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Emergency Department (ED)-Directed Interventions to Improve Asthma Guideline Compliance

Condition: Acute Asthma
Interventions: Behavioral: Opinion Leader; Behavioral: Usual care
Sponsor: University of Alberta
Not yet recruiting - verified February 2010
The Effectiveness of Antibiotic Cement (ABC) Compared to Regular Cement in Reducing the Rate of Infection Following Total Knee Arthroplasty: The ABC Trial

Conditions: Infection; Osteoarthritis of the Knee
Interventions: Device: Simplex™ P with Tobramycin; Device: Simplex™ P
Sponsor: University of Western Ontario, Canada
Not yet recruiting - verified March 2010
Trial of Best Supportive Care and Either Cisplatin or Paclitaxel to Treat Patients With Ovarian Cancer and Inoperable Malignant Bowel Obstruction

Conditions: Ovarian Cancer; Bowel Obstruction
Interventions: Drug: Cisplatin; Drug: Paclitaxel
Sponsor: University Health Network, Toronto
Recruiting - verified February 2010
A Dose Ranging Study of AIN457 in Patients With Moderate to Severe Chronic Plaque-type Psoriasis

Condition: Chronic Plaque-type Psoriasis
Interventions: Drug: AIN457; Drug: Placebo
Sponsor: Novartis Pharmaceuticals
Not yet recruiting - verified February 2010
Naloxone for the Treatment of Opioid-Induced Pruritus

Condition: Pruritus
Interventions: Drug: Naloxone; Drug: Saline/Morphine
Sponsor: University of British Columbia
Not yet recruiting - verified February 2010
The Electronic Asthma Action Plan System for Implementation in Primary Care

Condition: Asthma
Intervention: Other: Electronic Asthma Action Plan System
Sponsor: St. Michael's Hospital, Toronto
Not yet recruiting - verified February 2010
Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests

Conditions: Asthma; Cough Variant Asthma
Interventions: Drug: high-dose methacholine challenge test; Other: mannitol challenge test
Sponsor: Queen's University
Recruiting - verified March 2010
AMG 853 Phase 2 Study in Subjects With Inadequately Controlled Asthma

Condition: Asthma
Interventions: Drug: AMG 853; Drug: AMG 853; Drug: AMG 853; Drug: AMG 853; Drug: Placebo
Sponsor: Amgen
Recruiting - verified March 2010
A Study to Evaluate the Effectiveness and Safety of MEDI-528 in Adults

Condition: Asthma
Interventions: Biological: MEDI-528; Biological: MEDI-528; Biological: MEDI-528; Other: Placebo
Sponsor: MedImmune LLC
Recruiting - verified March 2010
Development of a Nation Program for Research in Severe Asthma: The Canadian Severe Asthma Network (CSAN)

Condition: Severe Asthma
Intervention:
Sponsor: University of Alberta
Not yet recruiting - verified March 2010
A Study of the Safety and Efficacy of JNJ-39758979 in the Treatment of Adults With Asthma

Condition: Asthma
Intervention: Drug: JNJ39758979
Sponsor: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Recruiting - verified February 2010
A Study of Icatibant in Patients With Acute Attacks of Hereditary Angioedema (FAST-3)

Condition: Hereditary Angioedema
Interventions: Drug: Icatibant; Drug: Placebo
Sponsors: Jerini AG; Shire Human Genetic Therapies, Inc.
Recruiting - verified November 2009
An Open-label Extension Study of Canakinumab in Patients With Systemic Juvenile Idiopathic Arthritis and Active Systemic Manifestations.

Condition: Systemic Juvenile Idiopathic Arthritis
Intervention: Drug: Canakinumab
Sponsors: Novartis Pharmaceuticals; PRINTO / PRCSG
Recruiting - verified August 2009
A 16-Week, International, Multicenter, Double-Blind, Randomized, Placebo-Controlled Study of the Efficacy and Safety of Oral UT-15C Sustained Release Tablets in Subjects With Pulmonary Arterial Hypertension (FREEDOM-C2)

Condition: Pulmonary Hypertension
Intervention: Drug: UT-15C
Sponsor: United Therapeutics
Recruiting - verified February 2010
Single-dose Study to Assess Efficacy of Canakinumab (ACZ885) in Patients With Active Systemic Juvenile Idiopathic Arthritis (SJIA)

Condition: Systemic Juvenile Idiopathic Arthritis
Interventions: Drug: Canakinumab; Drug: Placebo
Sponsors: Novartis Pharmaceuticals; PRINTO / PRCSG
Recruiting - verified August 2009
Flare Prevention Study of Canakinumab in Patients With Active Systemic Juvenile Idiopathic Arthritis (SJIA)

Condition: Systemic Juvenile Idiopathic Arthritis With Active Flare
Interventions: Drug: Canakinumab; Drug: Placebo
Sponsors: Novartis Pharmaceuticals; PRINTO / PRCSG
Recruiting - verified December 2009
ARTEMIS-PH - Study of Ambrisentan in Subjects With Pulmonary Hypertension Associated With Idiopathic Pulmonary Fibrosis

Conditions: Idiopathic Pulmonary Fibrosis; Pulmonary Hypertension
Intervention: Drug: Ambrisentan or placebo
Sponsor: Gilead Sciences
Recruiting - verified March 2010
An Efficacy and Long-Term Safety of Ragweed (Ambrosia Artemisiifolia) Sublingual Tablet in Adults With a History of Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (Study P05233AM1)

Conditions: Rhinitis; Allergic Conjunctivitis
Interventions: Biological: 6 Amb a 1-U; Biological: 12 Amb a 1-U; Biological: Placebo
Sponsor: Schering-Plough
Recruiting - verified March 2010
Evaluation of Tiotropium 5 µg/Day Delivered Via the Respimat® Inhaler Over 48 Weeks in Patients With Severe Persistent Asthma on Top of Usual Care

Condition: Asthma
Interventions: Drug: tiotropium 5mcg/day; Drug: tiotropium 5mcg/day
Sponsors: Boehringer Ingelheim Pharmaceuticals; Pfizer
Recruiting - verified March 2010
Evaluation of Tiotropium 5 µg/Day Delivered Via the Respimat® Inhaler Over 48 Weeks in Patients With Severe Persistent Asthma on Top of Usual Care

Condition: Asthma
Interventions: Drug: tiotropium 5mcg/day; Drug: tiotropium 5mcg/day
Sponsors: Boehringer Ingelheim Pharmaceuticals; Pfizer
Recruiting - verified March 2010
An Efficacy and Long-Term Safety of Ragweed (Ambrosia Artemisiifolia) Sublingual Tablet in Adults With a History of Ragweed-Induced Rhinoconjunctivitis With or Without Asthma (Study P05234AM2)

Conditions: Rhinitis; Allergic Conjunctivitis
Interventions: Biological: 1.5 Amb a 1-U; Biological: 6 Amb a 1-U; Biological: 12 Amb a 1-U; Biological: Placebo
Sponsor: Schering-Plough
Recruiting - verified March 2010
Oseltamivir Treatment for Children Less Than 24 Months of Age With Influenza

Condition: Influenza
Intervention: Drug: oseltamivir (Tamiflu®)
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified February 2010
Use of Montelukast to Treat Children With Mild to Moderate Acute Asthma

Condition: Asthma, Bronchial
Interventions: Drug: Montelukast plus prednisolone; Drug: Prednisolone
Sponsors: The Hospital for Sick Children; Merck Frosst Canada Ltd.
Recruiting - verified September 2006
Pleconaril Enteroviral Sepsis Syndrome

Condition: Enteroviral Sepsis
Interventions: Drug: Placebo; Drug: Pleconaril (VP63843)
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)
Recruiting - verified February 2010

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