Clinical Trials by University - Ohio

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Clinical Evaluation of Bioadhesive Gels for Oral Cancer Chemoprevention

Conditions: Oral Squamous Cell Carcinoma; Oral Epithelial Dysplasia
Interventions: Drug: Bioadhesive 10% freeze-dried black raspberry gel; Drug: Color/consistency matched placebo gel
Sponsors: Ohio State University; University of Louisville; University of North Carolina, Chapel Hill; National Cancer Institute (NCI)
Not yet recruiting - verified August 2010
Switching From Efavirenz to Atazanavir/ Ritonavir in HIV-infected Subjects With Good Virologic Suppression

Conditions: HIV Infection; Mitochondrial Dysfunction
Interventions: Drug: Atazanavir/ritonavir; Drug: Efavirenz
Sponsors: The Cleveland Clinic; National Institute of Allergy and Infectious Diseases (NIAID); Case Western Reserve University; Bristol-Myers Squibb
Not yet recruiting - verified September 2010
Stereotactic Body Radiation Therapy in Treating Patients With Liver Cancer That Cannot be Removed by Surgery or Transplant

Conditions: Adult Primary Hepatocellular Carcinoma; Advanced Adult Primary Liver Cancer; Localized Unresectable Adult Primary Liver Cancer; Recurrent Adult Primary Liver Cancer
Intervention: Radiation: stereotactic body radiation therapy
Sponsors: Case Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified September 2010
Use of 48 Hour Course of Antibiotics to Prevent Surgical Site Infection in Obese Patients Undergoing Cesarean Delivery

Condition: Surgical Site Infection in Obese Women Undergoing C-section
Interventions: Drug: cephalexin & metronidazole; Drug: placebo
Sponsors: University of Cincinnati; The University Hospital
Enrolling by invitation - verified September 2010
Sildenafil Trial in Children and Young Adults With CF

Conditions: Cystic Fibrosis With Mild to Moderate Lung Disease; CMRI of Lung Perfusion; Lung Perfusion; Lung Vascularization
Intervention: Drug: Sildenafil
Sponsor: Children's Hospital Medical Center, Cincinnati
Not yet recruiting - verified September 2010
Genetics of Congenital Heart Disease

Condition: Congenital Heart Disease
Intervention: Other: Blood Sample Collection
Sponsor: Nationwide Children's Hospital
Recruiting - verified August 2010
Erlotinib Hydrochloride and Radiation Therapy in Treating Patients With Stage III-IV Squamous Cell Cancer of the Head and Neck

Conditions: Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity
Interventions: Drug: erlotinib hydrochloride; Radiation: intensity-modulated radiation therapy; Other: pharmacogenomic studies; Other: gene expression analysis; Radiation: 3-dimensional conformal radiation therapy; Other: biopsy; Other: pharmacological study; Other: laboratory biomarker analysis; Other: questionnaire administration; Other: enzyme-linked immunosorbent assay; Other: polymorphism analysis
Sponsors: Case Comprehensive Cancer Center; National Cancer Institute (NCI)
Not yet recruiting - verified August 2010
Investigating Effects of Epidurals Upon Likelihood of Breast-Feeding

Conditions: Breastfeeding; Lactation; Analgesia
Intervention:
Sponsor: MetroHealth Medical Center
Not yet recruiting - verified August 2010
Study of Eltrombopag in Platelet Refractory Thrombocytopenia

Condition: Thrombocytopenia
Intervention: Drug: Eltrombopag
Sponsors: University of Cincinnati; GlaxoSmithKline
Recruiting - verified August 2010
Radiation Planning Study for High Grade Brain Tumors

Condition: High Grade Glioma
Intervention: Other: 3T MRI
Sponsor: University of Cincinnati
Recruiting - verified August 2010
Randomized Controlled Trial to Assess Effects of Lacosamide on Sleep and Wake in Adults With Focal Epilepsy

Condition: Partial Onset Epilepsy
Interventions: Drug: Lacosamide; Drug: Placebo
Sponsors: The Cleveland Clinic; UCB, Inc.
Recruiting - verified August 2010
Dexmedetomidine Versus Fentanyl Following Pressure Equalization Tube Placement

Condition: Myringotomy and Placement of PE (Pressure Equalization) Tubes
Interventions: Drug: Dexmedetomidine; Drug: Fentanyl
Sponsor: Nationwide Children's Hospital
Not yet recruiting - verified August 2010
Apnea, Bariatric Surgery Versus Continuous Positive Airway Pressure (CPAP) Trial

Conditions: Obstructive Sleep Apnea; Obesity
Interventions: Device: CPAP; Procedure: Laparoscopic Gastric Banding
Sponsors: Case Western Reserve University; National Heart, Lung, and Blood Institute (NHLBI); Brigham and Women's Hospital
Not yet recruiting - verified August 2010
Safety and Efficacy of Rasagiline in Restless Legs Syndrome

Condition: Restless Legs Syndrome
Interventions: Drug: rasagiline; Drug: placebo (sugar pill)
Sponsors: University of Virginia; Teva Neuroscience, Inc.
Not yet recruiting - verified August 2010
Corneal Biomechanics With Hydration in Normal and LASIK Eyes

Condition: Laser Corneal Surgery
Interventions: Procedure: LASIK surgery; Other: No Intervention
Sponsor: Ohio State University
Active, not recruiting - verified August 2010
BraveNet Multi-Center Study on Integrative Medicine Treatment Approaches for Pain

Condition: Chronic Pain
Intervention:
Sponsors: Duke University; The Bravewell Collaborative; Alliance Institute for Integrative Medicine; Allina Hospitals and Clinics; University of Maryland; The Continuum Center for Health and Healing; Thomas Jefferson University; University of California, San Francisco; Scripps Clinic; Venice Family Clinic Simms/Mann Health and Wellness Center
Enrolling by invitation - verified August 2010
The Effect of the Hyperinsulinemic Normoglycemic Clamp on Myocardial Function and Utilization of Glucose

Conditions: Hyperglycemia; Coronary Artery Bypass Graft; Coronary Artery Bypass
Interventions: Other: HNC; Other: control group
Sponsors: Outcomes Research Consortium; National Institutes of Health (NIH)
Recruiting - verified August 2010
EZN-3042 Administered With Re-induction Chemotherapy in Children With Relapsed Acute Lymphoblastic Leukemia (ALL)

Conditions: Lymphoblastic Leukemia, Acute; Lymphoblastic Leukemia, Acute, Childhood; Leukemia, Lymphoblastic, Acute, T Cell; Leukemia, Lymphoblastic, Acute
Interventions: Drug: EZN-3042; Drug: Cytarabine; Drug: Doxorubicin; Drug: Prednisone; Drug: Vincristine; Drug: Pegaspargase; Drug: Methotrexate
Sponsors: Therapeutic Advances in Childhood Leukemia Consortium; Enzon Pharmaceuticals, Inc.
Recruiting - verified August 2010
Masimo CO-Oximeter Study

Condition: Cardiac Surgical Procedures
Intervention:
Sponsor: Nationwide Children's Hospital
Enrolling by invitation - verified August 2010
A Research Trial of Aralast in New Onset Diabetes (RETAIN) - Part II

Condition: Diabetes Mellitus, Type 1
Interventions: Drug: Alpha 1-Antitrypsin (AAT, Aralast NP); Drug: Placebo
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); Immune Tolerance Network; Juvenile Diabetes Research Foundation
Not yet recruiting - verified August 2010
A Research Trial of Aralast in New Onset Diabetes (RETAIN) - Part I

Condition: Diabetes Mellitus, Type 1
Intervention: Drug: Alpha 1-Antitrypsin (AAT, Aralast NP)
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); Immune Tolerance Network; Juvenile Diabetes Research Foundation
Not yet recruiting - verified August 2010
Evaluation of the Trabecular Metal™ Revision Hip Cup Using Bone Mineral Density (DEXA)

Condition: Revision, Joint
Interventions: Device: Zimmer Trabecular Metal Revision Cup; Device: Zimmer Modular Cup
Sponsors: The Cleveland Clinic; Zimmer, Inc.
Recruiting - verified August 2010
Virtual Reality Laparoscopy Training

Condition: Differences in OSATS Scores
Intervention: Other: Trainer Curriculum
Sponsor: TriHealth Inc.
Completed - verified August 2010
New Treatment for Alcohol and Nicotine Dependence

Conditions: Alcohol Dependence; Nicotine Dependence
Interventions: Drug: Topiramate with brief behavioral enhancement therapy; Drug: Placebo plus brief behavioral enhancement therapy
Sponsors: University of Virginia; National Institute on Alcohol Abuse and Alcoholism (NIAAA); University of Houston; University of Cincinnati; M.D. Anderson Cancer Center
Not yet recruiting - verified August 2010
The Effect of Adding Intraoperative Regional Anesthesia on Cancer Recurrence in Patients Undergoing Lung Cancer Resection

Condition: Lung Cancer
Interventions: Other: General-epidural anesthesia and analgesia; Other: Balanced general anesthesia and postoperative opioids
Sponsor: Outcomes Research Consortium
Recruiting - verified August 2010
Oral Progesterone for Prevention of Preterm Birth

Condition: Preterm Birth
Interventions: Drug: oral micronized progesterone; Drug: Identical Placebo tablet
Sponsor: Fetal Medicine Foundation
Completed - verified August 2010
Effects of Intentional Weight Loss Interventions in Chronic Kidney Disease

Conditions: Chronic Kidney Disease; Obesity
Interventions: Behavioral: Diet and exercise; Procedure: Bariatric Surgery
Sponsor: The Cleveland Clinic
Recruiting - verified August 2010

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