- Condition: Healthy Volunteers
Interventions: Drug: LY2140023 Monohydrate (Reference); Drug: LY2140023 Monohydrate (Test - Low); Drug: LY2140023 Monohydrate (Test - Medium); Drug: LY2140023 Monohydrate (Test - High)
Sponsors: Eli Lilly and Company; Eli Lilly and Company
Recruiting - verified May 2012 - Condition: Idiopathic Pulmonary Arterial Hypertension
Interventions: Drug: (Pyr1)apelin-13; Drug: Saline
Sponsors: Imperial College London; Imperial College London
Recruiting - verified April 2012 - Condition: Healthy
Interventions: Dietary Supplement: 2 portions of fruit and vegetables per day; Dietary Supplement: 5 portions of fruit and vegetables per day; Dietary Supplement: 8 portions of fruit and vegetables per day
Sponsors: Queen's University, Belfast; Queen's University, Belfast
Recruiting - verified May 2012 - Condition: Healthy
Interventions: Drug: 600 mg ceftaroline fosamil in 50 ml infusion volume; Drug: Placebo in 50 ml infusion volume; Drug: 600 ceftaroline fosamil in 250 ml infusion volume; Drug: Placebo in 250 ml infusion volume; Drug: 600 mg ceftaroline in 100 ml infusion volume; Drug: Placebo in 100 ml infusion volume
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified May 2012 - Condition: Respiratory Disorders
Interventions: Drug: GSK1995057; Procedure: bronchoalveolar lavage; Drug: LPS; Drug: Placebo
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Recruiting - verified May 2012 - Condition: Healthy
Interventions: Drug: AZD8848; Drug: Placebo
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified May 2012 - Condition: TTR-mediated Amyloidosis
Interventions: Drug: ALN-TTR02; Drug: Sterile Normal Saline (0.9% NaCl)
Sponsors: Alnylam Pharmaceuticals; Alnylam Pharmaceuticals
Recruiting - verified March 2012 - Condition: Healthy Volunteers
Interventions: Drug: LY3016859 IV; Drug: Placebo IV; Drug: LY3016859 SC; Drug: Placebo SC
Sponsors: Eli Lilly and Company; Eli Lilly and Company
Recruiting - verified April 2012 - Condition: Chronic Kidney Disease
Intervention: Other: OxSalt care bundle
Sponsors: University of Oxford; University of Oxford; British Renal Society
Not yet recruiting - verified May 2012 - Condition: Healthy Adult Subjects
Interventions: Drug: ONO-4053; Drug: Placebo
Sponsors: Ono Pharmaceutical Co. Ltd; Ono Pharmaceutical Co. Ltd
Recruiting - verified March 2012 - Conditions: No Condition; Brain GABA-B Function
Interventions: Drug: Baclofen 10mg; Drug: Baclofen 60mg; Drug: placebo
Sponsors: Imperial College London; Imperial College London; Medical Research Council
Not yet recruiting - verified March 2012 - Condition: Retinal Diseases
Interventions: Drug: GW824575; Drug: GW824575 matched-placebo
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Recruiting - verified March 2012 - Condition: Healthy Volunteers
Interventions: Drug: LY2979165; Drug: LY2140023; Other: Placebo; Other: Ketamine
Sponsors: Eli Lilly and Company; Eli Lilly and Company
Recruiting - verified May 2012 - Condition: Idiopathic Thrombocytopenic Purpura
Interventions: Drug: 10-mg dose of E5501 2G tablet; Drug: 10-mg dose of E5501 cyclodextrin oral solution; Drug: 10-mg dose of E5501-P21% powder; Drug: 10-mg dose of E5501 lipid-based oral
Sponsors: Eisai Inc.; Eisai Inc.
Recruiting - verified March 2012 - Condition: Healthy Volunteers
Interventions: Drug: TMC435 150 mg capsule; Drug: TMC435 150 mg oral suspension (20 mg/mL); Drug: TMC435 150 mg oral solution (10 mg/mL); Drug: TMC435 150 mg capsule concept K; Drug: TMC435 150 mg capsule concept L
Sponsors: Janssen R&D Ireland; Janssen R&D Ireland
Recruiting - verified April 2012 - Condition: Acute Lung Injury
Intervention: Other: Microdose of NAP
Sponsors: University of Edinburgh; University of Edinburgh; Medical Research Council
Not yet recruiting - verified January 2012 - Condition: Cerebral Vasculature
Intervention: Other: cocoa
Sponsors: NHS Greater Glasgow and Clyde; NHS Greater Glasgow and Clyde; University of Glasgow
Not yet recruiting - verified January 2012 - Condition: HIV
Interventions: Biological: EN41-FPA2 HIV vaccine; Biological: EN41-FPA2 HIV vaccine; Biological: EN41-FPA2 HIV vaccine; Biological: EN41-FPA2 HIV vaccine; Biological: Na Cl Placebo vaccine
Sponsors: PX'Therapeutics; PX'Therapeutics; European Commission
Recruiting - verified January 2012 - Condition: Tuberculosis
Interventions: Biological: Aerosol inhaled MVA85A; Biological: Intradermal MVA85A
Sponsors: University of Oxford; University of Oxford
Recruiting - verified January 2012 - Condition: Hepatitis C
Intervention: Drug: Sildenafil and Boceprevir
Sponsors: Imperial College London; Imperial College London
Not yet recruiting - verified December 2011 - Condition: Healthy Volunteers
Interventions: Drug: NI-0501; Drug: Placebo
Sponsors: NovImmune SA; NovImmune SA
Recruiting - verified October 2011 - Condition: Parkinson's Disease
Interventions: Drug: AZD3241 ER formulation 1; Drug: Placebo; Drug: AZD3241 Alternative titration scheme with formulation 1 or 2
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified November 2011 - Condition: Healthy
Interventions: Drug: AZD2115; Drug: Placebo
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified April 2012 - Condition: Pain, Neuropathic
Interventions: Drug: Gabapentin lower dose; Drug: Donepezil; Other: Placebo (Dop); Other: Placebo (Gaba); Drug: Gabapentin higher dose
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Recruiting - verified February 2012 - Condition: Invasive Pneumococcal Disease
Interventions: Biological: 13-valent pneumococcal conjugate vaccine; Biological: 10-valent pneumococcal conjugate vaccine
Sponsors: University of Oxford; University of Oxford
Not yet recruiting - verified September 2011 - Condition: Obesity
Interventions: Drug: AZD2820; Drug: Placebo
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified March 2012 - Condition: Pneumococcal Disease
Interventions: Biological: Prevenar 13; Biological: Pneumovax II
Sponsors: University of Oxford; University of Oxford; Mason Medical Research Foundation
Not yet recruiting - verified August 2011 - Condition: Streptococcus Pneumoniae
Intervention:
Sponsors: Health Protection Agency, United Kingdom; Dr. Elizabeth Miller
Recruiting - verified March 2012 - Condition: Sepsis
Intervention: Biological: Lipopolysaccharide infusion
Sponsors: University of Nottingham; University of Nottingham
Recruiting - verified October 2011 - Condition: Healthy
Interventions: Drug: AZD8683; Drug: Placebo to match
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified March 2012 - Conditions: Healthy; Diabetes Mellitus, Type 2
Interventions: Drug: oral NNC 0113-0987; Drug: oral NNC 0113-0987; Drug: I.v. NNC 0113-0987; Drug: oral placebo
Sponsors: Novo Nordisk; Novo Nordisk
Recruiting - verified April 2012 - Conditions: Typhoid Fever; Enteric Fever; Typhoid
Interventions: Biological: Vaccine placebo (excipients only); Biological: Ty21a; Biological: M10ZH09 vaccine
Sponsors: University of Oxford; University of Oxford; Wellcome Trust; Imperial College London; University of Maryland
Recruiting - verified December 2011 - Study to Examine the Effect of Ulimorelin on the Pharmacokinetics of Midazolam in Healthy VolunteersCondition: Digestive System Disorders
Interventions: Drug: Midazolam; Drug: Ulimorelin
Sponsors: Norgine; Norgine
Recruiting - verified July 2011 - Study to Assess the Concentration of Avibactam and Ceftazidime in Epithelial Lining Fluid and PlasmaCondition: Healthy
Interventions: Drug: CAZ104; Drug: CAZ104
Sponsors: AstraZeneca; AstraZeneca
Recruiting - verified March 2012 - Condition: Atopic Dermatitis
Interventions: Drug: LEO 29102; Drug: Placebo
Sponsors: LEO Pharma; LEO Pharma
Recruiting - verified April 2012 - Conditions: Mood Modulation; Modulation of Cognition
Interventions: Dietary Supplement: Hops Extract; Other: Placebo (silica)
Sponsors: Northumbria University; Northumbria University; The New Zealand Institute for Plant and Food Research
Recruiting - verified August 2011 - Condition: Healthy Volunteers
Intervention: Other: cross-linking of an emulsion drink
Sponsors: Institute of Food Research; Institute of Food Research; Norfolk and Norwich University Hospitals NHS Foundation Trust
Recruiting - verified March 2012 - Condition: Chronic Obstructive Pulmonary Disease
Intervention: Drug: PUR118
Sponsors: Pulmatrix Inc.; Pulmatrix Inc.; Quotient Bioresearch
Recruiting - verified November 2011 - Conditions: Acute Respiratory Distress Syndrome (ARDS); Acute Lung Injury (ALI)
Interventions: Drug: GSK1995057 single dose; Drug: GSK1995057 repeat dose
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Recruiting - verified November 2011 - Condition: Healthy Subjects
Intervention: Drug: LEO 32731
Sponsors: LEO Pharma; LEO Pharma
Recruiting - verified March 2011 - Condition: Hepatitis C Infection
Interventions: Biological: MVA-NSmut; Biological: AdCh3NSmut; MVA-NSmut; Biological: AdCh3NSmut; MVA-NSmut; Biological: AdCh3NSmut ; MVA-NSmut; Biological: AdCh3NSmut; MVA-NSmut
Sponsors: Okairos; Okairos; University of Oxford; Oxford University Hospitals NHS Trust; University Hospital Birmingham
Recruiting - verified October 2011 - Conditions: Haemophilia A; Haemophilia B; Healthy
Interventions: Drug: NNC 0172-0000-2021; Drug: NNC 0172-0000-2021; Drug: placebo
Sponsors: Novo Nordisk; Novo Nordisk
Recruiting - verified April 2012 - Conditions: Asthma; Health
Intervention: Other: All patients
Sponsors: Centocor, Inc.; Centocor, Inc.
Recruiting - verified April 2012 - Condition: HIV-1 Infections
Interventions: Biological: ChAdV63.HIVconsv low dose.; Biological: ChAdV63.HIVconsv high dose.; Biological: pSG2.HIVconsv; Biological: MVA.HIVconsv; Other: Placebo
Sponsors: University of Oxford; University of Oxford
Recruiting - verified February 2012 - Conditions: Ischemic Heart Disease; Transient Ischemic Attack; Stroke; Peripheral Vascular Disease
Interventions: Dietary Supplement: Ateronon; Dietary Supplement: Placebo
Sponsors: Cambridge University Hospitals NHS Foundation Trust; Cambridge University Hospitals NHS Foundation Trust; Cambridge Theranostics Ltd
Recruiting - verified April 2010 - Conditions: Major Depressive Disorder; Healthy Volunteers
Intervention: Drug: Duloxetine
Sponsors: Eli Lilly and Company; Eli Lilly and Company
Recruiting - verified April 2012 - Condition: Bowel Disease, Inflammatory
Intervention: Drug: GSK1070806
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Recruiting - verified June 2011 - Condition: Influenza
Interventions: Biological: MVA-NP+M1; Biological: MVA-NP+M1; Biological: MVA-NP+M1
Sponsors: University of Oxford; University of Oxford; Wellcome Trust
Recruiting - verified June 2011
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