- Condition: Stroke
Interventions: Behavioral: Usual care; Behavioral: Overground visual cue training; Behavioral: Treadmill visual cue training
Sponsors: University of Salford; University of Salford; University of Birmingham; Nottingham Clinical Trials Unit; Stroke Research Network; The University of Newcastle, Australia
Not yet recruiting - verified May 2012 - Conditions: Multiple Conditions; Coronary Heart Disease; Diabetes; Hypertension; Chronic Obstructive Pulmonary Disease
Intervention:
Sponsors: University of Southampton; University of Southampton
Not yet recruiting - verified May 2012 - Conditions: Heart Failure; Endothelium
Intervention: Drug: Urocortin 2, Urocortin 3 and Substance P
Sponsors: University of Edinburgh; University of Edinburgh; NHS Lothian
Not yet recruiting - verified May 2012 - Conditions: Anxiety; Depression
Interventions: Behavioral: Individual Career Management (ICM); Behavioral: Standard Care
Sponsors: South London and Maudsley NHS Foundation Trust; South London and Maudsley NHS Foundation Trust
Recruiting - verified May 2012 - Condition: Lower Eyelid Entropion
Interventions: Procedure: 7/0 vicryl suture; Procedure: 5/0 vicryl test suture
Sponsors: The Royal Bournemouth Hospital; The Royal Bournemouth Hospital
Completed - verified May 2012 - Condition: Atrial Flutter
Interventions: Procedure: Radiofrequency ablation utilising the ECI contact software; Procedure: Radiofrequency ablation without the use of ECI contact data
Sponsors: Oxford University Hospitals NHS Trust; Oxford University Hospitals NHS Trust
Recruiting - verified May 2012 - Condition: Postoperative Delirium
Intervention: Other: Bedside Mirrors Intervention
Sponsors: Papworth Hospital NHS Foundation Trust; Papworth Hospital NHS Foundation Trust
Not yet recruiting - verified May 2012 - Condition: Cardiovascular Health
Interventions: Other: Yoga; Other: Usual care
Sponsors: Imperial College London; Imperial College London
Not yet recruiting - verified May 2012 - Condition: Obesity
Interventions: Other: Breakfast Study; Other: fMRI Study
Sponsors: University of Aberdeen; University of Aberdeen; European Union
Recruiting - verified May 2012 - Conditions: Neoplasm Metastasis; Neoplastic Processes; Neoplasm Recurrence, Local; Neoplasm, Residual; Pain
Intervention: Radiation: Radiosurgery
Sponsors: Wuerzburg University Hospital; Wuerzburg University Hospital; Royal Marsden NHS Foundation Trust
Active, not recruiting - verified May 2012 - Condition: Idiopathic Pulmonary Arterial Hypertension
Interventions: Drug: (Pyr1)apelin-13; Drug: Saline
Sponsors: Imperial College London; Imperial College London
Recruiting - verified April 2012 - Conditions: Mental Health Wellness 1; Pregnancy; Mother-Child Relations
Interventions: Other: Mellow Bumps; Other: Chill-out in Pregnancy
Sponsors: University of Glasgow; University of Glasgow
Not yet recruiting - verified May 2012 - Condition: Patients Requiring Forefoot Surgery
Interventions: Device: Darco shoe; Device: Podalux shoe; Device: Standard dressing shoe
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Teaching Hospitals NHS Foundation Trust
Not yet recruiting - verified May 2012 - Condition: Primary Hyperparathyroidism
Intervention: Device: Near infrared fluorescence detection
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Teaching Hospitals NHS Foundation Trust
Not yet recruiting - verified May 2012 - Conditions: Cancer; Non Small Cell Lung Cancer
Interventions: Drug: Vandetanib, Selumetinib; Drug: Vandetanib, Selumetinib; Drug: Vandetanib, Selumetinib; Drug: Vandetanib, Selumetinib
Sponsors: Cancer Research UK; Cancer Research UK
Recruiting - verified April 2012 - Condition: Paediatric Dentistry
Interventions: Procedure: compensatory extraction of upper FPMs; Procedure: no compensatory extraction of Upper FPMs
Sponsors: University of Dundee; Stephen McSwiggan; NHS Tayside
Not yet recruiting - verified May 2012 - Condition: Lung Cancer - Malignant Pleural Mesothelioma
Interventions: Drug: Ganetespib; Drug: Placebo
Sponsors: University College, London; University College, London; Cancer Research UK
Not yet recruiting - verified May 2012 - Condition: Healthy
Interventions: Dietary Supplement: Dietary supplement of iron; Drug: Ferrous sulphate
Sponsors: Imperial College London; Imperial College London
Active, not recruiting - verified April 2012 - Condition: Hereditary Haemorrhagic Telangiectasia
Interventions: Other: Aeroplane flight in the past- no active intervention for study; Other: Questionnaire
Sponsors: Imperial College London; Imperial College London
Completed - verified April 2012 - Condition: Differentiated Thyroid Cancer
Intervention:
Sponsors: Newcastle-upon-Tyne Hospitals NHS Trust; Newcastle-upon-Tyne Hospitals NHS Trust
Recruiting - verified April 2012 - Condition: Healthy
Interventions: Dietary Supplement: 2 portions of fruit and vegetables per day; Dietary Supplement: 5 portions of fruit and vegetables per day; Dietary Supplement: 8 portions of fruit and vegetables per day
Sponsors: Queen's University, Belfast; Queen's University, Belfast
Recruiting - verified May 2012 - Condition: Carpal Tunnel Syndrome
Intervention: Device: EMS Therasonic 460 Primo Ultrasound therapy
Sponsors: East Kent Hospitals University NHS Foundation Trust; East Kent Hospitals University NHS Foundation Trust
Not yet recruiting - verified May 2012 - Condition: Advanced Solid Tumours
Intervention: Biological: AT13148
Sponsors: Cancer Research UK; Cancer Research UK
Not yet recruiting - verified April 2012 - Condition: Cardiovascular Disease
Interventions: Drug: N(t)RTI) + boosted protease inhibitors (PI/r); Drug: maraviroc + boosted protease inhibitors (PI/r); Drug: maraviroc + N(t)RTI)
Sponsors: Kirby Institute; Kirby Institute
Not yet recruiting - verified April 2012 - Condition: Cardiovascular Disease
Intervention: Dietary Supplement: High/ Low Epicatechin Apples/ Apple Extract/ Granules
Sponsors: Queen's University, Belfast; Queen's University, Belfast
Recruiting - verified April 2012 - Condition: Atrial Fibrillation
Intervention: Device: THERMOCOOL® SMARTTOUCH™ Catheter
Sponsors: Barts & The London NHS Trust; Barts & The London NHS Trust
Recruiting - verified April 2012 - Conditions: Myocardial Infarction; Reperfusion Injury; Myocardial Ischemia; Cardiovascular Diseases
Interventions: Drug: Sodium Nitrite; Drug: Sodium Chloride Placebo
Sponsors: Barts & The London NHS Trust; Barts & The London NHS Trust; Queen Mary University of London
Recruiting - verified April 2012 - Conditions: Primary Bile Acid Malabsorption; Secondary Bile Acid Malabsorption; Chronic Diarrhoea
Intervention: Drug: Obeticholic acid
Sponsors: Imperial College London; Imperial College London
Not yet recruiting - verified April 2012 - Condition: Achilles Tendinopathy
Interventions: Procedure: Ultrasound guided injection of steroid and local anaesthetic; Procedure: High volume saline injection; Behavioral: exercise programme
Sponsors: Leeds Comunity Healthcare NHS Trust; Leeds Comunity Healthcare NHS Trust; National Insitute of Health Research FSF funding
Recruiting - verified April 2012 - Conditions: Adenocarcinoma of the Gastroesophageal Junction; Cervical Cancer; Endometrial Cancer; Esophageal Cancer; Fallopian Tube Cancer; Gastric Cancer; Ovarian Cancer; Sarcoma; Vaginal Cancer; Vulvar Cancer
Intervention:
Sponsors: Royal Marsden NHS Foundation Trust; Royal Marsden NHS Foundation Trust; University of Surrey
Recruiting - verified April 2012 - Condition: Cardiovascular Disease
Intervention:
Sponsors: Queen Mary University of London; Queen Mary University of London; King's College London
Not yet recruiting - verified April 2012 - Conditions: Guillain-Barré Syndrome; Miller Fisher Syndrome
Intervention:
Sponsors: Erasmus Medical Center; Erasmus Medical Center
Recruiting - verified May 2012 - Conditions: Meningitis; Meningococcal Disease; Septicaemia
Interventions: Biological: MenACWY-CRM conjugate vaccine (Menveo, Novartis); Biological: MenACWY-PS polysaccharide vaccine, ( ACWYVax, GSK) and MenACWY-CRM conjugate vaccine (Menveo, Novartis); Biological: MenACWY-PS polysaccharide vaccine, ( ACWYVax, GSK) and MenACWY-CRM conjugate vaccine (Menveo, Novartis); Biological: 1/5th dose MenACWY-PS polysaccharide vaccine, ( ACWYVax, GSK) and MenACWY-CRM conjugate vaccine (Menveo, Novartis)
Sponsors: University of Oxford; University of Oxford
Not yet recruiting - verified May 2012 - Condition: Cardiovascular Function
Intervention: Biological: Typhoid vaccine
Sponsors: Queen Mary University of London; Queen Mary University of London
Recruiting - verified April 2012 - Condition: Dilated Cardiomyopathy
Interventions: Drug: perindopril; Drug: placebo
Sponsors: Institut National de la Santé Et de la Recherche Médicale, France; Institut National de la Santé Et de la Recherche Médicale, France
Recruiting - verified April 2012 - Conditions: Health Behavior; Physical Activity
Interventions: Behavioral: Non-cash incentives; Behavioral: Self-monitoring physical activity levels
Sponsors: Queen's University, Belfast; Queen's University, Belfast
Completed - verified April 2012 - Conditions: Myocardial Infarction; Death
Intervention: Procedure: Bone Marrow aspiration and intracoronary reinfusion
Sponsors: Barts & The London NHS Trust; Barts & The London NHS Trust
Not yet recruiting - verified April 2012 - Condition: Diabetes
Intervention: Drug: Exenatide, Liraglutide
Sponsors: University of Dundee; Evan Pearson; Newcastle Hospitals NHS trust; Oxford Hospitals NHS trust; Royal Devon & Exeter NHS foundation trust
Recruiting - verified April 2012 - Condition: Cervical Cancer
Interventions: Drug: Paclitaxel; Drug: Carboplatin; Radiation: Radiotherapy; Drug: Cisplatin
Sponsors: University College, London; University College, London; Cancer Research UK
Not yet recruiting - verified March 2012 - Condition: Closed Fracture of Base of Fifth Metatarsal Bone
Interventions: Device: Compressive bandage; Device: Below knee walking cast
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Teaching Hospitals NHS Foundation Trust
Recruiting - verified May 2012 - Condition: Acute Kidney Injury
Interventions: Other: Proteomic assay; Other: Blood sampling; Other: Biomarker sampling
Sponsors: University of Glasgow; Dr Robert Docking
Not yet recruiting - verified April 2012 - Condition: Liver Fibrosis
Interventions: Procedure: Blood sample; Other: MRI Scan
Sponsors: University of Nottingham; University of Nottingham
Recruiting - verified April 2012 - Conditions: Cystic Fibrosis; Aspergillus Infections
Intervention: Drug: Itraconazole/voriconazole
Sponsors: Rennes University Hospital; Rennes University Hospital
Not yet recruiting - verified April 2012 - Condition: Lung Cancer
Interventions: Drug: Erlotinib; Drug: Bevacizumab
Sponsors: European Thoracic Oncology Platform; European Thoracic Oncology Platform; Spanish Lung Cancer Group
Not yet recruiting - verified April 2012 - Condition: Moderate to Severe Atopic Eczema
Intervention: Radiation: Narrowband Ultraviolet B phototherapy
Sponsors: Royal Victoria Infirmary; Royal Victoria Infirmary; British Skin Foundation
Completed - verified April 2012 - A Phase II Trial to Assess TroVax® Plus Chemotherapy in Patients With Malignant Pleural MesotheliomaConditions: Malignant; Pleural; Mesothelioma
Interventions: Biological: TroVax®; Drug: Pemetrexed; Drug: Cisplatin; Dietary Supplement: Vitamin B12; Dietary Supplement: Folic Acid; Drug: Dexamethasone
Sponsors: Wales Cancer Trials Unit; Wales Cancer Trials Unit; Velindre NHS Trust; June Hancock Mesothelioma Research Fund; Velindre Cancer Centre Stepping Stones Appeal
Not yet recruiting - verified March 2012 - Condition: Breast Cancer
Intervention:
Sponsors: Institute of Cancer Research, United Kingdom; Institute of Cancer Research, United Kingdom
Completed - verified March 2012 - Condition: Strongyloidiasis
Intervention: Drug: Ivermectin
Sponsors: Centro per le Malattie Tropicali; Centro per le Malattie Tropicali; European Commission
Not yet recruiting - verified April 2012 - Condition: Ocular Allergy
Interventions: Other: Non-Pharmaceutical Tear Supplement; Device: Eye Gel Mask Blue placed over the closed eyes; Drug: ELESTAT® (epinastine HCl ophthalmic solution) 0.05%
Sponsors: Aston University; Aston University; National Pollen and Aerobiology Research Unit, University of Worcester
Recruiting - verified April 2012 - Conditions: Cancer; Neoplasms; Lymphoma; Non-Hodgkin; B-Cell
Intervention: Drug: Chi Lob 7/4 (A chimeric monoclonal antibody)
Sponsors: Cancer Research UK; Cancer Research UK
Recruiting - verified April 2012 - Condition: Healthy Volunteers
Intervention: Other: sedimenting meal
Sponsors: Institute of Food Research; Institute of Food Research; Norfolk and Norwich University Hospitals NHS Foundation Trust; Top Institute Food and Nutrition
Completed - verified May 2012 - Condition: Renal Cancer
Intervention: Drug: Light activated WST11
Sponsors: University of Oxford; University of Oxford; Steba Biotech S.A.
Not yet recruiting - verified April 2012 - Conditions: Chest Pain; Unobstructed Coronary Arteries
Interventions: Behavioral: Hypnotherapy; Behavioral: Supportive therapy
Sponsors: Imperial College London; Imperial College London
Not yet recruiting - verified March 2012 - Condition: Huntington Disease, Juvenile
Intervention:
Sponsors: European Huntington's Disease Network; European Huntington's Disease Network
Recruiting - verified May 2012 - Condition: Bronchiectasis
Intervention:
Sponsors: University of Ulster; University of Ulster; Belfast Health and Social Care Trust; Western Health and Social Care Trust; Queen's University, Belfast; University of Strathclyde
Not yet recruiting - verified March 2012 - Conditions: Infertility; Ovarian Aging; Diminished Ovarian Reserve (DOR); Predicted Poor-responders
Interventions: Drug: Dehydroepiandrosterone; Drug: Placebo
Sponsors: University of Nottingham; University of Nottingham
Not yet recruiting - verified April 2012 - Condition: Type 1 Diabetes
Intervention: Procedure: Overnight closed-loop insulin delivery
Sponsors: University of Cambridge; Daniela Elleri; Cambridge University Hospitals NHS Foundation Trust
Not yet recruiting - verified March 2012 - Condition: Depression
Interventions: Drug: Amlodipine; Drug: Placebo
Sponsors: Gateshead Health NHS Foundation Trust; Gateshead Health NHS Foundation Trust; Newcastle-upon-Tyne Hospitals NHS Trust; National Institute for Health Research, United Kingdom
Not yet recruiting - verified March 2012 - Conditions: Mental Health Wellness 1; Depression; Anxiety
Intervention: Behavioral: Method of Levels Cognitive Therapy
Sponsors: University of Manchester; University of Manchester
Recruiting - verified March 2012 - Conditions: Enteral Feeding; Nasogastric Feeding; Diarrhoea
Interventions: Dietary Supplement: NG bolus feeding over 5 min; Dietary Supplement: Continuous NG feeding over 4 h
Sponsors: University of Nottingham; University of Nottingham
Recruiting - verified March 2012 - Condition: Stroke
Interventions: Device: 'Inmotion Arm Robot'; Other: Standard of care
Sponsors: NHS Greater Glasgow and Clyde; NHS Greater Glasgow and Clyde; University of Glasgow
Not yet recruiting - verified March 2012 - Condition: STEMI
Interventions: Procedure: Index of microvascular resistance; Other: Cardiac magnetic resonance; Other: Blood markers
Sponsors: University of Bristol; University of Bristol; David Telling Charitable Trust; NIHR Cardiovascular BRU
Active, not recruiting - verified March 2012 - Conditions: Multiple Sclerosis; Chronic Cerebrospinal Venous Insufficiency
Intervention: Procedure: percutaneous venoplasty to alleviate chronic cerebrospinal venous insufficiency
Sponsors: University of Stirling; University of Stirling
Not yet recruiting - verified March 2012 - Condition: Monitoring of Patients Following Surgery
Intervention: Device: Fitting of a wireless telemetry device
Sponsors: Guy's and St Thomas' NHS Foundation Trust; Guy's and St Thomas' NHS Foundation Trust; Engineering and physical sciences research council; King's College London; University of Oxford
Not yet recruiting - verified March 2012 - Condition: Sarcopenia
Interventions: Drug: Allopurinol; Drug: Lactose tablets
Sponsors: University of Dundee; University of Dundee
Not yet recruiting - verified March 2012 - Condition: Netherton Syndrome
Intervention: Genetic: One 5cm2 autologous skin sheet graft
Sponsors: Great Ormond Street Hospital for Children NHS Trust; Great Ormond Street Hospital for Children NHS Trust
Not yet recruiting - verified March 2012 - Conditions: Diabetes; Stroke; Obesity
Intervention:
Sponsors: Children's & Women's Health Centre of British Columbia; Children's & Women's Health Centre of British Columbia
Recruiting - verified March 2012 - Condition: Prediabetic State
Intervention: Behavioral: Lifestyle Modification
Sponsors: India Diabetes Research Foundation & Dr. A. Ramachandran's Diabetes Hospitals; India Diabetes Research Foundation & Dr. A. Ramachandran's Diabetes Hospitals; Indian Council of Medical Research; Medical Research Council; Imperial College London
Not yet recruiting - verified April 2012 - Conditions: Obstructive Sleep Apnoea; Obesity
Intervention: Behavioral: Combined lifestyle intervention
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Hallam University
Completed - verified March 2012 - Conditions: General Anaesthesia; Propofol; Target Controlled Infusion; Pharmacokinetics
Intervention:
Sponsors: University Hospital Birmingham NHS Foundation Trust; University Hospital Birmingham NHS Foundation Trust
Recruiting - verified March 2012 - Condition: Chronic Kidney Disease
Intervention: Other: OxSalt care bundle
Sponsors: University of Oxford; University of Oxford; British Renal Society
Not yet recruiting - verified May 2012 - Condition: Hypoxic Ischaemic Encephalopathy
Interventions: Drug: xenon gas; Device: Full body cooling
Sponsors: United Bristol Healthcare NHS Trust; United Bristol Healthcare NHS Trust; University of Bristol
Not yet recruiting - verified February 2012 - Condition: Cardiac Failure
Intervention:
Sponsors: Eastbourne General Hospital; Guy Lloyd
Not yet recruiting - verified March 2012 - Condition: Tinnitus
Intervention: Device: CR Neuromodulation
Sponsors: Nottingham University Hospitals NHS Trust; Nottingham University Hospitals NHS Trust; University of Nottingham; University College, London
Not yet recruiting - verified February 2012 - Condition: Aggression
Interventions: Dietary Supplement: Placebo; Dietary Supplement: Multi-vitamin/mineral; Dietary Supplement: Docosahexaenoic acid; Dietary Supplement: DHA plus vitamins/minerals
Sponsors: Swansea University; Swansea University
Completed - verified March 2012 - Condition: Intestinal Polyps
Intervention: Procedure: Colonoscope withdrawal strategy
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Teaching Hospitals NHS Foundation Trust
Recruiting - verified March 2012 - Condition: Atrial Fibrillation
Interventions: Procedure: Catheter ablation for atrial fibrillation, manual; Device: Ablation using Amigo remote catheter system
Sponsors: University of Leicester; University of Leicester
Recruiting - verified May 2012 - Conditions: Use of Video Education; Colorectal Surgery
Interventions: Procedure: The study group will get a video and leaflet on enhanced recovery; Procedure: The control group will receive a leaflet only
Sponsors: Ihedioha, Ugo, M.D.; Ihedioha, Ugo, M.D.
Completed - verified March 2012 - Conditions: Breast Neoplasms; Breast Reconstruction
Intervention:
Sponsors: NHS Greater Glasgow and Clyde; NHS Greater Glasgow and Clyde
Enrolling by invitation - verified May 2012 - Condition: Asthma
Interventions: Drug: Propranolol; Drug: Placebo; Drug: Qvar 50; Drug: Qvar 100
Sponsors: University of Dundee; University of Dundee; Chief Scientist Office of the Scottish Government
Not yet recruiting - verified February 2012 - Condition: Unipolar Depression
Intervention: Other: fMRI-based neurofeedback
Sponsors: Cardiff University; Cardiff University; Medical Research Council; National Institute for Social Care and Health Research
Recruiting - verified February 2012 - Condition: Type 1 Diabetes
Interventions: Drug: Pro insulin peptide; Drug: Pro insulin peptide; Drug: Saline
Sponsors: Cardiff University; Cardiff University; Diabetes Vaccine Development Centre; Juvenile Diabetes Research Foundation
Recruiting - verified April 2012 - Condition: Parkinson's Disease
Interventions: Drug: Deferiprone; Drug: Placebo
Sponsors: Imperial College London; Imperial College London
Not yet recruiting - verified February 2012 - Condition: Locally Advanced Non-small Cell Lung Cancer
Intervention: Radiation: Radiotherapy
Sponsors: Wales Cancer Trials Unit; Wales Cancer Trials Unit
Recruiting - verified February 2012 - Condition: Neurodegenerative Disorders
Intervention: Drug: nicotinamide
Sponsors: Imperial College London; Imperial College London
Not yet recruiting - verified April 2012 - Condition: Cardiovascular Disease
Interventions: Drug: morphine; Drug: saline
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Teaching Hospitals NHS Foundation Trust
Not yet recruiting - verified August 2011 - Condition: High Risk of Medication-related Problems
Intervention: Other: Medicines Management Outpatient service
Sponsors: Queen's University, Belfast; Queen's University, Belfast
Recruiting - verified February 2012 - Condition: Irritable Bowel Syndrome
Intervention:
Sponsors: University of Nottingham; University of Nottingham
Recruiting - verified February 2012 - Conditions: Liver Cirrhosis; Fatty Liver
Intervention:
Sponsors: University of Oxford; University of Oxford; British Heart Foundation; Oxford University Hospitals NHS Trust
Recruiting - verified March 2012 - Conditions: No Condition; Brain GABA-B Function
Interventions: Drug: Baclofen 10mg; Drug: Baclofen 60mg; Drug: placebo
Sponsors: Imperial College London; Imperial College London; Medical Research Council
Not yet recruiting - verified March 2012 - Condition: Neonatal Respiratory Failure
Intervention: Device: Ventilation protocol delivered by the SLE5000 ventilator
Sponsors: King's College London; King's College London
Completed - verified February 2012 - Condition: Type 1 Diabetes
Intervention: Other: Reducing post-exercise rapid-acting insulin (insulin lispro or aspart) dose
Sponsors: Northumbria University; Northumbria University; Diabetes UK
Recruiting - verified February 2012 - Condition: Obesity
Intervention:
Sponsors: Imperial College London; Imperial College London; Medical Research Council
Recruiting - verified February 2012 - Condition: Cerebral Blood Flow
Interventions: Dietary Supplement: Berry drink; Dietary Supplement: Control
Sponsors: Northumbria University; Northumbria University; The New Zealand Institute for Plant and Food Research
Recruiting - verified February 2012 - Condition: Dietary Modification
Interventions: Behavioral: Level 1 Dietary Intake; Behavioral: Level 2: Dietary Intake + Phenotype; Behavioral: Level 3 Dietary + Phenotype + Genotype; Behavioral: Level 0 Control Group
Sponsors: Newcastle University; Newcastle University; University College Dublin; Maastricht University; University of Oslo; University of Navarra; Harokopio University; University of Reading; National Food and Nutrition InstitutE; Technische Universität München; University of Newcastle Upon-Tyne
Not yet recruiting - verified February 2012 - Conditions: Cholecystitis; Gall Stone Pancreatitis
Interventions: Drug: Bupivacaine; Other: Normal saline
Sponsors: University Hospitals Coventry and Warwickshire NHS Trust; University Hospitals Coventry and Warwickshire NHS Trust
Completed - verified February 2012 - Condition: Emphysema
Interventions: Other: Autologous blood; Other: Normal saline
Sponsors: Royal Brompton & Harefield NHS Foundation Trust; Royal Brompton & Harefield NHS Foundation Trust
Recruiting - verified February 2012 - Condition: Obesity
Intervention: Other: Study visit procedures
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Teaching Hospitals NHS Foundation Trust; NIHR Biomedical Research Unit for Musculoskeletal Disease
Recruiting - verified February 2012 - Condition: Sleep
Interventions: Dietary Supplement: Cherry juice; Dietary Supplement: Fruit juice cordial
Sponsors: Northumbria University; Northumbria University; University of Surrey
Completed - verified February 2012 - Condition: Cardiovascular Disease Risk Reduction
Interventions: Dietary Supplement: Flavanone - supplement; Other: Flavanone - food; Other: Flavanone - placebo; Dietary Supplement: Isoflavone - supplement; Other: Isoflavone - food; Other: Isoflavone - placebo; Dietary Supplement: Isoflavone - metabolite supplement; Dietary Supplement: Flavan-3-ol - supplement; Other: Flavan-3-ol - food; Other: Flavan-3-ol - placebo; Dietary Supplement: Anthocyanin - supplement; Other: Anthocyanin - food; Other: Anthocyanin - placebo
Sponsors: University of East Anglia; University of East Anglia
Not yet recruiting - verified February 2012 - Condition: Asthma
Intervention: Drug: inhaled steroid
Sponsors: Belfast Health and Social Care Trust; Liam Heaney; Northern Ireland Chest Heart & Stroke
Recruiting - verified February 2012 - Condition: Obstructive Sleep Apnoea
Intervention:
Sponsors: Abertawe Bro Morgannwg University NHS Trust; Abertawe Bro Morgannwg University NHS Trust; National Institute for Health Research, United Kingdom; Hywel Dda NHS Trust; Swansea University
Recruiting - verified February 2012 - Condition: Type 1 Diabetes Mellitus
Intervention: Device: The Imperial College Closed-Loop Insulin Delivery System
Sponsors: Imperial College London; Imperial College London
Recruiting - verified February 2012 - Condition: Stroke
Interventions: Drug: Alteplase; Drug: Placebo
Sponsors: Universitätsklinikum Hamburg-Eppendorf; Universitätsklinikum Hamburg-Eppendorf
Not yet recruiting - verified January 2012 - Conditions: Colorectal Cancer; Colorectal Liver Metastasis; Liver Surgery; Exercise Intervention
Intervention: Behavioral: Exercise Intervention
Sponsors: Aintree University Hospitals NHS Foundation Trust; Aintree University Hospitals NHS Foundation Trust
Recruiting - verified February 2012 - Conditions: Anxiety; COPD
Intervention: Drug: escitalopram
Sponsors: Hull and East Yorkshire Hospitals NHS Trust; Hull and East Yorkshire Hospitals NHS Trust
Not yet recruiting - verified January 2012 - Condition: Allergic Rhinitis
Intervention: Biological: Allergovit grass or birch
Sponsors: Royal Sussex County Hospital; Royal Sussex County Hospital
Not yet recruiting - verified February 2012 - Conditions: Acute Leukaemia; Chronic Leukaemia; Myeloma; Lymphoma
Intervention: Radiation: Targeted radiotherapy
Sponsors: Southampton University Hospitals NHS Trust; Southampton University Hospitals NHS Trust; Royal Free and University College Medical School
Recruiting - verified January 2012 - Condition: Toxicity From Medication (Endocrine Treatment and Chemotherapy) Given for Breast Cancer Treatment.
Intervention:
Sponsors: Imperial College London; Imperial College London
Recruiting - verified March 2012 - Condition: Peripheral Bone Density
Intervention: Procedure: XtremeCT
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Teaching Hospitals NHS Foundation Trust
Active, not recruiting - verified February 2012 - Conditions: Chronic Obstructive Pulmonary Disease; Asthma; Healthy; Chronic Cough; Smokers
Interventions: Other: Cough challenge test; Other: 24 hour ambulatory cough recording; Other: Cough quality of life questionnaire
Sponsors: University Hospital of South Manchester NHS Foundation Trust; University Hospital of South Manchester NHS Foundation Trust
Completed - verified April 2012 - Condition: Acute ST Elevation Myocardial Infarction
Interventions: Drug: unfractionated heparin; Drug: Bivalirudin
Sponsors: Liverpool Heart and Chest Hospital NHS Foundation Trust; Liverpool Heart and Chest Hospital NHS Foundation Trust
Not yet recruiting - verified February 2012 - Condition: Chronic Obstructive Pulmonary Disease
Intervention: Device: Telehealth monitoring system (Honni Med)
Sponsors: South Eastern Health and Social Care Trust; South Eastern Health and Social Care Trust
Completed - verified January 2012 - Condition: Total Knee Replacement
Intervention:
Sponsors: NHS Fife; NHS Fife; De Puy International
Completed - verified January 2012 - Condition: Tracheal Intubation
Intervention: Device: Laryngoscopy
Sponsors: NHS Tayside; NHS Tayside
Not yet recruiting - verified January 2012 - Condition: Obesity
Intervention: Device: FreeStyle Navigator
Sponsors: University of Leicester; University of Leicester; University Hospitals, Leicester; Royal College of Surgeons
Not yet recruiting - verified January 2012 - Condition: Cough
Intervention:
Sponsors: Hull and East Yorkshire Hospitals NHS Trust; Hull and East Yorkshire Hospitals NHS Trust
Not yet recruiting - verified March 2012 - Condition: Total Knee Replacement
Intervention:
Sponsors: NHS Fife; NHS Fife; De Puy International
Completed - verified January 2012 - Condition: Mood
Interventions: Dietary Supplement: 5-Hydroxytryptophan; Dietary Supplement: Pharmaceutical grade silica
Sponsors: Northumbria University; Northumbria University
Completed - verified January 2012 - Condition: In-plane Ultrasound Guided Needling Training
Intervention:
Sponsors: University of Aberdeen; University of Aberdeen
Recruiting - verified April 2012 - Conditions: Iron Deficiency; Anaemia
Interventions: Dietary Supplement: alginate beads containing ferrous gluconate; Dietary Supplement: ferrous gluconate in a capsule; Dietary Supplement: ferrous gluconate in a capsule in presence of calcium; Dietary Supplement: alginate beads with ferrous gluconate in presence of calcium
Sponsors: University of East Anglia; University of East Anglia; Institute of Food Research
Recruiting - verified March 2012 - Conditions: Multiple Sclerosis; Fatigue
Interventions: Other: Cognitive behavioural therapy based self help; Other: Treatment as usual
Sponsors: University of Edinburgh; University of Edinburgh
Not yet recruiting - verified January 2012 - Condition: Infantile Colic
Intervention: Procedure: Manual therapy
Sponsors: Anglo-European College of Chiropractic; Professor Jennifer Bolton
Completed - verified January 2012 - Condition: Acute Lung Injury
Intervention: Other: Microdose of NAP
Sponsors: University of Edinburgh; University of Edinburgh; Medical Research Council
Not yet recruiting - verified January 2012 - Conditions: Gastrointestinal Ulcer Haemorrhage; Bacterial Infection Due to Helicobacter Pylori (H. Pylori)
Interventions: Drug: Lansoprazole 30mg, Clarithromycin 500mg, Metronidazole 400mg; Drug: Placebo lansoprazole 30mg, clarithromycin 500mg, metronidazole 400mg
Sponsors: University of Nottingham; University of Nottingham; Nottingham University Hospitals NHS Trust; University of Southampton; University of Durham; University of Birmingham; University of Oxford
Not yet recruiting - verified January 2012 - Conditions: Pulmonary Disease, Chronic Obstructive; Respiratory Tract Diseases; Lung Diseases; Lung Diseases, Obstructive; Bronchitis, Chronic; Pulmonary Emphysema; Disease Progression
Intervention:
Sponsors: Royal Brompton & Harefield NHS Foundation Trust; Royal Brompton & Harefield NHS Foundation Trust; Medical Research Council; The Hillingdon Hospitals NHS Foundation Trust; West Hertfordshire Hospitals NHS Trust
Recruiting - verified January 2012 - Conditions: Pulmonary Disease, Chronic Obstructive; Lung Diseases, Obstructive; Pulmonary Emphysema; Bronchitis, Chronic; Lung Diseases; Disease Progression
Intervention:
Sponsors: Royal Brompton & Harefield NHS Foundation Trust; Royal Brompton & Harefield NHS Foundation Trust; Medical Research Council
Recruiting - verified January 2012 - Condition: HIV Related Neurocognitive Impairment
Intervention:
Sponsors: St Stephens Aids Trust; St Stephens Aids Trust
Recruiting - verified January 2012 - Condition: Type 2 Diabetes,
Intervention: Other: No intervention, observational study
Sponsors: Royal Devon and Exeter NHS Foundation Trust; Royal Devon and Exeter NHS Foundation Trust; National Institute for Health Research, United Kingdom; University of Exeter
Recruiting - verified December 2011 - Condition: Cerebral Vasculature
Intervention: Other: cocoa
Sponsors: NHS Greater Glasgow and Clyde; NHS Greater Glasgow and Clyde; University of Glasgow
Not yet recruiting - verified January 2012 - Condition: Gastro-oesophageal Reflux Disease
Intervention:
Sponsors: Imperial College London; Imperial College London
Not yet recruiting - verified January 2012 - Conditions: Obesity Related Glomerulopathy; Impaired Renal Function; Bariatric Surgery
Intervention:
Sponsors: Imperial College London; Imperial College London
Recruiting - verified January 2012 - Condition: Paroxysmal Atrial Fibrillation
Interventions: Device: ILR insertion; Procedure: AF ablation
Sponsors: Eastbourne General Hospital; Neil Sulke
Recruiting - verified April 2012 - Condition: Atrial Fibrillation
Interventions: Device: Implantation of implantable loop recorder; Procedure: Percutaneous ablation of atrial fibrillation; Procedure: Surgical ablation of atrial fibrillation
Sponsors: Eastbourne General Hospital; Eastbourne General Hospital
Not yet recruiting - verified December 2011 - Condition: Critical Illness
Interventions: Drug: Valaciclovir/Aciclovir; Drug: Valganciclovir/Ganciclovir
Sponsors: University Hospital Birmingham NHS Foundation Trust; University Hospital Birmingham NHS Foundation Trust; National Institute for Health Research, United Kingdom
Recruiting - verified February 2012 - Condition: Alcoholism
Interventions: Other: Training and support (T&S); Other: Financial incentive; Other: E-SBI (online screening and brief intervention)
Sponsors: Fundacion Clinic per a la Recerca Biomédica; Fundacion Clinic per a la Recerca Biomédica; European Commission; Stichting Katholieke Universiteit; University of Newcastle Upon-Tyne; King's College London; Goeteborgs Universitet; Linkoeping University; Departament de Salut de la Generalitat de Catalunya; Panstwowa Agencja Rozwiazywania Problemow Alkoholowych; University College, London; Maastricht University; Pomorski Uniwersytet Medyczny w Szczecinie
Enrolling by invitation - verified December 2011 - Condition: Obesity
Interventions: Drug: Y242; Drug: 0.9% saline
Sponsors: Imperial College London; Imperial College London; Medical Research Council
Not yet recruiting - verified January 2012 - Conditions: Left Ventricular Function Systolic Dysfunction; Left Ventricular Function Diastolic Dysfunction; Ageing
Intervention: Drug: Ramipril
Sponsors: Newcastle-upon-Tyne Hospitals NHS Trust; Newcastle-upon-Tyne Hospitals NHS Trust
Not yet recruiting - verified January 2012 - Condition: Tuberculosis
Interventions: Biological: Aerosol inhaled MVA85A; Biological: Intradermal MVA85A
Sponsors: University of Oxford; University of Oxford
Recruiting - verified January 2012 - Condition: Respiratory Insufficiency
Interventions: Drug: Heliox21; Drug: Air O2
Sponsors: University College, London; University College, London
Not yet recruiting - verified December 2011 - Condition: Age Related Macular Degeneration (ARMD)
Interventions: Behavioral: Supervised Reading; Behavioral: EVT at the PRL; Behavioral: EVT at the TRL
Sponsors: Moorfields Eye Hospital NHS Foundation Trust; Moorfields Eye Hospital NHS Foundation Trust; British Eye Research Foundation, operating as Fight for Sight
Recruiting - verified December 2011 - Condition: Multiple Myeloma
Intervention: Drug: Bortezomib
Sponsors: University College, London; University College, London
Recruiting - verified January 2012 - Conditions: Autism Spectrum Disorders; Specifically Classic or Core Autism
Intervention: Behavioral: Click-East app
Sponsors: University of Edinburgh; University of Edinburgh; NHS Lothian; Newcastle University
Recruiting - verified November 2011 - Condition: Hypercholesterolemia
Intervention: Dietary Supplement: beetroot juice
Sponsors: Queen Mary University of London; Queen Mary University of London; British Heart Foundation
Recruiting - verified December 2011 - Two Step Versus the Standard Three Step Approach of the WHO Analgesic Ladder for Cancer Pain Relief.Conditions: Cancer; Pain
Interventions: Other: analgesic ladder; Other: analgesic ladder
Sponsors: University of Edinburgh; University of Edinburgh; NHS Lothian
Not yet recruiting - verified November 2011 - Condition: Depression
Intervention: Behavioral: SilverCloud Platform
Sponsors: University of Cambridge; University of Cambridge; Cambridgeshire and Peterborough Foundation Trust, United Kingdom; National Institute for Health Research, United Kingdom
Enrolling by invitation - verified February 2012 - Condition: CD19 Positive Non-Hodgkin Lymphoma
Intervention: Genetic: aCD19z cells, IL2, pre conditioning Cyclophosphamide & Fludarabine
Sponsors: Christie Hospital NHS Foundation Trust; Christie Hospital NHS Foundation Trust
Suspended - verified June 2009 - Conditions: Overweight; Obesity
Intervention: Behavioral: online lifestyle counseling and a fortified diet beverage
Sponsors: Baylor College of Medicine; Baylor College of Medicine; The Beverage Institute.; Temple University; MRC Human Nutrition Research, Cambridge, UK.; National Development and Research Institutes, Inc.
Completed - verified December 2011 - Conditions: Varicose Veins; Pain
Interventions: Other: Dedicated Nurse; Other: Music; Device: Transcutaneous electrical nerve stimulation; Behavioral: Massage and interaction
Sponsors: University of Surrey; University of Surrey
Not yet recruiting - verified January 2012 - Condition: Target Controlled Infusion of Propofol
Interventions: Drug: Propofol; Drug: Propofol
Sponsors: Golden Jubilee National Hospital; Golden Jubilee National Hospital
Recruiting - verified December 2011 - Condition: Osteoarthritis
Intervention:
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Teaching Hospitals NHS Foundation Trust; NIHR Biomedical Research Unit for Musculoskeletal Disease
Active, not recruiting - verified December 2011 - Conditions: Colonic Cancer; Metastasis
Interventions: Drug: Oral complex C3 curcumin + chemotherapy; Drug: Chemotherapy only
Sponsors: University of Leicester; University of Leicester
Not yet recruiting - verified December 2011 - Condition: Preterm Birth
Intervention:
Sponsors: University of Oxford; University of Oxford
Recruiting - verified December 2011 - Condition: Congenital Uterine Anomalies
Intervention:
Sponsors: University of Nottingham; University of Nottingham
Not yet recruiting - verified December 2011 - Condition: Weight Loss
Intervention: Other: Healthy eating diet (Diet A) or healthy eating diet combined with advice to increase fibre intake (Diet B) to at least 25g/day
Sponsors: University of Leeds; University of Leeds
Active, not recruiting - verified February 2012 - Condition: Osteoarthritis
Intervention:
Sponsors: University of Nottingham; University of Nottingham
Recruiting - verified April 2012 - Condition: Maltreated Infants.
Interventions: Behavioral: GIFT; Behavioral: FACS
Sponsors: University of Glasgow; University of Glasgow
Recruiting - verified March 2012 - Condition: Obesity Hypoventilation Syndrome
Intervention: Behavioral: Rehabilitation
Sponsors: Guy's and St Thomas' NHS Foundation Trust; Guy's and St Thomas' NHS Foundation Trust
Recruiting - verified November 2011 - Condition: Critically Ill
Intervention:
Sponsors: Cardiff and Vale University Health Board; Cardiff and Vale University Health Board; Cardiff University
Not yet recruiting - verified November 2011 - Condition: Intermittent Claudication
Intervention:
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Hallam University; University Hospital, Angers; Imperial College London
Completed - verified November 2011 - Condition: Syncope
Interventions: Device: Pacemaker implantation (Medtronic); Device: Pacemaker implantation (Medtronic); Device: Implantable Loop Recorder (Medtronic)
Sponsors: Newcastle-upon-Tyne Hospitals NHS Trust; Newcastle-upon-Tyne Hospitals NHS Trust
Recruiting - verified February 2012 - Condition: Obstructive Sleep Apnea
Intervention:
Sponsors: Bangor University; Bangor University
Recruiting - verified January 2012 - Conditions: Pain; Hyperalgesia; Chronic Illness; Neuropathic Pain
Interventions: Drug: Pregabalin; Drug: Ketamine infusion; Drug: Placebo capsules; Drug: Placebo infusion
Sponsors: Barts & The London NHS Trust; Barts & The London NHS Trust
Recruiting - verified May 2012 - Condition: Dementia
Interventions: Behavioral: The Talking Sense manual; Behavioral: Treatment as usual - communication information and advice
Sponsors: University of Portsmouth; University of Portsmouth; Solent NHS Primary Care Trust; The Sir Halley Stewart Trust
Recruiting - verified March 2012 - Conditions: Absorption and Metabolism; Effect on Vascular Function; Effect on Cytokine Concentrations
Intervention: Dietary Supplement: Olive leaf extract capsules
Sponsors: University of Reading; University of Reading; Comvita UK
Completed - verified November 2011 - Condition: Cardiovascular Disease
Interventions: Dietary Supplement: SFA diet; Dietary Supplement: MUFA diet; Dietary Supplement: n-6 PUFA diet
Sponsors: University of Reading; University of Reading
Recruiting - verified November 2011 - Condition: Vitiligo
Intervention: Device: 311 nm NB-UVB light
Sponsors: University of Nottingham; University of Nottingham
Not yet recruiting - verified January 2012 - Condition: Acute Bronchiolitis
Intervention: Device: 3% hypertonic saline
Sponsors: Sheffield Children's NHS Foundation Trust; Sheffield Children's NHS Foundation Trust; University of Sheffield
Recruiting - verified October 2011 - Conditions: Ovarian Cancer; Peritoneal Metastases
Intervention:
Sponsors: Institute of Cancer Research, United Kingdom; Institute of Cancer Research, United Kingdom; Cancer Research UK; Royal Marsden NHS Foundation Trust; Cambridge University Hospitals NHS Foundation Trust; Imperial College Healthcare NHS Trust; Northumbria Healthcare NHS Foundation Trust
Not yet recruiting - verified March 2012 - Condition: Healthy Schoolchildren
Intervention: Other: None - observational study
Sponsors: University of Manchester; University of Manchester
Active, not recruiting - verified November 2011 - Condition: Stroke
Interventions: Drug: Tenecteplase; Drug: alteplase
Sponsors: NHS Greater Glasgow and Clyde; NHS Greater Glasgow and Clyde; University of Glasgow
Not yet recruiting - verified November 2011 - Conditions: Type 2 Diabetes; Anxiety; Depression
Intervention: Behavioral: CBT-based Guided Self-Help
Sponsors: University of Edinburgh; University of Edinburgh
Not yet recruiting - verified November 2011 - Condition: Gout
Interventions: Other: Nurse intervention; Other: Standard care
Sponsors: University of Nottingham; University of Nottingham; Arthritis Research UK
Not yet recruiting - verified November 2011 - Condition: Chronic Obstructive Pulmonary Disease
Intervention:
Sponsors: Royal Brompton & Harefield NHS Foundation Trust; Royal Brompton & Harefield NHS Foundation Trust
Recruiting - verified December 2011 - Condition: Attention Deficit Hyperactivity Disorder (ADHD)
Intervention:
Sponsors: NHS Tayside; NHS Tayside; Zentralinstitut fuer Seelische Gesundheit; Universita degli Studi di Cagliari; Vadaskert Child and Adolescent Psychiatry Clinic
Recruiting - verified February 2012 - Effect of a Unique Web-based Behaviour Change Program on Weight Loss and Cardiovascular Risk FactorsCondition: Obesity
Intervention: Behavioral: Web-based program
Sponsors: Queen's University, Belfast; Queen's University, Belfast; AXA PPP Healthcare
Recruiting - verified November 2011 - Condition: Multiple Sclerosis, Relapsing-Remitting
Interventions: Biological: Hookworm larvae; Biological: Placebo
Sponsors: University of Nottingham; University of Nottingham; National Multiple Sclerosis Society
Not yet recruiting - verified November 2011 - Conditions: Mediastinal Lymphadenopathy; Hilar Lymphadenopathy; Carcinoma; Lymphoma; Sarcoidosis; Mycobacterial Disease
Intervention: Device: Endobronchial ultrasound guided lymph node sampling
Sponsors: Royal Brompton & Harefield NHS Foundation Trust; Royal Brompton & Harefield NHS Foundation Trust; Chelsea and Westminster NHS Foundation Trust; University of Heidelberg
Recruiting - verified November 2011 - Condition: Depression
Interventions: Other: Google Adwords; Other: Local organisation websites
Sponsors: University of Plymouth; University of Plymouth; University of Glasgow
Recruiting - verified November 2011 - Condition: STEMI
Intervention:
Sponsors: University of Bristol; University of Bristol
Recruiting - verified March 2012 - Conditions: Esophageal Atresia With Tracheo-esophageal Fistula; Congenital Diaphragmatic Hernia
Interventions: Procedure: Hypercapnia during thoracoscopy; Procedure: Open surgery
Sponsors: Great Ormond Street Hospital for Children NHS Trust; Great Ormond Street Hospital for Children NHS Trust
Recruiting - verified November 2011 - Condition: Hepatitis C
Intervention: Drug: Sildenafil and Boceprevir
Sponsors: Imperial College London; Imperial College London
Not yet recruiting - verified December 2011 - Condition: HIV
Intervention:
Sponsors: St Stephens Aids Trust; St Stephens Aids Trust
Recruiting - verified January 2012 - Condition: HIV Infection
Interventions: Drug: 1 Solvazinc tablet, day 2 to day 15; Drug: 1 Solvazinc tablet, day 15 to day 28
Sponsors: St Stephens Aids Trust; St Stephens Aids Trust
Completed - verified March 2012 - Condition: Breast Cancer
Interventions: Procedure: Both Superficial Inferior Artery and Vein Clamped; Procedure: Superficial Inferior Epigastric Vessels both unclamped; Procedure: SIE Artery Unclamped, Vein Clamped; Procedure: SIE Artery clamped, Vein unclamped
Sponsors: NHS Greater Glasgow and Clyde; NHS Greater Glasgow and Clyde; Canniesburn Research Trust
Enrolling by invitation - verified May 2012 - Condition: Choroideremia
Intervention: Drug: rAAV2.REP1
Sponsors: University of Oxford; University of Oxford; Oxford University Hospitals NHS Trust; Moorfields Eye Hospital NHS Foundation Trust; University College, London; Central Manchester University Hospitals NHS Foundation Trust; University of Manchester; Southampton University Hospitals NHS Trust; University of Southampton
Recruiting - verified October 2011 - Conditions: Pulmonary Arterial Hypertension; Heart Failure
Interventions: Drug: Apelin; Drug: Saline (Placebo); Drug: Saline (Placebo); Drug: Apelin
Sponsors: Golden Jubilee National Hospital; Golden Jubilee National Hospital; NHS Lothian; Imperial College Healthcare NHS Trust
Not yet recruiting - verified October 2011 - Conditions: Malaria; Plasmodium Falciparum
Interventions: Biological: Plasmodium falciparum sporozoites; Biological: Plasmodium falciparum sporozoites; Biological: Plasmodium falciparum sporozoites
Sponsors: University of Oxford; University of Oxford; Sanaria Inc (IND Sponsor)
Active, not recruiting - verified December 2011 - Condition: Type 1 Diabetes
Interventions: Drug: Diazoxide; Drug: Placebo
Sponsors: University of Dundee; University of Dundee; Juvenile Diabetes Research Foundation
Not yet recruiting - verified December 2011 - Condition: Hirsutism
Interventions: Device: Intense Pulsed Light (IPL); Device: Alexandrite Laser
Sponsors: NHS Greater Glasgow and Clyde; NHS Greater Glasgow and Clyde
Enrolling by invitation - verified May 2012 - Condition: Coronary Artery Disease
Interventions: Other: CT coronary angiography; Other: Standard of Care
Sponsors: Wellington Hospital; AJAY YERRAMASU; Wellington Hospital, London, UK; Barnet Hospital, Wellhouse Lane, Barnet, EN5 3DJ, UK; Chase Farm Hospital, The Ridgeway, Enfield, EN2 8JL, UK; Royal Free Hospital, Pond Street, London, NW3 2QG, UK
Recruiting - verified October 2011 - Condition: Antibody Persistance After Booster Dose of Men C Vaccine
Intervention: Other: Venepuncture and blood sample collection.
Sponsors: University of Oxford; University of Oxford
Not yet recruiting - verified October 2011 - Condition: Influenza
Interventions: Biological: MVA-NP+M1 and seasonal Influenza vaccine; Biological: Saline placebo and seasonal influenza vaccine
Sponsors: University of Oxford; University of Oxford
Recruiting - verified November 2011 - Condition: Healthy
Interventions: Dietary Supplement: Glucose; Dietary Supplement: Fructose; Dietary Supplement: Fructan; Dietary Supplement: Fructose and glucose
Sponsors: University of Nottingham; University of Nottingham
Active, not recruiting - verified November 2011 - Conditions: Respiratory Rate; Pulse Oximetry
Interventions: Other: Recording of 12 lead ECG; Other: Recording of lying and standing blood pressure; Other: Recording of chest wall movement; Other: Recording of heart rate variability; Other: Recording of ECG and Pulse oximeter waveform at rest; Other: Recording of ECG and Pulse oximeter waveform during exercise
Sponsors: Guy's and St Thomas' NHS Foundation Trust; Guy's and St Thomas' NHS Foundation Trust; Engineering and physical sciences research council; University of Oxford
Not yet recruiting - verified November 2011 - Condition: Melanoma
Intervention: Procedure: Surgical Excision Margin
Sponsors: Norfolk and Norwich University Hospitals NHS Foundation Trust; Norfolk and Norwich University Hospitals NHS Foundation Trust; Australia & New Zealand Melanoma Trials Group
Not yet recruiting - verified October 2011 - Condition: Lymphoma, Hodgkin
Intervention:
Sponsors: University College, London; University College, London
Recruiting - verified July 2011 - Conditions: Hip Fractures; Anesthesia
Intervention:
Sponsors: University of Nottingham; University of Nottingham; Nottingham University Hospitals NHS Trust; Brighton and Sussex University Hospitals NHS Trust
Not yet recruiting - verified November 2011 - Conditions: Burns; Smoke Inhalation Injury
Interventions: Behavioral: Injury Prevention Briefing Plus facilitation; Behavioral: Injury Prevention Briefing
Sponsors: University of Nottingham; University of Nottingham
Recruiting - verified October 2011 - Condition: Chronic Lymphocytic Leukemia
Intervention: Drug: Lenalidomide & Dexamethasone
Sponsors: University College, London; University College, London
Not yet recruiting - verified April 2012 - Condition: Polycystic Ovary Syndrome
Intervention: Behavioral: Structured Lifestyle Education
Sponsors: University of Leicester; University of Leicester; Society for Endocrinology
Recruiting - verified October 2011 - Condition: Chronic Stable Angina
Interventions: Drug: Allopurinol; Drug: Allopurinol; Drug: Placebo
Sponsors: University of Dundee; Stephen McSwiggan; British Heart Foundation
Recruiting - verified April 2012 - Conditions: Optic Neuritis; Multiple Sclerosis
Interventions: Drug: Phenytoin; Drug: Placebo
Sponsors: University College, London; University College, London; National Multiple Sclerosis Society; Multiple Sclerosis Society of Great Britain and Northern Ireland
Not yet recruiting - verified October 2011 - Condition: Metastatic Clear Cell Renal Cancer
Intervention:
Sponsors: Queen Mary University of London; Queen Mary University of London
Recruiting - verified January 2012 - Conditions: Alzheimer's Disease; Schizophrenia
Interventions: Drug: amisulpride; Drug: amisulpride; Drug: amisulpride
Sponsors: Institute of Psychiatry, London; Institute of Psychiatry, London
Not yet recruiting - verified October 2011 - Conditions: Mental and Behavioral Disorders; Withdrawal State
Intervention: Drug: Nicotine
Sponsors: Queen Mary University of London; Queen Mary University of London
Not yet recruiting - verified May 2012 - Condition: Mosquito Bite
Interventions: Drug: NSAI treatment; Drug: Steroid treatment
Sponsors: London School of Hygiene and Tropical Medicine; London School of Hygiene and Tropical Medicine
Not yet recruiting - verified October 2011 - Condition: Lung Disease
Intervention: Other: The Hospital2Home Service
Sponsors: Royal Marsden NHS Foundation Trust; Royal Marsden NHS Foundation Trust
Recruiting - verified December 2011 - Conditions: Idiopathic Pulmonary Arterial Hypertension; Iron Deficiency
Interventions: Drug: Saline; Drug: Ferinject
Sponsors: Imperial College London; Imperial College London
Recruiting - verified February 2012 - Condition: Chronic Pancreatitis
Intervention: Drug: Secretin
Sponsors: University of Nottingham; University of Nottingham
Completed - verified October 2011 - Condition: Cluster Headache
Interventions: Other: Polysomnography; Other: Actigraphy
Sponsors: University of Surrey; University of Surrey; University of California, San Francisco
Recruiting - verified October 2011 - Condition: Congestive Cardiac Failure
Intervention: Procedure: Renal Artery Denervation
Sponsors: Imperial College London; Imperial College London
Recruiting - verified April 2012 - Condition: Asthma
Interventions: Drug: Zithromax; Drug: Placebo
Sponsors: Imperial College London; Imperial College London; National Institute for Health Research, United Kingdom
Not yet recruiting - verified September 2011 - Condition: Esophageal Motility Disorders
Interventions: Drug: Azithromycin; Drug: Placebo
Sponsors: Queen Mary University of London; JAFAR JAFARI
Not yet recruiting - verified October 2011 - Condition: Atrial Fibrillation
Interventions: Procedure: Pulmonary vein isolation (PVI); Procedure: Pulmonary vein isolation + linear lesions; Drug: Pharmacological Substrate modification
Sponsors: Liverpool Heart and Chest Hospital NHS Foundation Trust; Liverpool Heart and Chest Hospital NHS Foundation Trust
Recruiting - verified November 2011 - Condition: Type 1 Diabetes Mellitus
Interventions: Other: Closed-loop; Other: Conventional insulin pump delivery
Sponsors: University of Cambridge; University of Cambridge; Diabetes UK
Not yet recruiting - verified September 2011 - Condition: Depression
Interventions: Other: OxIGen; Other: OxIGen: control version
Sponsors: University of Oxford; University of Oxford; Lupina Foundation
Recruiting - verified March 2012 - Condition: Invasive Pneumococcal Disease
Interventions: Biological: 13-valent pneumococcal conjugate vaccine; Biological: 10-valent pneumococcal conjugate vaccine
Sponsors: University of Oxford; University of Oxford
Not yet recruiting - verified September 2011 - Condition: Cholestasis of Pregnancy
Intervention:
Sponsors: Imperial College London; Imperial College London
Recruiting - verified December 2011 - Condition: Postoperative Respiratory Complications
Intervention: Procedure: Ventilation PEEP at 12 cmH2O :
Sponsors: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); European Society of Anaesthesiology
Recruiting - verified September 2011 - Condition: Stress Hyperglycaemia
Interventions: Other: Closed-loop insulin delivery; Other: Standard IV insulin infusion sliding scale
Sponsors: University of Cambridge; University of Cambridge; European Commission; Cambridge University Hospitals NHS Foundation Trust
Not yet recruiting - verified September 2011 - Conditions: Hematologic Malignancies; Multiple Myeloma
Interventions: Drug: Bz (Bortezomib); Drug: Len (lenalidomide)
Sponsors: European Myeloma Network; European Myeloma Network
Not yet recruiting - verified October 2011 - Condition: Acute Stroke
Interventions: Drug: Donepezil; Drug: Placebo
Sponsors: Imperial College London; Imperial College London; International Stem Cell Forum
Not yet recruiting - verified September 2011 - Conditions: Cerebral Palsy; Post-operative Pain
Intervention: Drug: botulinum toxin intramuscular injection
Sponsors: Guy's and St Thomas' NHS Foundation Trust; Guy's and St Thomas' NHS Foundation Trust
Recruiting - verified March 2012 - Condition: Leukemia
Interventions: Drug: multikinase inhibitor AT9283; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: Cancer Research UK; Cancer Research UK
Recruiting - verified April 2012 - Conditions: Osteoarthritis; Avascular Necrosis; Rheumatoid Arthritis; Developmental Dysplasia of the Hip
Intervention:
Sponsors: Wirral University Teaching Hospital NHS Trust; Hussain Kazi
Not yet recruiting - verified September 2011 - Conditions: Critical Illness; Intensive Care
Interventions: Other: Exercise Programme; Other: Standard Care
Sponsors: University of Ulster; University of Ulster; Belfast Health and Social Care Trust
Recruiting - verified February 2012 - Condition: Parkinson's Disease
Interventions: Behavioral: Exercise Programme; Behavioral: Hand Writing programme
Sponsors: Oxford Brookes University; Oxford Brookes University; National Institute for Health Research, United Kingdom; Royal Berkshire NHS Foundation Trust (participant identification centre); Nuffield Orthopaedic Centre NHS Trust (participant identification centre)
Recruiting - verified March 2012 - Condition: Stroke
Intervention: Other: Self-directed Upper Limb SaeboFlex Training
Sponsors: Colchester Hospital University NHS Foundation Trust; Colchester Hospital University NHS Foundation Trust
Recruiting - verified October 2011 - Condition: Pneumococcal Disease
Interventions: Biological: Prevenar 13; Biological: Pneumovax II
Sponsors: University of Oxford; University of Oxford; Mason Medical Research Foundation
Not yet recruiting - verified August 2011 - Condition: Osteoporosis
Interventions: Device: Strain Gauge; Other: Vibration therapy
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Teaching Hospitals NHS Foundation Trust; NIHR Biomedical Research Unit funding
Recruiting - verified September 2011 - Condition: Oral Allergy Syndrome
Interventions: Biological: Allergovit Birch pollen; Other: Placebo
Sponsors: Royal Sussex County Hospital; Royal Sussex County Hospital
Active, not recruiting - verified February 2012 - Condition: Peanut Hypersensitivity
Intervention: Other: Food challenge
Sponsors: Cambridge University Hospitals NHS Foundation Trust; Cambridge University Hospitals NHS Foundation Trust; Imperial College London; University of Manchester
Not yet recruiting - verified April 2012 - Condition: Treatment Resistant Depression
Intervention: Procedure: Deep Brain Stimulation, implanted
Sponsors: North Bristol NHS Trust; North Bristol NHS Trust; University of Bristol
Active, not recruiting - verified September 2011 - Glucose Variability in Type 1 Diabetes and Its Effect on Factors That Influence New Vessel FormationCondition: Type 1 Diabetes
Intervention: Device: Continuous Glucose Monitor (CGM) and Telemedicine (Enlite Guardian real-time system Medtronic®)
Sponsors: University of Dundee; University of Dundee
Not yet recruiting - verified September 2011 - Condition: Drug Safety
Intervention: Behavioral: DQIP Intervention
Sponsors: University of Dundee; University of Dundee; NHS Tayside; NHS Fife
Recruiting - verified August 2011 - Conditions: Graft Failure; Ischemia-reperfusion Injury
Interventions: Drug: Heme arginate (Normosang); Drug: 0.9% sodium chloride
Sponsors: University of Edinburgh; University of Edinburgh; NHS Lothian
Recruiting - verified August 2011 - Condition: Paediatric Thyrotoxicosis
Interventions: Procedure: Block and Replace; Procedure: Dose Titration; Drug: carbimazole; Drug: propylthiouracil; Drug: thyroxine
Sponsors: Newcastle-upon-Tyne Hospitals NHS Trust; Newcastle-upon-Tyne Hospitals NHS Trust
Recruiting - verified September 2011 - Condition: Inflammatory Bowel Disease
Intervention: Behavioral: Multi-Convergent Therapy
Sponsors: Cardiff and Vale University Health Board; Cardiff and Vale University Health Board
Enrolling by invitation - verified August 2011 - Condition: Streptococcus Pneumoniae
Intervention:
Sponsors: Health Protection Agency, United Kingdom; Dr. Elizabeth Miller
Recruiting - verified March 2012 - Condition: Carcinoid Syndrome
Intervention:
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Teaching Hospitals NHS Foundation Trust; NIHR Biomedical Research Unit for Musculoskeletal Disease
Recruiting - verified September 2011 - Condition: Endometriosis
Interventions: Procedure: Surgery for ovarian endometrioma; Procedure: Surgery for ovarian endometrioma
Sponsors: Derby Hospitals NHS Foundation Trust; Saad Amer; Derby Hospitals NHS Foundation Trust
Recruiting - verified August 2011 - Condition: Heart Transplantation
Intervention:
Sponsors: University Hospital Birmingham; Nigel E. Drury
Not yet recruiting - verified August 2011 - Conditions: Healthy Volunteers; Chuvash Polycythaemia
Intervention: Other: Commercial airline flight
Sponsors: University of Oxford; University of Oxford
Completed - verified August 2011 - Conditions: Stillbirths; Sudden Infant Death
Intervention:
Sponsors: Thayyil, Sudhin; Thayyil, Sudhin; Great Ormond Street Hospital for Children NHS Trust; University College London Hospitals
Active, not recruiting - verified August 2011 - Condition: Hallux Valgus
Interventions: Procedure: Landmark guided ankle block.; Procedure: PNS guided block.
Sponsors: Hull and East Yorkshire Hospitals NHS Trust; Hull and East Yorkshire Hospitals NHS Trust
Completed - verified September 2011 - Conditions: Cancer; Cachexia
Interventions: Other: Multimodal intervention; Other: Standard care
Sponsors: Norwegian University of Science and Technology; Norwegian University of Science and Technology; University of Edinburgh; Oslo University Hospital; NHS Greater Glasgow and Clyde
Recruiting - verified April 2012 - Condition: Knee Arthritis
Interventions: Drug: Femoral Nerve Block; Drug: peri-articular infiltration
Sponsors: University of Warwick; University of Warwick
Completed - verified March 2012 - Condition: HTLV-I Associated Adult T-cell Leukaemia/Lymphoma (ATLL)
Intervention: Drug: CHOP-daclizumab
Sponsors: King's College Hospital NHS Trust; King's College Hospital NHS Trust
Completed - verified July 2011 - Condition: Stroke
Intervention:
Sponsors: University of Southampton; University of Southampton
Completed - verified July 2009 - Conditions: Oral Cancer; Head and Neck Cancer; Free Flap; Hypotension
Interventions: Drug: Epinephrine; Drug: Norepinephrine; Drug: Dobutamine; Drug: Dopexamine
Sponsors: Oxford University Hospitals NHS Trust; Oxford University Hospitals NHS Trust
Completed - verified August 2011 - Condition: Multiple Sclerosis
Interventions: Other: Standard Physiotherapy Exercises; Other: Core Stability Training; Other: Relaxation
Sponsors: University of Plymouth; University of Plymouth
Recruiting - verified August 2011 - Condition: Clinical Skills Training
Interventions: Other: Emergency Psychiatry Immersion Course; Other: Observed SKills in the Emergency Room
Sponsors: King's College London; King's College London; Guy's and St Thomas' NHS Foundation Trust; South London and Maudsley Charitable Funds; South London and Maudsley NHS Foundation Trust
Active, not recruiting - verified August 2011 - Condition: Heart Failure
Intervention: Other: CMR Guidance in terms of guiding LV lead implantation
Sponsors: Royal Brompton & Harefield NHS Foundation Trust; Royal Brompton & Harefield NHS Foundation Trust
Recruiting - verified August 2011 - Condition: Sepsis
Intervention: Biological: Lipopolysaccharide infusion
Sponsors: University of Nottingham; University of Nottingham
Recruiting - verified October 2011 - Conditions: Breast Cancer; Ovarian Cancer
Interventions: Drug: 6-Mercaptopurine; Drug: Methotrexate
Sponsors: University of Oxford; University of Oxford
Recruiting - verified September 2011 - Condition: Nicotine Withdrawal
Interventions: Behavioral: Stress Ball vs Nicotine-free E-Cigarette; Behavioral: Nicotine-free E-Cigarette vs De-nicotinised Cigarette
Sponsors: Queen Mary University of London; Queen Mary University of London
Not yet recruiting - verified August 2011 - Conditions: Radiation Enteritis; Radiation Proctitis
Interventions: Dietary Supplement: FructoOligoSaccharide; Dietary Supplement: Maltodextrin
Sponsors: University College London Hospitals; University College London Hospitals
Recruiting - verified August 2010 - Condition: Life Experiences
Interventions: Other: Information Sheet; Other: Consent; Other: interview; Other: Debrief
Sponsors: University of East London; University of East London
Recruiting - verified August 2009 - Condition: Hepatitis C Virus
Intervention: Drug: rimantadine
Sponsors: The Leeds Teaching Hospitals NHS Trust; The Leeds Teaching Hospitals NHS Trust; Cancer Research UK
Not yet recruiting - verified July 2011 - Conditions: Stroke; Cerebral Infarction; Cerebrovascular Disorders; Brain Diseases
Interventions: Device: Anodal tDCS; Other: Motor Training
Sponsors: University of Oxford; University of Oxford; NIHR Biomedical Research Centre Oxford; The Dunhill Medical Trust
Recruiting - verified August 2011 - Condition: Metastatic Colorectal Cancer
Intervention: Other: Perfusion CT scan
Sponsors: University of Oxford; University of Oxford; Oxford University Hospitals NHS Trust; Oxfordshire Health Services Research Committee; University Hospitals, Leicester
Recruiting - verified August 2011 - Conditions: Wegener's Granulomatosis; Microscopic Polyangiitis
Interventions: Procedure: Plasma exchange; Drug: Intravenous methyl prednisolone; Drug: Methyl prednisolone
Sponsors: Cambridge University Hospitals NHS Foundation Trust; Cambridge University Hospitals NHS Foundation Trust; University Hospital Birmingham; Imperial College London; North West London Hospitals NHS Trust; University Hospitals, Leicester; Lund University Hospital; University Medical Centre Groningen; Fundacio Clinic; Helsinki University
Terminated - verified July 2011 - Condition: Vascular Diseases
Intervention:
Sponsors: York Teaching Hospitals NHS Foundation Trust; York Teaching Hospitals NHS Foundation Trust; National Institute of Academic Anaesthesia
Not yet recruiting - verified July 2011 - Condition: Postmenopausal Osteoporosis
Intervention: Other: Observation
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Teaching Hospitals NHS Foundation Trust; NIHR Biomedical Research Unit for Musculoskeletal Disease
Recruiting - verified August 2011 - Condition: Hypertension
Intervention: Dietary Supplement: beetroot juice
Sponsors: Queen Mary University of London; Queen Mary University of London
Recruiting - verified May 2012 - Conditions: Typhoid Fever; Enteric Fever; Typhoid
Interventions: Biological: Vaccine placebo (excipients only); Biological: Ty21a; Biological: M10ZH09 vaccine
Sponsors: University of Oxford; University of Oxford; Wellcome Trust; Imperial College London; University of Maryland
Recruiting - verified December 2011 - Conditions: Vasculitis; Microscopic Polyangiitis; Granulomatosis With Polyangiitis; Wegener's
Intervention: Drug: Alemtuzumab
Sponsors: Cambridge University Hospitals NHS Foundation Trust; Cambridge University Hospitals NHS Foundation Trust
Recruiting - verified July 2011 - Condition: Children
Intervention:
Sponsors: University of Bristol; University of Bristol
Completed - verified July 2011 - Condition: Human Immunodeficiency Virus
Intervention: Drug: P2G12
Sponsors: University of Surrey; University of Surrey; European Commission
Completed - verified December 2011 - Condition: Displaced Olecranon Fractures in Elderly Patients
Interventions: Other: Non-operative; Other: Operative
Sponsors: Royal Infirmary of Edinburgh; Royal Infirmary of Edinburgh
Recruiting - verified July 2011 - Condition: Sub-Acute Stroke
Intervention: Device: Robot therapy and transcranial direct current stimulation
Sponsors: University of Southampton; University of Southampton; Sobell Department of Motor Neuroscience and Movement Disorders, UCL, London
Not yet recruiting - verified May 2011 - Condition: Lowback and Leg Pain
Intervention: Device: High frequency spinal cord stimulation
Sponsors: Ensemble Hospitalier de la Côte; Ensemble Hospitalier de la Côte
Recruiting - verified June 2011 - Condition: Acne Vulgaris
Intervention: Drug: Isotretinoin
Sponsors: University of Aberdeen; University of Aberdeen
Completed - verified July 2011 - Condition: Lung Cancer
Interventions: Drug: nelfinavir; Radiation: Radical Radiotherapy
Sponsors: Oxford University Hospitals NHS Trust; Oxford University Hospitals NHS Trust
Not yet recruiting - verified December 2011 - Condition: Chronic Obstructive Pulmonary Disease (COPD).
Interventions: Drug: Moxifloxacin; Drug: Azithromycin; Drug: Doxycycline; Drug: Placebo
Sponsors: University College, London; University College, London; Royal Free Hampstead NHS Trust; University of Cambridge; National Institute for Health Research, United Kingdom
Recruiting - verified June 2011 - Condition: Brain and Central Nervous System Tumors
Interventions: Drug: olaparib; Drug: temozolomide; Genetic: gene expression analysis; Genetic: protein expression analysis; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: diffusion-weighted magnetic resonance imaging; Procedure: dynamic contrast-enhanced magnetic resonance imaging; Procedure: therapeutic conventional surgery
Sponsors: Cancer Research UK; Cancer Research UK
Recruiting - verified April 2012 - Condition: Thyroid Cancer
Intervention: Radiation: I131 1.1 GBq
Sponsors: University College, London; University College, London; Cancer Research UK
Not yet recruiting - verified July 2011 - Conditions: Migraine; Cluster Headache; Control; Menstrual Migraine
Intervention:
Sponsors: University College London Hospitals; University College London Hospitals
Not yet recruiting - verified May 2011 - Condition: Displaced Olecranon Fractures
Interventions: Procedure: Tension Band Wiring; Procedure: Plate fixation
Sponsors: Royal Infirmary of Edinburgh; Royal Infirmary of Edinburgh
Recruiting - verified July 2011 - Conditions: Renal Failure; Arteriovenous Fistula
Intervention: Procedure: Active ultrasound surveillance of fistula and proactive treatment of stenosis
Sponsors: University of Hull; University of Hull
Not yet recruiting - verified July 2011 - Condition: Chronic Obstructive Pulmonary Disease (COPD)
Intervention:
Sponsors: Centre for Research in Environmental Epidemiology, Spain; Centre for Research in Environmental Epidemiology, Spain; Katholieke Universiteit Leuven; University of Edinburgh; Royal Brompton & Harefield NHS Foundation Trust; University Medical Centre Groningen; University of Athens
Recruiting - verified October 2011 - Condition: Acute ST Elevation Myocardial Infarction
Interventions: Drug: sodium nitrite; Other: Placebo
Sponsors: University of Aberdeen; University of Aberdeen; NHS Grampian; Medical Research Council; St George's Healthcare NHS Trust; Brighton and Sussex University Hospitals NHS Trust; Imperial College London; University of Birmingham
Recruiting - verified April 2012 - Condition: Pain Relief After Forefoot Surgery
Interventions: Procedure: Ultrasound guided ankle block; Procedure: Medial forefoot block
Sponsors: Hull and East Yorkshire Hospitals NHS Trust; Hull and East Yorkshire Hospitals NHS Trust
Recruiting - verified September 2011 - Condition: Impact of Food Composition on Gastric Emptying
Intervention: Other: Food type
Sponsors: Institute of Food Research; Institute of Food Research; Norfolk and Norwich University Hospitals NHS Foundation Trust
Completed - verified June 2011 - Condition: Persistent Atrial Fibrillation
Interventions: Procedure: Thoracoscopically Assisted Surgical Ablation; Procedure: Catheter Ablation
Sponsors: Royal Brompton & Harefield NHS Foundation Trust; Royal Brompton & Harefield NHS Foundation Trust
Enrolling by invitation - verified June 2011 - Condition: Obesity (BMI>30)
Intervention:
Sponsors: University of Oxford; University of Oxford
Recruiting - verified June 2011 - Condition: Depression
Interventions: Drug: Metyrapone; Drug: placebo
Sponsors: Northumberland, Tyne and Wear NHS Foundation Trust; Northumberland, Tyne and Wear NHS Foundation Trust; National Institute for Health Research, Efficacy and Mechanism Evaluation Programme
Recruiting - verified April 2011 - Condition: Bronchial Asthma
Interventions: Drug: Keratinocyte Growth factor; Drug: Saline placebo
Sponsors: Southampton University Hospitals NHS Trust; Southampton University Hospitals NHS Trust
Recruiting - verified June 2010 - Condition: Granulomatous Disease, Chronic, X-linked, Variant
Intervention: Genetic: pCCLchimGp91s lentiviral vector transduced CD34+ cells infusion
Sponsors: Great Ormond Street Hospital for Children NHS Trust; Great Ormond Street Hospital for Children NHS Trust
Not yet recruiting - verified April 2012 - Conditions: Adenosine Deaminase Deficiency; Severe Combined Immunodeficiencies (SCID)
Intervention: Genetic: EF1αS-ADA lentiviral vector transduced patient Cd34+ cells
Sponsors: Great Ormond Street Hospital for Children NHS Trust; Great Ormond Street Hospital for Children NHS Trust
Not yet recruiting - verified April 2012 - Condition: Proliferative Diabetic Retinopathy
Intervention: Procedure: Pan retinal Photocoagulation
Sponsors: Moorfields Eye Hospital NHS Foundation Trust; Moorfields Eye Hospital NHS Foundation Trust; Insulin Dependant Diabetes Trust
Not yet recruiting - verified June 2011 - Condition: Myocardial Infarction
Intervention:
Sponsors: London School of Hygiene and Tropical Medicine; London School of Hygiene and Tropical Medicine
Active, not recruiting - verified June 2011 - Condition: Cardiovascular Diseases
Interventions: Dietary Supplement: Low fat diet; Dietary Supplement: Hgih saturated fat diet; Dietary Supplement: High saturated fat diet
Sponsors: University of Reading; University of Reading; Wellcome Trust
Completed - verified June 2011 - Conditions: Colon Cancer; Breast Cancer; Trauma; Inflammatory Bowel Disease; Hernia
Intervention:
Sponsors: Imperial College London; Imperial College London
Not yet recruiting - verified July 2011 - Condition: Chronic Obstructive Pulmonary Disease
Intervention:
Sponsors: Imperial College London; Imperial College London
Not yet recruiting - verified June 2011 - Condition: Mental Illness
Interventions: Behavioral: Decision Aid Tool; Other: Treatment as Usual
Sponsors: Institute of Psychiatry, London; Institute of Psychiatry, London
Recruiting - verified November 2011 - Conditions: Mood Modulation; Modulation of Cognition
Interventions: Dietary Supplement: Hops Extract; Other: Placebo (silica)
Sponsors: Northumbria University; Northumbria University; The New Zealand Institute for Plant and Food Research
Recruiting - verified August 2011 - Conditions: Cognitive Function; Mood; Cerebral Haemodynamics; Caffeine Withdrawal
Interventions: Dietary Supplement: Placebo; Dietary Supplement: Caffeine and Placebo; Dietary Supplement: Placebo and Caffeine; Dietary Supplement: Caffeine
Sponsors: Northumbria University; Northumbria University
Recruiting - verified June 2011 - Conditions: Obesity; Obesity Hypoventilation Syndrome
Intervention:
Sponsors: Oxford University Hospitals NHS Trust; Oxford University Hospitals NHS Trust
Not yet recruiting - verified June 2011 - Conditions: Vitamin D Deficiency; Insulin Resistance
Intervention: Drug: Vitamin D3 cholecalciferol
Sponsors: University of Leicester; University of Leicester
Not yet recruiting - verified June 2011 - Condition: Adverse Reaction to Peripheral Nerve- and Plexus-blocking Anesthetics
Intervention: Other: Interscalene brachial plexus block
Sponsors: Royal Surrey County Hospital; Royal Surrey County Hospital
Not yet recruiting - verified June 2011 - Conditions: Chronic Hypercapnic Respiratory Failure; Obesity Hypoventilation Syndrome; Neuromuscular Disease; Chronic Obstructive Pulmonary Disease
Intervention: Other: Surface parasternal electromyelography (EMG) set up
Sponsors: Guy's and St Thomas' NHS Foundation Trust; Guy's and St Thomas' NHS Foundation Trust; Royal Brompton & Harefield NHS Foundation Trust
Recruiting - verified January 2011 - Conditions: Chronic Obstructive Pulmonary Disease; Chronic Respiratory Hypercapnic Failure; Neuromuscular Disease; Obesity Hypoventilation Syndrome
Intervention: Device: non-invasive ventilation heated humidification (Fisher-Paykel MR810 and MR850 humidifiers)
Sponsors: Guy's and St Thomas' NHS Foundation Trust; Guy's and St Thomas' NHS Foundation Trust
Not yet recruiting - verified March 2011 - Condition: Coronary Heart Disease
Intervention: Radiation: Computed tomography scan
Sponsors: University of Edinburgh; University of Edinburgh; NHS Lothian
Recruiting - verified June 2006 - Condition: HIV Infections
Interventions: Biological: DNA.HIVA; Biological: MVA.HIVA; Biological: MVA.HIVA; Biological: MVA.HIVA
Sponsors: International AIDS Vaccine Initiative; International AIDS Vaccine Initiative; Medical Research Council-Oxford; University of Nairobi
Completed - verified June 2011 - Conditions: Obstructive Jaundice; Disease as Reason for ERCP; Immune Dysfunction; Immune Tolerance
Intervention:
Sponsors: University of Nottingham; University of Nottingham
Recruiting - verified August 2011 - Condition: Malaria
Interventions: Biological: Vaccination Schedule One; Biological: Vaccination Schedule Two; Biological: Vaccination Schedule Three; Biological: Vaccination Schedule Four; Biological: Vaccination Schedule Five; Biological: Vaccination Schedule Six; Biological: Vaccination Schedule Seven
Sponsors: University of Oxford; University of Oxford
Recruiting - verified July 2011 - Conditions: Infertility; Miscarriage
Intervention: Other: Creighton Model System in conjunction with Natural Procreative Technology (NPT)
Sponsors: University of Utah; University of Utah; International Institute for Restorative Reproductive Medicine
Enrolling by invitation - verified April 2012 - Condition: Neonatal Respiratory Failure
Intervention: Device: Treatment protocol designed to evaluate (SLE 5000 ventilator)
Sponsors: King's College London; King's College London
Completed - verified June 2011 - Conditions: Attention Deficit Hyperactivity Disorder; ADHD; Bipolar Disorder
Intervention:
Sponsors: King's College London; King's College London; South London and Maudsley NHS Trust (SLAM)
Recruiting - verified April 2012 - Condition: Chronic Obstructive Pulmonary Disease
Intervention:
Sponsors: Guy's and St Thomas' NHS Foundation Trust; Guy's and St Thomas' NHS Foundation Trust
Recruiting - verified November 2010 - Condition: Acute Myocardial Infarction
Intervention:
Sponsors: University College, London; University College, London; NICOR/MINAP, the United Kingdom; NICOR: National Institute for Cardiac Outcomes Research; MINAP: Myocardial Ischaemia National Audit Project; SWEDEHEART/RIKS-HIA, Sweden; SWEDEHEART: Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies; RIKS-HIA: Register of Information and Knowledge about Swedish Heart Intensive care Admissions
Active, not recruiting - verified May 2011 - Conditions: Bleeding; Thrombosis; Cardiac Events
Intervention:
Sponsors: European Society of Anaesthesiology; European Society of Anaesthesiology; University of Leeds; Erasmus Medical Center
Recruiting - verified February 2012 - Condition: Exercise Fat Oxidation
Interventions: Dietary Supplement: High calcium milk; Dietary Supplement: Control
Sponsors: Northumbria University; Northumbria University
Completed - verified May 2012 - Condition: Dysglycaemia
Interventions: Procedure: closed-loop insulin delivery; Drug: Usual diabetes treatment regimen
Sponsors: University of Cambridge; University of Cambridge; Cambridge University Hospitals NHS Foundation Trust
Recruiting - verified May 2012 - Condition: Parkinson's Disease
Interventions: Dietary Supplement: Ketone ester drink; Dietary Supplement: Placebo (carbohydrate containing) drink
Sponsors: University of Oxford; University of Oxford
Recruiting - verified May 2011 - Condition: Lymphoma
Intervention: Drug: AZD1152
Sponsors: Oxford University Hospitals NHS Trust; Oxford University Hospitals NHS Trust; Christie Hospital NHS Foundation Trust; University of Manchester; Early Phase Cancer Research Hub, Oxford
Recruiting - verified December 2011 - Conditions: Nonalcoholic Fatty Liver Disease; NAFLD; Nonalcoholic Steatohepatitis
Intervention: Drug: Rifaximin
Sponsors: Imperial College London; Imperial College London; National Health Service, United Kingdom
Recruiting - verified October 2011 - Condition: Type 2 Diabetes
Intervention: Biological: Glycaemic optimisation before surgery
Sponsors: Imperial College London; Imperial College London
Recruiting - verified January 2012 - Condition: Motor Activity
Interventions: Other: cocoa-based food; Other: cocoa-based food
Sponsors: Nestle Research Center; Nestle Research Center
Completed - verified January 2012 - Condition: Legally Induced Abortion, Complete, Without Mention of Complication
Intervention: Other: Alternative follow-up protocol
Sponsors: Gynuity Health Projects; Gynuity Health Projects; British Pregnancy Advisory Service (UK) (bpas)
Recruiting - verified May 2011 - Conditions: Insulin Resistance; Obesity; Dyslipidemia
Intervention: Dietary Supplement: Citrus Flavonoids
Sponsors: University of Nottingham; University of Nottingham; Florida Department of Citrus
Recruiting - verified January 2012 - Conditions: Ischemic Heart Disease; Coronary Artery Stenosis
Intervention: Device: Angioplasty (PROMUS Element™, and Xience™ Prime stent)
Sponsors: European Cardiovascular Research Center; European Cardiovascular Research Center
Active, not recruiting - verified March 2012 - Condition: Missing Teeth
Interventions: Procedure: Zirconia-based adhesive bridge; Procedure: Metal-based adhesive bridge
Sponsors: Queen Mary University of London; Queen Mary University of London
Not yet recruiting - verified January 2011 - Conditions: Colonic Cancer; Rectal Cancer; Colonic Diverticulum; Ulcerative Colitis
Interventions: Procedure: Ultrasound guided Transversus Abdominis Plane (TAP) bock; Procedure: Local anaesthetic infiltration of laparoscopic port sites
Sponsors: Oxford University Hospitals NHS Trust; Oxford University Hospitals NHS Trust
Recruiting - verified October 2011 - Conditions: Haemorrhoids; Haemorrhoidectomy; Milligan-Morgan Haemorrhoidectomy; Open Haemorrhoidectomy
Interventions: Procedure: Laser Haemorrhoidectomy; Procedure: Laser Haemorrhoidectomy
Sponsors: Northern Lincolnshire and Goole Hospitals NHS Foundation Trust; Northern Lincolnshire and Goole Hospitals NHS Foundation Trust
Completed - verified November 2011 - Conditions: Mucosal Lentiginous Melanoma; Acral Lentiginous Malignant Melanoma
Intervention: Drug: nilotinib
Sponsors: Institute of Cancer Research, United Kingdom; Institute of Cancer Research, United Kingdom; Royal Marsden NHS Foundation Trust
Recruiting - verified April 2011 - Condition: Premature Birth
Intervention: Device: Arabin Cervical Pessary
Sponsors: Maternal-Infantil Vall d´Hebron Hospital; Maternal-Infantil Vall d´Hebron Hospital
Recruiting - verified March 2012 - Conditions: Demineralisation; White Spot Lesions; Orthodontic Treatment
Intervention: Device: Tooth Mousse creme (Casein Phosphopeptide)(RECALDENT)
Sponsors: University of Dundee; University of Dundee; NHS Tayside
Recruiting - verified April 2012 - Condition: Healthy Volunteers
Intervention: Other: cross-linking of an emulsion drink
Sponsors: Institute of Food Research; Institute of Food Research; Norfolk and Norwich University Hospitals NHS Foundation Trust
Recruiting - verified March 2012 - Condition: Bladder Cancer
Interventions: Other: Blood sample collection; Other: urine collection
Sponsors: Christie Hospital NHS Foundation Trust; Christie Hospital NHS Foundation Trust; The Gray Institute for Radiation Oncology and Biology
Recruiting - verified April 2012 - Condition: Necrotizing Enterocolitis
Interventions: Procedure: cooling blanket/mattress; Procedure: Standard treatment of care at normothermia
Sponsors: Great Ormond Street Hospital for Children NHS Trust; Great Ormond Street Hospital for Children NHS Trust
Recruiting - verified March 2012 - Condition: Obstructive Sleep Apnea
Interventions: Device: Provent®; Device: Placebo-Provent®; Procedure: CPAP
Sponsors: University of Zurich; University of Zurich
Recruiting - verified January 2012 - Conditions: HIV; Lymphoma
Intervention:
Sponsors: St Stephens Aids Trust; St Stephens Aids Trust
Recruiting - verified October 2011 - Condition: Sepsis
Intervention:
Sponsors: University of Aberdeen; University of Aberdeen; UK Intensive Care Society
Recruiting - verified January 2012 - Condition: HIV
Intervention: Drug: Raltegravir
Sponsors: Imperial College London; Imperial College London
Recruiting - verified November 2011 - Condition: Tumor Colorectal
Intervention: Behavioral: Exercise programme
Sponsors: Aintree University Hospitals NHS Foundation Trust; Aintree University Hospitals NHS Foundation Trust; Southampton University Hospitals NHS Trust
Recruiting - verified March 2011 - Condition: Orthodontic Treatment
Intervention: Device: Conventional orthodontic bracket, passive self-ligating brackets and active self-ligating bracket
Sponsors: Barts & The London NHS Trust; Barts & The London NHS Trust; East Kent Hospitals University NHS Foundation Trust; Southend NHS Foundation Trust
Active, not recruiting - verified April 2012 - Condition: HIV
Intervention: Drug: Maraviroc
Sponsors: Imperial College London; Imperial College London
Not yet recruiting - verified December 2011 - Condition: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: NG-nitro-L-arginine; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: computed tomography; Procedure: dynamic contrast-enhanced magnetic resonance imaging
Sponsors: Cancer Research UK; Cancer Research UK
Active, not recruiting - verified March 2012 - Conditions: CMV Reactivation; Allogeneic Stem Cell Transplantation; Autologous CMV Specific CD8+ T Cells
Interventions: Procedure: Lymphopheresis; Procedure: CMV specific lymphocyte infusion; Procedure: Peripheral blood for CMV DNA PCR; Procedure: Haematology/Blood chemistry
Sponsors: Imperial College London; Imperial College London
Withdrawn - verified March 2012 - Conditions: Intensive Care Unit Acquired Paresis; Muscle Wasting
Intervention: Other: Active muscle stimulation
Sponsors: Imperial College London; Imperial College London; Medical Research Council; Royal Brompton & Harefield NHS Foundation Trust
Recruiting - verified August 2011 - Conditions: Haematological Malignancies; Allogeneic Stem Cell Transplant; CD56+CD3- NK Cells
Interventions: Procedure: Infusion of donor derived ex-vivo selected NK cells to patients after transplant; Procedure: Haematology / Blood chemistry sampling
Sponsors: Imperial College London; Imperial College London
Withdrawn - verified March 2012 - Conditions: Adenocarcinoma Pancreas; Chronic Pancreatitis
Intervention:
Sponsors: University of Medicine and Pharmacy Craiova; University of Medicine and Pharmacy Craiova; Copenhagen University Hospital, Denmark; Caritas-Krankenhaus, Bad Mergentheim, Germany; Institut Paoli-Calmettes; University of Witten/Herdecke; Hospital Meiningen Germany; Odense University Hospital; University of Santiago de Compostela; Università Vita-Salute San Raffaele; SRH Wald Klinikum Gera Germany; University of Bergen; Fundeni Clinical Institute of Digestive Diseases and Liver Transplant; Glasgow Royal Infirmary; University College, London
Recruiting - verified March 2012 - Condition: Depression
Intervention: Behavioral: Intervention: Exercise and motivational interviewing
Sponsors: University of Nottingham; University of Nottingham; National Institute for Health Research, United Kingdom
Recruiting - verified November 2011 - Conditions: Mania; Hypomania; Bipolar Affective Disorder
Interventions: Other: Cognitive Interpersonal Therapy; Other: Normal Clinical Care
Sponsors: NHS Greater Glasgow and Clyde; NHS Greater Glasgow and Clyde; Chief Scientist Office of the Scottish Government; University of Glasgow
Recruiting - verified December 2011 - Condition: Pelvic Organ Prolapse
Intervention:
Sponsors: Croydon University Hospital; Croydon University Hospital
Completed - verified April 2012 - Condition: Head and Neck Cancer
Interventions: Drug: docetaxel; Drug: everolimus; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: University College, London; University College, London
Terminated - verified December 2011 - Condition: Osteoarthritis of the Knee
Intervention: Other: Questionnaires
Sponsors: University of Nottingham; University of Nottingham; Arthritis Research Campaign
Recruiting - verified January 2012 - Condition: Nerve Degeneration
Interventions: Dietary Supplement: High flavanone orange juice; Dietary Supplement: Control orange juice
Sponsors: University of Reading; University of Reading
Completed - verified November 2011 - Condition: Neurodegeneration
Intervention: Other: Fruit juice beverage
Sponsors: University of Reading; University of Reading
Completed - verified November 2011 - Condition: Adrenal Failure
Intervention: Drug: depot tetracosactide
Sponsors: Newcastle University; Newcastle University
Recruiting - verified June 2011 - Condition: Childbirth Related Levator Injuries
Intervention:
Sponsors: Croydon University Hospital; Croydon University Hospital
Recruiting - verified April 2012 - Condition: Brain and Central Nervous System Tumors
Interventions: Drug: aminolevulinic acid hydrochloride; Drug: polifeprosan 20 with carmustine implant; Drug: temozolomide; Genetic: gene expression analysis; Other: laboratory biomarker analysis; Procedure: adjuvant therapy; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); Cancer Research UK
Recruiting - verified May 2011 - Condition: Colorectal Cancer
Interventions: Other: Placebo; Dietary Supplement: Experimental: Nutritional Supplementation with EPA
Sponsors: University of Nottingham; University of Nottingham; Derby Hospitals NHS Foundation Trust
Recruiting - verified April 2012 - Condition: Prostate Cancer
Interventions: Drug: TOOKAD® Soluble; Other: Active Surveillance
Sponsors: Steba Biotech S.A.; Steba Biotech S.A.
Recruiting - verified February 2012 - Condition: Atrial Fibrillation
Interventions: Procedure: NavX Fusion; Procedure: Cartomerge
Sponsors: Barts & The London NHS Trust; Barts & The London NHS Trust
Completed - verified September 2011 - Conditions: To Validate the Integrated Diagnostic System in the International Collaborative Microarray (INTERCOM); Study; To Develop a Clinically Feasible and Useful Reporting System for Molecular, Histopathology and Integrated; Diagnosis; To Incorporate the Integrated Diagnostic System Into International Diagnostic Standards
Intervention:
Sponsors: University of Alberta; University of Alberta
Active, not recruiting - verified March 2012 - Conditions: Chronic Obstructive Airway Disease; Asthma; Chronic Cough
Interventions: Other: Cough Challenge Tests; Other: ambulatory cough recording; Other: Cough questionnaires
Sponsors: University Hospital of South Manchester NHS Foundation Trust; University Hospital of South Manchester NHS Foundation Trust
Completed - verified September 2011 - Conditions: Cardiovascular Disease; Heart Failure
Interventions: Drug: Urocortin 2; Drug: Urocortin 3
Sponsors: University of Edinburgh; University of Edinburgh; NHS Lothian
Completed - verified August 2011 - Condition: Huntington's Disease
Intervention:
Sponsors: CHDI Foundation, Inc.; CHDI Foundation, Inc.; Monash University
Recruiting - verified February 2012 - Condition: Malignant Pleural Mesothelioma
Intervention: Drug: ADI-PEG 20
Sponsors: Barts & The London NHS Trust; Barts & The London NHS Trust; Cancer Research UK; UK: Barts Center for Experimental Cancer Medicine (CECM) for Trial Coordination
Recruiting - verified May 2012 - Condition: High Altitude Headache
Interventions: Drug: Acetazolamide; Drug: Lactose monohydrate
Sponsors: Bangor University; Bangor University; Research Center for Sport, Mountain and Health of Rovereto, University of Verona, Italy; North Wales Research Committee, UK
Completed - verified December 2011 - Condition: HIV Infections
Intervention: Biological: CN54gp140 glycoprotein-hsp70 conjugate vaccine
Sponsors: St George's, University of London; St George's, University of London; European Union
Active, not recruiting - verified October 2011 - Condition: Suspected Arterial Hypertension
Intervention: Other: no intervention performed
Sponsors: Klinikum Wels-Grieskirchen; Klinikum Wels-Grieskirchen; Austrian Society of Hypertension (Werner Klein Stipendium); Government of lower Austria and European Funds for Regional Development (WST3-T-81/015-2008); I.E.M. (Stolberg, Germany) - unrestricted grant
Recruiting - verified October 2011 - Condition: Adenosine Deaminase Deficiency
Intervention: Biological: Intravenous infusion of transduced cells
Sponsors: Great Ormond Street Hospital for Children NHS Trust; Great Ormond Street Hospital for Children NHS Trust
Recruiting - verified March 2012 - Conditions: Cancer; Peripheral Neuropathy
Interventions: Drug: Ethosuximide; Drug: Placebo
Sponsors: Royal Marsden NHS Foundation Trust; Royal Marsden NHS Foundation Trust; Imperial College London
Recruiting - verified December 2011 - Conditions: Persistent Cough; Whooping Cough
Interventions: Drug: Montelukast; Drug: Placebo
Sponsors: University of Oxford; University of Oxford
Recruiting - verified November 2011 - Condition: Chronic Lymphocytic Leukaemia (CLL)
Intervention: Drug: metronidazole, clarithromycin, ciprofloxacin and lansoprazole
Sponsors: King's College Hospital NHS Trust; King's College Hospital NHS Trust
Recruiting - verified July 2011 - Condition: Pre-Eclampsia
Intervention: Drug: Atorvastatin
Sponsors: University of Oxford; University of Oxford
Enrolling by invitation - verified November 2011 - Conditions: Pregnancy Complications; Obesity
Interventions: Drug: Metformin; Drug: Placebo
Sponsors: Epsom and St Helier University Hospitals NHS Trust; Epsom and St Helier University Hospitals NHS Trust; Fetal Medicine Foundation; King's College Hospital NHS Trust
Recruiting - verified January 2012 - Condition: HIV Infection
Interventions: Drug: TMC278LA; Drug: TMC278LA; Drug: TMC278LA; Drug: TMC278LA
Sponsors: St Stephens Aids Trust; St Stephens Aids Trust
Active, not recruiting - verified February 2012 - Condition: HIV Infection
Interventions: Drug: Efavirenz; Drug: Efavirenz
Sponsors: Kirby Institute; Kirby Institute; Imperial College London
Recruiting - verified October 2011 - Condition: HIV Infection
Interventions: Drug: Efavirenz; Drug: Efavirenz
Sponsors: Kirby Institute; Kirby Institute; Chelsea and Westminster NHS Foundation Trust
Recruiting - verified February 2012 - Condition: Breast Cancer
Intervention: Drug: Metformin
Sponsors: Oxford University Hospitals NHS Trust; Oxford University Hospitals NHS Trust; Cancer Research UK
Recruiting - verified December 2011 - Conditions: Fabry Disease; Fabry´s Disease; Anderson-Fabry Disease
Intervention:
Sponsors: University of Rostock; University of Rostock
Recruiting - verified November 2010 - Condition: Pigmented Villonodular Synovitis
Intervention: Drug: Tasigna
Sponsors: Centre Leon Berard; Centre Leon Berard; Ministry of Health, France
Recruiting - verified June 2011 - Condition: Peanut Allergy
Intervention: Dietary Supplement: Peanut oral immunotherapy
Sponsors: Cambridge University Hospitals NHS Foundation Trust; Cambridge University Hospitals NHS Foundation Trust
Active, not recruiting - verified July 2010 - Conditions: Type 2 Diabetes Mellitus; Obesity; Bariatric Surgery
Intervention: Drug: Insulin
Sponsors: Imperial College London; Imperial College London
Recruiting - verified January 2012 - Condition: Fecal Incontinence
Intervention: Device: Medtronic InterStim / InterStim II
Sponsors: University of Aarhus; University of Aarhus; North West London Hospitals NHS Trust - St. Marks Hospital
Completed - verified November 2011 - Condition: Chronic Total Occlusion of Artery of the Extremities
Interventions: Device: Balloon angioplasty; Device: Primary stenting
Sponsors: University of Patras; University of Patras
Recruiting - verified December 2010 - Condition: Coronary Heart Disease
Interventions: Procedure: Remote ischaemic preconditioning; Procedure: Control
Sponsors: University College, London; University College, London
Recruiting - verified January 2012 - Condition: Schizophrenia
Interventions: Drug: Amisulpride; Drug: placebo
Sponsors: Imperial College London; Imperial College London; University of Manchester; University College, London
Not yet recruiting - verified September 2011 - Condition: Chronic Cough
Interventions: Drug: 10 % Lidocaine; Drug: 10 % Lidocaine; Drug: 0.9% saline
Sponsors: University Hospital of South Manchester NHS Foundation Trust; University Hospital of South Manchester NHS Foundation Trust
Completed - verified September 2011 - Conditions: Bladder Carcinoma; Infiltrative Bladder Carcinoma; Cystectomy
Intervention: Drug: LAPATINIB
Sponsors: University Hospital, Bordeaux; University Hospital, Bordeaux
Recruiting - verified November 2011 - Conditions: Adenocarcinoma of the Gastroesophageal Junction; Esophageal Cancer
Interventions: Drug: gefitinib; Procedure: quality-of-life assessment
Sponsors: National Cancer Institute (NCI); Oncology Clinical Trials Office at University of Oxford
Recruiting - verified August 2011 - Condition: Melanoma
Interventions: Drug: Docetaxel and AZD6244; Drug: Docetaxel and placebo
Sponsors: University of Oxford; University of Oxford
Recruiting - verified August 2011 - Condition: Tuberculosis
Interventions: Biological: C-Tb; Biological: 2 TU Tuberculin PPD RT 23 SSI
Sponsors: Statens Serum Institut; Statens Serum Institut
Completed - verified February 2012 - Condition: Type 2 Diabetes
Intervention: Dietary Supplement: Mirtoselect
Sponsors: University of Aberdeen; University of Aberdeen
Recruiting - verified April 2012 - Conditions: Graft Versus Host Disease; Leukemia; Lymphoma
Interventions: Other: CD4 DLI; Other: No DLI
Sponsors: University College, London; University College, London
Recruiting - verified March 2012 - Condition: Breast Cancer
Intervention:
Sponsors: NHS Tayside; Liz Coote; University of Dundee
Recruiting - verified October 2011 - Condition: Urinary Incontinence
Interventions: Behavioral: Constructivist interactive workshop on urinary incontinence; Behavioral: Evidence-based self-management tool; Behavioral: General health lecture
Sponsors: Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal; Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal; Brunel University; Canadian Institutes of Health Research (CIHR)
Recruiting - verified June 2011 - Condition: Hypertension
Interventions: Dietary Supplement: Beetroot juice; Dietary Supplement: Water
Sponsors: Queen Mary University of London; Queen Mary University of London; University College, London
Completed - verified July 2011 - Condition: Brain and Central Nervous System Tumors
Interventions: Drug: boron phenylalanine; Drug: mannitol; Other: biologic sample preservation procedure; Radiation: radiation therapy treatment planning/simulation
Sponsors: Cancer Research UK; Cancer Research UK
Recruiting - verified February 2012 - Condition: Chronic Periodontitis
Intervention:
Sponsors: NHS South Birmingham; NHS South Birmingham; University of Birmingham
Not yet recruiting - verified July 2010 - Condition: HIV Infection
Intervention: Drug: Hydroxychloroquine
Sponsors: St Stephens Aids Trust; St Stephens Aids Trust
Recruiting - verified December 2011 - Condition: Leukemia
Interventions: Drug: hydroxychloroquine; Drug: imatinib mesylate; Genetic: cytogenetic analysis; Genetic: polymerase chain reaction; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: University of Glasgow; Lynn McMahon; Medical Research Council; CRUK Trials unit Glasgow
Recruiting - verified November 2011 - Condition: Brain and Central Nervous System Tumors
Interventions: Biological: glioblastoma multiforme multipeptide vaccine IMA950; Biological: sargramostim; Drug: temozolomide; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: adjuvant therapy; Radiation: radiation therapy
Sponsors: Cancer Research UK; Cancer Research UK
Recruiting - verified April 2012 - Condition: Diabetes Mellitus, Type 1
Intervention: Procedure: two step hyperinsulinaemic glucose clamp study.
Sponsors: The Royal Bournemouth Hospital; The Royal Bournemouth Hospital
Suspended - verified July 2011 - Condition: BRONCHIECTASIS
Intervention: Drug: ATORVASTATIN
Sponsors: University of Edinburgh; University of Edinburgh; NHS Lothian
Recruiting - verified November 2011 - Condition: Bronchiectasis
Intervention: Drug: Atorvastatin
Sponsors: University of Edinburgh; University of Edinburgh; NHS Lothian
Recruiting - verified November 2011 - Conditions: Postprandial Glycaemia,; Postprandial Insulinaemia; Appetite
Intervention: Drug: Test meal
Sponsors: Northumbria University; Northumbria University
Completed - verified May 2012 - Condition: Asthma
Intervention: Drug: Budesonide (directly observed)
Sponsors: Belfast Health and Social Care Trust; Liam Heaney; Queen's University, Belfast; Asthma UK; Northern Ireland Chest Heart & Stroke
Completed - verified February 2012 - Conditions: Energy Balance,; Appetite,; Cognitive Function.
Intervention: Drug: Breakfast & exercise
Sponsors: Northumbria University; Northumbria University
Completed - verified May 2012 - Condition: Colorectal Cancer
Interventions: Dietary Supplement: Maltodextrin and Amioca starch; Dietary Supplement: Hi-maize 260; Dietary Supplement: Polydextrose; Dietary Supplement: Hi-maize 260 and polydextrose
Sponsors: Newcastle University; Newcastle University; Northumbria Healthcare NHS Foundation Trust
Active, not recruiting - verified October 2011 - Condition: Heart Failure
Intervention:
Sponsors: Imperial College London; Imperial College London
Recruiting - verified June 2011 - Conditions: Breast Cancer; Colorectal Cancer; Gastric Cancer; Lung Cancer; Ovarian Cancer; Pancreatic Cancer; Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Biological: MFE23 scFv-expressing autologous anti-CEA MFEz T lymphocytes; Biological: aldesleukin; Drug: cyclophosphamide; Drug: fludarabine phosphate; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: Cancer Research UK; Cancer Research UK
Terminated - verified February 2012 - Conditions: Cardiomyopathies, Primary; Arrhythmia; Sudden Cardiac Death; Calcium Metabolism Disorders
Intervention:
Sponsors: University Medical Center Goettingen; University Medical Center Goettingen; UMC Utrecht; Katholieke Universiteit Leuven; University of Glasgow; University of Athens
Recruiting - verified April 2012 - Condition: Poisoning
Interventions: Drug: Chlorphenamine and Ranitidine; Drug: Paracetamol; Drug: Paracetamol
Sponsors: University of Edinburgh; University of Edinburgh; NHS Lothian
Recruiting - verified September 2010 - Condition: Lung Cancer
Interventions: Drug: pazopanib hydrochloride; Other: laboratory biomarker analysis; Other: pharmacogenomic studies; Other: pharmacological study; Procedure: quality-of-life assessment
Sponsors: National Cancer Institute (NCI); European Organization for Research and Treatment of Cancer - EORTC
Recruiting - verified July 2011 - Condition: Cystic Fibrosis
Intervention: Other: Tobramycin time of administration
Sponsors: University of Nottingham; University of Nottingham
Recruiting - verified December 2011 - Condition: Irritable Bowel Syndrome With Diarrhoea
Interventions: Drug: Mesalazine; Drug: Placebo
Sponsors: University of Nottingham; University of Nottingham; National Institute for Health Research, United Kingdom
Recruiting - verified January 2012 - Condition: Known Difficult Intubation
Intervention:
Sponsors: Oxford University Hospitals NHS Trust; Oxford University Hospitals NHS Trust
Recruiting - verified November 2010 - Condition: Haploidentical Stem Cell Transplantation
Intervention: Biological: HSVTK retrovirally-transduced donor T lymphocytes
Sponsors: Great Ormond Street Hospital for Children NHS Trust; Great Ormond Street Hospital for Children NHS Trust
Recruiting - verified March 2012 - Conditions: Depression; Personality Disorder
Interventions: Other: MBT; Other: treatment as usual
Sponsors: North East London Foundation Trust; North East London Foundation Trust
Recruiting - verified July 2011 - Condition: Non-cardiac Surgery
Intervention:
Sponsors: Queen Mary University of London; Queen Mary University of London; European Society of Anaesthesiology; European Society of Intensive Care Medicine
Completed - verified June 2011 - Conditions: Tobacco Dependence; Smoking Cessation
Interventions: Drug: Varenicline; Drug: Placebo; Drug: Varenicline
Sponsors: Queen Mary University of London; Queen Mary University of London
Recruiting - verified July 2011 - Conditions: Quorum Sensing; Prebiotics; Probiotics; Sepsis
Interventions: Dietary Supplement: Bifidobacterium longum BB536; Dietary Supplement: Active hexose correlated compound (AHCC); Dietary Supplement: Bifidobacterium longum BB536 and Active hexose correlated compound (AHCC); Dietary Supplement: Corn starch placebo capsule; Drug: Azithromycin
Sponsors: University of Nottingham; University of Nottingham
Completed - verified May 2011 - Conditions: Insulin Resistance; Obesity
Intervention: Dietary Supplement: orange juice
Sponsors: University of Nottingham; University of Nottingham; Florida Department of Citrus
Active, not recruiting - verified January 2012 - Condition: Gestational Hypertension
Interventions: Procedure: Intervention is blood pressure management approach; Procedure: Intervention is blood pressure management approach.
Sponsors: University of British Columbia; University of British Columbia; Canadian Institutes of Health Research (CIHR); Sunnybrook Research Institute
Recruiting - verified December 2011 - Condition: Varicose Veins
Intervention:
Sponsors: BTG Ltd.; BTG Ltd.
Active, not recruiting - verified June 2011 - Condition: Acute Lymphoblastic Leukemia
Interventions: Genetic: donor-derived EBV-specific cytotoxic T-cells (EBV-CTL) transduced with the retroviral vector SFGalpha-CD19-CD3zeta; Biological: Irradiated donor-derived Lymphoblastoid Cell Line
Sponsors: University College, London; University College, London; European Union; The Leukemia and Lymphoma Society; Children with Leukaemia; Department of Health, United Kingdom; JP Moulton Charitable Foundation
Recruiting - verified May 2012 - Conditions: Bladder Cancer; Transitional Cell Cancer of the Renal Pelvis and Ureter; Ureter Cancer; Urethral Cancer
Interventions: Drug: carboplatin; Drug: gemcitabine hydrochloride; Drug: vandetanib; Drug: Placebo
Sponsors: Wales Cancer Trials Unit; Wales Cancer Trials Unit; Cardiff University
Recruiting - verified March 2012 - Conditions: Male Erectile Disorder; Prostate Cancer; Therapy-related Toxicity; Urinary Incontinence
Interventions: Other: questionnaire administration; Procedure: assessment of therapy complications; Procedure: high-intensity focused ultrasound ablation; Procedure: multiparametric magnetic resonance imaging; Procedure: quality-of-life assessment; Procedure: transperineal prostate biopsy; Procedure: transrectal prostate biopsy
Sponsors: National Cancer Institute (NCI); University College London Hospitals
Recruiting - verified November 2010 - Condition: Prostate Cancer
Interventions: Drug: dutasteride; Drug: gadolinium-chelate; Other: active surveillance; Procedure: diffusion-weighted magnetic resonance imaging; Procedure: functional magnetic resonance imaging; Procedure: prostate biopsy; Procedure: ultrasound imaging
Sponsors: National Cancer Institute (NCI); University College London Hospitals
Recruiting - verified August 2011 - Condition: Lung Cancer
Interventions: Behavioral: Physician Advice; Behavioral: Intensive quit smoking support
Sponsors: Hywel Dda Health Board; Hywel Dda Health Board; Cardiff and Vale University Health Board
Recruiting - verified August 2010 - Condition: Tuberculosis
Interventions: Biological: BCG: 100 microlitres ~ 2-8 x 105 pfu; Biological: MVA85A: 1 x 108 pfu BCG: 100 microlitres ~ 2-8 x 105 pfu
Sponsors: University of Oxford; University of Oxford
Recruiting - verified October 2011 - Condition: Antiretroviral Therapy in HIV-1 Infected Children
Interventions: Drug: Kaletra dosed once daily; Drug: kaletra dosed twice daily
Sponsors: PENTA Foundation; PENTA Foundation; Medical Research Council; French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)
Recruiting - verified February 2012 - PK Switch Efavirenz to Maraviroc in Patients Initially Suppressed on an Efavirenz-containing RegimenCondition: HIV Infection
Intervention: Drug: Maraviroc
Sponsors: St Stephens Aids Trust; St Stephens Aids Trust
Completed - verified April 2012 - Condition: Coronary Artery Disease
Interventions: Device: Coronary Stent Cypher; Device: Coronary stent Xience
Sponsors: Royal Brompton & Harefield NHS Foundation Trust; Royal Brompton & Harefield NHS Foundation Trust
Completed - verified July 2011 - Conditions: Tobacco Dependence; Smoking Cessation
Interventions: Drug: Nicotine Patch; Drug: Placebo; Drug: Varenicline
Sponsors: Queen Mary University of London; Queen Mary University of London
Completed - verified October 2011 - Conditions: HIV; AIDS; Indicator Diseases/Indicator Conditions
Interventions: Other: HIV test (serological or salivary); Other: Interview
Sponsors: Chelsea and Westminster NHS Foundation Trust; Chelsea and Westminster NHS Foundation Trust; HIV in Europe (Co-Sponsor)
Recruiting - verified October 2009 - Condition: Type 2 Diabetes
Intervention: Dietary Supplement: Mirtoselect
Sponsors: University of Aberdeen; University of Aberdeen
Recruiting - verified April 2012 - Condition: Chronic Obstructive Pulmonary Disease
Interventions: Drug: Erdosteine; Drug: Placebo
Sponsors: Hull and East Yorkshire Hospitals NHS Trust; Hull and East Yorkshire Hospitals NHS Trust; Galen limited
Withdrawn - verified July 2010 - Condition: Smoking Cessation
Intervention: Other: Respiragene test
Sponsors: University of Surrey; University of Surrey; Lab 21, Cambridge; NHS Research and Development
Recruiting - verified March 2012 - Condition: Parkinson's Disease
Intervention: Drug: Exenatide
Sponsors: University College, London; University College, London
Active, not recruiting - verified March 2012 - Conditions: Atherosclerosis; Systemic Lupus Erythematosus
Interventions: Drug: Rosuvastatin; Drug: Placebo
Sponsors: Imperial College London; Imperial College London
Recruiting - verified August 2011 - Condition: X-linked Severe Combined Immunodeficiency
Intervention: Genetic: Single infusion of autologous CD34+ cells transduced with the self-inactivating (SIN) gammaretroviral vector pSRS11.EFS.IL2RG.pre
Sponsors: Great Ormond Street Hospital for Children NHS Trust; Great Ormond Street Hospital for Children NHS Trust
Recruiting - verified March 2012 - Condition: Myositis
Intervention: Procedure: Venepuncture
Sponsors: Salford Royal NHS Foundation Trust; Salford Royal NHS Foundation Trust
Recruiting - verified September 2011 - Conditions: Atrial Fibrillation; Heart Failure
Interventions: Procedure: Catheter ablation of persistent atrial fibrillation; Drug: Medical treatment alone
Sponsors: Barts & The London NHS Trust; Barts & The London NHS Trust; British Heart Foundation
Recruiting - verified May 2010 - Condition: Myocardial Infarction
Intervention:
Sponsors: London School of Hygiene and Tropical Medicine; London School of Hygiene and Tropical Medicine; British Medical Research Council; University College, London
Active, not recruiting - verified June 2011 - Conditions: Children; General Anesthesia; Intubation
Intervention: Device: Airtraq laryngoscopy
Sponsors: University Hospitals Bristol NHS Trust; University Hospitals Bristol NHS Trust; Oxford University Hospitals NHS Trust
Completed - verified December 2011 - Conditions: Hearing Loss; Cytomegalovirus
Intervention: Other: Screening urine and saliva tests for congenital Cytomegalovirus
Sponsors: Newcastle-upon-Tyne Hospitals NHS Trust; Janet Berrington
Recruiting - verified October 2011 - Condition: Mental Disorders
Intervention:
Sponsors: University of Bristol; University of Bristol; North Bristol NHS Trust
Active, not recruiting - verified August 2011 - Conditions: Left Ventricular Systolic Dysfunction; Mitral Regurgitation
Intervention:
Sponsors: Imperial College London; Imperial College London; Humboldt-Universität zu Berlin; British Heart Foundation
Recruiting - verified August 2011 - Condition: Haemodialysis
Intervention: Other: Use of ultrasound guidance in cannulation
Sponsors: University of Hull; University of Hull
Not yet recruiting - verified July 2010 - Condition: Pelvic Organ Prolapse
Intervention: Other: Pelvic Floor Muscle training
Sponsors: Glasgow Caledonian University; Glasgow Caledonian University; Wellbeing of Women; University of Birmingham; Birmingham Women's Hospital; University of Aberdeen; Aberdeen Royal Infirmary; Dunedin School of Medicine
Active, not recruiting - verified April 2012 - Condition: Caesarean Section
Interventions: Drug: 0.5% levobupivacaine; Drug: 0.75% Ropivacaine
Sponsors: Guy's and St Thomas' NHS Foundation Trust; Guy's and St Thomas' NHS Foundation Trust
Withdrawn - verified December 2011 - Condition: Bronchiolitis
Intervention:
Sponsors: Imperial College London; Imperial College London
Suspended - verified April 2012 - Condition: Nutritional Support
Intervention: Other: Hypocaloric feeding
Sponsors: Scarborough General Hospital; Scarborough General Hospital
Recruiting - verified June 2010 - Condition: Asthma
Interventions: Drug: Citalopram; Drug: Placebo
Sponsors: Belfast Health and Social Care Trust; Liam Heaney; Asthma UK
Recruiting - verified February 2012 - Condition: Asthma
Interventions: Drug: Ciclesonide; Drug: Placebo
Sponsors: University of Nottingham; University of Nottingham; Nottingham University Hospitals NHS Trust; University Hospitals, Leicester
Recruiting - verified January 2012 - Conditions: Gastric Cancer; Head and Neck Cancer; Lymphoma; Lymphoproliferative Disorder; Nonneoplastic Condition
Interventions: Biological: EBNA1 C-terminal/LMP2 chimeric protein-expressing recombinant modified vaccinia Ankara vaccine; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: Cancer Research UK; Cancer Research UK
Completed - verified February 2012 - Condition: HIV-1 Infections
Interventions: Biological: ChAdV63.HIVconsv low dose.; Biological: ChAdV63.HIVconsv high dose.; Biological: pSG2.HIVconsv; Biological: MVA.HIVconsv; Other: Placebo
Sponsors: University of Oxford; University of Oxford
Recruiting - verified February 2012 - Condition: Lentigo Maligna
Intervention: Drug: Imiquimod
Sponsors: University Hospital Birmingham NHS Foundation Trust; University Hospital Birmingham NHS Foundation Trust; Department of Health, United Kingdom
Active, not recruiting - verified May 2010 - Condition: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: angiogenesis inhibitor GSAO; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: dynamic contrast-enhanced magnetic resonance imaging
Sponsors: Cancer Research UK; Cancer Research UK
Terminated - verified April 2012 - Condition: Chronic Obstructive Pulmonary Disease
Interventions: Drug: Simvastatin; Drug: Lactose tablet
Sponsors: University of Nottingham; University of Nottingham
Recruiting - verified January 2012 - Condition: Lymphoma, T-Cell, Peripheral
Intervention:
Sponsors: Associazione Angela Serra per la ricerca sul cancro; Associazione Angela Serra per la ricerca sul cancro; Fondazione Italiana Linfomi ONLUS; International T-cell non-Hodgkin Lymphoma Study Group
Recruiting - verified June 2011 - Condition: Peripheral Arterial Disease
Interventions: Drug: Allopurinol; Drug: Placebo
Sponsors: University of Dundee; University of Dundee; NHS Tayside; British Heart Foundation
Active, not recruiting - verified January 2012 - Conditions: Postoperative Morbidity; Trauma; Wound Healing
Intervention: Dietary Supplement: Juice plus
Sponsors: University of Birmingham; University of Birmingham; NSA, Inc
Recruiting - verified January 2012 - Condition: HIV
Interventions: Other: Questionnaire; Other: Focus Group Discussion; Other: HIV test (serum or salivary); Other: Semi-structured telephone interview
Sponsors: Chelsea and Westminster NHS Foundation Trust; Chelsea and Westminster NHS Foundation Trust; Department of Health, Taiwan; Health Protection Agency, United Kingdom; Homerton University Hospital NHS Foundation Trust; King's College Hospital NHS Trust; Hammersmith and Fulham Primary Care Trust
Completed - verified May 2010 - Condition: Wheezing
Interventions: Drug: Mannitol; Drug: Montelukast
Sponsors: Queen Mary University of London; Queen Mary University of London; University of Aberdeen; University of Leicester
Recruiting - verified July 2011 - Condition: Parkinson Disease
Intervention:
Sponsors: Michael J. Fox Foundation for Parkinson's Research; Michael J. Fox Foundation for Parkinson's Research; Institute for Neurodegenerative Disorders
Recruiting - verified July 2011 - Conditions: Macrosomia; Low Birth Weight; Premature Birth; Childhood Obesity; Poverty
Intervention:
Sponsors: Swansea University; Swansea University; Cardiff University
Active, not recruiting - verified June 2010 - Condition: Renal Failure
Intervention:
Sponsors: University of Nottingham; University of Nottingham
Recruiting - verified October 2011 - Condition: Malnutrition
Intervention:
Sponsors: Ludwig-Maximilians - University of Munich; Ludwig-Maximilians - University of Munich
Active, not recruiting - verified March 2012 - Conditions: Skeletal Muscle Wasting; Insulin Resistance
Intervention: Procedure: Major abdominal surgery
Sponsors: University of Nottingham; University of Nottingham
Enrolling by invitation - verified January 2012 - Condition: Asthma
Intervention: Other: 50% step down reduction in inhaled corticosteroid dose
Sponsors: University of Nottingham; University of Nottingham
Active, not recruiting - verified March 2012 - Condition: Asthma
Intervention: Drug: Pioglitazone
Sponsors: University of Nottingham; University of Nottingham
Recruiting - verified November 2011 - Condition: Prostate Cancer
Interventions: Dietary Supplement: C-11 choline; Radiation: 18F-fluoromethylcholine
Sponsors: Cancer Research UK; Cancer Research UK
Withdrawn - verified February 2012 - Condition: Personality Disorders
Interventions: Behavioral: Personal Concerns Inventory; Behavioral: Treatment as usual
Sponsors: Nottinghamshire Healthcare NHS Trust; Nottinghamshire Healthcare NHS Trust; University of Nottingham; Bangor University
Recruiting - verified April 2012 - Evaluation of Effect of Angiotensin-converting Enzyme (ACE) Inhibitors on Small Aneurysm Growth RateCondition: Abdominal Aortic Aneurysm
Interventions: Drug: perindopril arginine; Drug: amlodipine 5mgs; Drug: placebo
Sponsors: Imperial College London; Imperial College London; National Institute for Health Research, United Kingdom
Recruiting - verified October 2011 - Condition: HIV Infections
Interventions: Biological: Opal-HIV-Gag(c) Low Dose; Biological: Opal-HIV-Gag(c) Medium dose; Biological: Opal-HIV-Gag(c) High dose; Other: Dimethyl Sulfoxide
Sponsors: Medicines Development Limited; Medicines Development Limited; Phillip T. and Susan M. Ragon Foundation; Imperial College London
Terminated - verified November 2011 - Condition: Cardiac Ion Channelopathy
Intervention:
Sponsors: Thayyil, Sudhin; Thayyil, Sudhin
Recruiting - verified June 2011 - Condition: Coronary Artery Bypass
Intervention:
Sponsors: Imperial College London; Imperial College London
Recruiting - verified July 2011 - Condition: Coronary Stenosis
Intervention:
Sponsors: Imperial College London; Imperial College London; Hospital San Carlos, Madrid
Recruiting - verified September 2011 - Condition: Cardiovascular Disease
Interventions: Dietary Supplement: Diet and Vascular Health; Dietary Supplement: Diet and Vascular Health; Dietary Supplement: Diet and Vascular Health Study
Sponsors: Institute of Food Research; Institute of Food Research; Clinical Research and Trials Unit (Norfolk & Norwich University Hospital, UK); University of East Anglia
Active, not recruiting - verified June 2011 - Condition: Metabolism and Clearance of Cyanidin 3 Glucoside
Intervention: Dietary Supplement: Cyanidin 3 glucoside
Sponsors: University of East Anglia; University of East Anglia; Institute of Food Research
Completed - verified October 2011 - Conditions: AIDS/HIV PROBLEM; Sexually Transmitted Diseases
Intervention: Behavioral: Financial incentive through lotteries
Sponsors: Bocconi University; Bocconi University; World Bank
Active, not recruiting - verified May 2012 - Condition: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: Aurora B/C kinase inhibitor GSK1070916A; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: diffusion-weighted magnetic resonance imaging + PET CT; Radiation: fludeoxyglucose F 18 dynomic contrast
Sponsors: Cancer Research UK; Cancer Research UK
Recruiting - verified April 2012 - Condition: Acute Coronary Syndrome
Intervention:
Sponsors: University College, London; University College, London; Barts & The London NHS Trust; Queen Mary University of London; University of Bristol; Yale University
Active, not recruiting - verified December 2011 - Condition: Breast Cancer
Interventions: Biological: trastuzumab; Drug: lapatinib ditosylate; Other: laboratory biomarker analysis; Procedure: adjuvant therapy; Procedure: neoadjuvant therapy; Procedure: therapeutic conventional surgery
Sponsors: National Cancer Institute (NCI); Institute of Cancer Research, United Kingdom
Recruiting - verified July 2011 - Condition: Kidney Cancer
Interventions: Drug: sunitinib malate; Genetic: gene expression analysis; Other: biologic sample preservation procedure; Other: laboratory biomarker analysis; Procedure: therapeutic conventional surgery
Sponsors: National Cancer Institute (NCI); European Organization for Research and Treatment of Cancer - EORTC
Recruiting - verified September 2011 - Condition: Pancreatic Cancer
Interventions: Drug: Notch signaling pathway inhibitor MK0752; Drug: gemcitabine hydrochloride; Other: imaging biomarker analysis; Other: laboratory biomarker analysis; Other: pharmacological study; Radiation: fludeoxyglucose F 18
Sponsors: Cancer Research UK; Cancer Research UK
Recruiting - verified February 2012 - Conditions: Systemic Lupus Erythematosus; Atherosclerosis
Interventions: Drug: Mycophenolate mofetil; Drug: sugar pill
Sponsors: Guy's and St Thomas' NHS Foundation Trust; Guy's and St Thomas' NHS Foundation Trust; Institute of Child Health, University College London, London, UK.
Completed - verified May 2005 - Conditions: Critical Illness; Sepsis
Intervention:
Sponsors: Intensive Care National Audit & Research Centre; Intensive Care National Audit & Research Centre; Wellcome Trust
Recruiting - verified July 2011 - Condition: Lymphoma
Interventions: Drug: lenalidomide; Other: clinical observation
Sponsors: European Organization for Research and Treatment of Cancer - EORTC; European Organization for Research and Treatment of Cancer - EORTC
Recruiting - verified March 2012 - Conditions: Wilms Tumor; Neuroblastoma; Soft Tissue Sarcoma; Acute Lymphoblastic Leukemia
Intervention: Drug: doxorubicin
Sponsors: University Hospital Muenster; University Hospital Muenster
Recruiting - verified March 2010 - Conditions: Chemotherapeutic Agent Toxicity; Fatigue; Lung Cancer; Musculoskeletal Complications
Interventions: Drug: carboplatin; Drug: vinorelbine tartrate; Other: neuromuscular electrical stimulation; Other: physiologic testing; Procedure: fatigue assessment and management; Procedure: quality-of-life assessment
Sponsors: National Cancer Institute (NCI); Wales Cancer Trials Unit
Recruiting - verified September 2010 - Condition: Dysphoria
Interventions: Drug: Escitalopram; Drug: Placebo
Sponsors: University of Oxford; University of Oxford; P1vital Limited; University of Manchester; Institute of Psychiatry, London
Completed - verified June 2011 - Condition: Breast Cancer
Interventions: Procedure: CT SCAN; Procedure: MRI scan; Procedure: 3D Ultrasound scan
Sponsors: United Bristol Healthcare NHS Trust; United Bristol Healthcare NHS Trust; Bosum Buddies; Friends of the Bristol Haematology and Oncology Centre
Recruiting - verified October 2010 - Condition: Kidney Transplantation
Interventions: Drug: Rituximab; Drug: Tacrolimus; Drug: Mycophenolate mofetil; Drug: Hydrocortisone; Drug: Prednisolone; Drug: Prednisolone
Sponsors: Guy's and St Thomas' NHS Foundation Trust; Guy's and St Thomas' NHS Foundation Trust; Astellas Pharma Ltd
Recruiting - verified December 2011 - Conditions: Vascular Disease; Heart Disease
Interventions: Drug: NO clamp; Drug: Saline; Drug: Fluconazole; Drug: Aspirin; Drug: Combined
Sponsors: University of Edinburgh; University of Edinburgh; NHS Lothian
Completed - verified May 2012 - Conditions: Vascular Disease; Heart Disease
Interventions: Drug: Urocortin 2, Urocortin 3; Drug: Saline placebo
Sponsors: University of Edinburgh; University of Edinburgh; NHS Lothian
Suspended - verified May 2012 - Conditions: Bladder Cancer; Transitional Cell Cancer of the Renal Pelvis and Ureter; Urethral Cancer
Interventions: Drug: cisplatin; Drug: gemcitabine hydrochloride; Drug: sunitinib malate
Sponsors: Wales Cancer Trials Unit; Wales Cancer Trials Unit; Cardiff University
Recruiting - verified March 2012 - Condition: Cardiovascular Disease
Interventions: Dietary Supplement: Dark chocolate enriched in flavan-3-ols and procyanidins; Dietary Supplement: Standard dark chocolate; Dietary Supplement: White chocolate
Sponsors: University of Aberdeen; University of Aberdeen; Rural and Environment Research and Analysis Directorate (RERAD, UK); Biotechnology and Biological Sciences Research Council (BBSRC, UK); Natraceutical Industrial S.L.U., Valencia, Spain
Completed - verified April 2012 - Condition: Attention Deficit Hyperactivity Disorder
Interventions: Other: CBT plus treatment as usual; Other: Treatment as usual
Sponsors: South London and Maudsley NHS Foundation Trust; South London and Maudsley NHS Foundation Trust
Recruiting - verified December 2011 - Condition: Palatally Impacted Canines
Intervention: Procedure: Alveolar-decortication.
Sponsors: University of Birmingham; University of Birmingham
Recruiting - verified January 2012 - Conditions: Fluid Overload; Water Electrolyte Imbalance; Acid Base Imbalance
Interventions: Drug: Crystalloid; Drug: Colloid
Sponsors: University of Nottingham; University of Nottingham
Completed - verified May 2011 - Conditions: Bladder Cancer; Cervical Cancer; Colorectal Cancer; Endometrial Cancer; Gastrointestinal Complications; Long-term Effects Secondary to Cancer Therapy in Adults; Ovarian Cancer; Prostate Cancer; Radiation Toxicity; Sarcoma; Testicular Germ Cell Tumor; Vaginal Cancer
Interventions: Other: questionnaire administration; Procedure: gastrointestinal complications management/prevention; Procedure: quality-of-life assessment
Sponsors: National Cancer Institute (NCI); Royal Marsden NHS Foundation Trust
Recruiting - verified March 2010 - Conditions: Leukemia; Mucositis; Oral Complications
Interventions: Biological: palifermin; Biological: rituximab; Drug: cyclophosphamide; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: etoposide; Drug: fludarabine phosphate; Drug: imatinib mesylate; Drug: melphalan; Drug: mercaptopurine; Drug: methotrexate; Drug: nelarabine; Drug: pegaspargase; Drug: vincristine sulfate; Procedure: allogeneic hematopoietic stem cell transplantation; Procedure: assessment of therapy complications; Radiation: total-body irradiation
Sponsors: National Cancer Institute (NCI); University College London Hospitals
Recruiting - verified June 2011 - Condition: Cardiovascular Disease
Interventions: Drug: Active Clonidine; Drug: Placebo Clonidine; Drug: Active ASA; Drug: Placebo ASA
Sponsors: McMaster University; Hamilton Health Sciences Corporation; McMaster University
Recruiting - verified December 2011 - Condition: Pulmonary Hypertension (Idiopathic, Familial or Anorexigen-associated)
Interventions: Drug: Dichloroacetate Sodium; Drug: Dichloroacetate Sodium; Drug: Dichloroacetate Sodium
Sponsors: University of Alberta; University of Alberta; Imperial College London
Enrolling by invitation - verified November 2011 - Condition: Breast Cancer Mortality
Intervention: Other: Invitation for breast screening
Sponsors: University of Oxford; University of Oxford; Department of Health, United Kingdom
Enrolling by invitation - verified June 2011 - Condition: Colorectal Cancer
Intervention:
Sponsors: Newcastle University; Newcastle University; Northumbria Healthcare NHS Foundation Trust
Active, not recruiting - verified October 2011 - Condition: Coronary Artery Disease
Intervention: Device: Radi pressure wire (pressure wire assessment)
Sponsors: Southampton University Hospitals NHS Trust; Southampton University Hospitals NHS Trust
Recruiting - verified July 2011 - Conditions: Attention; Memory; Mood; Mental Fatigue
Intervention:
Sponsors: Northumbria University; Northumbria University
Completed - verified August 2011 - Condition: Ischaemia-reperfusion (IR) Injury
Interventions: Drug: C-type natriuretic peptide (CNP); Drug: Saline; Drug: Acetylcholine
Sponsors: Queen Mary University of London; Queen Mary University of London; University College, London
Not yet recruiting - verified May 2012 - Condition: Type 1 Diabetes Mellitus
Intervention: Other: DAFNE course (Timing of delivery of education)
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Teaching Hospitals NHS Foundation Trust; University Hospitals, Leicester; Cambridge University Hospitals NHS Foundation Trust; University College London Hospitals; Northumbria Healthcare NHS Foundation Trust; NHS Greater Glasgow and Clyde; Norfolk and Norwich University Hospitals NHS Foundation Trust; East Lancashire Hospitals NHS Trust
Active, not recruiting - verified July 2011 - Conditions: Wegener's Granulomatosis; Microscopic Polyangiitis; Churg Strauss Syndrome; Polyarteritis Nodosa; Giant Cell Arteritis; Takayasu Arteritis
Intervention:
Sponsors: University of Oxford; University of Oxford; American College of Rheumatology; The European League Against Rheumatism (EULAR); The Vasculitis foundation
Recruiting - verified January 2012 - Condition: Asthma
Intervention: Drug: Hydrocortisone/ Placebo and Propranolol
Sponsors: University of Dundee; University of Dundee; NHS Tayside
Completed - verified October 2010 - Condition: Colorectal Cancer
Interventions: Drug: Eicosapentaenoic acid free fatty acid; Drug: Placebo
Sponsors: University of Leeds; University of Leeds
Completed - verified October 2011 - Condition: Influenza
Intervention: Dietary Supplement: Prebiotic and probiotic mix
Sponsors: University of Reading; University of Reading
Active, not recruiting - verified July 2011 - Conditions: Stroke; TIA; Surgery; Anaesthesia; Carotid Stenosis
Intervention: Device: OxyMask
Sponsors: Brighton and Sussex University Hospitals NHS Trust; Brighton and Sussex University Hospitals NHS Trust
Recruiting - verified February 2012 - Conditions: Rheumatoid Arthritis; Ankylosing Spondylitis; Psoriatic Arthritis
Intervention: Drug: anti-TNF therapy (etanercept or adalimumab)
Sponsors: Imperial College London; Imperial College London
Recruiting - verified September 2011 - Condition: Hypothermia
Intervention: Other: Under patient warming mattress
Sponsors: Brighton and Sussex University Hospitals NHS Trust; Brighton and Sussex University Hospitals NHS Trust
Recruiting - verified June 2011 - Condition: Nonalcoholic Steatohepatitis
Intervention: Drug: Losartan
Sponsors: Newcastle-upon-Tyne Hospitals NHS Trust; Newcastle-upon-Tyne Hospitals NHS Trust; Newcastle University; University of Newcastle Upon-Tyne
Recruiting - verified February 2011 - Condition: Chronic Kidney Disease
Interventions: Other: Post operative progressive handgrip exercise; Other: Treatment as usual
Sponsors: Bangor University; Bangor University; Betsi Cadwaladr University Health Board
Recruiting - verified November 2011 - Condition: Overdose
Interventions: Drug: Ondansetron; Drug: acetylcysteine; Drug: acetylcysteine
Sponsors: University of Edinburgh; University of Edinburgh; NHS Lothian; Chief Scientist Office of the Scottish Government
Recruiting - verified October 2010 - Conditions: Hypothermia; Shivering; Anesthesia, Obstetrical; Anesthesia, Regional; Cesarean Section
Intervention: Device: Warming with warming mattress
Sponsors: Brighton and Sussex University Hospitals NHS Trust; Brighton and Sussex University Hospitals NHS Trust
Completed - verified December 2011 - Condition: Palliative Care
Interventions: Drug: Alfentanil; Drug: Diamorphine
Sponsors: Gloucestershire Hospitals NHS Foundation Trust; Gloucestershire Hospitals NHS Foundation Trust
Recruiting - verified March 2012 - Condition: HIV Infections
Interventions: Drug: Maraviroc; Drug: placebo
Sponsors: St Stephens Aids Trust; St Stephens Aids Trust
Terminated - verified October 2011 - Condition: Myopathy
Intervention:
Sponsors: University of Nottingham; University of Nottingham; The Dunhill Medical Trust
Recruiting - verified October 2011 - Condition: Metabolic Syndrome
Interventions: Behavioral: Group lifestyle education; Other: Routine care
Sponsors: University of Leicester; University of Leicester; University Hospitals, Leicester
Completed - verified December 2011 - Conditions: Dental Caries; Oral Microbial Colonization
Interventions: Dietary Supplement: Xylitol consumption; Behavioral: Childsmile preventative programme
Sponsors: NHS Fife; NHS Fife; University of Turku
Active, not recruiting - verified December 2009 - Condition: Pancreatic Cancer
Interventions: Drug: capecitabine; Drug: gemcitabine hydrochloride; Procedure: quality-of-life assessment; Radiation: 3-dimensional conformal radiation therapy
Sponsors: National Cancer Institute (NCI); Wales Cancer Trials Unit
Recruiting - verified May 2011 - Condition: Tuberculosis
Intervention: Biological: rdESAT-6 + rCFP-10 (C-Tb)
Sponsors: Statens Serum Institut; Statens Serum Institut
Completed - verified February 2012 - Condition: Skin Cancer
Interventions: Dietary Supplement: Green tea + vitamin C high dose; Dietary Supplement: Placebo capsule
Sponsors: University of Manchester; University of Manchester; University of Leeds; University of Bradford
Recruiting - verified November 2011 - Condition: Skin Cancer
Interventions: Dietary Supplement: Omega-3 PUFA; Dietary Supplement: Gelatine
Sponsors: University of Manchester; University of Manchester
Completed - verified August 2011 - Conditions: Anaesthesia; Airway Management; Videolaryngoscopy
Interventions: Device: Macintosh Laryngoscope; Device: Pentax AWS Videolaryngoscope
Sponsors: NHS Grampian; NHS Grampian; Research and Development Department, NHS Grampian; University of Aberdeen
Not yet recruiting - verified December 2011 - Condition: Cardiac Failure
Intervention: Device: Biventricular pacing
Sponsors: Cardiff and Vale University Health Board; Cardiff and Vale University Health Board
Recruiting - verified June 2011 - Condition: Out-of-hospital Cardiac Arrest
Interventions: Procedure: Target temperature 36°C; Procedure: Target Temperature 33°C
Sponsors: Helsingborgs Hospital; Niklas Nielsen; Scandinavian Critical Care Trials Group; Copenhagen Trial Unit, Center for Clinical Intervention Research; Lund University; The George Institute of Global Health, Sydney, Australia
Recruiting - verified February 2012 - Conditions: Intrapartum Fetal Monitoring; Pregnancy
Interventions: Drug: Dinoprostone; Device: Monica AN 24
Sponsors: Liverpool Women's NHS Foundation Trust; Liverpool Women's NHS Foundation Trust; University of Liverpool
Completed - verified November 2011 - Condition: Renal Failure
Interventions: Procedure: Percutaneous Insertion catheter; Procedure: Open insertion Catheter
Sponsors: University of Hull; University of Hull
Not yet recruiting - verified May 2010 - Conditions: Infection; Inflammation; Allergy; Children
Intervention:
Sponsors: Imperial College London; Imperial College London
Recruiting - verified November 2011 - Condition: Full Thickness Macular Hole
Intervention: Behavioral: Face down posture
Sponsors: NHS Greater Glasgow and Clyde; NHS Greater Glasgow and Clyde
Completed - verified April 2012 - Condition: Chronic Obstructive Pulmonary Disease
Interventions: Drug: Fosinopril; Other: lactose
Sponsors: Imperial College London; Imperial College London; Medical Research Council
Recruiting - verified June 2011 - Condition: Factor X Deficiency
Intervention: Biological: FACTOR X
Sponsors: Bio Products Laboratory; Bio Products Laboratory; Bio Products Laboratory Ltd
Recruiting - verified May 2012 - Condition: Macular Degeneration
Interventions: Device: Epimacular Brachytherapy; Drug: Ranibizumab
Sponsors: King's College Hospital NHS Trust; King's College Hospital NHS Trust
Active, not recruiting - verified April 2012 - Condition: Food Allergy
Intervention:
Sponsors: Brighton & Sussex Medical School; Brighton & Sussex Medical School; Brighton and Sussex University Hospitals NHS Trust; Guy's and St Thomas' NHS Foundation Trust
Completed - verified October 2009 - Condition: Hypertension, Pulmonary
Intervention: Drug: propofol and isoflurane
Sponsors: University Hospitals Bristol NHS Trust; University Hospitals Bristol NHS Trust
Completed - verified December 2011 - Condition: Heart Failure
Interventions: Drug: Placebo; Drug: Forceval plus 50 micrograms Vitamin D3
Sponsors: Belfast Health and Social Care Trust; Belfast Health and Social Care Trust
Active, not recruiting - verified June 2011 - Conditions: Haemodialysis; Surgery
Intervention: Procedure: Arterial and venous duplex ultrasound examination
Sponsors: University of Hull; University of Hull
Recruiting - verified May 2010 - Condition: Carotid Atherosclerosis
Intervention: Other: PET-CT with CuATSM
Sponsors: King's College London; King's College London; Guy's and St Thomas' NHS Foundation Trust
Suspended - verified April 2012 - Condition: Chronic Kidney Disease
Interventions: Other: Progressive resistance training programme; Other: Sham exercise; Other: Progressive resistance training; Other: Sham exercise
Sponsors: Bangor University; Bangor University; Betsi Cadwaladr University Health Board
Completed - verified December 2011 - Condition: Influenza
Intervention: Biological: MVA-NP+M1
Sponsors: University of Oxford; University of Oxford; Wellcome Trust
Completed - verified January 2011 - Conditions: Type 2 Diabetes; Obesity
Intervention: Behavioral: 8-month group lifestyle programme
Sponsors: The Royal Bournemouth Hospital; The Royal Bournemouth Hospital
Recruiting - verified August 2011 - Condition: Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Drug: multikinase inhibitor AT9283; Other: enzyme-linked immunosorbent assay; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: Cancer Research UK; Cancer Research UK
Recruiting - verified April 2012 - Conditions: Myocardial Reperfusion Injury; Cardiac Output, Low; Hypertrophy, Left Ventricular
Interventions: Drug: Perhexiline; Drug: Placebo marked PEXSIG
Sponsors: University Hospital Birmingham; University Hospital Birmingham; University of Birmingham; Brighton and Sussex University Hospitals NHS Trust; British Heart Foundation
Recruiting - verified April 2011 - Condition: Stroke
Interventions: Drug: Transdermal glyceryl trinitrate patch; Drug: Pre-stroke antihypertensives
Sponsors: University of Nottingham; University of Nottingham
Recruiting - verified October 2011 - Condition: Prostate Cancer
Interventions: Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: computed tomography; Procedure: magnetic resonance imaging; Procedure: single photon emission computed tomography; Radiation: technetium Tc 99m demobesin-4
Sponsors: Cancer Research UK; Cancer Research UK
Terminated - verified February 2012 - Conditions: Prostate Cancer; Sexual Dysfunction
Interventions: Other: laboratory biomarker analysis; Other: questionnaire administration; Procedure: assessment of therapy complications; Procedure: high-intensity focused ultrasound ablation; Procedure: quality-of-life assessment
Sponsors: National Cancer Institute (NCI); University College London Hospitals
Recruiting - verified May 2011 - Conditions: Graft Versus Host Disease; Nonneoplastic Condition
Interventions: Biological: adoptive immunotherapy; Biological: alemtuzumab; Biological: in vitro-treated peripheral blood lymphocyte therapy; Drug: foscarnet sodium; Drug: ganciclovir; Genetic: polymerase chain reaction; Procedure: allogeneic hematopoietic stem cell transplantation; Procedure: infection prophylaxis and management; Procedure: peripheral blood stem cell transplantation; Procedure: standard follow-up care; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); University Hospital Birmingham
Recruiting - verified April 2010 - Condition: HIV Infections
Interventions: Drug: Ribavirin; Drug: Raltegravir
Sponsors: Imperial College London; Imperial College London
Completed - verified November 2011 - Conditions: Cognitive Function; Mood
Interventions: Dietary Supplement: EGCG; Dietary Supplement: Placebo
Sponsors: Northumbria University; Northumbria University
Completed - verified March 2012 - Condition: HIV Infections
Interventions: Drug: Maraviroc; Drug: Maraviroc
Sponsors: Imperial College London; Imperial College London; Mater Misericordiae University Hospital, Dublin, Ireland
Recruiting - verified May 2011 - Condition: Giant Cell Arteritis
Interventions: Procedure: Ultrasound of temporal and axillary arteries; Procedure: Temporal artery biopsy
Sponsors: University of Oxford; University of Oxford; University of Sheffield; Southend University Hospital; Nuffield Orthopaedic Centre NHS Trust; John Radcliffe Hospital; The Leeds Teaching Hospitals NHS Trust; University of Bristol; London School of Hygiene and Tropical Medicine; Medical Center for Rheumatology Berlin-Buch
Recruiting - verified January 2012 - Condition: Prostate Cancer
Interventions: Drug: WST11; Drug: WST11
Sponsors: Steba Biotech S.A.; Steba Biotech S.A.
Active, not recruiting - verified January 2012 - Condition: Hemophilia B
Intervention: Genetic: Gene Transfer
Sponsors: St. Jude Children's Research Hospital; St. Jude Children's Research Hospital; Stanford University; Katharine Dormandy Haemophilia Centre and Haemostasis Unit
Recruiting - verified November 2011 - Condition: Critical Illness Myopathy
Intervention: Other: Pulmonary Rehabilitation
Sponsors: Guy's and St Thomas' NHS Foundation Trust; Guy's and St Thomas' NHS Foundation Trust
Recruiting - verified November 2011 - Condition: Dyspnea
Intervention: Device: handheld fan directed to cheeks
Sponsors: Cambridge University Hospitals NHS Foundation Trust; Cambridge University Hospitals NHS Foundation Trust; St Catherines Hospice; Scarborough acute hospitals Trust; University hospitals Morecambe Bay; St Johns Hospice
Recruiting - verified June 2011 - Condition: Idiopathic Inflammatory Myopathy
Intervention:
Sponsors: Salford Royal NHS Foundation Trust; Salford Royal NHS Foundation Trust
Recruiting - verified October 2009 - Condition: Influenza
Intervention:
Sponsors: Imperial College London; Imperial College London; Wellcome Trust; Medical Research Council
Completed - verified June 2011 - Conditions: Anesthesia; Child; Infant
Intervention:
Sponsors: University Hospitals Bristol NHS Trust; University Hospitals Bristol NHS Trust; Royal United Hospital Bath NHS Trust
Terminated - verified December 2011 - Condition: Prostate Cancer
Interventions: Other: laboratory biomarker analysis; Other: medical chart review; Other: questionnaire administration
Sponsors: National Cancer Institute (NCI); Institute of Cancer Research, United Kingdom
Recruiting - verified August 2009 - Condition: Hematopoietic/Lymphoid Cancer
Interventions: Drug: cyclophosphamide; Drug: cyclosporine; Drug: fludarabine phosphate; Drug: mycophenolate mofetil; Other: laboratory biomarker analysis; Procedure: nonmyeloablative allogeneic hematopoietic stem cell transplantation; Procedure: umbilical cord blood transplantation; Radiation: total-body irradiation
Sponsors: National Cancer Institute (NCI); Cancer Research UK
Recruiting - verified April 2010 - Condition: Cancer
Interventions: Behavioral: Distress Thermometer and Problems List; Behavioral: Usual psychosocial support
Sponsors: University Hospitals Bristol NHS Trust; University Hospitals Bristol NHS Trust; Royal United Hospital Bath NHS Trust; University of Bristol
Active, not recruiting - verified July 2011 - Condition: Breast Cancer
Intervention: Procedure: Breast scan - Electrical Impedance Mammography
Sponsors: Oxford University Hospitals NHS Trust; Oxford University Hospitals NHS Trust
Recruiting - verified August 2009 - Condition: HPV Infections
Interventions: Biological: Cervarix; Biological: Gardasil
Sponsors: Health Protection Agency, United Kingdom; Dr. Elizabeth Miller
Recruiting - verified March 2012 - Condition: Schizophrenia
Interventions: Drug: Citalopram; Drug: Placebo
Sponsors: Imperial College London; Imperial College London; University of Manchester; University of Southampton; King's College London; University of Oxford; University College, London; University of Bristol
Recruiting - verified September 2011 - Conditions: Pelvic Floor Disorders; Sexual Function; Incontinence; Pelvic Organ Prolapse
Intervention:
Sponsors: International Urogynecological Society; International Urogynecological Society
Active, not recruiting - verified November 2011 - Conditions: Stroke; Hemispatial Neglect
Interventions: Drug: Guanfacine; Drug: Placebo
Sponsors: Imperial College London; Imperial College London; Wellcome Trust
Recruiting - verified June 2011 - Condition: Primary Mediastinal B-Cell Lymphoma
Intervention:
Sponsors: International Extranodal Lymphoma Study Group (IELSG); International Extranodal Lymphoma Study Group (IELSG)
Active, not recruiting - verified November 2011 - Condition: Influenza
Interventions: Biological: MVA-NP+M1; Biological: MVA-NP+M1; Biological: MVA-NP+M1
Sponsors: University of Oxford; University of Oxford; Wellcome Trust
Recruiting - verified June 2011 - Conditions: Deglutition Disorders; Esophageal Diseases; Eosinophilia
Intervention: Other: assessment of disease activity using the EEsAI
Sponsors: University Hospital Inselspital, Berne; University Hospital Inselspital, Berne; Institute of Social and Preventive Medicine, University Bern; Dept. of Gastroenterology, Kantonsspital Olten, Olten; Luzerner Kantonsspital; Mayo Clinic Rochester, Minnesota, USA; University of Cincinnati; University of Colorado, Denver; Northwestern University of Chicago, Illinois, USA; Indiana University School of Medicine; Philadelphia University
Recruiting - verified March 2012 - Condition: Depression
Intervention: Behavioral: Mindfulness Based Cognitive Therapy (MBCT)
Sponsors: Lahtinen, Marika; Lahtinen, Marika; University of East London; South London and Maudsley NHS Foundation Trust
Completed - verified February 2012 - Condition: Hypoxic Ischaemic Encephalopathy
Intervention: Other: Xenon gas
Sponsors: Imperial College London; Imperial College London; University College London Hospitals; Guy's and St Thomas' NHS Foundation Trust
Recruiting - verified April 2012 - Conditions: Isolated Mediastinal Lymphadenopathy; Sarcoidosis; Tuberculosis; Lung Cancer; Lymphoma
Intervention: Procedure: EBUS
Sponsors: University College London Hospitals; University College London Hospitals
Active, not recruiting - verified October 2011 - Conditions: Migraine Disorders; Obesity
Intervention:
Sponsors: Alder Hey Children's NHS Foundation Trust; Alder Hey Children's NHS Foundation Trust; University of Liverpool
Completed - verified February 2012 - Conditions: Chronic Obstructive Pulmonary Disease; Pulmonary Rehabilitation
Intervention: Behavioral: Pulmonary Intervention
Sponsors: University of East Anglia; University of East Anglia
Active, not recruiting - verified August 2011 - Condition: Factor X Deficiency
Intervention: Biological: Human Coagulation FACTOR X
Sponsors: Bio Products Laboratory; Bio Products Laboratory
Recruiting - verified February 2012 - Condition: Diabetes (Insulin-requiring, Type 1 or Type 2)
Intervention: Device: Mobile phone telehealth application: Think Positive (T+)
Sponsors: University College London Hospitals; University College London Hospitals; University College, London; Department of Health, United Kingdom
Completed - verified April 2012 - Condition: Compartment Syndrome
Intervention: Device: Monitoring of StO2
Sponsors: University Hospital Birmingham NHS Foundation Trust; University Hospital Birmingham NHS Foundation Trust
Completed - verified September 2011 - Conditions: Obstructive Lung Disease; Chronic Obstructive Pulmonary Disease; Asthma
Intervention: Dietary Supplement: AKL1
Sponsors: University of East Anglia; University of East Anglia
Active, not recruiting - verified August 2011 - Conditions: Myelodysplastic Syndromes; Leukemia, Myeloid, Acute
Interventions: Drug: Fludarabine; Drug: Busulphan; Drug: Thymoglobuline (Anti-thymocyte globulin [rabbit]) - Genzyme; Procedure: Haematopoietic stem cell infusion
Sponsors: King's College Hospital NHS Trust; King's College Hospital NHS Trust
Terminated - verified June 2011 - Conditions: Appetite Regulation; Obesity
Interventions: Dietary Supplement: Oligofructose; Dietary Supplement: Placebo
Sponsors: Imperial College London; Imperial College London
Completed - verified December 2011 - Conditions: Disorder Related to Renal Transplantation; Pain
Interventions: Procedure: TAP block; Procedure: TAP block with placebo
Sponsors: Royal Liverpool and Broadgreen University Hospitals NHS Trust; Royal Liverpool and Broadgreen University Hospitals NHS Trust
Completed - verified October 2010 - Condition: Ovarian Cancer
Interventions: Genetic: DNA methylation analysis; Genetic: microarray analysis; Genetic: polymerase chain reaction; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); Scottish Gynaecological Cancer Study Group
Recruiting - verified July 2009 - Condition: Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Genetic: molecular genetic technique; Other: mass spectrometry; Other: pharmacological study
Sponsors: National Cancer Institute (NCI); Children's Cancer and Leukaemia Group
Recruiting - verified June 2009 - Condition: Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Drug: carboplatin; Drug: cyclophosphamide; Drug: etoposide phosphate; Genetic: gene expression analysis; Genetic: polymorphism analysis; Other: pharmacological study
Sponsors: National Cancer Institute (NCI); Children's Cancer and Leukaemia Group
Recruiting - verified June 2009 - Condition: Sarcoma
Interventions: Genetic: microarray analysis; Genetic: molecular diagnostic method; Other: biologic sample preservation procedure
Sponsors: National Cancer Institute (NCI); Christie Hospital NHS Foundation Trust
Recruiting - verified April 2008 - Condition: Migraine
Intervention:
Sponsors: The City of London Migraine Clinic; The City of London Migraine Clinic; Genomics Research Centre, Griffith University, Australia
Recruiting - verified July 2011 - Condition: Melanoma (Skin)
Interventions: Genetic: gene expression analysis; Genetic: mutation analysis; Other: diagnostic laboratory biomarker analysis; Other: immunohistochemistry staining method; Procedure: sentinel lymph node biopsy
Sponsors: National Cancer Institute (NCI); Leeds Cancer Centre at St. James's University Hospital
Recruiting - verified April 2008 - Condition: Diabetic Neuropathy
Intervention:
Sponsors: Tameside Hospital NHS Foundation Trust; Tameside Hospital NHS Foundation Trust
Recruiting - verified May 2009 - Condition: Atrial Fibrillation
Intervention: Procedure: catheter ablation
Sponsors: Barts & The London NHS Trust; Barts & The London NHS Trust
Completed - verified August 2011 - Condition: Malaria
Interventions: Biological: AdCh63 ME-TRAP; Biological: AdCh63 ME-TRAP; MVA ME-TRAP
Sponsors: University of Oxford; University of Oxford
Completed - verified October 2011 - Condition: Phenylketonuria
Interventions: Dietary Supplement: high oleic sunflower oil; Dietary Supplement: microalgal oil; Dietary Supplement: microalgal oil; Dietary Supplement: microalgal oil; Dietary Supplement: microalgal oil
Sponsors: Ludwig-Maximilians - University of Munich; Ludwig-Maximilians - University of Munich; European Union
Active, not recruiting - verified October 2011 - Condition: Carotid Stenosis
Intervention: Procedure: CEA, CAS
Sponsors: University of Oxford; University of Oxford; NHS Health Technology Assessment Programme; BUPA Foundation
Recruiting - verified November 2011 - Condition: Dental Caries
Intervention: Other: Fluoride varnish
Sponsors: University of St Andrews; University of St Andrews
Recruiting - verified July 2011 - Condition: Diabetes Mellitus, Type 2
Intervention: Behavioral: CD-ROM
Sponsors: Queen's University, Belfast; Queen's University, Belfast
Completed - verified August 2011 - Catheter Ablation Versus Medical Rate Control for Atrial Fibrillation in Patients With Heart FailureConditions: Atrial Fibrillation; Heart Failure
Interventions: Drug: Medication to control ventricular rate in AF; Procedure: Catheter Ablation for Persistent Atrial Fibrillation
Sponsors: Royal Brompton & Harefield NHS Foundation Trust; Royal Brompton & Harefield NHS Foundation Trust
Active, not recruiting - verified December 2011 - Condition: Cardiovascular Disease
Intervention: Other: Fruit and vegetable intervention
Sponsors: Queen's University, Belfast; Queen's University, Belfast
Completed - verified August 2011 - Condition: Sarcoidosis
Interventions: Procedure: EUS-FNA/EBUS-TBNA + BAL; Procedure: EBB + TBLB + BAL
Sponsors: Leiden University Medical Center; Leiden University Medical Center
Active, not recruiting - verified January 2012 - Condition: Adenocarcinoma of the Stomach
Intervention: Drug: capecitabine
Sponsors: Cambridge University Hospitals NHS Foundation Trust; Cambridge University Hospitals NHS Foundation Trust
Recruiting - verified May 2010 - Conditions: Polycythemia Vera; Essential Thrombocythemia
Intervention: Drug: HDAC inhibitor (MK-0683)
Sponsors: Copenhagen University Hospital at Herlev; Copenhagen University Hospital at Herlev
Active, not recruiting - verified December 2011 - Condition: Laparoscopic Cholecystectomy
Intervention: Other: Succinylated gelatine, 40g/L, (Gelofusine - B Braun)
Sponsors: University of Nottingham; University of Nottingham; Sherwood Forest Hospitals NHS Foundation Trust
Completed - verified November 2011 - Condition: Bladder Cancer
Interventions: Procedure: therapeutic conventional surgery; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); Institute of Cancer Research, United Kingdom
Active, not recruiting - verified March 2009 - Condition: Pancreatic Adenocarcinoma
Intervention: Drug: capecitabine
Sponsors: Cambridge University Hospitals NHS Foundation Trust; Cambridge University Hospitals NHS Foundation Trust
Recruiting - verified May 2010 - Condition: Asthma
Interventions: Drug: Azithromycin; Drug: Placebo
Sponsors: University of Glasgow; Euan J Cameron; University of Glasgow; NHS Greater Glasgow and Clyde
Completed - verified October 2011 - Condition: Bronchiectasis
Interventions: Procedure: Chest physiotherapy; Procedure: Chest Physiotherapy + Exercise Program
Sponsors: NHS Lothian; NHS Lothian
Completed - verified November 2011 - Condition: Type 2 Diabetes Mellitus
Intervention: Dietary Supplement: cinnamon 2g per day for 12 weeks
Sponsors: Thames Valley University; Thames Valley University; Wembley Health Care centre, NHS, UK.; Monks Park Primary care centre, NHS UK.; Willesden Health centre, NHS, UK.
Completed - verified February 2009 - Condition: Infertility
Intervention: Drug: Nafarelin acetate, Oestradiol Valerate, Progesterone
Sponsors: University of Oxford; University of Oxford; Oxford Fertility Unit, UK
Enrolling by invitation - verified January 2012 - Condition: Chronic Heart Failure
Interventions: Drug: Perhexiline; Drug: Placebo
Sponsors: University Hospital Birmingham NHS Foundation Trust; University Hospital Birmingham NHS Foundation Trust; British Heart Foundation
Completed - verified November 2011 - Conditions: Venous Insufficiency; Varicose Veins
Interventions: Procedure: Surgery; Procedure: EVLT
Sponsors: University of Hull; University of Hull; Hull and East Yorkshire Hospitals NHS Trust
Active, not recruiting - verified May 2012 - Condition: Polymyalgia Rheumatica
Interventions: Drug: Timed Release Tablet Prednisone; Drug: Prednisolone
Sponsors: University Hospitals Bristol NHS Trust; University Hospitals Bristol NHS Trust
Active, not recruiting - verified August 2011 - Condition: Heart Failure
Interventions: Drug: Beta blocker; Other: Placebo
Sponsors: Royal Brompton & Harefield NHS Foundation Trust; Royal Brompton & Harefield NHS Foundation Trust; University of Oxford
Enrolling by invitation - verified January 2009 - Conditions: Asthma; Rhinitis
Intervention: Other: no intervention
Sponsors: University of Dundee; University of Dundee
Completed - verified May 2009 - Conditions: Myotonia; Non-Dystrophic Myotonia
Interventions: Drug: Mexiletine; Drug: Placebo
Sponsors: University of Kansas; University of Kansas
Active, not recruiting - verified June 2011 - Conditions: Post-operative Pain; Postoperative Nausea; Postoperative Complications
Intervention: Drug: Levobupivicaine 0.25%
Sponsors: University of Nottingham; University of Nottingham
Completed - verified January 2012 - Conditions: Malignant Mesothelioma; Metastatic Cancer
Interventions: Other: talc; Procedure: therapeutic thoracoscopy; Procedure: therapeutic videothoracoscopy
Sponsors: Papworth Hospital NHS Foundation Trust; Papworth Hospital NHS Foundation Trust
Active, not recruiting - verified March 2012 - Condition: Heterogeneous Emphysema
Intervention: Device: Intra-bronchial valve (Spiration IBV)
Sponsors: Royal Brompton & Harefield NHS Foundation Trust; Royal Brompton & Harefield NHS Foundation Trust
Completed - verified February 2012 - Condition: Leukemia
Interventions: Biological: pegfilgrastim; Biological: rituximab; Drug: cyclophosphamide; Drug: fludarabine phosphate; Genetic: cytogenetic analysis; Genetic: fluorescence in situ hybridization; Genetic: gene expression analysis; Genetic: mutation analysis; Genetic: protein expression analysis; Other: flow cytometry; Other: laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); All Ireland Cooperative Oncology Research Group
Recruiting - verified January 2009 - Condition: Adipose Tissue
Intervention: Other: GIP (glucose dependent insulinotropic peptide) infusion
Sponsors: Aintree University Hospitals NHS Foundation Trust; Aintree University Hospitals NHS Foundation Trust
Recruiting - verified December 2011 - Conditions: End-stage Renal Failure; Graft Rejection
Interventions: Drug: Tacrolimus (Kidney transplant maintenance immunosuppression); Drug: Kidney transplant maintenance immunosuppression
Sponsors: Hammersmith Hospitals NHS Trust; Hammersmith Hospitals NHS Trust
Recruiting - verified June 2011 - Condition: Ulcerative Colitis
Intervention: Other: Synbiotic (Synergy1/B. longum)
Sponsors: University of Dundee; University of Dundee; National Association for Colitis and Crohn's Disease
Completed - verified July 2011 - Condition: Meniere's Disease
Interventions: Drug: Methylprednisolone; Drug: Gentamicin
Sponsors: Imperial College London; Imperial College London; Meniere's Society; Imperial College Healthcare NHS Trust; Medical Research Council
Recruiting - verified September 2011 - Conditions: Femoropopliteal Disease; Intermittent Claudication
Interventions: Procedure: Percutaneous Transluminal Angioplasty (PTA); Procedure: Supervised Exercise Programme (SEP); Procedure: Combined Treatment
Sponsors: University of Hull; University of Hull; Hull and East Yorkshire Hospitals NHS Trust
Active, not recruiting - verified May 2012 - Condition: Trachoma
Interventions: Drug: Azithromycin; Drug: Azithromycin
Sponsors: Johns Hopkins University; Johns Hopkins University; Bill and Melinda Gates Foundation
Active, not recruiting - verified March 2012 - Conditions: Type 1 Diabetes; Type 2 Diabetes
Intervention: Biological: Autologous CD34+ stem cells
Sponsors: Imperial College London; Imperial College London
Recruiting - verified July 2011 - Condition: Venous Thromboembolism
Intervention:
Sponsors: Ottawa Hospital Research Institute; Ottawa Hospital Research Institute; Heart and Stroke Foundation of Ontario
Recruiting - verified June 2011 - Condition: Rheumatoid Arthritis
Intervention:
Sponsors: Imperial College London; Imperial College London; Medical Research Council
Completed - verified September 2011 - Condition: Asthma
Intervention: Other: bronchoscopy
Sponsors: Imperial College London; Imperial College London; Asthma UK; Royal Brompton & Harefield NHS Foundation Trust
Recruiting - verified June 2011 - Conditions: Alcohol Abuse; Drug Abuse; Depression; Panic Disorder; Conduct Disorder
Intervention: Behavioral: Personality-targeted interventions
Sponsors: King's College London; King's College London; Action on Addiction
Completed - verified December 2010 - Condition: Breast Cancer
Interventions: Drug: abiraterone acetate; Other: laboratory biomarker analysis; Other: pharmacogenomic studies
Sponsors: Cancer Research UK; Cancer Research UK
Recruiting - verified April 2012 - Conditions: Varicose Veins; Venous Insufficiency; Venous Ulceration
Interventions: Procedure: Surgery - Saphenofemoral ligation, saphenous strip and avulsions; Procedure: EVLT
Sponsors: University of Hull; University of Hull; Hull and East Yorkshire Hospitals NHS Trust
Active, not recruiting - verified May 2012 - Condition: Breast Cancer
Interventions: Drug: letrozole; Other: placebo
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group; Eastern Cooperative Oncology Group; North Central Cancer Treatment Group; Southwestern Oncology Group (SWOG); Cancer and Leukemia Group B
Active, not recruiting - verified May 2012 - Condition: Multiple Myeloma and Plasma Cell Neoplasm
Interventions: Drug: cyclophosphamide; Drug: melphalan; Procedure: autologous hematopoietic stem cell transplantation
Sponsors: National Cancer Institute (NCI); Leeds Cancer Centre at St. James's University Hospital
Recruiting - verified June 2009 - Condition: Abdominal Aortic Aneurysm
Interventions: Procedure: Open repair; Procedure: EVAR
Sponsors: Imperial College London; Imperial College London; London School of Hygiene and Tropical Medicine; University of Cambridge; The Leeds Teaching Hospitals NHS Trust; St George's, University of London
Recruiting - verified January 2012 - Condition: Colorectal Cancer
Interventions: Drug: capecitabine; Drug: fluorouracil; Drug: oxaliplatin
Sponsors: Cancer Research UK, Glasgow; Cancer Research UK, Glasgow
Recruiting - verified April 2012 - Condition: Irritable Bowel Syndrome With Diarrhoea
Interventions: Drug: Ondansetron; Drug: Placebo
Sponsors: University of Nottingham; University of Nottingham; National Institute for Health Research, United Kingdom
Completed - verified January 2012 - Conditions: Angina Pectoris; Coronary Heart Disease
Intervention:
Sponsors: University of Edinburgh; University of Edinburgh; Imperial College London
Active, not recruiting - verified November 2011 - Condition: Dizziness
Interventions: Behavioral: Self-treatment booklet; Behavioral: Remote telephone support
Sponsors: University of Southampton; University of Southampton
Completed - verified January 2010 - Conditions: Type 2 Diabetes Mellitus; Coronary Artery Disease
Interventions: Drug: clopidogrel; Drug: placebo
Sponsors: Newcastle-upon-Tyne Hospitals NHS Trust; Newcastle-upon-Tyne Hospitals NHS Trust; British Heart Foundation; University of Newcastle Upon-Tyne
Active, not recruiting - verified November 2009 - Condition: Normal Pressure Hydrocephalus
Intervention: Procedure: Surgical treatment
Sponsors: University College London Hospitals; University College London Hospitals
Terminated - verified July 2008 - Conditions: Deep Vein Thrombosis; Pulmonary Embolism
Interventions: Other: Discontinue anticoagulant therapy (Negative d-dimer); Other: Continue on anticoagulant therapy (positive d-dimer)
Sponsors: McMaster University; McMaster University; Canadian Institutes of Health Research (CIHR)
Active, not recruiting - verified April 2012 - Condition: Coronary Artery Disease
Interventions: Drug: Metformin; Drug: Placebo
Sponsors: University of Glasgow; University of Glasgow; NHS Greater Glasgow and Clyde; Chief Scientist Office of the Scottish Government
Active, not recruiting - verified April 2011 - Condition: Subclinical Cushing's
Intervention: Drug: Mifepristone
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Teaching Hospitals NHS Foundation Trust
Completed - verified July 2010 - Condition: Head and Neck Cancer
Interventions: Procedure: positron emission tomography/computed tomography; Procedure: therapeutic conventional surgery
Sponsors: National Cancer Institute (NCI); Warwick Medical School
Recruiting - verified December 2008 - Condition: Breast Cancer
Interventions: Biological: trastuzumab; Drug: parenteral chemotherapy
Sponsors: National Cancer Institute (NCI); Warwick Medical School
Recruiting - verified November 2008 - Conditions: Intracerebral Hemorrhage; Stroke; Hypertension
Intervention: Other: Blood pressure management policies
Sponsors: The George Institute; The George Institute; National Health and Medical Research Council, Australia
Recruiting - verified February 2012 - Condition: Prostate Cancer
Intervention: Drug: WST11
Sponsors: Steba Biotech S.A.; Steba Biotech S.A.
Active, not recruiting - verified January 2012 - Conditions: COPD; Emphysema
Interventions: Drug: Simvastatin; Drug: Placebo
Sponsors: University of East Anglia; University of East Anglia
Active, not recruiting - verified August 2011 - Condition: Asthma
Intervention: Other: Fiberoptic bronchoscopy; blood test
Sponsors: Imperial College London; Imperial College London; Royal Brompton & Harefield NHS Foundation Trust; Medical Research Council
Recruiting - verified June 2011 - Condition: Crohn's Disease
Interventions: Drug: Colecalciferol D3 (Vigantol Oil); Drug: Medium chain triglycerides
Sponsors: Imperial College London; Imperial College London
Withdrawn - verified June 2011 - Conditions: Acute Liver Failure; Intracranial Hypertension
Intervention: Device: Hypothermia by the use of Blanketrol II, Cincinnati Sub-Zero
Sponsors: Rigshospitalet, Denmark; Rigshospitalet, Denmark; University Hospital Birmingham; King's College London; Feinberg School of Medicine, Northwestern University
Completed - verified July 2010 - Conditions: Lymphoma; Neurotoxicity
Interventions: Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: prednisolone; Drug: procarbazine hydrochloride; Drug: vincristine sulfate; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); Cancer Research UK
Recruiting - verified January 2009 - Conditions: brca1 Mutation Carrier; brca2 Mutation Carrier; Breast Cancer; Ovarian Cancer
Interventions: Drug: rucaparib (CO-338; formally AG-014699 or PF-01367338); Genetic: protein expression analysis; Genetic: western blotting; Other: immunohistochemistry staining method; Other: liquid chromatography; Other: mass spectrometry; Other: pharmacological study
Sponsors: Cancer Research UK; Cancer Research UK
Recruiting - verified April 2012 - Condition: Asthma
Intervention: Drug: budesonide
Sponsors: Imperial College London; Imperial College London; Royal Brompton & Harefield NHS Foundation Trust
Withdrawn - verified June 2011 - Condition: Asthma
Intervention: Drug: prednisolone
Sponsors: Imperial College London; Imperial College London; Royal Brompton & Harefield NHS Foundation Trust
Recruiting - verified June 2011 - Condition: Bronchogenic Carcinoma
Interventions: Procedure: Endobronchial or Endoscopic Ultrasound; Procedure: Bronchoscopy, CT-guided biopsy, PET scan, Mediastinoscopy
Sponsors: University College London Hospitals; University College London Hospitals; North Middlesex University Hospital; Barnet and Chase Farm Hospitals NHS Trust; The Whittington Hospital NHS Trust
Active, not recruiting - verified October 2011 - Condition: Acute Lung Injury
Interventions: Drug: N-acetylcysteine; Drug: 0.9% saline
Sponsors: Imperial College London; Imperial College London; Royal College of Physicians; Royal Brompton & Harefield NHS Foundation Trust
Completed - verified December 2011 - Condition: Colorectal Cancer
Interventions: Biological: cetuximab; Drug: capecitabine; Drug: fluorouracil; Drug: leucovorin calcium; Drug: oxaliplatin; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis
Sponsors: Medical Research Council; Cheryl Pugh
Active, not recruiting - verified February 2012 - Condition: Transient Hypothyroxinemia
Interventions: Drug: sodium iodide; Drug: sodium chloride
Sponsors: University of Oxford; University of Oxford; University of Dundee; Medical Research Council
Recruiting - verified December 2011 - Conditions: Anxiety Disorder; Long-term Effects Secondary to Cancer Therapy in Adults; Prostate Cancer; Sexual Dysfunction; Urinary Complications
Interventions: Drug: cyproterone acetate; Drug: releasing hormone agonist therapy; Other: active surveillance; Other: medical chart review; Other: questionnaire administration; Procedure: assessment of therapy complications; Procedure: quality-of-life assessment; Procedure: therapeutic conventional surgery; Procedure: therapeutic lymphadenectomy; Radiation: 3-dimensional conformal radiation therapy
Sponsors: National Cancer Institute (NCI); Oxford Radcliffe Hospital
Active, not recruiting - verified October 2011 - Condition: Brain and Central Nervous System Tumors
Interventions: Drug: temozolomide; Genetic: DNA methylation analysis; Other: laboratory biomarker analysis; Procedure: adjuvant therapy; Procedure: quality-of-life assessment; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); European Organization for Research and Treatment of Cancer - EORTC; NCIC Clinical Trials Group; Radiation Therapy Oncology Group; Medical Research Council; Cooperative Trials Group for Neuro-Oncology
Recruiting - verified May 2011 - Condition: Tracheal Intubation
Interventions: Device: McGrath; Device: Tracheal intubation using Macintosh Laryngoscope
Sponsors: NHS Grampian; NHS Grampian
Completed - verified March 2008 - Conditions: Intracranial Aneurysm; Subarachnoid Hemorrhage
Intervention: Procedure: endovascular coil embolization
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM)
Recruiting - verified January 2012 - Condition: Multiple Sclerosis
Interventions: Biological: Live Hookworm Larvae; Other: Histamine
Sponsors: University of Nottingham; University of Nottingham
Not yet recruiting - verified November 2011 - Conditions: Pain; Bone Metastasis
Interventions: Radiation: Radiotherapy; Radiation: Radiotherapy; Radiation: Radiotherapy; Radiation: Radiotherapy
Sponsors: International Atomic Energy Agency; International Atomic Energy Agency
Recruiting - verified October 2011 - Condition: Cancer
Intervention: Behavioral: EPAT© Educational Package
Sponsors: University of Edinburgh; University of Edinburgh; Cancer Research UK
Recruiting - verified September 2011 - Condition: Myelodysplastic Syndromes
Intervention:
Sponsors: Radboud University; Radboud University
Recruiting - verified July 2011 - Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the TesticleCondition: Testicular Germ Cell Tumor
Interventions: Other: questionnaire administration; Procedure: computed tomography; Procedure: magnetic resonance imaging; Procedure: quality-of-life assessment
Sponsors: National Cancer Institute (NCI); Medical Research Council
Recruiting - verified July 2009 - Conditions: Overweight; Obesity; Metabolic Syndrome
Interventions: Other: control diet, supported by dietary supplement twice daily; Other: high cereal fiber diet, supported by dietary supplement twice daily; Other: high protein diet, supported by dietary supplement twice daily; Other: diet moderately high both in cereal fiber and protein, supported by dietary supplement twice daily
Sponsors: German Institute of Human Nutrition; German Institute of Human Nutrition; German Federal Ministry of Education and Research; University of Warwick; University Hospitals Coventry and Warwickshire NHS Trust; Medical University of Vienna; Heinrich-Heine University, Duesseldorf; University Hospital Tuebingen; Charite University, Berlin, Germany; Klinikum Ernst von Bergmann Potsdam; Institute for Cereal Processing Potsdam-Rehbruecke
Completed - verified April 2012 - Condition: Head and Neck Cancer
Interventions: Other: questionnaire administration; Procedure: psychosocial assessment and care; Procedure: quality-of-life assessment; Procedure: regional lymph node dissection; Procedure: therapeutic conventional surgery
Sponsors: National Cancer Institute (NCI); The Facial Surgery Research Foundation
Recruiting - verified July 2009 - Condition: Colorectal Cancer
Interventions: Procedure: psychosocial assessment and care; Procedure: quality-of-life assessment
Sponsors: National Cancer Institute (NCI); European Organization for Research and Treatment of Cancer - EORTC
Completed - verified August 2009 - Condition: Colorectal Cancer
Interventions: Other: laboratory biomarker analysis; Procedure: computed tomography; Procedure: magnetic resonance imaging; Procedure: quality-of-life assessment
Sponsors: National Cancer Institute (NCI); Southampton University Hospitals NHS Trust
Recruiting - verified August 2009 - Condition: Cellulitis/Erysipelas of the Leg
Interventions: Drug: Penicillin VK; Other: placebo
Sponsors: University of Nottingham; University of Nottingham; Action Medical Research; UK Dermatology Clinical Trials Network
Active, not recruiting - verified January 2012 - Condition: Breast Cancer
Interventions: Drug: Letrozole; Drug: Letrozole
Sponsors: International Breast Cancer Study Group; International Breast Cancer Study Group
Recruiting - verified March 2012 - Condition: Testicular Germ Cell Tumor
Interventions: Other: biomarker analysis; Procedure: computed tomography
Sponsors: National Cancer Institute (NCI); Royal Marsden NHS Foundation Trust
Recruiting - verified October 2007 - Conditions: Nausea; Vomiting
Interventions: Device: Acupressure Wrist Bands (Sea-Bands); Device: Placebo wristbands
Sponsors: Sue Ryder Care; Sue Ryder Care
Recruiting - verified March 2012 - Conditions: Gastrointestinal Complications; Prostate Cancer; Sexual Dysfunction; Urinary Complications
Interventions: Drug: bicalutamide; Drug: goserelin acetate; Drug: leuprolide acetate; Procedure: adjuvant therapy; Procedure: quality-of-life assessment; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); Medical Research Council
Recruiting - verified July 2009 - Condition: Breast Cancer
Interventions: Genetic: gene expression analysis; Genetic: molecular diagnostic method; Genetic: polymorphism analysis; Genetic: protein expression analysis; Other: medical chart review; Other: questionnaire administration
Sponsors: National Cancer Institute (NCI); National Cancer Research Network
Recruiting - verified September 2007 - Condition: Childhood Obesity
Intervention: Behavioral: Obesity management framework
Sponsors: University of Bristol; University of Bristol
Completed - verified February 2009 - Condition: Acute Myocardial Infarction
Interventions: Other: CD133+ infusion; Other: placebo infusion
Sponsors: Onze Lieve Vrouw Hospital; Onze Lieve Vrouw Hospital; King's College London
Recruiting - verified May 2011 - Condition: Dermatitis, Photocontact
Intervention: Drug: 19 organic sunscreen filters and 5 topical NSAIDs
Sponsors: NHS Tayside; NHS Tayside
Completed - verified July 2011 - Conditions: Lung Cancer; Thromboembolism
Interventions: Drug: dalteparin; Procedure: quality-of-life assessment
Sponsors: National Cancer Institute (NCI); Velindre NHS Trust
Recruiting - verified March 2008 - Condition: Breast Cancer
Interventions: Biological: pegfilgrastim; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: epirubicin hydrochloride; Genetic: proteomic profiling; Other: diagnostic laboratory biomarker analysis; Other: matrix-assisted laser desorption/ionization time of flight mass spectrometry; Other: pharmacological study; Other: surface-enhanced laser desorption/ionization-time of flight mass spectrometry; Procedure: adjuvant therapy
Sponsors: National Cancer Institute (NCI); Charing Cross Hospital
Recruiting - verified September 2007 - CYP3A5 Gene as a Risk Factor for Kidney Damage in Young Patients With Cancer Treated With IfosfamideConditions: Chemotherapeutic Agent Toxicity; Sarcoma; Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Genetic: gene expression analysis; Genetic: polymorphism analysis; Procedure: management of therapy complications
Sponsors: National Cancer Institute (NCI); Children's Cancer and Leukaemia Group
Recruiting - verified June 2009 - Condition: Brain and Central Nervous System Tumors
Interventions: Drug: motexafin gadolinium; Drug: temozolomide; Procedure: adjuvant therapy; Procedure: quality-of-life assessment; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); Children's Cancer and Leukaemia Group
Recruiting - verified June 2009 - Condition: Malignant Mesothelioma
Interventions: Drug: bortezomib; Procedure: quality-of-life assessment
Sponsors: National Cancer Institute (NCI); All Ireland Cooperative Oncology Research Group
Recruiting - verified August 2007 - Condition: Depression
Interventions: Drug: Folic Acid; Drug: Placebo
Sponsors: Bangor University; Bangor University; NHS Health Technology Assessment Programme; Swansea University; Cardiff University; University of Liverpool; North West Wales NHS Trust; North East Wales NHS Trust; Swansea NHS Trust
Completed - verified February 2009 - Conditions: Lung Cancer; Precancerous Condition
Interventions: Other: cytology and cytometry specimen collection procedure; Other: Chest x ray; Procedure: Autofluorescence bronchoscopy; Procedure: CT scan
Sponsors: University College, London; University College, London
Completed - verified December 2011 - Condition: Kidney Cancer
Interventions: Drug: sorafenib tosylate; Procedure: adjuvant therapy
Sponsors: National Cancer Institute (NCI); Medical Research Council
Recruiting - verified April 2008 - Conditions: Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer
Interventions: Biological: bevacizumab; Drug: carboplatin; Drug: paclitaxel; Other: questionnaire administration; Other: study of socioeconomic and demographic variables; Procedure: quality-of-life assessment
Sponsors: National Cancer Institute (NCI); Medical Research Council
Recruiting - verified April 2012 - Conditions: Colorectal Cancer; Metastatic Cancer
Interventions: Biological: cetuximab; Drug: capecitabine; Drug: fluorouracil; Drug: leucovorin calcium; Drug: oxaliplatin; Other: study of socioeconomic and demographic variables; Procedure: adjuvant therapy; Procedure: neoadjuvant therapy; Procedure: quality-of-life assessment
Sponsors: National Cancer Institute (NCI); Southampton University Hospitals NHS Trust
Recruiting - verified April 2008 - Conditions: Heartburn; Gastro-esophageal Reflux
Intervention:
Sponsors: Guy's and St Thomas' NHS Foundation Trust; Guy's and St Thomas' NHS Foundation Trust
Completed - verified June 2011 - Condition: Gastroesophageal Reflux
Intervention:
Sponsors: Guy's and St Thomas' NHS Foundation Trust; Guy's and St Thomas' NHS Foundation Trust
Completed - verified June 2011 - Condition: Breast Cancer
Interventions: Other: Interview; Procedure: Blood and Tissue Collection
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified February 2012 - Conditions: Pancreatic Cancer; Thromboembolism
Interventions: Drug: dalteparin; Drug: gemcitabine hydrochloride; Other: diagnostic laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); Hull and East Yorkshire Hospitals NHS Trust
Recruiting - verified April 2007 - Condition: the Efficacy and Safety of Off-pump CABG
Interventions: Procedure: Coronary Artery Bypass Graft with the use of CPB; Procedure: Coronary Artery Bypass Graft without the use of CPB
Sponsors: Population Health Research Institute; Population Health Research Institute; McMaster University; University of Oxford; Instituto Dante Pazzanese de Cardiologia; ECLA Clinical Research Organization,; Fu Wai Hospital, Beijing, China; Facultad de Medicina, Universidad de La Frontera, Temuco, Chile; Fundación Cardiovascular de Colombia; Charles University, Czech Republic; Hopital Jean Minjoz; Centre for Chronic Disease Control, India; S. C. di Cardiochirurgia, Ospedale Santa Croce a Carle, Cuneo, Italy; Medical University of Gdansk; Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); Ankara University; Hotel Dieu Hospital; Centre hospitalier de l'Université de Montréal (CHUM); SAL Hospital, Ahmedabad, India
Recruiting - verified July 2011 - Conditions: Graft Versus Host Disease; Infection; Leukemia; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Neoplasms
Interventions: Genetic: polymerase chain reaction; Other: bronchoalveolar lavage; Other: immunoenzyme technique; Other: laboratory biomarker analysis; Procedure: bronchoscopy; Procedure: management of therapy complications
Sponsors: National Cancer Institute (NCI); St. Bartholomew's Hospital
Recruiting - verified September 2007 - Conditions: Breast Cancer; Hypercalcemia of Malignancy; Metastatic Cancer; Musculoskeletal Complications; Pain
Interventions: Drug: zoledronic acid; Procedure: quality-of-life assessment
Sponsors: National Cancer Institute (NCI); University of Leeds
Recruiting - verified November 2007 - Conditions: Leukemia; Myelodysplastic Syndromes
Interventions: Biological: alemtuzumab; Drug: arsenic trioxide; Drug: azacitidine; Drug: busulfan; Drug: clofarabine; Drug: cytarabine; Drug: daunorubicin hydrochloride; Drug: fludarabine phosphate; Drug: gemtuzumab ozogamicin; Drug: melphalan; Drug: tipifarnib; Genetic: DNA methylation analysis; Genetic: cytogenetic analysis; Genetic: gene expression analysis; Genetic: mutation analysis; Other: diagnostic laboratory biomarker analysis; Other: immunologic technique; Procedure: allogeneic hematopoietic stem cell transplantation; Procedure: nonmyeloablative allogeneic hematopoietic stem cell transplantation
Sponsors: National Cancer Institute (NCI); The University of New South Wales
Recruiting - verified August 2008 - Condition: Oesophagogastric Cancer
Interventions: Biological: bevacizumab; Drug: capecitabine; Drug: cisplatin; Drug: epirubicin hydrochloride; Procedure: adjuvant therapy; Procedure: conventional surgery; Procedure: neoadjuvant therapy
Sponsors: Medical Research Council; Professor David Cunningham; Cancer Research UK
Recruiting - verified January 2012 - Condition: Lung Cancer
Interventions: Drug: carboplatin; Drug: cisplatin; Drug: etoposide phosphate; Drug: pravastatin sodium
Sponsors: University College, London; University College, London
Recruiting - verified December 2011 - Condition: Respiratory Insufficiency of Prematurity
Interventions: Device: nCPAP; Device: NIPPV
Sponsors: McMaster University; McMaster University; Canadian Institutes of Health Research (CIHR)
Completed - verified March 2012 - Condition: Lymphoma
Interventions: Biological: bleomycin sulfate; Drug: carmustine; Drug: cyclophosphamide; Drug: cytarabine; Drug: dacarbazine; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: etoposide phosphate; Drug: ifosfamide; Drug: melphalan; Drug: prednisolone; Drug: prednisone; Drug: procarbazine hydrochloride; Drug: vinblastine sulfate; Drug: vincristine sulfate; Procedure: autologous hematopoietic stem cell transplantation; Radiation: fludeoxyglucose F 18; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); Martin-Luther-Universität Halle-Wittenberg
Recruiting - verified June 2007 - Conditions: Breast Cancer; Infertility; Menopausal Symptoms
Interventions: Drug: cyclophosphamide; Drug: goserelin acetate; Procedure: adjuvant therapy; Procedure: fertility assessment and management; Procedure: neoadjuvant therapy
Sponsors: National Cancer Institute (NCI); Anglo Celtic Cooperative Oncology Group
Recruiting - verified May 2007 - Condition: Pancreatic Cancer
Interventions: Biological: sargramostim; Biological: telomerase peptide vaccine GV1001; Drug: capecitabine; Drug: gemcitabine hydrochloride
Sponsors: National Cancer Institute (NCI); Royal Liverpool University Hospital
Recruiting - verified May 2009 - Condition: Sarcoma
Interventions: Procedure: adjuvant therapy; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); Cancer Research Campaign Clinical Trials Centre
Recruiting - verified December 2007 - Conditions: Multiple Myeloma and Plasma Cell Neoplasm; Renal Failure
Interventions: Drug: chemotherapy; Drug: dexamethasone; Procedure: plasmapheresis
Sponsors: National Cancer Institute (NCI); University of Glasgow
Recruiting - verified June 2007 - Conditions: Mitral Regurgitation; Coronary Artery Disease
Interventions: Procedure: Mitral annuloplasty; Procedure: Coronary Artery Bypass Graft Surgery
Sponsors: Imperial College London; Imperial College London; Department of Health, United Kingdom; British Heart Foundation; British Medical Association; Royal Brompton & Harefield NHS Foundation Trust; Imperial College Healthcare NHS Trust; University Hospitals, Leicester; Medical University of Silesia; United Bristol Healthcare NHS Trust; Blackpool, Flyde and Wyre Hospitals NHS Foundation Trust
Active, not recruiting - verified March 2012 - Conditions: Asthma; Smoking; Steroid Resistance; Corticosteroid Insensitivity
Intervention: Drug: oral steroid-dexamethasone
Sponsors: University of Glasgow; University of Glasgow; Chief Scientist Office of the Scottish Government
Completed - verified September 2008 - Conditions: Angina Pectoris; Coronary Disease
Intervention: Behavioral: Cardiac rehabilitation
Sponsors: National Heart and Lung Institute; National Heart and Lung Institute; British Heart Foundation; Royal Brompton & Harefield NHS Foundation Trust
Completed - verified April 2010 - Conditions: Lung Cancer; Metastatic Cancer
Interventions: Drug: dexamethasone; Procedure: quality-of-life assessment; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); Medical Research Council
Recruiting - verified January 2007 - Condition: Coronary Heart Disease
Interventions: Procedure: Remote ischemic preconditioning; Procedure: Placebo
Sponsors: University College London Hospitals; University College London Hospitals
Recruiting - verified June 2010 - Condition: Multiple Sclerosis
Intervention: Procedure: MSC Treatment
Sponsors: University of Cambridge; University of Cambridge; Cambridge University Hospitals NHS Foundation Trust; Medical Research Council
Completed - verified October 2011 - Condition: Hemorrhage
Interventions: Drug: Tranexamic acid; Drug: Sodium Chloride 0.9%
Sponsors: London School of Hygiene and Tropical Medicine; London School of Hygiene and Tropical Medicine
Completed - verified June 2011 - Conditions: Extrahepatic Bile Duct Cancer; Gallbladder Cancer; Liver Cancer
Interventions: Drug: capecitabine; Other: clinical observation; Procedure: adjuvant therapy
Sponsors: National Cancer Institute (NCI); Southampton University Hospitals NHS Trust
Recruiting - verified October 2011 - Conditions: Glaucoma; Glaucoma, Open Angle; Ocular Hypertension; Keratoconus
Intervention:
Sponsors: Aston University; Aston University
Completed - verified June 2011 - Conditions: Alcohol Abuse; Drug Abuse; Depression; Panic Disorder; Conduct Disorder
Intervention: Behavioral: PRE-Venture: Personality Risk Education
Sponsors: King's College London; King's College London; Action on Addiction
Completed - verified February 2006 - Condition: Healthy
Interventions: Drug: Propofol; Device: Patient maintained sedation
Sponsors: University of Glasgow; Sonia Allam; NHS Greater Glasgow and Clyde
Completed - verified February 2012 - Condition: Lung Cancer
Interventions: Drug: Control arm (SEQ):; Drug: Experimental arm (CON):
Sponsors: University College, London; University College, London
Active, not recruiting - verified March 2012 - Condition: Fecal Incontinence
Intervention: Drug: oestradiol
Sponsors: North West London Hospitals NHS Trust; North West London Hospitals NHS Trust
Terminated - verified February 2007 - Conditions: Anemia; Cardiovascular Complications; Hot Flashes; Osteoporosis; Prostate Cancer
Interventions: Drug: releasing hormone agonist therapy; Drug: transdermal estrogen
Sponsors: National Cancer Institute (NCI); Imperial College London
Recruiting - verified June 2008 - Conditions: Extragonadal Germ Cell Tumor; Teratoma; Testicular Germ Cell Tumor
Interventions: Biological: bleomycin sulfate; Drug: carboplatin; Drug: cisplatin; Drug: etoposide phosphate; Drug: vincristine sulfate
Sponsors: National Cancer Institute (NCI); Medical Research Council
Recruiting - verified May 2007 - Condition: Crohn Disease
Intervention: Procedure: Autologous haematopoietic stem cell transplant
Sponsors: European Group for Blood and Marrow Transplantation; European Group for Blood and Marrow Transplantation; The Broad Foundation
Active, not recruiting - verified May 2012 - Conditions: Anovulation; Obesity
Intervention: Procedure: weight reduction minimal access surgery
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Teaching Hospitals NHS Foundation Trust
Completed - verified July 2011 - Condition: Lymphoma
Interventions: Biological: pegfilgrastim; Biological: rituximab; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: prednisone; Drug: vincristine sulfate; Other: pharmacological study; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); German High-Grade Non-Hodgkin's Lymphoma Study Group
Recruiting - verified March 2010 - Condition: Childhood Langerhans Cell Histiocytosis
Interventions: Drug: leucovorin calcium; Drug: methotrexate; Drug: prednisolone; Drug: vinblastine sulfate
Sponsors: National Cancer Institute (NCI); Histiocyte Society
Recruiting - verified May 2007 - Conditions: Brain and Central Nervous System Tumors; Childhood Germ Cell Tumor; Extragonadal Germ Cell Tumor; Ovarian Cancer
Interventions: Biological: bleomycin sulfate; Drug: carboplatin; Drug: etoposide; Procedure: conventional surgery
Sponsors: National Cancer Institute (NCI); Children's Cancer and Leukaemia Group
Active, not recruiting - verified February 2006 - Condition: Prostate Cancer
Interventions: Drug: celecoxib; Drug: docetaxel; Drug: prednisolone; Drug: releasing hormone agonist therapy; Drug: zoledronic acid; Drug: abiraterone; Procedure: orchiectomy
Sponsors: Medical Research Council; Medical Research Council
Recruiting - verified March 2012 - Conditions: Diabetic Neuropathy; Painful
Intervention: Drug: Cannabis based medicine extract (CBME)
Sponsors: Sheffield Teaching Hospitals NHS Foundation Trust; Sheffield Teaching Hospitals NHS Foundation Trust; Diabetes UK
Completed - verified October 2005 - Condition: Malignant Mesothelioma
Interventions: Drug: cisplatin; Drug: pemetrexed disodium; Procedure: adjuvant therapy; Procedure: conventional surgery; Procedure: neoadjuvant therapy; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified November 2006 - Condition: Brain and Central Nervous System Tumors
Interventions: Drug: temozolomide; Radiation: radiation therapy
Sponsors: European Organization for Research and Treatment of Cancer - EORTC; European Organization for Research and Treatment of Cancer - EORTC; NCIC Clinical Trials Group; British Medical Research Council; Trans-Tasman Radiation Oncology Group (TROG)
Active, not recruiting - verified February 2012 - Condition: Lymphoma, Mucosa-Associated Lymphoid Tissue
Interventions: Drug: chlorambucil (drug); Drug: rituximab+chlorambucil; Drug: rituximab
Sponsors: International Extranodal Lymphoma Study Group (IELSG); International Extranodal Lymphoma Study Group (IELSG)
Active, not recruiting - verified November 2011 - Conditions: Need for Tracheal Tube Exchange; Presence of Post-extubation Laryngeal Oedema
Intervention: Device: Intubation using tracheal tubes with or without cuff
Sponsors: University Children's Hospital, Zurich; University Children's Hospital, Zurich
Completed - verified December 2011 - Condition: Acromegaly
Intervention: Drug: Somatuline Autogel
Sponsors: Plymouth Hospitals NHS Trust; Plymouth Hospitals NHS Trust
Completed - verified September 2005 - Condition: Apnea of Prematurity
Intervention: Drug: Caffeine citrate injection
Sponsors: McMaster University; McMaster University; Canadian Institutes of Health Research (CIHR); National Health and Medical Research Council, Australia
Active, not recruiting - verified March 2012 - Conditions: Pneumococcal Infections; Meningococcal Infections
Interventions: Biological: menjugate; Biological: Men C conjugate vaccine; Biological: Men C conjugate; Biological: Men C Conjugate; Biological: Men C conjugate; Biological: Men C conjugate
Sponsors: Health Protection Agency, United Kingdom; Health Protection Agency, United Kingdom
Completed - verified March 2012 - Condition: Toxemia
Intervention: Behavioral: preeclampsia
Sponsors: University of British Columbia; University of British Columbia
Recruiting - verified March 2012 - Condition: B-Cell Lymphoma
Interventions: Drug: half cyclophosphamide; Drug: without COPADM3; Drug: mini CYVE, without 3 maintenance courses; Drug: LMB B; Drug: LMB C
Sponsors: Institut Gustave Roussy; Institut Gustave Roussy
Completed - verified March 2012 - Condition: Glioma
Intervention: Drug: Temozolomide, Cisplatinum
Sponsors: Institut Gustave Roussy; Institut Gustave Roussy
Completed - verified September 2006 - Condition: Larynx Carcinoma
Interventions: Radiation: Accelerated radiotherapy; Radiation: ARCON
Sponsors: Radboud University; Radboud University; Dutch Cancer Society
Active, not recruiting - verified May 2008 - Conditions: Coronary Disease; Ventricular Dysfunction, Left
Intervention: Drug: Ivabradine
Sponsors: Servier; Institut De Recherche International Servier
Completed - verified June 2011 - Condition: Coronary Arteriosclerosis
Intervention: Procedure: Coronary artery bypass surgery
Sponsors: Imperial College London; Imperial College London; The Royal College of Surgeons of England; Royal Brompton & Harefield NHS Foundation Trust; National Heart Foundation, Australia; Victor Phillip Dahdaleh Charitable Foundation
Completed - verified October 2011 - Conditions: Cerebellar Ataxias; Spastic Paraplegias
Intervention:
Sponsors: Institut National de la Santé Et de la Recherche Médicale, France; Institut National de la Santé Et de la Recherche Médicale, France; Institut des Maladies Rares; Agence Nationale de la Recherche
Recruiting - verified March 2012 - Condition: Cervix Cancer
Interventions: Radiation: Radiotherapy; Radiation: Radiotherapy; Radiation: Radiotherapy/Cisplatin; Radiation: Radiotherapy/Cisplatin
Sponsors: International Atomic Energy Agency; International Atomic Energy Agency
Completed - verified October 2011 - Conditions: Metastatic Cancer; Pain; Prostate Cancer
Intervention: Drug: ibandronate sodium
Sponsors: National Cancer Institute (NCI); Cancer Research UK
Completed - verified June 2009 - Condition: Breast Cancer
Interventions: Genetic: cytogenetic analysis; Genetic: proteomic profiling; Other: cytology specimen collection procedure; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Procedure: breast duct lavage
Sponsors: National Cancer Institute (NCI); Royal Marsden NHS Foundation Trust
Recruiting - verified December 2005 - Condition: Breast Cancer
Interventions: Genetic: cytogenetic analysis; Genetic: proteomic profiling; Other: cytology specimen collection procedure; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Procedure: breast duct lavage
Sponsors: National Cancer Institute (NCI); Royal Marsden NHS Foundation Trust
Recruiting - verified December 2005 - Condition: Breast Cancer
Intervention: Drug: anastrozole
Sponsors: Queen Mary University of London; Jill Knox
Active, not recruiting - verified April 2012 - Conditions: Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer
Interventions: Drug: carboplatin; Drug: paclitaxel; Procedure: adjuvant therapy; Procedure: conventional surgery; Procedure: neoadjuvant therapy
Sponsors: National Cancer Institute (NCI); Royal College of Obstetricians and Gynecologists
Recruiting - verified May 2007 - Condition: Breast Cancer
Interventions: Drug: tamoxifen citrate; Drug: Anastrozole
Sponsors: Queen Mary University of London; Jill Knox; Cancer Research UK
Active, not recruiting - verified May 2012 - Condition: Colorectal Cancer
Interventions: Drug: FOLFOX regimen; Drug: capecitabine; Drug: fluorouracil; Drug: leucovorin calcium; Drug: oxaliplatin; Procedure: quality-of-life assessment
Sponsors: National Cancer Institute (NCI); University of Leeds; Medical Research Council
Active, not recruiting - verified June 2011 - Condition: Lung Cancer
Interventions: Drug: Carboplatin, etoposide & thalidomide; Drug: Carboplatin, etoposide & placebo
Sponsors: University College, London; University College, London
Completed - verified March 2012 - Condition: Kidney Cancer
Interventions: Biological: aldesleukin; Biological: recombinant interferon alfa; Drug: fluorouracil; Procedure: adjuvant therapy
Sponsors: National Cancer Institute (NCI); European Organization for Research and Treatment of Cancer - EORTC; University of Glasgow
Active, not recruiting - verified July 2011 - Condition: Kidney Cancer
Interventions: Biological: dactinomycin; Drug: carboplatin; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: vincristine sulfate; Procedure: adjuvant therapy; Procedure: conventional surgery; Procedure: neoadjuvant therapy; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); University Hospitals, Leicester; Societe Francaise Oncologie Pediatrique; Children's Cancer and Leukaemia Group; Gesellschaft fur Padiatrische Onkologie und Hamatologie - Germany
Recruiting - verified June 2009 - Condition: Esophageal Cancer
Interventions: Drug: cisplatin; Drug: epirubicin hydrochloride; Drug: fluorouracil; Procedure: conventional surgery; Procedure: neoadjuvant therapy
Sponsors: National Cancer Institute (NCI); Medical Research Council
Recruiting - verified March 2007 - Condition: Cervical Cancer
Interventions: Procedure: conventional surgery; Procedure: neoadjuvant chemotherapy; Radiation: brachytherapy; Radiation: radiation therapy; Drug: cisplatin
Sponsors: European Organization for Research and Treatment of Cancer - EORTC; European Organization for Research and Treatment of Cancer - EORTC
Recruiting - verified March 2012 - Condition: Breast Cancer
Interventions: Drug: exemestane; Drug: tamoxifen citrate; Procedure: adjuvant therapy
Sponsors: National Cancer Institute (NCI); Cancer Research Campaign Clinical Trials Centre
Active, not recruiting - verified March 2007 - Condition: Neuroblastoma
Interventions: Biological: filgrastim; Biological: monoclonal antibody Ch14.18; Drug: busulfan; Drug: carboplatin; Drug: cyclophosphamide; Drug: etoposide; Drug: isotretinoin; Drug: melphalan; Drug: vincristine sulfate; Procedure: bone marrow ablation with stem cell support; Procedure: conventional surgery; Procedure: peripheral blood stem cell transplantation; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); University Hospitals, Leicester
Recruiting - verified August 2010 - Condition: Pancreatic Cancer
Interventions: Drug: erlotinib hydrochloride; Drug: gemcitabine hydrochloride
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified September 2011 - Condition: Anal Cancer
Interventions: Drug: cisplatin; Drug: fluorouracil; Drug: mitomycin C; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); University College London (UCL) Cancer Institute
Recruiting - verified March 2007 - Condition: Bladder Cancer
Interventions: Drug: fluorouracil; Drug: mitomycin C; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); University Hospital Birmingham
Active, not recruiting - verified May 2007 - Condition: Breast Cancer
Interventions: Biological: filgrastim; Drug: cyclophosphamide; Drug: docetaxel; Drug: epirubicin hydrochloride; Drug: fluorouracil; Genetic: microarray analysis; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Procedure: biopsy; Procedure: conventional surgery; Procedure: neoadjuvant therapy; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); European Organization for Research and Treatment of Cancer - EORTC; Swedish Breast Cancer Group; Swiss Group for Clinical Cancer Research; Anglo Celtic Cooperative Oncology Group
Active, not recruiting - verified January 2010 - Condition: Head and Neck Cancer
Interventions: Biological: epoetin alfa; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); European Organization for Research and Treatment of Cancer - EORTC; Trans-Tasman Radiation Oncology Group (TROG); Charite University, Berlin, Germany; Groupe Oncologie Radiotherapie Tete et Cou; Radius Hungaricus Oncology Group; Grup per l'Estudi dels Limfomes de Catalunya i Balears
Active, not recruiting - verified June 2006 - Condition: Colorectal Cancer
Interventions: Drug: FOLFIRI regimen; Drug: FOLFOX regimen; Drug: fluorouracil; Drug: irinotecan hydrochloride; Drug: leucovorin calcium; Drug: oxaliplatin
Sponsors: National Cancer Institute (NCI); Medical Research Council
Active, not recruiting - verified March 2002 - Condition: Lymphoma
Interventions: Drug: cyclophosphamide; Drug: cytarabine; Drug: dexamethasone; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: ifosfamide; Drug: leucovorin calcium; Drug: methotrexate; Drug: therapeutic hydrocortisone; Drug: vinblastine sulfate
Sponsors: National Cancer Institute (NCI); Institut Gustave Roussy
Active, not recruiting - verified August 2011 - Condition: Lymphoma
Interventions: Drug: chlorambucil; Drug: dexamethasone; Drug: fludarabine phosphate; Drug: mitoxantrone hydrochloride
Sponsors: National Cancer Institute (NCI); Lymphoma Trials Office
Active, not recruiting - verified March 2007 - Condition: Melanoma (Skin)
Interventions: Biological: pegylated interferon alfa; Procedure: adjuvant therapy
Sponsors: National Cancer Institute (NCI); European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified October 2000 - Condition: Lung Cancer
Interventions: Drug: carboplatin; Drug: paclitaxel; Drug: rebimastat
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified August 2011 - Condition: Breast Cancer
Interventions: Drug: tamoxifen citrate; Procedure: conventional surgery; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); British Association of Surgical Oncology: Breast Group
Active, not recruiting - verified December 2006 - Condition: Ovarian Cancer
Interventions: Drug: carboplatin; Drug: thalidomide
Sponsors: National Cancer Institute (NCI); Cancer Research UK
Recruiting - verified November 2011 - Condition: Leukemia
Interventions: Drug: chlorambucil; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: fludarabine phosphate; Drug: prednisolone; Drug: vincristine sulfate
Sponsors: National Cancer Institute (NCI); Leukemia Research Fund; Medical Research Council
Active, not recruiting - verified January 2006 - Condition: Neuroblastoma
Intervention: Procedure: surgical procedure
Sponsors: National Cancer Institute (NCI); Societe Internationale d'Oncologie Pediatrique
Recruiting - verified July 2007 - Condition: Breast Cancer
Interventions: Drug: cyclophosphamide; Drug: epirubicin hydrochloride; Drug: paclitaxel
Sponsors: National Cancer Institute (NCI); Medical Research Council
Active, not recruiting - verified December 2005 - Conditions: Extragonadal Germ Cell Tumor; Teratoma; Testicular Germ Cell Tumor
Interventions: Biological: bleomycin sulfate; Biological: filgrastim; Drug: cisplatin; Drug: etoposide; Drug: paclitaxel
Sponsors: European Organization for Research and Treatment of Cancer - EORTC; European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified March 2012 - Conditions: Fallopian Tube Cancer; Ovarian Cancer; Primary Peritoneal Cavity Cancer
Interventions: Drug: carboplatin; Drug: cisplatin; Procedure: conventional surgery; Procedure: neoadjuvant therapy
Sponsors: European Organization for Research and Treatment of Cancer - EORTC; European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified March 2012 - Condition: Sarcoma
Interventions: Drug: doxorubicin hydrochloride; Drug: ifosfamide
Sponsors: European Organization for Research and Treatment of Cancer - EORTC; European Organization for Research and Treatment of Cancer - EORTC
Completed - verified January 2012 - Condition: Melanoma (Skin)
Intervention: Biological: recombinant interferon alfa
Sponsors: National Cancer Institute (NCI); European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified November 2011 - Condition: Brain and Central Nervous System Tumors
Interventions: Drug: lomustine; Drug: procarbazine hydrochloride; Drug: vincristine sulfate; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); European Organization for Research and Treatment of Cancer - EORTC; Medical Research Council
Active, not recruiting - verified November 2011 - Condition: Endometrial Cancer
Interventions: Procedure: adjuvant therapy; Procedure: conventional surgery; Radiation: brachytherapy; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); Medical Research Council
Active, not recruiting - verified April 1999 - Condition: Brain and Central Nervous System Tumors
Intervention: Drug: temozolomide
Sponsors: European Organization for Research and Treatment of Cancer - EORTC; European Organization for Research and Treatment of Cancer - EORTC
Completed - verified March 2012 - Condition: Hodgkin Lymphoma
Interventions: Biological: bleomycin sulfate; Drug: dacarbazine; Drug: doxorubicin hydrochloride; Drug: vinblastine; Radiation: radiation therapy
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group; Eastern Cooperative Oncology Group
Completed - verified January 2012 - Condition: Lymphoma
Intervention: Biological: recombinant interferon alfa
Sponsors: National Cancer Institute (NCI); Lymphoma Study Association
Active, not recruiting - verified May 2007 - Condition: Breast Cancer
Intervention: Drug: tamoxifen citrate
Sponsors: National Cancer Institute (NCI); Institute of Cancer Research, United Kingdom
Active, not recruiting - verified July 2011 - Condition: Head and Neck Cancer
Interventions: Drug: cisplatin; Radiation: low-LET cobalt-60 gamma ray therapy; Radiation: low-LET electron therapy; Radiation: low-LET photon therapy
Sponsors: National Cancer Institute (NCI); European Organization for Research and Treatment of Cancer - EORTC
Active, not recruiting - verified May 2007 - Condition: Prostate Cancer
Interventions: Drug: flutamide; Drug: triptorelin; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); Saint Luke's Hospital
Active, not recruiting - verified December 2011 - Condition: Leukemia
Interventions: Biological: recombinant interferon alfa; Drug: cytarabine; Drug: hydroxyurea
Sponsors: National Cancer Institute (NCI); Medical Research Council
Active, not recruiting - verified February 2008 - Condition: Lymphoma
Interventions: Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: mitoxantrone hydrochloride; Drug: prednisolone; Drug: vincristine sulfate
Sponsors: National Cancer Institute (NCI); Cancer Research Campaign Clinical Trials Centre
Active, not recruiting - verified May 2007 - Condition: Lung Cancer
Interventions: Biological: BCG vaccine; Biological: monoclonal antibody BEC2
Sponsors: European Organization for Research and Treatment of Cancer - EORTC; European Organization for Research and Treatment of Cancer - EORTC
Completed - verified March 2012 - Condition: Ovarian Cancer
Intervention: Drug: ISIS 5132
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified September 2011
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