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Safety and Efficacy of Dutogliptin in Patients With Type 2 Diabetes Mellitus Receiving Background Treatment With Glimepiride Alone or in Combination With Metformin or With Pioglitazone Alone

Condition: Diabetes Mellitus, Type 2
Interventions: Drug: Dutogliptin; Drug: Sitagliptin
Sponsors: Forest Laboratories; Phenomix
Enrolling by invitation - verified March 2010
Investigate the Effect of AZD1656 on the Pharmacokinetics of Pioglitazone and Vice Versa in Type 2 Diabetes Mellitus

Condition: Type 2 Diabetes Mellitus
Interventions: Drug: AZD1656; Drug: Pioglitazone
Sponsor: AstraZeneca
Recruiting - verified March 2010
A Study to Characterize the Effect on the Pharmacokinetics of ASP1941 and Pioglitazone Hydrochloride When Given Together to Healthy Subjects

Condition: Healthy
Interventions: Drug: ASP1941; Drug: pioglitazone hydrochloride
Sponsor: Astellas Pharma Inc
Completed - verified March 2010
A Methodological Study To Evaluate The Effects of Single Oral Doses Of Pioglitazone 45 mg And Rosiglitazone 8 mg On Sodium Balance In Healthy Male Volunteers

Condition: Type 2 Diabetes Mellitus
Interventions: Drug: pioglitazone/rosiglitazone/placebo; Drug: rosiglitazone/pioglitazone/placebo; Drug: placebo/pioglitazone/rosiglitazone; Drug: pioglitazone/placebo/rosiglitazone; Drug: rosiglitazone/placebo/pioglitazone; Drug: placebo/rosiglitazone/pioglitazone
Sponsor: Solvay Pharmaceuticals
Completed - verified March 2010
A Study to Evaluate the Safety and Efficacy of Sitagliptin 100 mg in Patients With Type 2 Diabetes Mellitus Who Have Inadequate Glycemic Control

Condition: Type 2 Diabetes Mellitus
Interventions: Drug: sitagliptin phosphate; Drug: Comparator: placebo to pioglitazone; Drug: Comparator: placebo to sitagliptin; Drug: Comparator: pioglitazone; Drug: Comparator: glimepiride or gliclazide; Drug: Comparator: metformin; Drug: Comparator: pioglitazone rescue therapy
Sponsor: Merck
Not yet recruiting - verified February 2010

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