Immune System Diseases

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Paid Clinical Trials - : Immune System Diseases

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  • OTIS Autoimmune Diseases in Pregnancy Project

    Conditions:   Ankylosing Spondylitis;   Psoriatic Arthritis;   Psoriasis;   Rheumatoid Arthritis
    Intervention:  
    Sponsors:   University of California, San Diego;   Organization of Teratology Information Specialists (OTIS);   Amgen
    Recruiting - verified November 2009
  • Valproic Acid in Treating Patients With Previously Treated Non-Hodgkin Lymphoma, Hodgkin Lymphoma, or Chronic Lymphocytic Leukemia

    Conditions:   Leukemia;   Lymphoma
    Interventions:   Drug: valproic acid;   Genetic: western blotting;   Other: laboratory biomarker analysis;   Other: pharmacological study
    Sponsor:   Centro de Cancer del Hospital Auxilio Mutuo
    Recruiting - verified November 2009
  • Evaluation of Influenza H1N1 Vaccine in Adults With Lymphoid Malignancies on Chemotherapy

    Conditions:   Lymphoma;   Multiple Myeloma;   Influenza A Virus, H1N1 Subtype
    Intervention:   Biological: AS03-adjuvanted H1N1 pandemic influenza vaccine
    Sponsors:   University Health Network, Toronto;   Princess Margaret Hospital, Canada
    Recruiting - verified November 2009
  • Safety and Immunogenicity of AERAS-402 in HIV-infected, Bacillus Calmette-Guerin (BCG)-Vaccinated Adults

    Conditions:   Tuberculosis;   HIV Infections
    Interventions:   Biological: AERAS-402;   Biological: Placebo Control
    Sponsors:   Aeras Global Tuberculosis Vaccine Foundation;   Crucell Holland BV
    Not yet recruiting - verified November 2009
  • Real-Time Continuous Glucose Monitoring in Pre-School Children With Type-1 Diabetes Mellitus

    Condition:   Diabetes Mellitus
    Intervention:   Device: Guardian RT
    Sponsor:   Sheba Medical Center
    Recruiting - verified November 2009
  • Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphysims

    Condition:   Acute Asthma
    Intervention:  
    Sponsors:   MetroHealth Medical Center;   GlaxoSmithKline
    Not yet recruiting - verified November 2009
  • Stem Cell Factor (SCF) Priming of Haematopoietic Stem Cell Grafts in Malignant Lymphoma

    Condition:   Malignant Lymphoma
    Interventions:   Drug: r-metHuSCF and Filgrastim;   Drug: r-metHuSCF and Filgrastim;   Drug: Chemotherapy plus Filgrastim
    Sponsors:   Aalborg Hospital;   Herlev Hospital;   Rigshospitalet, Denmark;   Helsinki University Central Hospital;   Turku University Hospital;   University Hospital, Linkoeping;   Umeå University;   Radiumhospitalet Oslo Norway;   Nordic Lymphoma Group;   Amgen
    Suspended - verified November 2009
  • Studying DNA in Blood and Bone Marrow Samples From Young Patients With Acute Lymphoblastic Leukemia

    Condition:   Leukemia
    Interventions:   Genetic: DNA analysis;   Other: biologic sample preservation procedure;   Other: laboratory biomarker analysis
    Sponsors:   Children's Oncology Group;   National Cancer Institute (NCI)
    Active, not recruiting - verified November 2009
  • Aggressive Combination Drug Therapy in Very Early Polyarticular Juvenile Idiopathic Arthritis

    Condition:   Juvenile Idiopathic Arthritis
    Interventions:   Drug: Infliximab plus methotrexate versus methotrexate alone;   Drug: Infliximab plus methotrexate versus Combination of DMARDs;   Drug: Combination of DMARDs versus Methotrexate alone
    Sponsors:   Helsinki University Central Hospital;   Foundation for Pediatric Research, Finland;   Päivikki and Sakari Sohlberg Foundation, Finland;   Rheumatism Foundation Hospital;   Scandinavian Rheumatology Research Foundation;   Paijat-Hame Hospital District
    Active, not recruiting - verified November 2009
  • Unrelated Double Umbilical Cord Blood Units Transplantation

    Conditions:   Leukemia, Myeloid, Acute;   Leukemia, Lymphoblastic, Acute;   Leukemia, Myeloid, Chronic
    Intervention:   Drug: Stem cell Transplantation
    Sponsors:   Tehran University of Medical Sciences;   Hematology-Oncology and Stem Cell Transplantation Research Center
    Recruiting - verified November 2009
  • Allogenic Bone Marrow Transplantation (BMT) Compare With Cytoreduction and Chemotherapy in Acute Lymphoblastic Leukemia (ALL) Patients

    Condition:   Acute Lymphoblastic Leukemia
    Interventions:   Procedure: Bone Marrow Transplantation;   Procedure: Chemotherapy
    Sponsors:   Tehran University of Medical Sciences;   Hematology-Oncology and Stem Cell Transplantation Research Center
    Recruiting - verified November 2009
  • Trial of Bendamustine And Rituximab for Patients With Previously Untreated Extranodal Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma

    Condition:   MALT Lymphoma
    Intervention:   Drug: Rituximab and Bendamustine
    Sponsor:   Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea
    Recruiting - verified November 2009
  • Genetic Screening for Filaggrin Mutation in Atopic Dermatitis and Ichthyosis Vulgaris in the African American Population

    Conditions:   Atopic Dermatitis;   Ichthyosis Vulgaris
    Intervention:  
    Sponsors:   Northwestern University;   IBT laboratories
    Not yet recruiting - verified November 2009
  • The Efficacy of Enteric-coated Mycophenolate Sodium (EC-MPS) (Myfortic) in The Treatment of Relapse or Resistant Proliferative Lupus Nephritis

    Condition:   Lupus Nephritis
    Interventions:   Drug: mycophenolate sodium;   Drug: cyclophosphamide
    Sponsors:   Chulalongkorn University;   Clinical Research Collaborative Network;   Health Intervention and Technology Assessment Program (HITAP)
    Not yet recruiting - verified November 2009
  • Computerized Counseling to Promote Positive Prevention and HIV Health in Kenya

    Condition:   HIV Infections
    Interventions:   Other: CARE+ Kenya brief computer risk assessment session;   Other: CARE+ Kenya computer counseling session
    Sponsors:   New York University;   Indiana University;   Moi University
    Not yet recruiting - verified November 2009
  • Cardiovascular Risk Evaluation and Antiretrovirals in HIV

    Conditions:   Cardiovascular Risk;   HIV Infections
    Intervention:  
    Sponsors:   King's College London;   Guys and St Thomas' Foundation Hospitals Trust
    Completed - verified November 2009
  • Study of MDX-1100 (Anti-CXCL10 Human Monoclonal Antibody) in Combination With Methotrexate in Subjects With Active Rheumatoid Arthritis (RA)

    Condition:   Rheumatoid Arthritis
    Interventions:   Drug: MDX-1100;   Drug: Placebo
    Sponsor:   Medarex
    Completed - verified November 2009
  • Appropriate Timing of HAART in Co-infected HIV/TB Patients

    Conditions:   HIV Infections;   Tuberculosis
    Intervention:   Drug: tenofovir, lamivudine, efavirenz
    Sponsors:   Bamrasnaradura Infectious Diseases Institute;   Mahidol University;   Thai Red Cross AIDS Research Centre
    Recruiting - verified November 2009
  • Protection of Ovarian Function in Female Patients With Hodgkin Lymphoma

    Condition:   Hodgkins Lymphoma
    Interventions:   Drug: 8 cycles BEACOPPesc plus oral contraceptive;   Drug: 8 cycles BEACOPPesc plus Goserelin
    Sponsor:   University of Cologne
    Terminated - verified November 2009
  • Risk of Psychopathology and Neurocognitive Impairment in Leukemia Survivors

    Conditions:   Neurocognitive Impairment;   Acute Lymphoblastic Leukemia
    Intervention:   Other: Neurocognitive and behavioral evaluation
    Sponsors:   St. Jude Children's Research Hospital;   National Cancer Institute (NCI);   National Institute of Mental Health (NIMH)
    Not yet recruiting - verified November 2009
  • A Dose-escalation Trial of SGN-75 in CD70-positive Non-Hodgkin Lymphoma or Renal Cell Carcinoma

    Conditions:   Carcinoma, Renal Cell;   Lymphoma, Non-Hodgkin
    Intervention:   Drug: SGN-75
    Sponsor:   Seattle Genetics, Inc.
    Recruiting - verified November 2009
  • A Spanish-Language Intervention to Enhance Routine HIV Patient Care Delivery [CARE+ Spanish]

    Condition:   HIV Infections
    Interventions:   Other: CARE+ Spanish computer counseling session;   Other: CARE+ Spanish brief computer risk assessment session
    Sponsors:   New York University;   St. Vincent's Medical Center
    Not yet recruiting - verified November 2009
  • A Study of the Safety and Efficacy of 4 Doses of BI 1744 CL Delivered Via the Respimat in Patients With Asthma.

    Condition:   Asthma
    Interventions:   Drug: BI 1744 CL;   Drug: Placebo;   Drug: Respimat
    Sponsor:   Boehringer Ingelheim Pharmaceuticals
    Not yet recruiting - verified November 2009
  • Rituximab and Alemtuzumab in Treating Older Patients With Progressive Chronic Lymphocytic Leukemia

    Condition:   Leukemia
    Interventions:   Biological: alemtuzumab;   Biological: rituximab
    Sponsors:   Eastern Cooperative Oncology Group;   National Cancer Institute (NCI)
    Not yet recruiting - verified November 2009
  • Safety and Tolerability Trial of Abatacept-based Immunosuppression for Prevention of Acute Graft Versus Host Disease (aGVHD) During Transplant

    Conditions:   AML;   ALL;   Undifferentiated Leukemia;   Biphenotypic Leukemia;   Refractory Anemia;   Refractory Anemia With Ringed Sideroblasts;   Refractory Cytopenia With Multilineage Dysplasia;   Refractory Cytopenia With Multilineage Dysplasia and Ringed Sideroblasts;   Refractory Anemia With Excess Blasts-1 (5-10% Blasts);   Refractory Anemia With Excess Blasts-2 (10-20% Blasts);   Myelodysplastic Syndrome, Unclassified;   MDS Associated With Isolated Del (5q)
    Intervention:   Drug: Abatacept
    Sponsor:   Emory University
    Recruiting - verified November 2009
  • Efficacy, Safety, Tolerability and Pharmacokinetics of Indacaterol Maleate Via Concept1 or Simoon Devices

    Condition:   Asthma
    Interventions:   Drug: QAB149 placebo;   Drug: QAB149;   Drug: QAB149;   Drug: QAB149
    Sponsor:   Novartis Pharmaceuticals
    Recruiting - verified November 2009
  • Clinical Study to Evaluate the Efficacy, Pharmacokinetics, and Safety of Immunoglobulin Intravenous (Human) 10% (NewGam) in Patients With Primary Immunodeficiency Diseases

    Condition:   Primary Immunodeficiency Diseases
    Interventions:   Biological: NewGam;   Biological: NewGam
    Sponsors:   Octapharma;   Premeir Research
    Recruiting - verified November 2009
  • Prospective Observational Long-term Safety Registry of Multiple Sclerosis Patients Who Have Participated in Cladribine Clinical Trials

    Condition:   Multiple Sclerosis
    Intervention:  
    Sponsor:   EMD Serono
    Recruiting - verified November 2009
  • A Multicenter Study to Evaluate Safety and Efficacy of Specific Immunotherapy With Modified Allergen Extracts

    Conditions:   Allergic Rhinitis;   Allergic Conjunctivitis
    Interventions:   Biological: modified allergen extract;   Biological: Placebo
    Sponsor:   Roxall Medizin
    Not yet recruiting - verified November 2009
  • Efficacy and Safety of Sublingual Immunotherapy (SLIT)

    Condition:   Allergic Rhinitis
    Interventions:   Biological: sublingual immunotherapy with allergen extract;   Biological: sublingual immunotherapy with placebo
    Sponsor:   Roxall Medizin
    Not yet recruiting - verified November 2009
  • Lenalidomide in Patients With Chronic Lymphocytic Leukemia Older Than 65 Years of Age

    Conditions:   Chronic Lymphocytic Leukemia;   Leukemia
    Intervention:   Drug: lenalidomide
    Sponsors:   Memorial Sloan-Kettering Cancer Center;   Celgene Corporation
    Recruiting - verified November 2009
  • Acute Montelukast in Asthma

    Condition:   Acute Asthma Exacerbation
    Interventions:   Drug: Montelukast;   Drug: Placebo
    Sponsors:   University of East Anglia;   Norfolk Association of Asthma Nurses;   Merck Sharp and Dohne
    Completed - verified November 2009
  • A Multiple-dose Study of the Safety and Tolerability of REGN88 in Rheumatoid Arthritis Subjects

    Condition:   Rheumatoid Arthritis
    Intervention:   Biological: REGN88
    Sponsors:   Regeneron Pharmaceuticals;   Sanofi-Aventis
    Completed - verified November 2009
  • Safety and Efficacy of Reduced Dose Efavirenz (EFV) With Standard Dose EFV Plus Two Nucleotide Reverse Transcriptase Inhibitors (N(t)RTI) in Antiretroviral-naïve HIV-infected Individuals.

    Condition:   HIV Infections
    Interventions:   Drug: Efavirenz;   Drug: Efavirenz
    Sponsor:   The National Centre in HIV Epidemiology and Clinical Research
    Not yet recruiting - verified November 2009
  • Trial for Patients With Newly Diagnosed Primary Central Nervous System (CNS) Lymphoma

    Condition:   Central Nervous System Lymphoma
    Interventions:   Drug: Methotrexate;   Drug: Ara-C;   Drug: Rituximab;   Drug: Thiotepa;   Radiation: radiotherapy;   Drug: BCNU;   Other: APBSCT
    Sponsor:   International Extranodal Lymphoma Study Group (IELSG)
    Active, not recruiting - verified November 2009
  • A Study of Tocilizumab With or Without Methotrexate in Patients With Rheumatoid Arthritis

    Condition:   Rheumatoid Arthritis
    Intervention:   Drug: tocilizumab
    Sponsor:   Hoffmann-La Roche
    Active, not recruiting - verified November 2009
  • Efficacy and Tolerability of Prednisolone Acetate 0.5% Cream Versus Betamethasone Valerate 0.1% Cream in Cortisosensitive Dermatosis

    Conditions:   Dermatitis, Atopic;   Dermatitis, Contact;   Dermatitis, Seborrheic;   Psoriasis
    Interventions:   Drug: 0.5% prednisolone acetate cream;   Drug: 0.1% betamethasone valerate cream
    Sponsor:   Mantecorp Industria Quimica e Farmaceutica Ltd.
    Not yet recruiting - verified November 2009
  • Safety Study of a Chemokine Receptor (CXCR4) Antagonist in Multiple Myeloma Patients

    Condition:   Multiple Myeloma
    Intervention:   Drug: BKT140
    Sponsor:   Biokine Therapeutics Ltd
    Recruiting - verified November 2009
  • Boosted Lexiva With Lovaza Adjunctive Therapy in Hypertriglyceridemic, HIV-Infected Subjects

    Conditions:   Hypertriglyceridemia;   HIV Infection
    Interventions:   Dietary Supplement: Lovaza;   Drug: fosamprenavir/ritonavir
    Sponsors:   Felizarta, Franco, M.D.;   GlaxoSmithKline
    Recruiting - verified November 2009
  • SC12267 (4SC-101) in Combination With Methotrexate in Patients With Rheumatoid Arthritis

    Condition:   Rheumatoid Arthritis
    Interventions:   Drug: SC12267 (4SC-101);   Drug: Placebo;   Drug: Methotrexate;   Drug: Folic Acid
    Sponsor:   4SC AG
    Recruiting - verified November 2009
  • Immunization With HIV-1 Peptides in Adjuvant for Treatment of Patients With Chronic HIV-infection

    Condition:   HIV Infections
    Intervention:   Biological: peptide vaccine (AFO-18)
    Sponsors:   Hvidovre University Hospital;   Statens Serum Institut;   Rigshospitalet, Denmark;   Ministry of the Interior and Health, Denmark
    Enrolling by invitation - verified November 2009
  • A Study of RO5072759 With Chlorambucil in Patients With Previously Untreated Chronic Lymphocytic Leukemia

    Condition:   Lymphocytic Leukemia, Chronic
    Interventions:   Drug: RO5072759;   Drug: rituximab;   Drug: chlorambucil
    Sponsors:   Hoffmann-La Roche;   Genentech
    Not yet recruiting - verified November 2009
  • IV Busulfan for Transplant in Multiple Myeloma

    Condition:   Multiple Myeloma
    Intervention:   Drug: IV busulfan and bortezomib combination
    Sponsor:   Otsuka Pharmaceutical Development & Commercialization, Inc.
    Not yet recruiting - verified November 2009
  • CD3/CD28 Bead Activated T-Cells Following Chemo-Immunotherapy in Patients With Chronic Lymphocytic Leukemia

    Condition:   Chronic Lymphocytic Leukemia
    Intervention:   Biological: Infusion of CD3/CD28 stimulated T cells
    Sponsors:   University of Pennsylvania;   M.D. Anderson Cancer Center
    Recruiting - verified November 2009
  • Subcutaneous Immunoglobulin Treatment of Patients With Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)

    Condition:   Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
    Intervention:   Drug: Subcutaneous immunoglobulin
    Sponsors:   University of Aarhus;   Baxter Healthcare Corporation;   GCP-unit at Aarhus University Hospital, Aarhus, Denmark
    Not yet recruiting - verified November 2009
  • Third-line Therapy of Multiple Myeloma a Prospective Phase I /II Trial

    Condition:   Multiple Myeloma
    Intervention:   Drug: Lenalidomide, Pioglitazone, dexamethasone, treosulfan
    Sponsors:   University of Regensburg;   ClinAssess GmbH
    Recruiting - verified November 2009
  • Clinical Trial to Assess the Efficacy and Safety of Ciclesonide HFA Nasal Aerosol for the Treatment of Seasonal Allergic Rhinitis (SAR) to Mountain Cedar in Subjects 12 Years and Older

    Condition:   Seasonal Allergic Rhinitis
    Interventions:   Drug: Ciclesonide HFA 160 μg;   Drug: Ciclesonide HFA 80 μg;   Drug: Placebo
    Sponsor:   Sepracor, Inc.
    Not yet recruiting - verified November 2009
  • Study With Rituximab, Cyclophosphamide, Doxorubicin Liposomal (Myocet®), Vincristine, Prednisone, (R-COMP) to Treat Non-Hodgkin's Lymphoma

    Condition:   Diffuse Large B-cell Lymphoma
    Interventions:   Drug: Rituximab;   Drug: Cyclophosphamide;   Drug: Vincristine;   Drug: Prednisone;   Drug: Doxorubicin
    Sponsor:   Fondazione Intergruppo Italiano Linfomi Onlus
    Not yet recruiting - verified November 2009
  • Asparaginase-Erwinia in Treating Patients With Acute Lymphoblastic Leukemia, T- Cell Lymphoma, or B-Cell Lymphoma Who Are Allergic to Asparaginase or Pegaspargase

    Conditions:   Leukemia;   Lymphoma;   Lymphoproliferative Disorder
    Intervention:   Drug: asparaginase-Erwinia
    Sponsors:   Vanderbilt-Ingram Cancer Center;   National Cancer Institute (NCI)
    Recruiting - verified January 2009
  • Clinical Trial to Compare the Immunogenicity and Safety of an Adjuvanted A(H1N1)v Influenza Vaccine to a Non-adjuvanted A(H1N1)v Influenza Vaccine in HIV-infected Patients (ANRS 151 Hifluvac)

    Condition:   HIV Infections
    Interventions:   Biological: adjuvanted A(H1N1)v influenza vaccine;   Biological: non-adjuvanted A(H1N1)v influenza vaccine
    Sponsors:   French National Agency for Research on AIDS and Viral Hepatitis;   GlaxoSmithKline
    Active, not recruiting - verified November 2009
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