on Skin

Condition: Melanoma
Intervention:
Sponsor: University of Pittsburgh
Not yet recruiting - verified March 2010
Study of the Sensitivity of Manual vs Electric Aspiration to Detect Completed Early Abortion

Condition: Induced Abortion
Intervention: Procedure: D & C abortion
Sponsors: Planned Parenthood of New York City, Inc.; Society of Family Planning
Not yet recruiting - verified March 2010
Single Site, Masked, Randomized, Controlled Study to Assess Efficacy of Osurdex as Adjunct to Avastin Compared With Avastin Alone in the Treatment of Patients With Macular Edema Due to Central or Branch Retinal Vein Occlusion

Condition: Retinal Vein Occlusions
Interventions: Drug: Avastin; Drug: Osurdex; Drug: Avastin
Sponsor: Maturi, Raj K., M.D., P.C.
Recruiting - verified March 2010
Cognitive Rehabilitation in PD

Condition: Parkinson's Disease
Intervention: Behavioral: PC based training
Sponsors: Department of Veterans Affairs; University of California, Davis
Not yet recruiting - verified March 2010
Mastery Learning Inguinal Hernia Repair

Condition: Inguinal Hernia
Intervention: Behavioral: Mastery Learning TEP Curriculum
Sponsors: Mayo Clinic; National Center for Research Resources (NCRR)
Recruiting - verified March 2010
Single and Multiple Dose Study to Explore the Safety and Pharmacokinetics of JNJ-39758979 In Healthy Male Volunteers of Either Caucasian or Japanese Descent

Condition: Healthy
Interventions: Drug: multi-dose JNJ-39758979 /matching placebo; Drug: single dose NJ-39758979/ matching placebo
Sponsor: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Recruiting - verified March 2010
Lifestyle Intervention to Limit Excessive Weight Gain During Pregnancy in Minority Women

Conditions: Pregnancy; Weight Gain
Interventions: Behavioral: Lifestyle Intervention group; Behavioral: Standard of Care
Sponsor: Emory University
Not yet recruiting - verified March 2010
Pharmacokinetic Study Comparing Aspirin and Effervescent Aspirin

Condition: Pharmacokinetics
Interventions: Drug: Acetylsalicylic Acid (Aspirin BAY1019036); Drug: Alka Seltzer Extra Strength; Drug: Aspirin Migraine; Drug: Aspirin Aspro
Sponsor: Bayer
Recruiting - verified March 2010
A Safety, Tolerability and Pharmacokinetic Study of a Single Dose of CMX157 in Healthy Volunteers

Condition: Healthy
Interventions: Drug: CMX157; Drug: Placebo; Drug: Viread
Sponsor: Chimerix
Not yet recruiting - verified March 2010
Impact of PCV on Disease and Colonization Among Native American Communities

Conditions: Pneumococcal Nasopharyngeal Colonization; Invasive Pneumococcal Disease
Intervention:
Sponsors: Johns Hopkins Bloomberg School of Public Health; National Institutes of Health (NIH); Centers for Disease Control and Prevention
Recruiting - verified March 2010
Healthy Homes/Healthy Kids Preschool

Condition: Obesity
Interventions: Behavioral: Busy Bodies/Better Bites; Behavioral: Healthy Spots/Safe Tots
Sponsors: HealthPartners Research Foundation; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Not yet recruiting - verified March 2010
Prophylactic Continuous Positive Airway Pressure (CPAP) in Delivery Room, in the Prevention of Transient Tachypnea of Newborn (TTN): A Randomized Controlled Trial

Condition: Transient Tachypnea
Intervention: Other: Prophylactic CPAP Administration
Sponsor: New York Hospital Queens
Recruiting - verified February 2010
Pilot Pharmacokinetic Study of Daily Versus Monthly High-Dose Cholecalciferol Supplementation

Condition: Healthy Volunteers
Interventions: Dietary Supplement: Single High Dose Cholecalciferol; Dietary Supplement: Daily Dose Cholecalciferol
Sponsor: Mayo Clinic
Recruiting - verified March 2010
The Effect of Lubiprostone on Patterns of Contractions in the Small Bowel in Female Patients With Constipation Irritable Bowel Syndrome (C-IBS)

Condition: Constipation-predominant Irritable Bowel Syndrome
Intervention: Drug: Lubiprostone
Sponsors: Cedars-Sinai Medical Center; Takeda Pharmaceuticals North America, Inc.
Not yet recruiting - verified December 2009
Use of Cyclobenzaprine After Vaginal Surgery

Condition: Postoperative Pain
Intervention: Drug: cyclobenzaprine
Sponsor: NorthShore University HealthSystem Research Institute
Not yet recruiting - verified March 2010
Building Social Networks to Enhance Postpartum Weight Loss and Appropriate Infant Feeding Practices

Condition: Obesity
Interventions: Behavioral: Social network building intervention; Behavioral: Home visit
Sponsors: Vanderbilt University; American Heart Association
Not yet recruiting - verified March 2010
Continuous Glucose Monitoring in Type 2 Diabetes Mellitus

Condition: Diabetic Vascular Complications
Intervention:
Sponsor: Winthrop University Hospital
Recruiting - verified March 2010
The Impact of a Topical Vasodilating Cream on Female Sexual Experience

Condition: Female Sexual Dysfunction
Intervention:
Sponsors: East Suburban Ob Gyn; West Penn Allegheny Health System
Not yet recruiting - verified February 2010
PEAK PlasmaBlade 4.0 Versus Traditional Electrosurgery in Total Knee Replacement.

Conditions: Degenerative Joint Disease; Osteoarthritis; Total Knee Arthroplasty
Interventions: Device: PEAK PlasmaBlade 4.0; Device: Traditional Electrosurgery with scalpel
Sponsor: Peak Surgical, Inc.
Recruiting - verified March 2010
Substudy of Change in Cardiometabolic Disease (CMD) Risk Factors During an Interactive Fitness Program

Condition: Insulin Resistance
Intervention:
Sponsors: Children's Hospital Boston; University of Massachusetts
Recruiting - verified March 2010
Comparing Google With A Focused Diabetes Search Engine

Condition: Diabetes
Intervention:
Sponsor: Beth Israel Deaconess Medical Center
Recruiting - verified March 2010
Azilsartan Medoxomil Study in Hypertensive Children

Condition: Hypertension
Interventions: Drug: Azilsartan medoxomil (TAK-491); Drug: Azilsartan medoxomil (TAK-491); Drug: Azilsartan medoxomil (TAK-491); Drug: Azilsartan medoxomil (TAK-491)
Sponsor: Takeda Global Research & Development Center, Inc.
Not yet recruiting - verified February 2010
Growth of Infants Fed New Starter Formula

Condition: Nutrition
Interventions: Other: test starter infant formula; Other: test starter infant formula with synbiotics; Other: control standard formula
Sponsor: Nestlé Nutrition Corporate
Not yet recruiting - verified March 2010
Internet Intervention for the Prevention of Depression - Approaches to Improving Mood

Condition: Individuals at Risk for Depression
Interventions: Behavioral: AIM Web based intervention + surveillance; Behavioral: AIM web based intervention; Behavioral: Educational website
Sponsor: Northwestern University
Recruiting - verified March 2010
Assessing the Effects of a Topically Applied Cream to Clitoral Blood Flow

Condition: Female Sexual Dysfunction
Interventions: Drug: arginine 20%, nicotinamide .01%, niacin.1%, in LipodermPG 50%; Drug: Topical study cream; Drug: GRAS cream
Sponsor: East Suburban Ob Gyn
Not yet recruiting - verified March 2010
The Effect of Aromatase Inhibitors on Cardiovascular Risk Factors in Women With Breast Cancer

Condition: Breast Cancer
Intervention:
Sponsors: University of Pittsburgh; National Center for Research Resources (NCRR)
Recruiting - verified March 2010
Efficacy and Safety Study of Iontophoretic Application of Terbinafine Gel in Subjects With Onychomycosis

Condition: Distal Subungual Onychomycosis
Interventions: Drug: Terbinafine Hydrochloride; Other: Purified Water
Sponsor: Nitric BioTherapeutics, Inc
Not yet recruiting - verified March 2010
Alzheimer's Disease Neuroimaging Initiative Grand Opportunity

Conditions: Mild Cognitive Impairment; Alzheimer's Disease
Intervention:
Sponsors: Alzheimer's Disease Cooperative Study (ADCS); National Institute on Aging (NIA); National Institutes of Health (NIH)
Not yet recruiting - verified March 2010
Dose Response Effects of Marine Omega-3 Fatty Acids on Inflammation

Conditions: Cardiovascular Disease; Inflammation
Intervention: Dietary Supplement: Eicosapentaenoic Acid and Docosahexaenoic Acid (EPA + DHA)
Sponsors: Penn State University; United States Department of Agriculture
Not yet recruiting - verified February 2010
Sleep Promotion in Critically Ill and Injured Patients Cared for in the Intensive Care Unit

Condition: Sleep Deprivation
Intervention: Other: Sleep Enhancement Program (SEP)
Sponsors: University of Arizona; Arizona Biomedical Research Commission (ABRC)
Not yet recruiting - verified March 2010
Ascending Dose Study of the Safety and Tolerability of REGN727 (SAR236553) in Healthy Volunteers

Condition: Healthy
Interventions: Biological: REGN727; Biological: Placebo
Sponsors: Regeneron Pharmaceuticals; Sanofi-Aventis
Not yet recruiting - verified February 2010
Plerixafor and Filgrastim For Mobilization of Donor Peripheral Blood Stem Cells Before A Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Conditions: Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With T(15;17)(q22;q12); Adult Acute Myeloid Leukemia With T(16;16)(p13;q22); Adult Acute Myeloid Leukemia With T(8;21)(q22;q22); Atypical Chronic Myeloid Leukemia; Blastic Phase Chronic Myelogenous Leukemia; Chronic Phase Chronic Myelogenous Leukemia; De Novo Myelodysplastic Syndromes; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Myelodysplastic/Myeloproliferative Disease, Unclassifiable; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Previously Treated Myelodysplastic Syndromes; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Refractory Multiple Myeloma; Relapsing Chronic Myelogenous Leukemia; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndromes; Splenic Marginal Zone Lymphoma; Stage I Multiple Myeloma; Stage II Multiple Myeloma; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Diffuse Mixed Cell Lymphoma; Stage III Adult Diffuse Small Cleaved Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Immunoblastic Large Cell Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Multiple Myeloma; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma
Interventions: Drug: plerixafor; Biological: filgrastim; Procedure: peripheral blood stem cell transplantation; Procedure: allogeneic hematopoietic stem cell transplantation
Sponsor: Fred Hutchinson Cancer Research Center
Not yet recruiting - verified February 2010
Autoimmunity in Sisters of Lupus Patients

Condition: Systemic Lupus Erythematosus
Intervention:
Sponsors: North Shore Long Island Jewish Health System; National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified February 2010
Performance Evaluation Study for Clearblue Pregnancy Test

Condition: Pregnancy
Intervention:
Sponsor: SPD Development Company Limited
Recruiting - verified February 2010
Detection of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activity in Rectal Tissues From Human Subjects

Condition: Cystic Fibrosis
Intervention:
Sponsors: CF Therapeutics Development Network Coordinating Center; Cystic Fibrosis Foundation
Recruiting - verified March 2010
Initiation of Colon Cancer Screening in Veterans or "Start Screening Now"

Condition: Colorectal Neoplasms
Interventions: Behavioral: Stepped CRCS Interventions; Behavioral: Control
Sponsors: The University of Texas Health Science Center, Houston; Duke University; Boston University
Recruiting - verified March 2010
An Study to Evaluate Rosuvastatin in Children and Adolescents With Familial Hypercholesterolaemia

Condition: Familial Hypercholesterolaemia
Interventions: Drug: rosuvastatin calcium; Drug: rosuvastatin calcium; Drug: rosuvastatin calcium
Sponsor: AstraZeneca
Recruiting - verified March 2010
Techniques to Enhance Patient Comfort in Sedation-risk Free Colonoscopy

Condition: Screening of Colonic Polyps
Interventions: Other: Warm water; Other: Control
Sponsor: VA Greater Los Angeles Healthcare System
Recruiting - verified February 2010
Effects of a Spiced Meat Patty on Inflammation in Men With Type 2 Diabetes

Condition: Type II Diabetes Mellitus
Intervention: Other: Spice polyphenols
Sponsor: University of California, Los Angeles
Recruiting - verified February 2010
Vertos Mild - Post Market Patient Outcomes

Condition: Lumbar Spinal Stenosis
Intervention: Procedure: Minimally Invasive Lumbar Decompression
Sponsors: The Center for Pain Relief, Inc.; Vertos Medical
Recruiting - verified March 2010
Elective Induction of Nulliparous Labor

Condition: Pregnancy
Intervention: Procedure: Induction of Labor
Sponsor: Madigan Army Medical Center
Recruiting - verified February 2010
Comparison of Critical Flicker Fusion Versus Automated Visual Fields in the Detection of Early Glaucoma

Condition: Glaucoma
Intervention:
Sponsors: North Shore Long Island Jewish Health System; Nassau University Medical Center
Recruiting - verified February 2010
Comparison of Two Exercise Interventions to Improve Gait in Older Persons

Condition: Gait
Interventions: Behavioral: skill based exercise; Behavioral: aerobic conditioning
Sponsors: University of Pittsburgh; National Institute on Aging (NIA)
Not yet recruiting - verified February 2010
Evaluation of the Safety and Immune Response of Two Admixtures of a Tetravalent Dengue Virus Vaccine

Condition: Dengue
Interventions: Biological: TetraVax-DV Vaccine-Admixture 1; Biological: TetraVax-DV Vaccine-Admixture 2; Biological: Placebo
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); Center for Immunization Research (CIR), Johns Hopkins Bloomberg School of Public Health
Not yet recruiting - verified February 2010
Collection of Bone Marrow From Healthy Volunteers and Patients for the Production of Clinical Bone Marrow Stromal Cell (BMSC) Products

Conditions: Bone Marrow; Bone Marrow Stromal Cells; Mesenchymal Stem Cells; Blood Donors
Intervention:
Sponsor: National Institutes of Health Clinical Center (CC)
Recruiting - verified January 2010
Potassium-Magnesium Citrate as a Blood Pressure Lowering Agent in Hypertensive Patients

Conditions: Pre-Hypertension; Hypertension
Interventions: Drug: Potassium, Magnesium, Citrate; Drug: Potassium Chloride
Sponsor: University of Texas Southwestern Medical Center
Recruiting - verified April 2009
Safety and Pharmacokinetic Study of C13-URA in Healthy Volunteers

Condition: Gastroparesis
Interventions: Drug: [2-13C] uracil; Drug: [2-13C] uracil, placebo
Sponsor: Otsuka Pharmaceutical Co., Ltd.
Recruiting - verified February 2010
Multimodal Neurodiagnostic Imaging of Traumatic Brain Injury and Post-Traumatic Stress Disorder

Conditions: Traumatic Brain Injury; Post-Traumatic Stress Disorder
Intervention:
Sponsors: St. Louis University; Department of Defense
Recruiting - verified February 2010
The Molecular Anatomy of Oral Wound Healing

Conditions: Wounds and Injuries; Wound Healing; Ulcer
Intervention:
Sponsor: National Institute of Dental and Craniofacial Research (NIDCR)
Recruiting - verified November 2009
Safety and Immune Response to an Investigational Dengue Type 2 Vaccine

Condition: Dengue Virus
Interventions: Biological: Investigational Vaccine for Dengue Virus Subtype 2; Other: Placebo
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified February 2010
Apremilast in the Treatment of Moderate to Severe Acne

Condition: Acne
Intervention: Drug: apremilast
Sponsors: The University of North Carolina, Chapel Hill; Celgene Corporation
Recruiting - verified February 2010
The Cymbalta Pregnancy Registry

Condition: Pregnancy
Intervention: Drug: duloxetine
Sponsors: Eli Lilly and Company; Kendle International
Recruiting - verified February 2010
Measuring Musculoskeletal Symptoms in Patients Receiving Aromatase Inhibitors

Condition: Breast Cancer
Intervention:
Sponsor: Park Nicollet Institute
Recruiting - verified February 2010
Effect of Yoga on Objective and Subjective Menopausal Hot Flashes

Condition: Vasomotor Symptoms
Intervention: Behavioral: Yoga
Sponsors: Wake Forest University; National Center for Complementary and Alternative Medicine (NCCAM)
Recruiting - verified October 2009
Effects of Niaspan™ on High-density Lipoprotein (HDL) in Healthy Male Subjects

Condition: Dyslipidemia
Interventions: Drug: Niaspan; Drug: Comparator: Placebo
Sponsor: Merck
Recruiting - verified February 2010
Maternal Newborn Health Registry

Condition: Pregnancy Outcome Trends in Low-resource Geographic Areas
Intervention: Other: There is no intervention associated with this study.
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified December 2009
e-Care for Heart Wellness

Condition: CVD
Intervention: Behavioral: Dietician electonic support
Sponsors: Group Health Cooperative; National Heart, Lung, and Blood Institute (NHLBI)
Not yet recruiting - verified February 2010
Oral Fluid, Plasma and Whole Pharmacokinetics and Stability Following Smoked Cannabis

Conditions: Cannabis Use; Drug Abuse
Intervention: Drug: Cannabis Cigarette
Sponsor: National Institute on Drug Abuse (NIDA)
Recruiting - verified December 2009
Effects of Tiotropium on Breathing Capacity and Exercise Limitation in Early Stages of Chronic Obstructive Pulmonary Disease

Condition: Pulmonary Disease, Chronic Obstructive
Interventions: Drug: Placebo; Drug: Tiotropium
Sponsors: Boehringer Ingelheim Pharmaceuticals; Pfizer
Recruiting - verified March 2010
The LIFE Study - Lifestyle Interventions and Independence for Elders

Conditions: Sedentary Lifestyle; Risk of Disability; Aging
Intervention: Behavioral: Lifestyle modification
Sponsors: University of Florida; National Institute on Aging (NIA); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified February 2010
Rivastigmine as a Treatment for Methamphetamine Dependence

Condition: Methamphetamine Addiction
Interventions: Other: Placebo; Drug: Rivastigmine
Sponsor: National Institute on Drug Abuse (NIDA)
Recruiting - verified March 2010
Chitinases and Transforming Growth Factor Beta (TGFB) in Human Asthma

Condition: Asthma
Intervention:
Sponsors: University of California, San Francisco; National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified February 2010
Assessing Respiratory Variability During Mechanical Ventilation in Acute Lung Injury (ALI)

Conditions: Acute Lung Injury; Adult Respiratory Distress Syndrome
Intervention:
Sponsor: Boston Medical Center
Not yet recruiting - verified February 2010
Efficacy of Statins In Prevention of CIN

Condition: Nephropathy
Interventions: Drug: placebo; Drug: atorvastatin
Sponsor: University of Oklahoma
Not yet recruiting - verified February 2010
Serine Proteases in Gastrointestinal Function and Irritable Bowel Syndrome (IBS)

Condition: Colon, Irritable
Intervention:
Sponsors: The University of North Carolina, Chapel Hill; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified February 2010
Clinical Efficacy of an Experimental Toothpaste

Condition: Gingivitis
Interventions: Drug: Marketed toothpaste; Drug: Experimental toothpaste
Sponsor: GlaxoSmithKline
Not yet recruiting - verified February 2010
Clinical Evaluation of the Nucleus 5 CI System

Condition: Speech Perception
Intervention: Device: Nucleus 5 Cochlear implant
Sponsor: Cochlear
Not yet recruiting - verified February 2010
Supporting Education Goals of Operations Iraqi Freedom and Enduring Freedom (OIF/OEF) Veterans With PTSD: Pilot Process and Outcome

Condition: PTSD
Intervention: Other: Supported Education
Sponsor: Department of Veterans Affairs
Not yet recruiting - verified February 2010
The Role of Intestinal Inflammation in Irritable Bowel Syndrome (IBS)

Conditions: Inflammation; Colon, Irritable; Colonic Diseases, Functional; Irritable Bowel Syndrome
Intervention:
Sponsors: The University of North Carolina, Chapel Hill; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified February 2010
Top-Down Executive Control in Traumatic Brain Injury (TBI), PTSD and Combined TBI/PTSD

Conditions: PTSD; TBI (Traumatic Brain Injury)
Intervention:
Sponsors: Department of Veterans Affairs; University of California, Berkeley
Not yet recruiting - verified February 2010
Effects of California Walnuts on Vascular Function in Postmenopausal Women

Condition: Cardiovascular Diseases
Interventions: Other: Walnuts; Other: Walnuts; Other: Walnuts; Other: Walnuts
Sponsors: University of California, Davis; California Walnut Commission
Not yet recruiting - verified February 2010
Bioequivalence Study of 2.5 mg Saxagliptin and 850 mg Glucophage Combination Formulations in Healthy Subjects

Condition: Type 2 Diabetes Mellitus
Interventions: Drug: Saxagliptin; Drug: Metformin
Sponsors: Bristol-Myers Squibb; AstraZeneca
Not yet recruiting - verified February 2010
Bioequivalence Study of 2.5 mg Saxagliptin and 500 mg Glucophage Combination Formulations in Healthy Subjects

Condition: Type 2 Diabetes Mellitus
Interventions: Drug: Saxagliptin; Drug: Saxagliptin; Drug: Metformin; Drug: Metformin
Sponsors: Bristol-Myers Squibb; AstraZeneca
Not yet recruiting - verified February 2010
Drug Interaction Study Between GSK1349572 and Tipranavir/Ritonavir in Healthy Volunteers

Condition: Infection, Human Immunodeficiency Virus
Intervention: Drug: GSK1349572
Sponsors: GlaxoSmithKline; Shionogi
Recruiting - verified March 2010
Tadalafil in Becker Muscular Dystrophy

Condition: Becker Muscular Dystrophy
Interventions: Drug: Tadalafil; Drug: Placebo
Sponsors: Cedars-Sinai Medical Center; Muscular Dystrophy Association
Recruiting - verified March 2010
Intensive Motivational Interviewing for Methamphetamine Dependence

Condition: Methamphetamine Dependence
Intervention: Behavioral: Intensive Motivational Interviewing
Sponsor: Public Health Institute, California
Recruiting - verified February 2010
Bioequivalence Study of 500 mg and 1000 mg Glucophage (Metformin) Tablets in Healthy Subjects

Condition: Type 2 Diabetes Mellitus
Interventions: Drug: Metformin (Diabex); Drug: Metformin (Glucophage™); Drug: Metformin (Diabex); Drug: Metformin (Glucophage™)
Sponsors: Bristol-Myers Squibb; AstraZeneca
Not yet recruiting - verified February 2010
Relative Bioavailibilty for Pediatric Powder for Suspension (PfOS) Formulation and Food Effect

Condition: Purpura, Thrombocytopenic, Idiopathic
Interventions: Drug: Eltrombopag; Drug: Eltrombopag
Sponsor: GlaxoSmithKline
Recruiting - verified February 2010
Effect of Rifampin on the Pharmacokinetics of Dapagliflozin in Healthy Subjects

Condition: Type 2 Diabetes Mellitus
Interventions: Drug: Dapagliflozin; Drug: Rifampin
Sponsor: Bristol-Myers Squibb
Not yet recruiting - verified February 2010
Two-Part Study to Evaluate the Dose Response of SCH 527123 on Sputum Neutrophilia Following Ozone Challenge in Healthy Subjects and Chronic Obstructive Pulmonary Disease (COPD) Patients (P05567 AM7)

Condition: Chronic Obstructive Pulmonary Disease
Interventions: Drug: SCH 527123; Drug: SCH 527123; Drug: SCH 527123; Drug: SCH 527123; Drug: Placebo; Drug: SCH 527123; Drug: SCH 527123; Drug: SCH 527123; Drug: Placebo
Sponsor: Schering-Plough
Recruiting - verified March 2010
Protocol to Obtain Blood for Discovery of Novel Biomarkers and Potential Therapeutic Targets in Chronic Lymphocytic Leukemia

Condition: Chronic Lymphocytic Leukemia
Intervention: Other: No Intervention
Sponsor: Dartmouth-Hitchcock Medical Center
Not yet recruiting - verified February 2010
Safety and Tolerability of Odanacatib (MK0822)

Condition: Osteoporosis
Interventions: Drug: Odanacatib; Drug: Comparator: Placebo
Sponsor: Merck
Recruiting - verified March 2010
A Study in Healthy Volunteers to Assess Safety and Blood Levels of AZD9742 After Multiple Doses Over 14 Days

Condition: Healthy
Interventions: Drug: AZD9742; Drug: Placebo
Sponsor: AstraZeneca
Recruiting - verified March 2010
Drug Interaction Oral Contraceptive Pill (OCP)

Condition: Hepatitis C Virus
Interventions: Drug: Ortho Tri-Cyclen®; Drug: BMS-650032
Sponsor: Bristol-Myers Squibb
Not yet recruiting - verified February 2010
Non-Invasive Assessment of Atherosclerosis in Patients With CGD and Other Disorders of the Immune System

Conditions: Chronic Granulomatous Disease (CGD); Atherosclerosis; Immune Deficiencies; Inflammatory Bowel Disease
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified November 2009
Imaging Cannabinoid CB1 Receptors in Schizophrenia

Condition: Schizophrenia
Intervention:
Sponsor: National Institute of Mental Health (NIMH)
Recruiting - verified January 2010
Use of Plasmapheresis for Nephrogenic Fibrosing Dermopathy (NFD)/Nephrogenic Systemic Fibrosis (NSF) and Understanding Its Etiology

Conditions: Nephrogenic Fibrosing Dermopathy; Nephrogenic Systemic Fibrosis
Intervention: Procedure: Plasmapheresis
Sponsor: Loma Linda University
Recruiting - verified March 2010
Topical Cyclosporine Suspension for the Treatment of Brittle Nails

Condition: Brittle Nail Syndrome
Interventions: Drug: topical cyclosporine ophthalmic suspension 0.05%; Drug: vehicle
Sponsors: The University of North Carolina, Chapel Hill; Allergan
Recruiting - verified February 2010
NAC as a Potential Treatment for Methamphetamine Dependence

Condition: Methamphetamine Addiction
Interventions: Drug: Placebo (Solution without NAC); Drug: N-acetylcysteine; Drug: N-Acetylcysteine
Sponsors: Baylor College of Medicine; National Institute on Drug Abuse (NIDA)
Not yet recruiting - verified March 2010
Investigation of Cycloserine as a Smoking Cessation Treatment

Condition: Nicotine Addiction
Interventions: Drug: Cycloserine; Drug: Placebo
Sponsors: Baylor College of Medicine; National Institute on Drug Abuse (NIDA)
Recruiting - verified March 2010
An Ace Inhibitor as a Treatment for Methamphetamine Dependence.

Condition: Methamphetamine Addiction
Interventions: Drug: Perindopril; Other: Placebo
Sponsors: Baylor College of Medicine; National Institute on Drug Abuse (NIDA)
Recruiting - verified March 2010
Effects of a CRF1 Receptor Antagonist on Human Startle in Normal Female Volunteers

Condition: Anxiety Disorders
Intervention:
Sponsor: National Institute of Mental Health (NIMH)
Recruiting - verified December 2009
Multiple Dose Japanese Bridging Study

Condition: Alzheimer Disease
Interventions: Drug: BMS-708163; Drug: Placebo
Sponsor: Bristol-Myers Squibb
Not yet recruiting - verified January 2010
Safety and Immune Response of Candidate H1N1 Influenza Vaccine GSK2340274A Following Seasonal Influenza Vaccination in Adults

Condition: Influenza
Interventions: Biological: GSK Biologicals' investigational H1N1 Influenza Vaccine - GSK2340274A; Biological: GSK Biologicals' FluLaval®; Biological: Placebo (saline); Biological: GSK Biologicals' investigational H1N1 Influenza Vaccine - GSK2340273A
Sponsor: GlaxoSmithKline
Recruiting - verified March 2010
A Comparison Study of Two Community Outreach-Based Approaches to Increase Participation of Women Living in the Mississippi Delta in Cervical Cancer Screening

Conditions: Cervical Intraepithelial Neoplasia; Human Papillomavirus
Intervention:
Sponsor: National Cancer Institute (NCI)
Recruiting - verified December 2009
Dietary Supplements and Aging Muscle

Condition: Sarcopenia
Interventions: Dietary Supplement: Juven; Dietary Supplement: Juven
Sponsors: University of Alabama at Birmingham; National Center for Complementary and Alternative Medicine (NCCAM)
Recruiting - verified February 2010
Assessment of Fatty Acids in Infants' Blood Cells When Consuming Infant Formula Containing Long-Chain Polyunsaturated Fatty Acids

Condition: Levels of Fatty Acids in the Blood Cells of Infants
Intervention:
Sponsors: Mead Johnson; University of Alberta
Recruiting - verified March 2010
Treximet for Prevention of Post Traumatic Headache Associated With Cognitive Dysfunction

Condition: Post-Traumatic Headache
Interventions: Drug: sumatriptan/naproxen sodium; Drug: Placebo
Sponsors: Cady, Roger, M.D.; GlaxoSmithKline
Not yet recruiting - verified March 2010
Single Ascending Dose (BMS-813160) Study

Condition: Accelerated Intimal Hyperplasia
Interventions: Drug: BMS-813160; Drug: BMS-813160; Drug: BMS-813160; Drug: BMS-813160; Drug: BMS-813160; Drug: BMS-813160; Drug: [14C] BMS-813160; Drug: Placebo
Sponsor: Bristol-Myers Squibb
Recruiting - verified January 2010
Anesthetizing the Tympanic Membrane in Healthy Volunteers

Condition: Otitis Media
Intervention: Device: Acclarent Iontophoresis System
Sponsor: Acclarent
Recruiting - verified January 2010
ENGAGED: E-Networks Guiding Adherence to Goals for Exercise and Diet

Condition: Obesity
Interventions: Behavioral: Technology Supported; Behavioral: Gold Standard
Sponsors: Northwestern University; Illinois Institute of Technology
Not yet recruiting - verified March 2010
Feasibility Study of Anti-inflammatory Cytokines in Whole Blood in Osteoarthritis Patients

Condition: Osteoarthritis
Intervention:
Sponsor: Biomet, Inc.
Not yet recruiting - verified March 2010
To Evaluate Safety, Tolerability, Plasma Drug Levels And Other Biological Effects In Healthy Volunteers

Condition: Healthy
Interventions: Drug: PF-03382792 Cohort 1; Drug: PF-03382792 Cohort 2; Drug: PF-03382792; Drug: Food Effect cohort; Drug: CSF cohort
Sponsor: Pfizer
Recruiting - verified March 2010
Preventative Misconception Intervention

Conditions: HIV; HIV Infections
Interventions: Behavioral: 1-sided messages; Behavioral: 2-sided messages
Sponsors: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); National Institute on Drug Abuse (NIDA); National Institute of Mental Health (NIMH)
Recruiting - verified February 2010
Glutamine Therapy for Hemolysis-Associated Pulmonary Hypertension

Conditions: Pulmonary Hypertension; Sickle Cell Disease; Thalassemia
Interventions: Drug: L-Glutamine; Drug: L-Glutamine
Sponsor: Children's Hospital & Research Center Oakland
Recruiting - verified February 2010
A Study of V503 in Females 12-26 Years of Age Who Have Previously Received GARDASIL™

Conditions: Cervical Cancers; Vulvar Cancers; Vaginal Cancers; Genital Warts; Human Papillomavirus (HPV) Infection
Interventions: Biological: V503; Biological: Comparator: Placebo to V503
Sponsor: Merck
Recruiting - verified March 2010
Oral Glutathione Supplementation on the Levels of Blood Glutathione

Conditions: Glutathione; Healthy
Interventions: Drug: Glutathione supplementation; Drug: Glutathione supplementation; Other: Placebo
Sponsor: Penn State University
Recruiting - verified January 2010
Pharmacokinetics of MK4305 in Patients With Hepatic Insufficiency

Conditions: Insomnia; Hepatic Insufficiency
Intervention: Drug: MK4305
Sponsor: Merck
Recruiting - verified March 2010
Ridaforolimus in Patients With Hepatic Insufficiency

Conditions: Sarcoma; Hepatic Insufficiency
Intervention: Drug: ridaforolimus
Sponsors: Merck; Ariad Pharmaceuticals
Recruiting - verified March 2010
TMC435-TiDP16-C113: A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics of TMC435

Condition: Hepatitis C Virus
Intervention: Drug: TMC435
Sponsor: Tibotec Pharmaceuticals, Ireland
Recruiting - verified February 2010
Delivering an Evidence-Based Lifestyle Intervention Via the Internet: A Randomized Controlled Study

Condition: Obesity
Interventions: Behavioral: More-Intensive; Behavioral: Less-Intensive
Sponsors: University of Pittsburgh; Milton S. Hershey Medical Center; Department of Defense
Not yet recruiting - verified March 2010
Effects of Age on Response to the 2009 H1N1 Virus Vaccine

Condition: 2009 H1N1 Influenza Virus
Intervention: Biological: 2009 H1N1 Virus Vaccine
Sponsors: University of Rochester; National Institutes of Health (NIH)
Not yet recruiting - verified March 2010
Assessment of Multiple Intrauterine Gestations From Ovarian Stimulation

Conditions: Pregnancy; Unexplained Infertility
Interventions: Drug: Letrozole (aromatase inhibitor); Drug: Clomiphene Citrate; Drug: Follicle Stimulating Hormone (gonadotropin)
Sponsors: Yale University; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); Penn State University; University of Colorado, Denver; University of Michigan; University of Pennsylvania; University of Texas; University of Vermont; Wayne State University
Not yet recruiting - verified March 2010
Purple Grape Juice in Improving Vascular Health in Childhood Cancer Survivors

Condition: Cardiovascular Disease
Interventions: Other: Apple Juice/Grape Juice; Other: Grape Juice/Apple Juice
Sponsor: Masonic Cancer Center, University of Minnesota
Recruiting - verified March 2010
Effects of Exercise and Cognitive Training on Cognitive Function in Older Adults

Conditions: Aging; Alzheimer's Disease
Interventions: Other: Exercise Training; Other: Cognitive Training; Other: Flexibility Training; Other: Educational Sessions
Sponsors: The Cleveland Clinic; National Institutes of Health (NIH)
Recruiting - verified February 2009
Measuring Distress Tolerance With Functional MRI

Condition: Cocaine Dependence
Intervention:
Sponsors: National Institute on Drug Abuse (NIDA); National Institute on Drug Abuse and University of Maryland, College Park, MD
Recruiting - verified December 2009
Evaluation of the Cellular Pharmacology of Tenofovir and Emtricitabine According to HIV Infection Status

Condition: HIV Infections
Interventions: Drug: Emtricitabine (FTC); Drug: Tenofovir disoproxil fumarate (TDF); Drug: Efavirenz (EFV)
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting - verified December 2009
Drug-Drug Interaction Study With Aricept® (Donepezil)

Condition: Alzheimer Disease
Interventions: Drug: Donepezil; Drug: BMS-708163
Sponsor: Bristol-Myers Squibb
Recruiting - verified February 2010
Drug-Drug Interaction to Study the Effect of BMS-708163 on Pharmacokinetics (PK) of Galantamine Extended Release (ER)

Condition: Alzheimer Disease
Interventions: Drug: galantamine; Drug: galantamine; Drug: BMS-708163
Sponsor: Bristol-Myers Squibb
Recruiting - verified February 2010
Dopamine Function and Reward Processing In Schizophrenia

Condition: Schizophrenia
Intervention:
Sponsor: National Institute on Drug Abuse (NIDA)
Recruiting - verified October 2009
Effects of Sativex(Registered Trademark) and Oral THC on Attention, Affect, Working Memory, Reversal Learning, Physiology and Brain Activation

Conditions: Cannabis; Dependence; Cannabis Abuse; Pharmacokinetics; fMRI
Interventions: Drug: Sativex(Registered Trademark); Drug: THC
Sponsor: National Institute on Drug Abuse (NIDA)
Recruiting - verified February 2009
Effects of Nicotine on Cognitive Task Performance and Brain Activity as Measured by fMRI

Conditions: Nicotine Dependence; Drug Abuse
Intervention:
Sponsor: National Institute on Drug Abuse (NIDA)
Recruiting - verified March 2009
Effects of Nicotine on Brain Activity as Measured by fMRI

Conditions: Nicotine Dependence; Drug Abuse
Intervention:
Sponsor: National Institute on Drug Abuse (NIDA)
Recruiting - verified January 2009
Screening Protocol for the Evaluation of Research Participants

Conditions: Substance Abuse; Disorders
Intervention:
Sponsor: National Institute on Drug Abuse (NIDA)
Recruiting - verified February 2010
A Study of HM10760A (Long-acting Erythropoietin) in Healthy Adult Caucasian and Japanese Subjects

Condition: Healthy
Intervention: Drug: HM10760A or placebo
Sponsor: Hanmi Pharmaceutical Company Limited
Recruiting - verified February 2010
Cerebral Activity Related to Primary Motor Stereotypies in Children: An EEG Study.

Condition: Movement Disorder
Intervention:
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified October 2009
A Study to Assess Relative Bioavailability and Food Effect of New Formulations of GSK2248761

Condition: Infection, Human Immunodeficiency Virus
Interventions: Drug: GSK2248761 formulation 3; Drug: GSK2248761 formulation 1; Drug: GSK2248761 reference formulation; Drug: GSK2248761 formulation 2 or 4
Sponsor: GlaxoSmithKline
Recruiting - verified February 2010
Pilot Study of Transcranial Magnetic Stimulation (TMS) in Nicotine Addiction

Condition: Nicotine Dependence
Intervention: Device: Transcranial Magnetic Stimulation
Sponsor: National Institute on Drug Abuse (NIDA)
Recruiting - verified February 2010
The Effects of Expectation on Natural and Drug -Induced Rewards

Condition: Drug Abuse
Intervention:
Sponsor: National Institute on Drug Abuse (NIDA)
Not yet recruiting - verified June 2009
Risk Perception in Drug-Dependent Adults With and Without Schizophrenia

Conditions: Cocaine Dependence; Cannabis Dependence; Schizophrenia
Intervention:
Sponsor: National Institute on Drug Abuse (NIDA)
Recruiting - verified July 2009
A Phase II, Open Label Trial of a Vaccine (FSME-IMMUN 0.5 mL Baxter) Against Tick-borne Encephalitis (TBE) for NIAID Workers Manipulating Tick Borne Encephalitis Virus (TBEV) in the Laboratory

Conditions: Tick-Borne Encephalitis; Encephalitis, Tick-Borne; Tick-Borne Disease; Glycoprotein E, Flavivirus; NSI Protein, Flavivirus
Intervention: Biological: FSME-IMMUN 0.5ml Baxter
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified September 2009
Breath Carbon Monoxide and Cotinine as Biomarkers to Distinguish Smokers From Nonsmokers

Condition: Nicotine Dependence
Intervention:
Sponsor: National Institute on Drug Abuse (NIDA)
Recruiting - verified May 2009
Screening Protocol for the Evaluation of Research Participants at the Maryland Psychiatric Research Center (MPRC)

Condition: Substance Use Disorders
Intervention:
Sponsor: National Institute on Drug Abuse (NIDA)
Recruiting - verified April 2009
Immunogenicity of Off-Schedule Dosing of HPV Vaccine

Condition: Human Papillomavirus
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting - verified March 2010
Rivastigmine and Huperzine for Cocaine Dependence

Condition: Cocaine Dependence
Interventions: Other: Placebo; Drug: Rivastigmine
Sponsors: Baylor College of Medicine; National Institute on Drug Abuse (NIDA)
Recruiting - verified March 2010
Study to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of MBX-2982 Administered Daily for 4 Weeks as Monotherapy in Patients With Type 2 Diabetes

Condition: Diabetes
Interventions: Drug: MBX-2982; Drug: MBX-2982; Drug: MBX-2982; Drug: Sitagliptin; Drug: placebo
Sponsor: Metabolex
Recruiting - verified March 2010
Multiple Oral Dose Safety, Tolerability And Pharmacokinetic Study Of PF-04287881 In Healthy Adult Subjects

Condition: Respiratory Tract Infections
Interventions: Drug: PF-04287881; Drug: Placebo; Drug: PF-04287881; Drug: Placebo; Drug: PF-04287881; Drug: Placebo; Drug: PF-04287881; Drug: Placebo; Drug: PF-04287881; Drug: Placebo; Drug: PF-04287881; Drug: Placebo
Sponsor: Pfizer
Recruiting - verified March 2010
Pilot Study Repetitive Transcranial Magnetic Stimulation (rTMS) in Cannabis Craving

Condition: Cannabis Use
Intervention: Device: Repetitive Transcranial Magnetic Stimulation
Sponsor: National Institute on Drug Abuse (NIDA)
Not yet recruiting - verified January 2010
A Study of the Taste of Different Oral Liquid Preparations of CP-690,550 in Trained Adult Product Testers

Condition: Arthritis, Rheumatoid
Intervention: Drug: CP 690,550 oral solutions
Sponsor: Pfizer
Not yet recruiting - verified February 2010
Hepatic Impaired Subjects Compared to Healthy Subjects Receiving Multi-dose BMS-650032

Condition: Hepatic Insufficiency
Intervention: Drug: BMS-650032
Sponsor: Bristol-Myers Squibb
Recruiting - verified December 2009
Ascending Dose Study of the Safety and Tolerability of REGN727(SAR236553) in Healthy Volunteers

Condition: Healthy
Interventions: Biological: REGN727; Biological: Placebo
Sponsors: Regeneron Pharmaceuticals; Sanofi-Aventis
Recruiting - verified February 2010
Study Evaluating Persistence of Antibody Response Elicited by 13vPnC in Healthy Adults Previously Vaccinated

Condition: Healthy
Intervention: Procedure: Blood draw
Sponsor: Wyeth
Recruiting - verified March 2010
Prenatal Drug Exposure: Effects on the Adolescent Brain and Behavior Development

Conditions: Drug Abuse; Prenatal Drug Exposure
Intervention:
Sponsor: National Institute on Drug Abuse (NIDA)
Recruiting - verified September 2009
Ascending Dose Study of the Safety and Tolerability of REGN668(SAR231893) in Normal Healthy Volunteers

Condition: Healthy
Intervention: Biological: REGN668
Sponsors: Regeneron Pharmaceuticals; Sanofi-Aventis
Recruiting - verified February 2010
First In Human Study To Evaluate The Safety, Tolerability, Pharmacokinetics And Pharmacodynamics Of PF-04427429 Administered Intravenously To Healthy Adult Volunteers

Condition: Healthy Volunteers
Interventions: Drug: PF-04427429; Drug: PF-04427429; Drug: PF-04427429
Sponsor: Pfizer
Recruiting - verified March 2010
Internal Monitoring of Eye Movement in Schizophrenia

Condition: Schizophrenia
Intervention:
Sponsor: National Eye Institute (NEI)
Recruiting - verified October 2009
The Natural History of Severe Viral Infections and Characterization of Immune Defects in Patients Without Known Immunocompromise

Conditions: Herpesvirus; Adenovirus; Cytomegalovirus; Human Papillomavirus; Human Polyomavirus; Influenza Virus; Rhinovirus; Coronavirus; Respiratory Syncytial Virus
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified October 2009
To Demonstrate Superiority of Decitabine Over Azacitidine in Subjects With Intermediate- or High-risk MDS.

Condition: Myelodysplastic Syndromes
Interventions: Drug: decitabine; Drug: azacitidine
Sponsor: Eisai Inc.
Not yet recruiting - verified February 2010
Caverject User Study

Condition: Erectile Dysfunction
Intervention: Other: delivery system
Sponsor: Pfizer
Not yet recruiting - verified March 2010
Effect of PF-04360365 On ABETA In Patients With Alzheimer's Disease And Healthy Volunteers

Condition: Alzheimer's Disease
Interventions: Biological: PF-04360365; Drug: Placebo
Sponsor: Pfizer
Not yet recruiting - verified March 2010
Effect of Veramyst and Olopadatine 0.2% Opthalmic Solution on Allergy Symptoms

Condition: Seasonal Allergic Rhinitis
Interventions: Drug: Veramyst /Artificial tears; Drug: Veramyst / Artificial tears lubricant eye drops; Drug: Veramyst nasal spray and Olopatadine eye drops; Other: Veramyst placebo and Olopatadine0.2% eye drops
Sponsors: University of Chicago; GlaxoSmithKline
Recruiting - verified November 2009
Molecular and Morphologic Characterization of Circulating Endothelial Cells

Condition: Acute Myocardial Infarction
Intervention:
Sponsor: Scripps Translational Science Institute
Recruiting - verified March 2010
Bioavailability Study of Fixed Dose Combination (FDC) Formulations of Dapagliflozin and Metformin XR Versus Individual Component Coadministered to Healthy Subjects in a Fasted State

Condition: Type 2 Diabetes Mellitus (T2DM)
Interventions: Drug: Dapagliflozin; Drug: Metformin XR; Drug: Glucophage
Sponsors: Bristol-Myers Squibb; AstraZeneca
Recruiting - verified January 2010
Consistency & Immunogenicity Study of 3 Lots of GSK's Hib Conjugate Vaccine Versus ActHIB & Pentacel in Healthy Infants

Conditions: Haemophilus Influenzae Type B Related Disease; Pneumonia; Meningitis; Cellulitis; Osteomyelitis; Epiglottis
Interventions: Biological: InfanrixTM; Biological: GSK Biologicals' Haemophilus inluenzae type b vaccine (GSK 208108); Biological: ActHIBTM; Biological: PentacelTM; Biological: PediarixTM; Biological: PrevnarTM; Biological: RotarixTM; Biological: EngerixTM-B
Sponsor: GlaxoSmithKline
Not yet recruiting - verified March 2010
Clinical Trial of the PfSPZ Vaccine

Condition: Plasmodium Falciparum
Intervention: Biological: Plasmodium falciparum Sporozoite (strain NF-54; Anopheles stephensi mosquitoes) Vaccine, Live, Inactivated (gamma irradiation)
Sponsors: Sanaria Inc.; The PATH Malaria Vaccine Initiative (MVI)
Recruiting - verified March 2010
A Study of ABT-384 Levels and Pharmacodynamic Activity Measured in Cerebrospinal Fluid

Condition: Healthy
Intervention: Drug: ABT-384
Sponsor: Abbott
Recruiting - verified February 2010
VRC 309: A Multi-Center, Open-Label, Randomized Phase I Study of an Investigational Influenza DNA Vaccine Followed by 2009/2010 Seasonal Influenza Trivalent Inactivated Vaccine (TIV) Compared to Two Injections of TIV in Adults 45-70 Years

Condition: Influenza, Human
Intervention: Biological: VRC-FLUDNA056-00VP
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified October 2009
Study to Assess the Effect of BMS-791325 on the Pharmacokinetics of Midazolam in Healthy Subjects

Condition: Hepatitis C
Interventions: Drug: Midazolam; Drug: BMS-791325
Sponsor: Bristol-Myers Squibb
Not yet recruiting - verified November 2009
A Study of a Levonorgestrel-Releasing Intrauterine System for Long-Term, Reversible Contraception

Condition: Contraception
Interventions: Drug: LNG20; Drug: Mirena
Sponsor: Medicines360
Recruiting - verified February 2010
Safety, Tolerability, Pharmacokinetics And Measurement Of Whole Blood Activity (WBA) Of PNU-100480 After Multiple Oral Doses In Healthy Adult Volunteers

Condition: Tuberculosis
Interventions: Drug: PNU-100480; Drug: Placebo; Drug: PNU-100480; Drug: Placebo; Drug: PNU-100480; Drug: Placebo; Drug: PNU-100480; Drug: Placebo; Drug: PNU-100480; Drug: Placebo; Drug: PNU-100480; Drug: Placebo; Drug: Linezolid
Sponsor: Pfizer
Recruiting - verified March 2010
Novartis H1N1 Vaccine in Pregnant Women

Condition: Influenza
Intervention: Biological: Inactivated H1N1 Vaccine
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified November 2009
To Compare Positron Emission Tomography (PET) Measurements of Fibrillar Amyloid Burden

Condition: Alzheimer's Disease
Intervention: Drug: [18F]AZD4694
Sponsors: AstraZeneca; Banner Alzheimer's Institute
Recruiting - verified February 2010
Durability of Adherence in Self-Management of HIV (The DASH Study)

Condition: HIV Infections
Intervention: Behavioral: Modified client adherence profiling and intervention tailoring (CAP-IT)
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified October 2009
Sugammadex Hypersensitivity Study (Study P06042)

Condition: Hypersensitivity
Interventions: Drug: Sugammadex 4 mg/kg; Drug: Sugammadex 16 mg/kg; Drug: Placebo
Sponsor: Schering-Plough
Recruiting - verified March 2010
Neural Prostheses and Gait Performance: Model-Based Strategies

Condition: Hemiplegia
Intervention: Device: EMS 2000
Sponsor: Department of Veterans Affairs
Recruiting - verified March 2010
A Study of V503 Given Concomitantly With Menactra™ and Adacel™ in 11 to 15 Year Olds

Condition: Human Papillomavirus Infection
Interventions: Biological: V503; Biological: Comparator: Menactra™ (Concomitant); Biological: Comparator: Adacel™ (concomitant); Biological: Comparator: Menactra™ (Non-Concomitant); Biological: Comparator: Adacel™ (Non-concomitant)
Sponsor: Merck
Recruiting - verified March 2010
The Effects AZD8529 on Ketamine-induced Impairment of Working Memory in Healthy Volunteers

Conditions: Healthy; Memory Impairment
Interventions: Drug: AZD8529; Drug: Placebo to match AZD8529
Sponsor: AstraZeneca
Recruiting - verified February 2010
Study to Assess the Effect of BMS-790052 on the Pharmacokinetics of Ortho Tri-Cyclen® in Healthy Female Subjects

Condition: Chronic Hepatitis C
Interventions: Drug: BMS-790052; Drug: Ortho Tri-Cyclen®
Sponsor: Bristol-Myers Squibb
Recruiting - verified November 2009
Molecular Correlates of Sensitivity and Resistance to Therapy in Prostate Cancer

Condition: Metastatic Prostate Cancer
Intervention:
Sponsor: Fred Hutchinson Cancer Research Center
Recruiting - verified February 2010
Studying the Effects of Antihypertensives on Individuals at Risk for Alzheimer's

Conditions: Alzheimer's Disease; Hypertension
Interventions: Drug: Ramipril; Drug: Placebo
Sponsor: University of Wisconsin, Madison
Recruiting - verified March 2010
A Study To Investigate Whether PF-04457845 Is Effective In Treating Pain, Is Safe And Tolerable In Patients With Osteoarthritis Of The Knee

Condition: Osteoarthritis, Knee
Interventions: Drug: PF-04457845; Drug: PF-04457845; Drug: Naproxen; Drug: Naproxen
Sponsor: Pfizer
Recruiting - verified March 2010
Simulated Diabetes Training for Resident Physicians

Condition: Type 2 Diabetes
Intervention: Other: Simulated Diabetes Training
Sponsors: HealthPartners Research Foundation; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Not yet recruiting - verified March 2010
Phase I STEBVax in Healthy Adults

Condition: Staphylococcus Enterotoxin B
Intervention: Biological: STEBVax
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting - verified February 2010
Assessment of Older Adults With Cancer: Feasibility of Computer Survey Methodology

Condition: Assessment, Geriatric
Intervention:
Sponsors: City of Hope Medical Center; National Institutes of Health (NIH)
Recruiting - verified March 2010
Safety Study of AMG 157 in Healthy Subjects

Condition: Healthy Volunteers
Interventions: Drug: AMG 157; Drug: AMG 157 Placebo
Sponsor: Amgen
Recruiting - verified February 2010
Thyroid Function in Late Preterm Infants

Condition: Transient Hypothyroxinemia
Intervention:
Sponsor: Christiana Care Health Services
Recruiting - verified March 2010
Muscle Mass During Space Exploration

Condition: Sarcopenia
Interventions: Dietary Supplement: Leucine; Dietary Supplement: Leucine
Sponsors: The University of Texas, Galveston; National Space Biomedical Research Institute
Recruiting - verified March 2010
Understanding the Psychosocial Needs of Parents Who Have Lost a Child to Cancer

Condition: Parents Who Have Lost a Child to Cancer
Intervention: Behavioral: Questionnaires/Interviews
Sponsors: Memorial Sloan-Kettering Cancer Center; National Cancer Institute (NCI); Dana Farber Cancer Institute/Harvard Medical School; Ohio State University; University of Memphis
Recruiting - verified March 2010
Flu Vaccine in Preventing Influenza Infection in Healthy Volunteers and in Patients Who Have Undergone Stem Cell Transplant

Conditions: Chronic Myeloproliferative Disorders; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Diseases; Nonmalignant Neoplasm
Interventions: Biological: trivalent influenza vaccine; Other: immunoenzyme technique; Other: laboratory biomarker analysis
Sponsors: Beckman Research Institute; National Cancer Institute (NCI)
Recruiting - verified August 2009
NAVISTAR® THERMOCOOL® Catheter for the Radiofrequency Ablation of Drug Refractory Recurrent Symptomatic Paroxysmal Atrial Fibrillation

Condition: Paroxysmal Atrial Fibrillation
Interventions: Procedure: Atrial Fibrillation ablation procedure; Device: NAVISTAR THERMOCOOL and NAVISTAR EZ STEER THERMOCOOL
Sponsor: Biosense Webster, Inc.
Recruiting - verified February 2010
A Multiple Dose Study Of PF-04620110 In Overweight And Obese, Otherwise Healthy Volunteers

Conditions: Obesity; Overweight; Healthy
Interventions: Drug: PF-04620110; Drug: Placebo
Sponsors: Pfizer; Bristol-Myers Squibb
Recruiting - verified March 2010
OsseoFix™ Spinal Fracture Reduction System in Treating Spinal Compression Fracture

Condition: Vertebral Compression Fractures
Intervention: Device: OsseoFix Spinal Fracture Reduction System
Sponsor: Alphatec Spine, Inc.
Recruiting - verified March 2010
Biomarkers of the Response to Osteopathic Manipulation

Condition: Healthy
Interventions: Other: Osteopathic Manipulation; Other: Placebo
Sponsors: West Virginia School of Osteopathic Medicine; American Osteopathic Association
Recruiting - verified March 2010
Bacterial Overgrowth Associated With Chronic Multisymptom Illness Complex

Condition: Gulf War Syndrome
Interventions: Procedure: Lactulose Breath Test; Drug: Rifaximin; Drug: Placebo; Drug: Erythromycin ethylsuccinate (EES); Drug: Placebo; Drug: Bismuth subsalicylate
Sponsor: VA Merit Review, DOD (Department of Defense)
Recruiting - verified February 2010
Omega-3 Supplementation Decreases Inflammation and Fetal Obesity in Pregnancy

Conditions: Inflammation; Obesity; Pregnancy; Fetal Growth
Intervention: Dietary Supplement: Omega-3 Fish Oil
Sponsors: MetroHealth Medical Center; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified March 2010
Does Small Intestinal Bacterial Overgrowth Contribute to Functional Dyspepsia

Conditions: Functional Dyspepsia; Small Intestinal Bacterial Overgrowth; Chronic Abdominal Discomfort
Interventions: Drug: Rifaximin; Procedure: Lactulose Breath Test; Drug: Placebo
Sponsor: National Institutes of Health (NIH)
Recruiting - verified February 2010
Influenza Vaccine in Preventing Flu in Patients Who Have Undergone Stem Cell Transplant and in Healthy Volunteers

Conditions: Chronic Myeloproliferative Disorders; Leukemia; Lymphoma; Lymphoproliferative Disorder; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Diseases; Nonmalignant Neoplasm; Viral Infection
Interventions: Other: cytology specimen collection procedure; Other: fluorescent antibody technique; Procedure: assessment of therapy complications
Sponsors: Beckman Research Institute; National Cancer Institute (NCI)
Recruiting - verified August 2009
The Genetics of Evoked Responses to Niacin and Endotoxemia: The GENE Study

Condition: Healthy Volunteers
Intervention: Drug: Immediate Release Niacin, Extended Release Niacin, Endotoxin
Sponsor: University of Pennsylvania
Recruiting - verified March 2010
Treatment De-Intensification for Squamous Cell Carcinoma of the Oropharynx

Condition: Squamous Cell Carcinoma of Oropharynx
Interventions: Radiation: IMRT; Drug: Cisplatin; Drug: Carboplatin
Sponsor: Sidney Kimmel Comprehensive Cancer Center
Recruiting - verified March 2010
Japanese Bridging Study Conducted in the United States

Condition: Hepatitis C Virus
Interventions: Drug: BMS-791325; Drug: BMS-791325; Drug: BMS-791325; Drug: BMS-791325; Drug: BMS-791325; Drug: BMS-791325; Drug: Placebo; Drug: Placebo; Drug: Placebo; Drug: Placebo
Sponsor: Bristol-Myers Squibb
Not yet recruiting - verified November 2009
Pioglitazone for Oral Premalignant Lesions

Conditions: Mouth Cancer; Oral Cancer
Interventions: Drug: Pioglitazone; Drug: Placebo
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting - verified March 2010
Wiser Choices in Osteoporosis Choice II: A Decision Aid for Patients and Clinicians

Conditions: Osteoporosis; Osteopenia; Fragility Fractures
Interventions: Behavioral: FRAX + Decision Aid; Behavioral: FRAX estimated fracture risk
Sponsors: Mayo Clinic; Foundation for Informed Medical Decision Making; Olmsted Medical Center
Recruiting - verified February 2010
Xenin-25: Novel Regulator of Insulin Secretion and Beta-cell Function

Condition: Type 2 Diabetes Mellitus
Intervention: Other: There are no interventions, this is not a treatment study.
Sponsor: Washington University School of Medicine
Not yet recruiting - verified February 2010
Fat Mediated Modulation of Reproductive and Endocrine Function in Young Athletes

Conditions: Amenorrhea; Female Athlete Triad Syndrome
Interventions: Drug: Transdermal 17Beta-estradiol, progesterone; Drug: Ethinyl Estradiol + Desogestrel; Dietary Supplement: Elemental Calcium and Vitamin D
Sponsors: Massachusetts General Hospital; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified March 2010
Safety and Tolerability of Repeat Doses of ACU-4429 in Healthy Subjects

Condition: Healthy
Interventions: Drug: ACU-4429; Drug: matching placebo tablet
Sponsors: Acucela Inc.; Otsuka Pharmaceutical Co., Ltd.
Recruiting - verified March 2010
A Study of the Effects of Multiple Doses of Dexlansoprazole, Lansoprazole, Omeprazole or Esomeprazole on the Pharmacokinetics and Pharmacodynamics of Clopidogrel in Healthy Subjects.

Condition: Healthy
Interventions: Drug: Clopidogrel; Drug: Clopidogrel and Lansoprazole; Drug: Clopidogrel and Dexlansoprazole; Drug: Clopidogrel and Omeprazole; Drug: Clopidogrel and Esomeprazole
Sponsor: Takeda Global Research & Development Center, Inc.
Recruiting - verified March 2010
A Study of V503 in Preadolescents and Adolescents

Conditions: Cervical Cancer; Vulvar Cancer; Vaginal Cancer; Genital Lesions; PAP Test Abnormalities; HPV Infections
Intervention: Biological: V503
Sponsor: Merck
Recruiting - verified March 2010
College Students and Smoking Cessation

Conditions: Smoking Cessation; Habits; Smoking
Interventions: Behavioral: Survey; Behavioral: Counseling; Behavioral: Survey; Behavioral: Counseling
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting - verified March 2010
Drug Interaction Study Between Inhaled Beclomethasone and Protease Inhibitors in Healthy Volunteers

Conditions: HIV; Asthma
Interventions: Drug: Darunavir; Drug: Ritonavir; Drug: Beclomethasone Dipropionate HFA
Sponsor: National Institutes of Health Clinical Center (CC)
Recruiting - verified July 2009
Daily Wear Corneal Infiltrative Event Study

Conditions: Myopia; Hyperopia; Corneal Infiltrative Events
Intervention: Device: lotrafilcon A contact lenses
Sponsors: University Hospital Case Medical Center; Alcon Laboratories
Recruiting - verified January 2010
Development of Self-Regulation in Individuals With Type 2 Diabetes

Condition: Type 2 Diabetes
Interventions: Behavioral: Dietary; Behavioral: Physical Activity; Behavioral: Self-Regulatory Approaches
Sponsors: University of Tennessee; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Abbott Diabetes Care
Recruiting - verified March 2010
GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression

Conditions: Epilepsy; Epilepsy, Temporal Lobe; Depression; Depressive Disorder, Major
Intervention:
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2010
Evaluation of BAY 94-9172 PET Imaging of ß-amyloid in Individuals With Down Syndrome Compared to Individuals Without Down SyndromeEvaluation of BAY 94-9172 PET Imaging of ß-amyloid in Individuals With Down Syndrome Compared to Individuals Without Down Syndrome

Conditions: Down Syndrome; Amyloid Beta-Protein
Intervention: Drug: BAY94-9172
Sponsor: Bayer
Recruiting - verified February 2010
An Exploratory Evaluation of Biomarkers in Blister Fluid in Healthy Volunteers and Irradiated Skin

Conditions: Breast Cancer; Healthy Volunteer
Intervention:
Sponsor: National Cancer Institute (NCI)
Recruiting - verified March 2010
A Study of the Safety and How the Body Affects a Drug (CNTO 1959) in Healthy Volunteers and in Patients With Psoriasis

Condition: Psoriasis
Intervention: Drug: CNTO 1959; Placebo
Sponsor: Centocor, Inc.
Recruiting - verified February 2010
Biomarkers in the Evaluation of Chronic Lung Disease

Conditions: Pulmonary Hypertension; Pulmonary Arterial Hypertension; Interstitial Lung Disease
Interventions: Other: Blood Gas; Other: Pulmonary Exercise Test; Other: Spirometry; Other: Breath Condensate Collector
Sponsor: North Shore Long Island Jewish Health System
Recruiting - verified March 2010
Safety and Tolerability of STP206 in Healthy Adult Subjects

Condition: Healthy
Intervention: Drug: STP206 or vehicle control
Sponsor: Sigma Tau Pharmaceuticals, Inc.
Recruiting - verified March 2010
Exercise or Relaxation for Smoking Cessation

Conditions: Nicotine Dependence; Smoking Cessation
Interventions: Other: Varenicline and smoking cessation counseling; Behavioral: Exercise or relaxation treatment
Sponsors: University of Connecticut Health Center; National Institutes of Health (NIH); National Institute on Drug Abuse (NIDA)
Recruiting - verified February 2010
Investigation of Neuroserpin as an Autism Candidate Gene

Condition: Autism
Intervention:
Sponsor: State University of New York - Upstate Medical University
Not yet recruiting - verified February 2010
Lyophilized IMVAMUNE® (1x10^8 TCID50) Versus Liquid IMVAMUNE® (1x10^8 TCID50) Administered Subcutaneously and a Lower Dose Liquid IMVAMUNE® (2x10^7 TCID50) Administered Intradermally

Condition: Variola Major (Smallpox)
Interventions: Biological: IMVAMUNE® (liquid, intradermal); Biological: IMVAMUNE® (lyophilized); Biological: IMVAMUNE® (liquid, subcutaneous)
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified January 2010
Selective Depletion of CD45RA+T Cells From Allogeneic Peripheral Blood Stem Cell Grafts for the Prevention of GVHD

Conditions: Graft Versus Host Disease; Leukemia; Myelodysplastic Syndromes
Interventions: Drug: Fludarabine Phosphate; Drug: Tacrolimus; Drug: Thiotepa; Radiation: Total-Body Irradiation (TBI); Device: Magnetic-Activated Cell Sorter (CliniMACS, Miltenyi)
Sponsors: Yale University; National Cancer Institute (NCI); Fred Hutchinson Cancer Research Center
Recruiting - verified March 2010
Booster Trial to 07-0019 With A/Anhui/05 With and Without MF59

Condition: Influenza
Interventions: Biological: A/Anhui/05; Biological: MF-59; Drug: Placebo
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting - verified December 2009
Repetitive Transcranial Magnetic Stimulation (rTMS) to Promote Hand Recovery in Stroke

Condition: Stroke
Interventions: Device: rTMS; Procedure: Motor learning training; Procedure: rTMS and Tracking; Device: Sham rTMS
Sponsor: University of Minnesota - Clinical and Translational Science Institute
Recruiting - verified March 2010
Nontypeable H. Influenzae in Healthy Adults

Condition: Haemophilus Influenzae (NTHI)
Intervention: Biological: NTHi Strain 2019
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified December 2009
Safety, Pharmacokinetics and Pharmacodynamics Study to Evaluate BMS-830216 in Obese Subjects

Condition: Obesity
Interventions: Drug: BMS-830216; Drug: BMS-830216; Drug: BMS-830216; Drug: BMS-830216; Drug: BMS-830216; Drug: BMS-830216; Drug: Placebo
Sponsor: Bristol-Myers Squibb
Recruiting - verified January 2010
Functional Magnetic Resonance Imaging (fMRI) of Anosognosia in Amnestic Mild Cognitive Impairment (MCI) and Alzheimer's Disease (AD)

Conditions: Anosognosia; Alzheimer's Disease; Mild Cognitive Impairment
Intervention:
Sponsor: University of Wisconsin, Madison
Recruiting - verified March 2010
Changes in the Posterior Parietal Cortex - Primary Motor Cortex Pathway Induced by Motor Training

Conditions: Movement Disorders; Heathly Subjects
Intervention:
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2010
Laboratory Assay in Determining Cancer Resistance in Patients With Metastatic Cancer and in Healthy Participants

Condition: Cancer
Interventions: Other: immunological diagnostic method; Other: physiologic testing
Sponsors: Wake Forest University; National Cancer Institute (NCI)
Recruiting - verified June 2009
Magnetic Resonance Elastography for Assessment of Liver Fibrosis

Conditions: Liver Fibrosis; Hepatitis C Virus
Intervention: Procedure: Comparator: Magnetic Resonance Elastography (MRE)
Sponsor: Merck
Recruiting - verified March 2010
Establishing Fibroblast-Derived Cell Lines From Skin Biopsies of Patients With Immunodeficiency or Immunodysregulation Disorders

Conditions: Lymphohistiocytosis, Hemophagocytic; Common Variable Immunodeficiency; Severe Combined Immunodeficiency
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified February 2010
Multimodal Neuroimaging of Treatment Effects in Adolescent Mania

Condition: Adolescent Mania
Interventions: Drug: Quetiapine & Placebo; Drug: Lithium and Placebo; Other: Healthy Controls
Sponsors: University of Cincinnati; Children's Hospital Medical Center, Cincinnati
Recruiting - verified March 2010
Functional MRI Before and After Treatment for Depression

Conditions: Depression; Mood Disorders; Depressive Disorder
Intervention: Drug: Citalopram
Sponsor: Stanford University
Recruiting - verified February 2010
Biomarkers of Cardiometabolic Risk in Children Treated With Antipsychotics: A Preliminary Study of Direct Measures

Condition: Mental Disorders
Intervention: Procedure: Testing (MRS, US, DEXA)
Sponsor: Washington University School of Medicine
Recruiting - verified March 2010
Evaluation of Limb-Girdle Muscular Dystrophy

Conditions: Becker Muscular Dystrophy; Limb-Girdle Muscular Dystrophy, Type 2A; Calpain-3 Deficiency; Limb-Girdle Muscular Dystrophy, Type 2B; Miyoshi Myopathy; Dysferlin Deficiency; Limb-Girdle Muscular Dystrophy, Type 2I; FKRP-deficiency
Intervention:
Sponsors: Cooperative International Neuromuscular Research Group; Children's Research Institute; Muscular Dystrophy Association; Levine Children's Hospital at Carolinas Medical Center
Recruiting - verified March 2010
Phase I Study of the Safety and Immunogenicity of BSAM-2/Alhydrogel(Registered Trademark)+CPG 7909, an Asexual Blood Stage Vaccine for Plasmodium Falciparum Malaria in Adults in the US and Mali

Condition: Malaria
Intervention: Drug: BSAM2/Alhydrogel + CPG 7909
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified April 2009
Fatigue in Healthy Individuals

Conditions: Healthy Volunteer; Fatigue; Depression
Intervention:
Sponsor: National Institute of Nursing Research (NINR)
Recruiting - verified February 2010
An Evaluation of a New Technique Utilizing a Biologic Glue and Tissue Patch to Seal the Cut Edge of the Pancreas Following Removal of the Tail of the Pancreas

Conditions: Pancreatic Fistula; Distal Pancreatectomy Complications; Falciform Patch Pancreatic Closure; Fibrin Glue Pancreatic Closure
Interventions: Procedure: Falciform patch and fibrin glue application; Procedure: standard pancreatic closure
Sponsor: Thomas Jefferson University
Recruiting - verified February 2010
Technology-Enhanced Quitline Services to Prevent Smoking Relapse

Condition: Smoking Cessation
Interventions: Behavioral: Quitline Service + 10 automated monitoring calls; Behavioral: Quitline service + 20 automated monitoring calls
Sponsors: Indiana University; Free and Clear, Inc.; Kaiser Foundation Hospitals, Center for Health Research; University of Washington
Not yet recruiting - verified March 2010
The Role of Family Functioning in Adaptation to Being a Caregiver of an Individual With Rett Syndrome

Condition: Rett Syndrome
Intervention:
Sponsor: National Human Genome Research Institute (NHGRI)
Recruiting - verified April 2009
Pilot Study of Nicotine Replacement for Smoking Cessation During Pregnancy

Condition: Tobacco Use Disorder
Intervention: Drug: Nicotrol Inhaler
Sponsors: Hartford Hospital; University of Connecticut Health Center
Recruiting - verified February 2010
A Study of the Safety, Pharmacokinetics, and Pharmacodynamics of CNTO 3649 in Healthy Adults and Patients With Type 2 Diabetes Mellitus

Condition: Diabetes Mellitus, Type 2
Intervention: Drug: CNTO 3649; Placebo
Sponsor: Centocor, Inc.
Recruiting - verified February 2010
Broccoli Sprout Extract Effects on Allergic Inflammation in the Nose

Condition: Allergic Airway Disease
Intervention: Drug: Broccoli sprout extract
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified May 2009
Irritable Bowel Syndrome (IBS) Functional Magnetic Resonance Imaging (fMRI) With Desipramine

Condition: Irritable Bowel Syndrome
Intervention: Drug: Desipramine
Sponsor: Washington University School of Medicine
Recruiting - verified March 2010
Assessment of Screening Modalities for Gynecologic Cancers

Conditions: Ovarian Cancer; Endometrial Cancer
Intervention:
Sponsor: National Cancer Institute (NCI)
Recruiting - verified February 2010
Pharmacokinetic Assessment of Sodium Sulfide in Subjects With Impaired Renal Function

Condition: Renal Impairment
Intervention: Drug: IK-1001
Sponsor: Ikaria Holdings Inc.
Recruiting - verified February 2010
Exploring a Motor Learning Technique Based on the Mirror Motor Neuron System

Condition: Healthy
Intervention:
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2010
Laparoscopic Radiofrequency Ablation of Symptomatic Uterine Fibroids

Conditions: Uterine Fibroids; Uterine Myomas
Intervention: Device: Halt System
Sponsor: Halt Medical, Inc
Recruiting - verified March 2010
Model 4195 Left Ventricular (LV) Lead Chronic Performance Study

Condition: Heart Failure
Intervention:
Sponsor: Medtronic Cardiac Rhythm Disease Management
Recruiting - verified February 2010
Iron & Vitamin C Study

Condition: Spinal Cord Injury
Intervention:
Sponsor: Department of Veterans Affairs
Recruiting - verified March 2010
Pregnancy-Induced Analgesia - A Longitudinal Study of DNIC

Conditions: Pregnancy; Pregnant Women
Intervention:
Sponsors: University of Washington; Stanford University
Recruiting - verified March 2010
Psychology of Reward and Punishment: Functional and Molecular Brain Imaging and Monoaminergic Correlates

Conditions: Cocaine Addiction; Cocaine Abuse
Intervention:
Sponsor: National Institute on Drug Abuse (NIDA)
Not yet recruiting - verified January 2010
Vitamin E Pharmacokinetics and Biomarkers in Normal and Obese Women

Condition: Diabetes Mellitus Type II Non Insulin Dependent
Interventions: Dietary Supplement: Vitamin E; Dietary Supplement: Vitamin C; Dietary Supplement: Lipid Oxidation
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified January 2010
Combination Pain Therapy in HIV Neuropathy

Conditions: HIV Infections; Peripheral Neuropathy
Interventions: Drug: Duloxetine; Drug: Duloxetine placebo; Drug: Methadone; Drug: Methadone placebo
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified May 2009
Utilizing Blood Volume Measurements in the Treatment of Heart Failure Patients

Condition: Congestive Heart Failure
Interventions: Other: Ultrafiltration; Other: Ultrafiltration using BVM
Sponsors: Christiana Care Health Services; Daxor Corporation
Recruiting - verified March 2010
Neurosciences Research Repository

Condition: Neurological Conditions
Intervention: Other: tissue and data repository
Sponsors: The University of Texas Health Science Center, Houston; The Vivian L. Smith Center for Neurologic Research
Recruiting - verified March 2010
The Effect of Hypertension Medications on Renal Blood Flow Measurements in Healthy Males

Condition: Hypertension
Interventions: Drug: Aliskiren; Drug: Aliskiren; Drug: Comparator: Losartan; Drug: Comparator: Placebo to Aliskiren; Drug: Comparator: Placebo to Losartan
Sponsor: Merck
Recruiting - verified March 2010
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee

Conditions: Osteoarthritis; Traumatic Arthritis; Avascular Necrosis of the Femoral Condyle; Moderate Varus; Valgus; Flexion Deformities
Intervention: Device: NexGen LPS-Flex Mobile Bearing Knee
Sponsor: Zimmer, Inc.
Recruiting - verified March 2010
Family Weight Management Study

Conditions: Obesity; Diabetes
Intervention: Behavioral: lifestyle intervention
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified January 2010
Evaluation of VA's Traumatic Brain Injury (TBI) Clinical Reminder and Comprehensive TBI Evaluation

Condition: Mild Traumatic Brain Injury
Intervention:
Sponsor: Department of Veterans Affairs
Not yet recruiting - verified February 2010
Evaluating Post-test HIV Counseling Videos for Teens

Conditions: HIV; HIV Infections
Intervention: Behavioral: Video
Sponsors: North Bronx Healthcare Network; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified March 2010
A Comparison of Two Freezing Techniques

Condition: Infertility
Intervention: Procedure: oocyte freezing
Sponsors: North Shore Long Island Jewish Health System; EMD Serono
Recruiting - verified March 2010
Recalcitrant Pruritus in Cutaneous T-Cell Lymphoma

Condition: Cutaneous T-Cell Lymphoma
Intervention: Procedure: skin biopsy
Sponsor: University of Minnesota - Clinical and Translational Science Institute
Recruiting - verified March 2010
A Preliminary Study Utilizing a Flexible Endoscope for Pelvic Culdoscopy

Condition: Diagnostic or Therapeutic Laparoscopy
Intervention:
Sponsor: University of Arkansas
Recruiting - verified March 2010
Protocol For The Quantitation Of Pain In The Diagnosis Of Polymyalgia Rheumatica

Conditions: Polymyalgia Rheumatica; Rheumatoid Arthritis; Rheumatic Disease
Intervention:
Sponsor: Lahey Clinic
Recruiting - verified March 2010
Ghrelin Regulation and Structure: Effect of Thiazolidinedione Therapy on Ghrelin

Conditions: Obesity; Insulin Resistance
Interventions: Drug: placebo; Drug: pioglitazone
Sponsor: Oregon Health and Science University
Recruiting - verified March 2010
fMRI of Language Recovery Following Stroke in Adults

Conditions: Aphasia; Stroke
Intervention:
Sponsors: University of Cincinnati; National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified March 2010
Chronic Rhinosinusitis With or Without Nasal Polyps Steroid Study

Conditions: Chronic Sinusitis; Chronic Rhinosinusitis; Nasal Polyps
Intervention: Drug: Prednisone
Sponsor: Northwestern University
Recruiting - verified February 2010
Effects of Weight Loss From Bariatric Surgery on IOP

Condition: Intraocular Pressure
Intervention:
Sponsor: The University of Texas Health Science Center, Houston
Not yet recruiting - verified February 2010
An Alternative Dosing Schedule of Varenicline for Smoking Cessation

Condition: Smoking Cessation
Interventions: Drug: varenicline; Drug: placebo
Sponsors: Roswell Park Cancer Institute; Pfizer
Recruiting - verified March 2010
Brief Interventions to Increase HPV Vaccine Acceptance in School-based Health Centers

Condition: Human Papillomavirus Infection
Interventions: Behavioral: Compliance; Behavioral: Message sidedness
Sponsors: Indiana University; Merck
Not yet recruiting - verified February 2010
Longitudinal Study of the Human Intestinal Microbiome

Condition: Intestinal Microbiome
Intervention: Drug: Ciprofloxacin hydrochloride
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified March 2009
Collecting Blood and Tissue Samples From Family Members of Patients With Pancreatic Diseases, Pancreatic Cancer, and Melanoma

Condition: Health Status Unknown
Interventions: Other: biologic sample preservation procedure; Other: medical chart review; Other: survey administration; Procedure: evaluation of cancer risk factors
Sponsors: Mayo Clinic; National Cancer Institute (NCI)
Recruiting - verified January 2009
Stress Management Intervention for Caregivers of Patients Undergoing Bone Marrow Transplant

Conditions: Breast Cancer; Chronic Myeloproliferative Disorders; Gestational Trophoblastic Tumor; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Diseases; Neuroblastoma; Ovarian Cancer; Testicular Germ Cell Tumor
Interventions: Other: educational intervention; Other: laboratory biomarker analysis; Other: questionnaire administration; Other: survey administration; Procedure: psychosocial assessment and care; Procedure: stress management therapy; Procedure: support group therapy
Sponsors: University of Colorado, Denver; National Cancer Institute (NCI)
Recruiting - verified January 2009
A Pilot Study of Pulmonary Function in Dysphagic Infants

Condition: Chronic Lung Disease
Intervention: Procedure: Infant Pulmonary Function Tests
Sponsors: University of Tennessee; University of Tennessee Health Science Center
Recruiting - verified March 2010
Study Evaluating Prevnar Infant Long-term Immune Response Versus Prevnar Naive Cohort

Condition: Pneumococcal Conjugate Vaccine
Intervention: Biological: 13vPnC
Sponsor: Wyeth
Recruiting - verified February 2010
Understanding Patient's Knowledge and Use of Acetaminophen

Condition: Liver Failure
Interventions: Behavioral: Focus Groups; Behavioral: Personal Interviews
Sponsor: M.D. Anderson Cancer Center
Recruiting - verified February 2010
Behavior and Exercise Versus Drug Treatment in Men With Nocturia (BEDTiMe)

Condition: Nocturia
Interventions: Behavioral: Behavioral; Drug: tamsulosin (alpha-adrenergic antagonist medication); Drug: placebo; Behavioral: placebo
Sponsors: Atlanta VA Medical Center; Emory University; University of Alabama at Birmingham
Recruiting - verified March 2010
African American Church-based Cohort

Condition: Cancer
Interventions: Behavioral: Questionnaire; Other: Body Measurements; Behavioral: Self-help Materials
Sponsor: M.D. Anderson Cancer Center
Recruiting - verified February 2010
Safety of and Immune Response to a Prime-Boost Vaccine Regimen in HIV-Uninfected Vaccine-Naive Adults

Condition: HIV Infections
Interventions: Biological: Vaccine; Biological: Placebo
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified May 2009
Improving the Delivery of Smoking Cessation Guidelines in Hospitalized Veterans

Condition: Cigarette Smoking
Intervention: Behavioral: Smoking Cessation Guideline Implementation
Sponsors: Department of Veterans Affairs; National Jewish Hospital Quitline; Iowa State University
Recruiting - verified March 2010
Pharmacogenomic Response to Thyrotropin-Releasing Hormone Stimulation in Healthy Volunteers: The Influence of a Common Type 2 Deiodinase Genetic Polymorphism on Serum T3

Conditions: Thyroid Disease; Healthy
Intervention:
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified October 2009
Safety and Efficacy of Tapentadol Immediate Release (IR) and Oxycodone Immediate Release (IR) for Treatment of Acute Post-op Pain Following Elective Arthroscopic Shoulder Surgery

Condition: Postoperative Pain
Interventions: Drug: Oxycodone IR; Drug: Tapentadol IR
Sponsors: Ortho-McNeil Janssen Scientific Affairs, LLC; Grünenthal GmbH
Recruiting - verified February 2010
Physical Activity in Women With Infants

Condition: Physical Activity
Interventions: Behavioral: physical activity; Behavioral: physical activity information
Sponsor: University of Hawaii
Recruiting - verified March 2010
Safety Study of GSK Biologicals' Human Papillomavirus Vaccine in 580299/008 Subjects From Canada or the US

Condition: Human Papillomavirus (HPV) Type 16/18 Infections and Cervical Neoplasia.
Intervention: Biological: GSK580299, GSK Biological's HPV vaccine
Sponsor: GlaxoSmithKline
Recruiting - verified March 2010
Prediction of Post-Cesarean Section Pain

Condition: Postoperative Pain
Intervention: Other: Psychophysical testing, questionnaires, and genetics
Sponsor: University of Washington
Recruiting - verified March 2010
Web-delivered Provider Intervention for Tobacco Control

Condition: Smoking Cessation
Interventions: Behavioral: Decide2Quit; Behavioral: Smoking Coach
Sponsors: University of Alabama at Birmingham; Johns Hopkins University
Not yet recruiting - verified February 2010
Training Effects on Skeletal Muscle Fatty Acid Metabolism

Condition: Healthy Subjects
Interventions: Drug: 20% lipid infusion; Drug: glycerol
Sponsor: University of Minnesota - Clinical and Translational Science Institute
Recruiting - verified February 2010
Continued Safety and Immunogenicity Study of a Live Francisella Tularensis Vaccine

Condition: Tularemia
Intervention: Biological: Live Francisella Tularensis Vaccine
Sponsor: U.S. Army Medical Research and Materiel Command
Recruiting - verified February 2010
Role of T-cells in Post-Menopausal Osteoporosis

Condition: Osteoporosis
Intervention:
Sponsor: Emory University
Recruiting - verified February 2010
Prospective Study of Rapamycin for the Treatment of SLE

Condition: Systemic Lupus Erythematosus (SLE)
Intervention: Drug: Rapamycin
Sponsors: State University of New York - Upstate Medical University; Wyeth
Recruiting - verified February 2010
Combination Chemotherapy, Donor Stem Cell Transplant, Tacrolimus, Mycophenolate Mofetil, and Cyclophosphamide in Treating Patients With Hematologic Cancer

Conditions: Leukemia; Lymphoma; Myelodysplastic Syndromes
Interventions: Drug: busulfan; Drug: cyclophosphamide; Drug: fludarabine phosphate; Drug: mycophenolate mofetil; Drug: tacrolimus; Procedure: allogeneic hematopoietic stem cell transplantation; Procedure: peripheral blood stem cell transplantation
Sponsor: Northside Hospital, Inc.
Recruiting - verified March 2010
Caloric Restriction, Exercise, and Glucoregulation in Humans

Condition: Diabetes
Interventions: Other: Calorie Restriction; Other: Exercise; Other: Calorie Restriction plus Exercise
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified February 2010
Treatment of Systemic Lupus Erythematosus (SLE) With N-acetylcysteine

Condition: Systemic Lupus Erythematosus
Interventions: Other: Sugar Pill; Drug: N-acetylcysteine; Drug: N-acetylcysteine; Drug: N-acetylcysteine; Drug: N-acetylcysteine
Sponsor: State University of New York - Upstate Medical University
Recruiting - verified February 2010
NINDS CRC Chronic Migraine Treatment Trial

Condition: Chronic Migraine
Interventions: Drug: propranolol LA; Drug: topiramate; Drug: placebo
Sponsors: The EMMES Corporation; National Institute of Neurological Disorders and Stroke (NINDS); Ortho-McNeil Janssen Scientific Affairs, LLC; CRC Operations Center
Recruiting - verified March 2010
A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Viral Shedding of MEDI-559 in Healthy 1 to <24 Month-Old Children

Condition: Healthy
Interventions: Biological: MEDI-559; Other: Placebo; Biological: MEDI-559
Sponsor: MedImmune LLC
Recruiting - verified March 2010
Pharmacokinetic Study of the Penetration of Ceftobiprole in the Bone

Condition: Hip Replacement, Total
Intervention: Drug: Ceftobiprole
Sponsor: Ortho-McNeil Janssen Scientific Affairs, LLC
Recruiting - verified February 2010
Problem-Solving Education for Caregivers and Patients During Stem Cell Transplant

Conditions: Distress; Hematopoietic Stem Cell Transplantation
Intervention: Behavioral: Problem Solving Education
Sponsor: National Institutes of Health Clinical Center (CC)
Recruiting - verified August 2009
A Multi-Center Protocol for Obtaining and Storing Human Samples for Immediate or Future Microbial, Immune, or Host-Microbe Scientific Study

Condition: Infections
Intervention:
Sponsor: Southwest Regional Wound Care Center
Recruiting - verified March 2010
COPE Intervention for Parents of Children With Epilepsy

Condition: Epilepsy
Interventions: Behavioral: COPE (Creating Opportunities for Parent Empowerment); Behavioral: Standard education
Sponsors: Children's Hospital Boston; National Institute of Nursing Research (NINR)
Recruiting - verified March 2010
Circulating Markers That Underlie the Transition From Compensated Hypertrophy to Heart Failure

Conditions: Acute Decompensated Heart Failure; Heart Failure
Intervention:
Sponsors: University of Connecticut Health Center; CT Department of Public Health
Recruiting - verified February 2010
Circulating Markers for Ischemic Heart Disease

Conditions: Myocardial Infarction; Ischemia; Congestive Heart Failure
Intervention:
Sponsor: University of Connecticut Health Center
Recruiting - verified February 2010
Feasibility of "At-home" Titration of Solifenacin

Condition: Overactive Bladder
Intervention: Drug: Solifenicin (Vesicare)
Sponsor: New York University School of Medicine
Recruiting - verified March 2010
Obtaining and Storing Standard of Care Wound Biopsies for Immediate or Future Wound-Related Scientific Study

Conditions: Diabetic Foot; Leg Ulcer; Decubitus Ulcer
Intervention:
Sponsor: Southwest Regional Wound Care Center
Recruiting - verified March 2010
Circulating Adenosine Levels Before and After IV Persantine

Conditions: Ischemia; Coronary Disease
Intervention:
Sponsors: University of Connecticut Health Center; U.S. Army Research, Department of Defense
Recruiting - verified February 2010
Obtaining and Storing Wound Debridment Samples For Immediate or Future Wound-Related Scientific Study

Condition: Wound
Intervention:
Sponsor: Southwest Regional Wound Care Center
Recruiting - verified March 2010
A Study To Investigate The Pharmacokinetics, Safety And Tolerability Of An Intravenous And Oral Form Of A Compound In Subjects With Varying Degrees Of Renal Impairment And Normal Renal Function

Condition: Pneumonia
Intervention: Drug: CP-70,429 and PF-03709270
Sponsor: Pfizer
Recruiting - verified March 2010
Safety and Efficacy of Positron Emission Tomography Imaging With BAY 94-9172 (ZK 6013443)

Conditions: Alzheimer Disease; Amyloid Beta-Protein
Intervention: Drug: BAY94-9172 (ZK 6013443)
Sponsor: Bayer
Recruiting - verified March 2010
Exercise and Inflammation in the Elderly

Conditions: Inflammation; Insulin Sensitivity
Interventions: Other: Weight Loss; Other: Aerobic Exercise Training
Sponsor: Department of Veterans Affairs
Recruiting - verified February 2010
Study to Promote Weight Loss in Primary Care Practices

Condition: Obesity
Interventions: Behavioral: Individual telephone intervention; Behavioral: Group telephone intervention
Sponsors: State University of New York - Upstate Medical University; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified February 2010
Can Simple and Inexpensive Techniques Enhance Patient Comfort

Condition: Colonoscopy
Intervention: Other: Colonoscopy
Sponsor: Department of Veterans Affairs
Recruiting - verified February 2010
Malaria Challenge With NF54 Strain

Condition: Plasmodium Falciparum Malaria
Intervention: Other: NF54 P. falciparum isolate
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified March 2010
HPV Infections in Older Women

Condition: Papillomavirus Infections
Intervention:
Sponsors: University of Washington; National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified February 2010
Effect of Calcium on Tasigna Pharmacokinetics (PK) in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Nilotinib Hydrochloride; Dietary Supplement: calcium carbonate
Sponsors: University of Pittsburgh; Novartis Pharmaceuticals
Recruiting - verified February 2010
Effect of Calcium on Gleevec Pharmacokinetics (PK) in Healthy Volunteers

Condition: Healthy
Interventions: Drug: Imatinib mesylate; Dietary Supplement: calcium carbonate
Sponsors: University of Pittsburgh; Novartis Pharmaceuticals
Recruiting - verified February 2010
Evaluate the Side Effects and Benefits of Rosiglitazone With or Without Diet and Exercise in Type II Diabetes Mellitus

Condition: Type II Diabetes Mellitus
Intervention: Other: Rosiglitazone with diet and exercise
Sponsors: American Scitech International; Proactive Clinical Research; GlaxoSmithKline
Not yet recruiting - verified March 2010
Determinants of Age Related Breathing Instability During Non-Rapid-Eye-Movement (NREM) Sleep

Conditions: Sleep Apnea; Age
Intervention: Other: hyperventilation and episodic hypoxia
Sponsor: Department of Veterans Affairs
Recruiting - verified March 2010
Pharmacogenetic Determinants Of Treatment Response In Children With Cancer

Condition: Metabolism
Intervention: Procedure: Blood draw
Sponsor: St. Jude Children's Research Hospital
Recruiting - verified February 2010
Aldosterone and Glucose Homeostasis

Condition: Diabetes Mellitus
Interventions: Drug: Comparison of the effect of aldosterone versus vehicle infusion; Drug: Comparison of the effect of aldosterone versus vehicle infusion
Sponsors: Vanderbilt University; National Heart, Lung, and Blood Institute (NHLBI); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified February 2010
CDP-Choline and Working Memory After TBI: A Neuroimaging Study

Condition: Brain Injuries
Interventions: Drug: CDP-Choline; Drug: Placebo
Sponsors: University of Pittsburgh; National Institutes of Health (NIH); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified March 2010
Mechanisms by Which Strength Training Ameliorates the Metabolic Syndrome

Condition: Subjects With Metabolic Syndrome Are at High Risk for Diabetes
Intervention: Behavioral: strength training
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Not yet recruiting - verified March 2010
Immune Response to Yellow Fever Vaccination in Adults With Atopic Dermatitis

Condition: Atopic Dermatitis
Intervention: Biological: YFV-17D
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified February 2010
Effects of Intensity of Early Communication Intervention

Conditions: Communication Disorders; Developmental Disabilities
Intervention: Behavioral: Milieu Communication Teaching
Sponsors: University of Kansas; National Institute on Deafness and Other Communication Disorders (NIDCD)
Recruiting - verified March 2010
Effects of Vitamin D on Lipids

Condition: Hypercholesterolemia
Interventions: Drug: Vitamin D2; Drug: Vitamin D3; Drug: Placebo
Sponsors: Jewish Home, San Francisco; National Institute on Aging (NIA)
Recruiting - verified December 2009
Post PMA-Approval Study: New Enrollment Post PMA-Approval Study Post-approval Study Group (New Enrollment)

Conditions: Osteoarthritis; Avascular Necrosis; Rheumatoid Arthritis
Intervention: Device: Cormet Hip Resurfacing
Sponsor: Corin
Recruiting - verified February 2010
Computer-Assisted Self-Administration of Ethanol

Condition: Alcoholic Intoxication
Interventions: Drug: Alcohol; Procedure: Self-Administration
Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting - verified May 2009
Screening for Early Pancreatic Neoplasia (Cancer of the Pancreas Screening or CAPS4 Study)

Conditions: Early Pancreatic Neoplasia; Familial Pancreatic Neoplasia
Intervention:
Sponsors: Sidney Kimmel Comprehensive Cancer Center; V Foundation for Cancer Research
Recruiting - verified March 2010
Pertussis Vaccine in Healthy Pregnant Women

Conditions: Diphtheria; Pertussis; Tetanus
Interventions: Drug: Placebo; Biological: Tdap
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified March 2010
Thyroid Hormones Homeostasis and Energy Metabolism Changes During Stimulation of Endogenously Secreted Bile Acids (BAs)

Condition: Obesity
Interventions: Drug: Sincalide; Drug: Ursodiol Acid; Procedure: High Fat/Low Fat Diet
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified February 2010
Varenicline to Reduce Alcohol Consumption in Heavy Drinkers

Condition: Alcohol Drinking
Interventions: Drug: Varenicline; Drug: Varenicline (Chantix)
Sponsor: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting - verified January 2010
Genetic Mutations and Environmental Exposure in Young Patients With Retinoblastoma and in Their Parents and Young Healthy Unrelated Volunteers

Condition: Retinoblastoma
Interventions: Genetic: DNA ploidy analysis; Genetic: DNA stability analysis; Genetic: Southern blotting; Genetic: genetic linkage analysis; Genetic: loss of heterozygosity analysis; Genetic: mutation analysis; Genetic: polymorphism analysis; Genetic: reverse transcriptase-polymerase chain reaction; Other: questionnaire administration; Other: study of socioeconomic and demographic variables; Procedure: evaluation of cancer risk factors; Procedure: mutation carrier screening
Sponsors: Children's Oncology Group; National Cancer Institute (NCI)
Recruiting - verified March 2010
Circuit Training and Motivational Interviewing to Reduce Type 2 Diabetes in Youth

Condition: Obesity and Type 2 Diabetes
Interventions: Behavioral: Circuit Training; Behavioral: Circuit training + motivational interviewing; Behavioral: Control
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified March 2010
Ghrelin Regulation and Structure: Effect of Diet Composition on Ghrelin

Condition: Obesity
Interventions: Dietary Supplement: Low fat diet; Dietary Supplement: High fat diet; Dietary Supplement: MCT diet
Sponsor: Oregon Health and Science University
Recruiting - verified February 2009
Investigating Superion™ In Spinal Stenosis [ISISS]

Conditions: Lumbar Spinal Stenosis; Neurogenic Intermittent Claudication
Interventions: Device: Superion™ Interspinous Spacer; Device: X-STOP® IPD® Device
Sponsor: VertiFlex, Incorporated
Recruiting - verified February 2010
Peripheral Dopamine in Postural Tachycardia Syndrome

Conditions: Postural Tachycardia Syndrome; Orthostatic Intolerance
Interventions: Drug: Carbidopa; Drug: Placebo
Sponsor: Vanderbilt University
Recruiting - verified March 2010
Sleepiness and Brain Function: The Effect of Armodafinil in Shift Work Sleep Disorder

Condition: Shift Work Sleep Disorder
Intervention:
Sponsors: Henry Ford Health System; Cephalon
Recruiting - verified March 2010
Magnetoencephalographic (MEG) Localization of Ramelteons Effects on Brain Function and Cortical Arousal in Insomnia

Condition: Insomnia
Intervention:
Sponsors: Henry Ford Health System; Takeda Pharmaceuticals North America, Inc.
Recruiting - verified March 2010
Literacy and Smoking Risk Communications

Condition: Smoking
Interventions: Behavioral: Focus Group; Behavioral: Questionnaire
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting - verified March 2010
Human Tissue Distribution of Orally Supplemented Natural Vitamin E Tocotrienol

Conditions: End-stage Heart Failure; End-stage Pulmonary Failure; End Stage Liver Failure; Morbid Obesity; Recalcitrant Epilepsy Requiring Surgery; Healthy Subjects
Interventions: Dietary Supplement: To surgery patients, Tocotrienol or Tocopherol capsules.; Dietary Supplement: Tocotrienol or Tocopherol to healthy subjects.
Sponsor: Ohio State University
Recruiting - verified March 2010
Aerobic Exercise in Patients With Pulmonary Hypertension

Condition: Hypertension, Pulmonary
Interventions: Procedure: Excerise Training; Procedure: Patient Education (Placebo)
Sponsor: National Institutes of Health Clinical Center (CC)
Recruiting - verified April 2009
Open Label Study Etanercept's Maintenance Dose in Obese Patients With Moderate to Severe Plaque Type Psoriasis

Condition: Psoriasis
Interventions: Procedure: Narrow band (310-312 nm) ultraviolet light B phototherapy; Drug: etanercept
Sponsor: University of California, San Francisco
Recruiting - verified February 2010
Linkage Analysis in Interstitial Cystitis

Conditions: Prostatitis; Cystitis, Interstitial; Urinary Bladder, Overactive; Chronic Pelvic Pain Syndrome; Painful Bladder Syndrome
Intervention:
Sponsors: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Children's Hospital Boston
Recruiting - verified March 2010
Evaluating the Effects of Omega-3 Fatty Acids on Heart Disease and Behavior

Conditions: Cardiovascular Diseases; Mood Disorders; Inflammation
Interventions: Dietary Supplement: Fish Oil; Dietary Supplement: Soybean Oil (Placebo)
Sponsors: National Heart, Lung, and Blood Institute (NHLBI); National Center for Complementary and Alternative Medicine (NCCAM); Office of Dietary Supplements (ODS)
Recruiting - verified March 2010
Vitamin D Supplementation in Younger Women

Condition: Hypovitaminosis D
Interventions: Drug: vitamin D3; Drug: vitamin D3
Sponsors: Creighton University; University of Nebraska
Recruiting - verified March 2010
Safety and Immunogenicity of Peru-15-pCTB in Healthy Adult Subjects

Condition: Escherichia Coli Infections
Interventions: Drug: Ciprofloxacin 500 mg; Biological: Peru-15-pCTB; Drug: Placebo
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified February 2010
Assess the Feasibility and Safety of Granulocyte Colony Stimulating Factor (GCSF) Mobilization of CD34+ Hematopoietic Progenitor Cells in Patients With Betathalassemia Major

Conditions: Beta Thalassemia Major; Congenital Anemias
Intervention: Genetic: GCSF, Central venous line placement, Stem cell Collection (leukapheresis)
Sponsor: Memorial Sloan-Kettering Cancer Center
Recruiting - verified March 2010
Host Response to Urinary Tract Infection in Women

Condition: Urinary Tract Infection
Intervention:
Sponsors: University of Washington; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified March 2010
Advanced Cardiovascular Imaging Consortium

Conditions: Chest Pain; Coronary Occlusion; Coronary Artery Disease
Intervention:
Sponsor: William Beaumont Hospitals
Recruiting - verified March 2010
Eating Behavior in Adolescents

Conditions: Overweight; Eating Behavior; Binge Eating
Intervention:
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified November 2009
Screening for Familial Colorectal Cancer (CRC) Patients

Condition: Colorectal Cancer
Intervention: Behavioral: Questionnaire
Sponsor: M.D. Anderson Cancer Center
Recruiting - verified March 2010
Characterization of Interferon Beta -1b-Induced Tolerizing Effect in Dendritic Cells

Condition: Multiple Sclerosis
Intervention: Drug: INFNb-1b
Sponsor: The University of North Carolina, Chapel Hill
Recruiting - verified February 2010
Vitamin A, Its Receptors and Asthma

Condition: Asthma
Intervention:
Sponsors: University of Kansas; Kansas University Endowment Association
Recruiting - verified March 2010
Neurobiology and Treatment of Reading Disability in NF-1

Conditions: Neurofibromatosis Type 1; Reading Disabilities
Interventions: Behavioral: Tutoring Program I; Behavioral: Tutoring Program II
Sponsors: Vanderbilt University; National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2010
Safety of and Immune Response to an Adenoviral HIV-1 Vaccine in Healthy Adults

Condition: HIV Infections
Intervention: Biological: Ad26.ENVA.01 HIV-1 vaccine
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified November 2008
Evaluation Of Sperm Production With Healthy Male Volunteers Receiving Lyrica Or Placebo

Condition: Healthy
Interventions: Drug: Pregabalin; Drug: Placebo
Sponsor: Pfizer
Recruiting - verified March 2010
Effects of Smoking on Opioid Receptor Binding: A PET Study

Condition: Substance-related Discorder
Interventions: Drug: Nicotine; Drug: Carfentanil
Sponsor: National Institute on Drug Abuse (NIDA)
Recruiting - verified October 2009
HLA-Identical Sibling Renal Transplant Tolerance With Donor Hematopoietic Stem Cells and Campath-1H

Conditions: Immunosuppression; Kidney Transplantation; Graft Rejection
Intervention: Procedure: Infusion of Donor Hematopoietic Stem Cells and Campath-1H
Sponsors: Northwestern University; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified March 2010
Gene Expression Profiles in Healing and Non-Healing Wounds

Condition: Wounds and Injuries
Intervention:
Sponsors: Ohio State University; National Healing Corporation
Recruiting - verified March 2010
Female Sexual Dysfunction Intervention

Condition: Sexual Dysfunction
Interventions: Behavioral: Focus Group; Behavioral: TENDRILS; Behavioral: Questionnaires; Behavioral: Sexual Counseling Sessions
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting - verified March 2010
Premenstrual Dysphoric Disorder and Antiepileptic Drugs

Condition: Epilepsy
Intervention:
Sponsors: Beth Israel Deaconess Medical Center; Newton-Wellesley Hospital; Brigham and Women's Hospital
Recruiting - verified March 2010
Examining the Genetic Factors That May Cause Chronic Obstructive Pulmonary Disease (COPD)

Conditions: Pulmonary Disease, Chronic Obstructive; Emphysema; Bronchitis, Chronic
Intervention:
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified July 2009
Computer Assisted Relaxation Learning for Dental Offices

Condition: Dental Anxiety
Interventions: Behavioral: Computer Assisted Relaxation Learning; Behavioral: Pamphlet
Sponsors: University of Washington; National Institute of Dental and Craniofacial Research (NIDCR)
Recruiting - verified March 2010
The Vascutek AnacondaTM Stent Graft System Phase II IDE Study

Condition: Infrarenal Abdominal Aortic Aneurysm
Intervention: Device: Anaconda Stent Graft System
Sponsors: Terumo CVS; Vascutek Ltd., Scotland
Recruiting - verified March 2010
Depression Prevention for Pregnant Women on Public Assistance

Conditions: Depression, Postpartum; Depression
Interventions: Behavioral: The Postpartum Prevention Program (PPP); Behavioral: Enhanced care as usual (ECU)
Sponsor: National Institute of Mental Health (NIMH)
Recruiting - verified March 2009
PREGNANT Short Cervix Trial

Conditions: Preterm Delivery; Short Cervix; Short Uterine Cervical Length
Interventions: Drug: progesterone; Drug: placebo
Sponsors: Columbia Laboratories; Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified March 2010
Improving Functional Outcomes in Patients With Unilateral Vocal Cord Paralysis: Assessment of Adaptation Using Functional Magnetic Resonance Imaging

Conditions: Intrathoracic Malignancies; Unilateral Vocal Cord Paralysis
Interventions: Other: voice evaluation and fMRI; Other: undergo voice evaluation and fMRI prior
Sponsor: Memorial Sloan-Kettering Cancer Center
Recruiting - verified March 2010
Family Based Contingency Management for Adolescent Alcohol Abuse

Condition: Alcohol Abuse
Interventions: Behavioral: Motivational Enhancement Therapy (MET)/CBT+CM; Behavioral: Motivational Enhancement Therapy (MET)/CBT
Sponsors: University of Arkansas; National Institutes of Health (NIH)
Recruiting - verified March 2010
Development and Efficacy Test of Computerized Treatment for Marijuana Dependence

Condition: Marijuana Abuse and Dependence
Interventions: Behavioral: Psychotherapy; Behavioral: Computerized Psychotherapy; Behavioral: Motivational enhancement therapy
Sponsor: University of Arkansas
Recruiting - verified March 2010
Study of Fibrinogen Metabolism During Severe Trauma and Burns

Conditions: Severe Burns; Major Trauma
Intervention:
Sponsor: United States Army Institute of Surgical Research
Recruiting - verified February 2010
A Phase I, Randomized, Double-Blind, Single-Dose, Dose Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of MEDI-557

Condition: Healthy
Interventions: Biological: MEDI-557; Biological: MEDI-557; Biological: MEDI-557; Biological: MEDI-557
Sponsor: MedImmune LLC
Recruiting - verified February 2010
Safety and Immunogenicity Study of Eastern Equine Encephalitis (EEE) Vaccine

Condition: Eastern Equine Encephalitis
Intervention: Biological: Inactivated, Dried, TSI-GSD 104, EEE
Sponsor: U.S. Army Medical Research and Materiel Command
Recruiting - verified March 2010
Safety and Immunogenicity Study of the Venezuelan Equine Encephalomyelitis Vaccine

Condition: Venezuelan Equine Encephalomyelitis
Intervention: Biological: VEE TC-83
Sponsor: U.S. Army Medical Research and Materiel Command
Recruiting - verified March 2010
Safety and Immunogenicity of Venezuelan Equine Encephalomyelitis Vaccine (VEE C-84) as a Booster to VEE TC-83

Condition: Venezuelan Equine Encephalomyelitis
Intervention: Biological: VEE C-84
Sponsor: U.S. Army Medical Research and Materiel Command
Recruiting - verified March 2010
The Study of Barrett's Esophagus: What Are the Factors of Progression

Conditions: Barrett's Esophagus; Esophageal Neoplasms
Intervention:
Sponsors: Kansas City Veteran Affairs Medical Center; TAP Pharmaceutical Products Inc.
Recruiting - verified February 2010
Treatment for Adolescent Marijuana Abuse

Condition: Marijuana Abuse
Interventions: Behavioral: Motivational Enhancement Therapy (MET)/CBT+CM; Behavioral: Motivational Enhancement Therapy (MET)/CBT+CM; Behavioral: Motivational Enhancement Therapy (MET)/CBT
Sponsors: University of Arkansas; National Institutes of Health (NIH)
Recruiting - verified March 2010
Effects of Fish Oils on Inflammation and Insulin Resistance

Conditions: Metabolic Syndrome; Insulin Resistance
Interventions: Drug: omega-3 fatty acid; Drug: placebo
Sponsors: University of Kentucky; GlaxoSmithKline; National Institutes of Health (NIH)
Recruiting - verified March 2010
Intensive Chemotherapy and Autotransplantation for Patients With Newly Diagnosed Anaplastic Oligodendroglioma

Conditions: CNS Cancer; CNS BRAIN
Intervention: Drug: temozolomide followed by high dose busulfan and thiotepa
Sponsors: Memorial Sloan-Kettering Cancer Center; University of Calgary; Northwestern University; Northwestern Memorial Hospital; University of Wisconsin, Madison; Massachusetts General Hospital
Recruiting - verified March 2010
Demographics and Findings of Upper Endoscopy Patients

Conditions: Barrett Esophagus; Gastroesophageal Reflux
Intervention:
Sponsor: Kansas City Veteran Affairs Medical Center
Recruiting - verified February 2010
Evaluation Using Computed Tomography Angiography (CTA) to Investigate and Detect Atherosclerotic Graft Disease (ELUCIDATE)

Conditions: Coronary Angiography; Coronary Artery Bypass Grafting; Coronary Artery Disease
Intervention:
Sponsor: William Beaumont Hospitals
Recruiting - verified February 2010
Assisted Exercise in Prematurity; Effects and Mechanisms

Conditions: Growth; Development
Interventions: Other: assisted exercise; Other: cuddle
Sponsor: University of California, Irvine
Recruiting - verified March 2010
Progression of Gastroesophageal Reflux Disease and Barrett's Esophagus and the Creation of a Barrett's Registry

Conditions: Barrett's Esophagus; Gastroesophageal Reflux Disease; Esophageal Adenocarcinoma
Intervention:
Sponsor: Midwest Biomedical Research Foundation
Recruiting - verified February 2009
A Study to Evaluate the Use of Placenta Protein 13 (PP13) in the First Trimester of Pregnancy as a Diagnostic Aiding Tool in the Assessment of the Risk for Developing Preeclampsia in Women With Low and Unknown Risk

Condition: Preeclampsia
Intervention:
Sponsors: University of Kansas; Diagnostic Technologies Ltd.
Recruiting - verified March 2010
Safety, Reactogenicity and Immunogenicity of MVA in HSCT Subjects

Condition: Variola Major (Smallpox)
Interventions: Biological: MVA-BN; Drug: Placebo
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified October 2009
Impaired Adipogenesis in Insulin Resistance: Pilot Clinical and In Vitro Studies

Conditions: Adipocyte Differentiation; Insulin Resistance
Intervention: Other: Administration of 70% deuterated water
Sponsors: University of Vermont; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified March 2010
Acupuncture Treatment of Dry Eye

Conditions: Keratoconjunctivitis Sicca; Xeropthalmia
Interventions: Procedure: Acupuncture; Procedure: Sham acupuncture
Sponsors: Walter Reed Army Medical Center; Malcolm Grow USAF Medical Center
Recruiting - verified March 2010
Central Auditory Processing Disorders Associated With Blast Exposure

Conditions: Central Auditory Processing Disorder; Traumatic Brain Injury; Hearing Loss
Intervention: Procedure: Audiological testing
Sponsors: Department of Veterans Affairs; Walter Reed Army Medical Center
Recruiting - verified February 2010
ADVN Biomarker Registry Study

Condition: Atopic Dermatitis
Intervention:
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); Atopic Dermatitis and Vaccinia Network
Recruiting - verified February 2010
Cardiac Computed Tomography In the Management of Patients With indeterminAte or inConclusive Stress Tests

Condition: Coronary Disease
Intervention:
Sponsor: William Beaumont Hospitals
Recruiting - verified February 2010
SARS Coronavirus Vaccine (SARS-CoV)

Condition: Coronavirus (SARS-CoV)
Interventions: Drug: Aluminum hydroxide; Biological: SARS-CoV; Drug: Placebo
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Not yet recruiting - verified March 2010
Safety and Efficacy Study of REOLYSIN® in the Treatment of Recurrent Malignant Gliomas

Condition: Malignant Glioma
Intervention: Biological: REOLYSIN®
Sponsor: Oncolytics Biotech
Recruiting - verified March 2010
Zero Calorie Drink Products

Condition: Obesity
Interventions: Other: Glucose tolerance test; Other: glucose tolerance test solution; Other: Diet Coke; Other: Coke Zero
Sponsor: Christiana Care Health Services
Recruiting - verified March 2010
Cancer Genetics CD-ROM for Hispanics

Condition: Breast Cancer
Interventions: Behavioral: Computer Program; Behavioral: Focus Group; Other: Written Materials
Sponsors: M.D. Anderson Cancer Center; National Human Genome Research Institute (NHGRI); National Institutes of Health (NIH)
Recruiting - verified March 2010
Identifying Genetic Determinants of Eczema Herpeticum and Other Viral Infections in Individuals With Atopic Dermatitis

Condition: Atopic Dermatitis
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified February 2010
Effectiveness and Safety of Topical Bevacizumab (Avastin) for Treatment of Corneal Neovascularization

Condition: Corneal Neovascularization
Intervention: Drug: Bevacizumab (Avastin)
Sponsors: Walter Reed Army Medical Center; Massachusetts Eye and Ear Infirmary
Recruiting - verified March 2010
Preparing the Personal Physician for Practice (P4)

Condition: Healthy
Intervention: Other: Evaluating Educational Models
Sponsor: Christiana Care Health Services
Recruiting - verified March 2010
Role of CYP2B6, CYP3A4, and MDR1 in the Metabolic Clearance of Methadone

Condition: Substance-Related Disorders
Interventions: Drug: midazolam(drug), digoxin (drug); Drug: Bupropion (drug); Drug: Methadone (drug)
Sponsor: University of Washington
Recruiting - verified March 2010
Direct Measurements of Cardiometabolic Risk in Treated Schizophrenia Patients

Conditions: Schizophrenia; Cardiovascular Disease
Intervention:
Sponsors: Washington University School of Medicine; National Alliance for Research on Schizophrenia and Depression
Recruiting - verified March 2010
NICU Asthma Education and Secondhand Smoke Reduction Study

Condition: Respiratory Illness
Interventions: Behavioral: Secondhand Smoke Reduction, Smoking Cessation; Behavioral: Asthma Education with Secondhand Smoke Reduction
Sponsors: University of Rochester; Halcyon Hill Foundation
Recruiting - verified December 2007
Study of Insulin Resistance and Endometrial Cancer in Harris County, Texas

Condition: Endometrial Cancer
Intervention: Behavioral: Questionnaire
Sponsor: M.D. Anderson Cancer Center
Recruiting - verified March 2010
Pulmonary Hypertension, Hypoxia and Sickle Cell Disease

Conditions: Chuvash Polycythemia; Cerebrovascular Disease; Pulmonary Hypertension; Sickle Cell Anemia
Intervention:
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 2010
Fludarabine, Cyclophosphamide, and Total-Body Irradiation Followed By Donor Bone Marrow Transplant in Treating Patients With Sickle Cell Anemia

Condition: Sickle Cell Disease
Interventions: Biological: filgrastim; Drug: cyclophosphamide; Drug: fludarabine phosphate; Drug: mycophenolate mofetil; Drug: tacrolimus; Procedure: allogeneic bone marrow transplantation; Procedure: allogeneic hematopoietic stem cell transplantation; Procedure: nonmyeloablative allogeneic hematopoietic stem cell transplantation; Radiation: total-body irradiation
Sponsors: Sidney Kimmel Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified March 2010
MATCh Parents' Supplemental Survey

Condition: Epidemiology
Intervention: Behavioral: Supplemental Survey
Sponsor: M.D. Anderson Cancer Center
Recruiting - verified March 2010
Study to Determine if Shock Wave Therapy Applied to Traumatic Wounds of the Extremity Improves Healing Time

Condition: Soft Tissue Injuries
Intervention: Device: Extracorporeal shock wave therapy
Sponsor: Tissue Regeneration Technologies
Recruiting - verified March 2010
Improving Risk Factors for Diabetes Complications in Primary Care

Condition: Type 2 Diabetes
Intervention: Behavioral: Practice Facilitation
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified March 2010
Health and Cancer Issues in the South Asian Community

Condition: Health
Interventions: Behavioral: Focus Groups; Behavioral: Questionnaire; Behavioral: Interview
Sponsor: M.D. Anderson Cancer Center
Recruiting - verified March 2010
School Reintegration Outcomes in Pediatric Cancer Patients

Condition: Pediatric Cancers
Intervention: Behavioral: Questionnaires
Sponsor: M.D. Anderson Cancer Center
Recruiting - verified March 2010
Awareness of Deficit After Combat-related Brain Injury

Conditions: Traumatic Brain Injury; Veterans
Intervention:
Sponsors: University of Wisconsin, Madison; Department of Veterans Affairs
Recruiting - verified March 2010
Health Habits and Cancer Risk Comparison Among Migrant Sri Lankans and Sri Lankans

Condition: Acculturation
Intervention: Behavioral: Questionnaire
Sponsor: M.D. Anderson Cancer Center
Recruiting - verified March 2010
Sweetened Beverages and Food Intake

Conditions: Overweight; Obesity
Interventions: Behavioral: Fructose; Behavioral: glucose; Behavioral: non-caloric sweetener
Sponsors: University of Washington; Seattle Children's Hospital
Recruiting - verified March 2010
Effects of PPAR Ligands on Ectopic Fat Accumulation and Inflammation

Conditions: Metabolic Syndrome X; Prediabetic State
Interventions: Drug: Fenofibrate; Drug: Pioglitazone and Fenofibrate; Drug: Fenofibrate; Drug: Pioglitazone and Fenofibrate
Sponsor: Department of Veterans Affairs
Recruiting - verified March 2010
Domestic Violence Enhanced Home Visitation Program (DOVE)

Condition: Intimate Partner Violence
Interventions: Behavioral: Public Health Nurse Home Visit; Behavioral: Intimate Partner Violence (IPV) Protocol
Sponsors: Johns Hopkins University; National Institute of Nursing Research (NINR)
Recruiting - verified February 2010
5-Alpha Reductase and Anabolic Effects of Testosterone

Conditions: Male Hypogonadism; Muscle Atrophy; Prostate Enlargement; Sarcopenia
Interventions: Drug: Testosterone Enanthate; Behavioral: Collection of 3-day food logs with counseling of subjects; Drug: Finasteride; Behavioral: Collection of 3-day food logs with counseling of subjects; Drug: Testosterone Enanthate; Drug: Finasteride; Behavioral: Collection of 3-day food logs with counseling of subjects
Sponsors: Department of Veterans Affairs; Endo Pharmaceuticals Solutions Inc.; Merck
Recruiting - verified March 2010
Effect of Race on Gonadotropin Responses

Conditions: Premenopause; Healthy
Interventions: Drug: Estradiol steroid infusion; Drug: Progesterone steroid infusion
Sponsors: Massachusetts General Hospital; National Institutes of Health (NIH)
Recruiting - verified March 2010
Cancer Prevention and Treatment Demonstration for Ethnic and Racial Minorities

Conditions: Breast Cancer; Cervical Cancer; Prostate Cancer; Colorectal Cancer; Lung Cancer
Interventions: Behavioral: Questionnaire; Behavioral: Patient Navigator (PN)
Sponsors: M.D. Anderson Cancer Center; Centers for Medicare and Medicaid Services
Recruiting - verified March 2010
Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Other Diseases

Conditions: Chronic Myeloproliferative Disorders; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes
Interventions: Biological: anti-thymocyte globulin; Biological: filgrastim; Biological: graft-versus-tumor induction therapy; Biological: therapeutic allogeneic lymphocytes; Drug: busulfan; Drug: fludarabine phosphate; Drug: melphalan; Drug: methotrexate; Drug: mycophenolate mofetil; Drug: tacrolimus; Procedure: allogeneic bone marrow transplantation; Procedure: allogeneic hematopoietic stem cell transplantation; Procedure: nonmyeloablative allogeneic hematopoietic stem cell transplantation; Procedure: peripheral blood stem cell transplantation
Sponsors: Wake Forest University; National Cancer Institute (NCI)
Recruiting - verified June 2009
Fludarabine, Busulfan, and Alemtuzumab Followed By Donor Peripheral Stem Cell Transplant in Treating Patients With Hematologic Cancer or Other Diseases

Conditions: Chronic Myeloproliferative Disorders; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes
Interventions: Biological: alemtuzumab; Biological: therapeutic allogeneic lymphocytes; Drug: busulfan; Drug: fludarabine phosphate; Drug: tacrolimus; Procedure: allogeneic hematopoietic stem cell transplantation; Procedure: peripheral blood stem cell transplantation
Sponsors: UNC Lineberger Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified July 2008
Biobank For MS And Other Demyelinating Diseases

Conditions: Multiple Sclerosis; Transverse Myelitis; Neuromyelitis Optica; Acute Disseminated Encephalomyelitis; Optic Neuritis
Intervention:
Sponsor: Accelerated Cure Project for Multiple Sclerosis
Recruiting - verified March 2010
Education Sessions for Young Relative Stem Cell Donors

Condition: Cancer
Interventions: Other: counseling intervention; Other: educational intervention; Procedure: psychosocial assessment and care
Sponsor: National Cancer Institute (NCI)
Recruiting - verified December 2008
Cyclophosphamide and Busulfan Followed By Donor Stem Cell Transplant in Treating Patients With Myelofibrosis

Conditions: Chronic Myeloproliferative Disorders; Secondary Myelofibrosis
Interventions: Drug: busulfan; Drug: cyclophosphamide; Drug: methotrexate; Drug: tacrolimus; Other: pharmacological study; Procedure: allogeneic hematopoietic stem cell transplantation; Procedure: peripheral blood stem cell transplantation
Sponsors: Fred Hutchinson Cancer Research Center; National Cancer Institute (NCI)
Recruiting - verified July 2009
A Pilot Clinical Trial Of Memantine for Essential Tremor

Condition: Essential Tremor
Intervention: Drug: Memantine
Sponsors: Forest Laboratories; Ralph M. Parsons Foundation
Recruiting - verified February 2007
Characterization of Clonal B Cell Populations in HCV Infection

Condition: Hepatitis C
Intervention:
Sponsors: Rockefeller University; New York Presbyterian Hospital
Recruiting - verified March 2010
Physical and Behavioral Traits of Overweight and Obese Adults

Conditions: Morbid Obesity; Diabetes Mellitus Type 2; Insulin Resistance; Obstructive Sleep Apnea; Mood Disorders
Intervention:
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified July 2009
Interest in Spirituality and Oncology: Is It An International Phenomenon?

Condition: Stress
Intervention: Behavioral: Survey
Sponsor: M.D. Anderson Cancer Center
Recruiting - verified March 2010
Using Focus Groups to Assess the Impact of Environmental Health Science Programs for K-12 Educational Community

Condition: Healthy
Intervention: Behavioral: Focus Group Discussion
Sponsor: M.D. Anderson Cancer Center
Recruiting - verified March 2010
Role of Antimicrobial Peptides in Host Defense Against Vaccinia Virus

Condition: Atopic Dermatitis
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified February 2010
Human BNP (Nesiritide) to Help Heart, Kidney, and Hormonal Functions in Persons With Lower Heart Pumping Function

Condition: Congestive Heart Failure
Intervention: Drug: Human BNP Natrecor
Sponsors: Mayo Clinic; National Institutes of Health (NIH)
Recruiting - verified February 2010
Monoamine Transporters Genotypes: Risk of PTSD and Related Comorbidities

Condition: PTSD
Intervention: Drug: Paroxetine
Sponsor: Department of Veterans Affairs
Recruiting - verified March 2010
BCG Vaccination Delivered Intradermally, Orally and by Combined Routes

Condition: Tuberculosis
Interventions: Biological: BCG (ID); Biological: BCG (PO); Biological: Connaught strain BCG; Drug: Placebo (ID); Drug: Placebo (PO)
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified February 2010
Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Cancer or Other Disease

Conditions: Chronic Myeloproliferative Disorders; Graft Versus Host Disease; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Diseases; Secondary Myelofibrosis; Small Intestine Cancer
Interventions: Biological: therapeutic allogeneic lymphocytes; Drug: cyclophosphamide; Drug: cyclosporine; Drug: fludarabine phosphate; Drug: tacrolimus; Procedure: allogeneic hematopoietic stem cell transplantation; Procedure: in vitro-treated peripheral blood stem cell transplantation; Procedure: peripheral blood stem cell transplantation; Radiation: total-body irradiation
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified June 2009
Chemoradiation-Induced Nausea and Emesis: Quality of Life

Conditions: Gastric Cancer; Pancreatic Cancer; Cervical Cancer; Vulvar Cancer; Endometrial Cancer; Anal Cancer
Interventions: Behavioral: Interview; Other: Questionnaire
Sponsors: M.D. Anderson Cancer Center; Merck
Recruiting - verified March 2010
GI-Reasons- A Trial Of GI Safety Of Celecoxib Compared With Non-Selective Nonsteroidal Antiinflammatory Drugs (NSAIDS)

Condition: Osteoarthritis
Interventions: Drug: Celecoxib; Drug: Any commercially available NSAID with the indication for osteoarthritis
Sponsor: Pfizer
Recruiting - verified March 2010
Diagnosis and Treatment of Patients With Inborn Errors of Metabolism

Condition: Metabolism
Intervention:
Sponsor: National Human Genome Research Institute (NHGRI)
Recruiting - verified January 2010
Protein Synthesis in the Brain of Patients With Fragile X Syndrome

Condition: Fragile X Syndrome
Intervention:
Sponsor: National Institute of Mental Health (NIMH)
Recruiting - verified February 2010
The Influence of Maternal Age, Employment Status, and Parenthood Status on Children's Cognitive Development

Conditions: Adolescent Mothers; Healthy; Mother-Child Relations
Intervention:
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified October 2009
Letrozole Treatment in Normal and GnRH Deficient Women

Conditions: Kallmann's Syndrome; Hypogonadotropic Hypogonadism; Healthy Volunteers
Interventions: Drug: Letrozole; Drug: NAL-GLU GnRH antagonist; Drug: GnRH
Sponsors: Massachusetts General Hospital; National Institutes of Health (NIH)
Recruiting - verified March 2010
Environmental Polymorphisms Registry

Condition: Polymorphism
Intervention:
Sponsor: National Institute of Environmental Health Sciences (NIEHS)
Recruiting - verified December 2009
Fetal Anatomy by Three-Dimensional Ultrasound

Conditions: Congenital Anomalies; Imaging; Prenatal Care
Intervention:
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified August 2009
Fat Cell Size in Insulin Resistance

Conditions: Obesity; Adipose Cell Turn Over
Intervention:
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified February 2010
Fludarabine, Cyclophosphamide, and Total-Body Irradiation Followed By Umbilical Cord Blood Stem Cell Transplant, Cyclosporine, and Mycophenolate Mofetil in Treating Patients With Hematologic Cancer and Other Diseases

Conditions: Chronic Myeloproliferative Disorders; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes
Interventions: Biological: filgrastim; Drug: cyclophosphamide; Drug: cyclosporine; Drug: fludarabine phosphate; Drug: mycophenolate mofetil; Procedure: umbilical cord blood transplantation; Radiation: total-body irradiation
Sponsors: Fred Hutchinson Cancer Research Center; National Cancer Institute (NCI)
Recruiting - verified December 2009
Thyroid Dysfunction in Women With Newly Diagnosed Stage I, Stage II, or Stage III Breast Cancer Who Are Planning to Undergo Chemotherapy Compared to Thyroid Dysfunction in Healthy Volunteers

Conditions: Breast Cancer; Fatigue; Hypothyroidism
Interventions: Other: physiologic testing; Procedure: fatigue assessment and management; Procedure: management of therapy complications
Sponsors: H. Lee Moffitt Cancer Center and Research Institute; National Cancer Institute (NCI)
Recruiting - verified November 2009
Aromatase Activity and Ovarian Growth Factors in African-American Versus Caucasian Women

Conditions: Healthy; Fragile X Syndrome
Intervention: Procedure: Follicle Aspiration
Sponsors: Massachusetts General Hospital; National Institutes of Health (NIH)
Recruiting - verified March 2010
Mechanisms of Insulin Resistance in Humans

Conditions: Inflammation; Insulin Resistance
Interventions: Drug: 20% Intralipid; Drug: Salicylate
Sponsor: Department of Veterans Affairs
Recruiting - verified February 2010
Biomarkers in Multiple Sclerosis

Condition: Multiple Sclerosis
Intervention:
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2010
An Evaluation of Safety and Efficacy of Escalating Doses of AMD3100 to Mobilize CD34+ Cells in Healthy Volunteers

Condition: Stem Cell Mobilization
Intervention: Drug: AMD3100
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified March 2010
Diagnosis, Evaluation and Treatment of Patients in Need of Third Molar Removal

Condition: Wisdom Teeth
Intervention:
Sponsor: National Institute of Dental and Craniofacial Research (NIDCR)
Recruiting - verified March 2009
Physiology of Weakness in Movement Disorders

Condition: Movement Disorders
Intervention:
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2010
Fludarabine, Cyclophosphamide, and Total-Body Irradiation in Treating Patients Who Are Undergoing an Umbilical Cord Blood Transplant for Hematologic Cancer

Conditions: Chronic Myeloproliferative Disorders; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes
Interventions: Biological: filgrastim; Drug: cyclophosphamide; Drug: cyclosporine; Drug: fludarabine phosphate; Drug: mycophenolate mofetil; Procedure: umbilical cord blood transplantation; Radiation: total-body irradiation
Sponsors: Masonic Cancer Center, University of Minnesota; National Cancer Institute (NCI)
Recruiting - verified October 2008
Statewide (Rhode Island and Neighboring States) Partnerships for Worksite Weight Management

Conditions: Overweight; Obesity
Intervention: Behavioral: WOW, Working On Wellness weight management
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified February 2010
Body Weight Regulation in Patients With Narcolepsy

Condition: Narcolepsy
Intervention:
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified November 2009
Biomagnetic Signals of Intestinal Ischemia

Condition: Ischemia
Intervention:
Sponsors: University of South Alabama; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified September 2009
C2P (With Venues): Connect to Protect® Partnerships For Youth Prevention Interventions

Condition: HIV Infections
Intervention: Behavioral: Community Mobilization
Sponsors: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); National Institute on Drug Abuse (NIDA); National Institute of Mental Health (NIMH); National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Recruiting - verified February 2010
Body Heat Content and Dissipation in Obese and Normal Weight Adults

Condition: Obesity
Intervention:
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified August 2009
SMART: Somatotrophics, Memory, and Aging Research Trial

Conditions: Aging; Mild Cognitive Impairment
Intervention: Drug: TH9507 human growth hormone releasing hormone (GHRH)
Sponsors: University of Washington; National Institute on Aging (NIA)
Recruiting - verified March 2010
Diagnostic Innovations in Glaucoma Study

Conditions: Primary Open Angle Glaucoma; Persons at Risk for Glaucoma
Intervention:
Sponsors: University of California, San Diego; National Eye Institute (NEI)
Recruiting - verified June 2008
Oral Contraceptives in the Metabolic Syndrome

Conditions: Metabolic Syndrome X; Insulin Resistance; Obesity; Cardiovascular Diseases
Intervention: Drug: Ortho Tri Cyclen
Sponsor: Virginia Commonwealth University
Recruiting - verified February 2010
Improving Outcome in Schizophrenia Through Identification of Genetic Risk Factors

Conditions: Schizophrenia; Schizoaffective Disorder; Bipolar Disorder; Major Depression
Interventions: Procedure: genetic analysis; Procedure: genetic assay
Sponsor: Vanderbilt University
Recruiting - verified February 2010
Autologous Transplant for Multiple Myeloma

Condition: Multiple Myeloma
Interventions: Procedure: Stem Cell Transplant; Drug: cyclophosphamide, melphalan; Drug: Thalidomide and Dexamethasone
Sponsor: Masonic Cancer Center, University of Minnesota
Recruiting - verified March 2010
Arthroscopy and Manipulation vs a Home Therapy Program in the Treatment of Adhesive Capsulitis

Condition: Adhesive Capsulitis of the Shoulder
Interventions: Procedure: Arthroscopy; Procedure: Arthroscopic manipulation; Other: Home therapy
Sponsor: University of Florida
Recruiting - verified February 2010
Biomechanics/Motion Analysis Laboratory Data Bank

Condition: Kinematics
Intervention: Behavioral: joint motion analysis
Sponsor: University of Florida
Recruiting - verified January 2010
Effects of Citicoline on Brain Function and Behavior in Marijuana-Dependent Individuals

Condition: Marijuana Abuse
Interventions: Drug: citicoline; Drug: placebo
Sponsors: Mclean Hospital; National Institute on Drug Abuse (NIDA)
Recruiting - verified March 2010
Stem Cell Transplant for Hematological Malignancy

Conditions: Leukemia, Myeloid, Chronic; AML; Leukemia, Lymphocytic, Acute; MDS; Leukemia, Lymphocytic, Chronic; JMML; Hodgkin's Disease; Non-Hodgkin's Lymphoma; Multiple Myeloma
Interventions: Procedure: Stem Cell Transplant; Drug: Cyclophosphamide; Radiation: Total Body Irradiation; Drug: Busulfan
Sponsor: Masonic Cancer Center, University of Minnesota
Recruiting - verified March 2010
New Challenge Pool of Norwalk Virus Inocula

Condition: Norovirus
Interventions: Biological: Norwalk Virus; Drug: Placebo
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified February 2010
gB/MF59 Vaccine in Preventing Cytomegalovirus Infection in Healthy Adolescent Females

Condition: Cytomegalovirus Infections
Interventions: Biological: CMV gB vaccine; Drug: Placebo; Biological: MF-59
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified November 2009
Combination Chemotherapy, Tacrolimus, and Mycophenolate Mofetil in Treating Patients Who Are Undergoing a Donor Bone Marrow Transplant For Hematologic Cancer

Conditions: Chronic Myeloproliferative Disorders; Leukemia; Lymphoma; Multiple Myeloma and Plasma Cell Neoplasm; Myelodysplastic Syndromes
Interventions: Drug: busulfan; Drug: cyclophosphamide; Drug: mycophenolate mofetil; Drug: tacrolimus; Procedure: allogeneic bone marrow transplantation; Procedure: bone marrow ablation with stem cell support
Sponsors: Sidney Kimmel Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified March 2010
MRS Measurement of Glutamate and GABA Metabolism in Brain

Condition: Healthy
Intervention: Procedure: Magnetic Resonance Spectroscopy
Sponsor: National Institute of Mental Health (NIMH)
Recruiting - verified December 2009
Brain Changes in Children and Adolescents With Behavioral Problems

Conditions: Attention Deficit Disorder With Hyperactivity; Mental Disorders Diagnosed in Childhood; Conduct Disorder
Intervention:
Sponsor: National Institute of Mental Health (NIMH)
Recruiting - verified January 2010
Clinical and Laboratory Investigation of Humans With Informative Iron or Erythroid Phenotypes

Conditions: Hemoglobinopathies; Hemolysis; Iron Deficiency and Overload; Anemias
Intervention:
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified February 2010
Event Related Potentials in Infants and Adults

Condition: Healthy
Intervention:
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified January 2010
Clinical and Genetic Studies on Holoprosencephaly

Condition: Holoprosencephaly
Intervention:
Sponsor: National Human Genome Research Institute (NHGRI)
Recruiting - verified October 2009
Procurement and Analysis of Specimens From Individuals With Pulmonary Fibrosis

Condition: Pulmonary Fibrosis
Intervention:
Sponsor: National Human Genome Research Institute (NHGRI)
Recruiting - verified October 2009
Exemestane in Preventing Cancer in Postmenopausal Women at Increased Risk of Developing Breast Cancer

Condition: Breast Cancer
Intervention: Drug: exemestane
Sponsor: NCIC Clinical Trials Group
Recruiting - verified March 2010
Urinary Vitamin C Loss in Diabetic Subjects

Condition: Diabetes Mellitus
Intervention:
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified January 2010
Family Study of Affective and Anxiety Spectrum Disorders

Conditions: Mood Disorders; Anxiety Disorders
Intervention:
Sponsor: National Institute of Mental Health (NIMH)
Recruiting - verified March 2009
Collection of Tissue Specimens From Patients With Solid Tumors or Blood Disorders and Their HLA-Compatible Family Members

Conditions: Neoplasms; Hematologic Neoplasms
Intervention:
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified January 2010
Harvesting Cells for Experimental Cancer Treatments

Condition: Neoplasms
Intervention:
Sponsor: National Cancer Institute (NCI)
Recruiting - verified December 2009
Investigating the Use of Quercetin on Glucose Absorption in Obesity, and Obesity With Type 2 Diabetes

Conditions: Diabetes Mellitus; Obesity
Intervention: Procedure: Oral glucose tolerance test
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified September 2009
Evaluation of Primary Chronic Autonomic Failure

Condition: Autonomic Nervous System Diseases
Intervention:
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 2010
Expectation of Unpleasant Events in Anxiety Disorders

Condition: Anxiety Disorders
Intervention:
Sponsor: National Institute of Mental Health (NIMH)
Recruiting - verified December 2009
Cell Lines From High-Risk Breast Tissue

Condition: Healthy
Intervention:
Sponsor: National Cancer Institute (NCI)
Recruiting - verified October 2009
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

Conditions: Mood Disorder; Anxiety Disorder
Intervention:
Sponsor: National Institute of Mental Health (NIMH)
Recruiting - verified November 2009
Clinical Trial of Fluoxetine in Anxiety and Depression in Children, and Associated Brain Changes

Conditions: Depression; Mood Disorder; Anxiety Disorder; Healthy
Intervention:
Sponsor: National Institute of Mental Health (NIMH)
Recruiting - verified February 2010
Physiologic Studies of Spasticity

Conditions: Muscle Spasticity; Healthy
Intervention:
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified February 2010
Collection and Storage of Umbilical Cord Stem Cells for Treatment of Sickle Cell Disease

Conditions: Healthy; Sickle Cell Anemia
Intervention:
Sponsors: National Heart, Lung, and Blood Institute (NHLBI); National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified October 2009
Endocrine Studies in Health and Disease

Condition: Endocrine Diseases
Intervention:
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified March 2009
Study of New Magnetic Resonance Imaging Methods of the Brain

Condition: Healthy
Intervention:
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified January 2010
Evaluation of Healthy Volunteer Marrow Donors Participating in the National Marrow Donor Program (NMDP)

Condition: Healthy
Intervention:
Sponsor: National Institutes of Health Clinical Center (CC)
Recruiting - verified February 2010
Brain Imaging of Childhood Onset Psychiatric Disorders, Endocrine Disorders and Healthy Children

Conditions: Autoimmune Disease; Congenital Adrenal Hyperplasia; Healthy; Mental Disorder Diagnosed in Childhood; Neurologic Manifestations
Intervention:
Sponsor: National Institute of Mental Health (NIMH)
Recruiting - verified November 2009
Improved Methods of Cell Selection for Bone Marrow Transplant Alternatives

Conditions: Graft vs Host Disease; Healthy; Lymphopenia
Intervention: Drug: G-CSF
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified December 2009
The Effects of Reproductive Hormones on Mood and Behavior

Condition: Hypogonadism
Intervention:
Sponsor: National Institute of Mental Health (NIMH)
Recruiting - verified February 2010
Role of Genetic Factors in the Development of Lung Disease

Conditions: Cystic Fibrosis; Sarcoidosis; Tuberous Sclerosis; Asthma
Intervention:
Sponsor: National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified January 2010
Heart Disease Risk Factors in African Americans

Conditions: Coronary Disease; Obesity
Intervention:
Sponsor: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified January 2010
Genetic Study of Schizophrenia

Conditions: Psychotic Disorder; Schizoaffective Disorder; Schizophrenia
Intervention:
Sponsor: National Institute of Mental Health (NIMH)
Recruiting - verified June 2009
Metabolic Differences of Overweight Children and Children of Overweight Parents

Conditions: Cardiovascular Disease; Hypertension; Non Insulin Dependent Diabetes Mellitus; Obesity
Intervention:
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified February 2010
Hormonal Effects on the Uterus and Endometrium

Condition: Pregnancy
Intervention:
Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Recruiting - verified January 2010
Evaluation and Follow-up of Patients With Cryptococcosis

Conditions: Cryptococcosis; Lymphopenia
Intervention:
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified December 2009
Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer

Conditions: Chronic Myeloproliferative Disorders; Leukemia; Lymphoma; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Diseases; Nonmalignant Neoplasm; Unspecified Adult Solid Tumor, Protocol Specific; Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Biological: anti-thymocyte globulin; Drug: busulfan; Drug: carboplatin; Drug: cyclophosphamide; Drug: etoposide; Drug: fludarabine phosphate; Drug: melphalan; Drug: thiotepa; Radiation: total-body irradiation
Sponsor: Roswell Park Cancer Institute
Recruiting - verified June 2009

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