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Determine Central 5-HT1B Receptor Occupancy of ZOMIG® Rapimelt (Zolmitriptan) in Healthy Male Volunteers

Condition: Migraine
Interventions: Drug: Rapimelt; Drug: [11C]AZ10419369
Sponsor: AstraZeneca
Not yet recruiting - verified March 2010
To Evaluate the Effect of Gemfibrozil on the Pharmacokinetics and Pharmacodynamics of a Single Dose of AZD1656

Condition: Type 2 Diabetes Mellitus
Interventions: Drug: AZD1656; Drug: Gemfibrozil; Drug: Placebo
Sponsor: AstraZeneca
Not yet recruiting - verified March 2010
Effect of a Pharmaceutical Intervention on the Level of Control of the Asthmatic Patient

Condition: Asthma
Interventions: Other: 1; Other: 2
Sponsor: AstraZeneca
Not yet recruiting - verified March 2010
Phase I, Single Centre, Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD3043

Conditions: Safety; Tolerability; Pharmacokinetics; Sedation
Intervention: Drug: AZD3043
Sponsor: AstraZeneca
Not yet recruiting - verified March 2010
Montelukast and Inhaled Nasal Steroid Tx in Adult Obstructive Sleep Apnea (OSA)

Condition: Obstructive Sleep Apnea
Interventions: Drug: budesonide nasal spray and a montelukast pill; Drug: Placebo: sugar pill and salt water nasal spray
Sponsors: Romaker & Associates; Merck; AstraZeneca
Not yet recruiting - verified March 2010
Investigate the Effect of AZD1656 on the Pharmacokinetics of Pioglitazone and Vice Versa in Type 2 Diabetes Mellitus

Condition: Type 2 Diabetes Mellitus
Interventions: Drug: AZD1656; Drug: Pioglitazone
Sponsor: AstraZeneca
Recruiting - verified March 2010
Survey Conducted Among Early Breast Cancer Patients Treated With Arimidex for Evaluation of Treatment Adherence

Condition: Breast Cancer
Intervention:
Sponsor: AstraZeneca
Not yet recruiting - verified March 2010
Economic Evaluation of Heart Failure Management in Colombian Clinics

Conditions: Heart Failure; Asthma
Intervention:
Sponsor: AstraZeneca
Completed - verified March 2010
Open Label Study to Assess Efficacy and Safety of Olaparib in Confirmed Genetic BRCA1 or BRCA2 Mutation Pats

Conditions: Ovarian; Breast; Prostate; Pancreatic; Advanced Tumours
Intervention: Drug: olaparib
Sponsor: AstraZeneca
Recruiting - verified March 2010
Risk of Hospitalized Infections Among Patients With Type 2 Diabetes Exposed to Oral Antidiabetic Treatment

Condition: Diabetes Mellitus, Type 2
Intervention: Other: Observational Study
Sponsors: Bristol-Myers Squibb; AstraZeneca; University of Pennsylvania
Active, not recruiting - verified March 2010
Risk of Hospitalization for Severe Hypersensitivity (Including Severe Skin Reactions) in Patients With Type 2 Diabetes Exposed to Oral Antidiabetic Treatments

Condition: Diabetes Mellitus, Type 2
Intervention: Other: Observational Study
Sponsors: Bristol-Myers Squibb; AstraZeneca; University of Pennsylvania
Active, not recruiting - verified March 2010
Risk of Cardiovascular Events in Patients With Type 2 Diabetes Exposed to Oral Antidiabetic Treatments

Condition: Diabetes Mellitus, Type 2
Intervention: Other: Observational Study
Sponsors: Bristol-Myers Squibb; AstraZeneca; University of Pennsylvania
Active, not recruiting - verified March 2010
Risk of Acute Kidney Injury and Acute Liver Failure Among Patients With Type 2 Diabetes Exposed to Oral Antidiabetic Treatments

Condition: Diabetes Mellitus, Type 2
Intervention: Other: Observational Study
Sponsors: Bristol-Myers Squibb; AstraZeneca; University of Pennsylvania
Active, not recruiting - verified March 2010
Study to Compare the Efficacy and Safety of Olaparib When Given in Combination With Carboplatin and Paclitaxel, Compared With Carboplatin and Paclitaxel in Patients With Advanced Ovarian Cancer

Condition: Ovarian Cancer
Interventions: Drug: olaparib; Drug: paclitaxel; Drug: carboplatin
Sponsor: AstraZeneca
Recruiting - verified March 2010
Epidemiological Study to Evaluate the Prevalence of Epidermal Growth Factor Receptor (EGFR) Mutation Status in Patients With Newly Diagnosed Locally Advanced or Metastatic Non Small Cell Lung Cancer (NSCLC)

Condition: Non Small Cell Lung Cancer
Intervention:
Sponsor: AstraZeneca
Not yet recruiting - verified March 2010
Evaluation of the Frequency of Limitation of Activity in Patients With Persistent Asthma

Condition: Persistent Asthma
Intervention:
Sponsor: AstraZeneca
Recruiting - verified March 2010
An Study to Evaluate Rosuvastatin in Children and Adolescents With Familial Hypercholesterolaemia

Condition: Familial Hypercholesterolaemia
Interventions: Drug: rosuvastatin calcium; Drug: rosuvastatin calcium; Drug: rosuvastatin calcium
Sponsor: AstraZeneca
Recruiting - verified March 2010
Study to Compare Zoladex™ 10.8 mg With Zoladex 3.6 mg in Pre-menopausal Women With Breast Cancer

Condition: Breast Cancer
Interventions: Drug: ZD9393 (Zoladex); Drug: ZD9393 (Zoladex)
Sponsor: AstraZeneca
Not yet recruiting - verified February 2010
Gastroesophageal Reflux Disease (GERD)/Nighttime Heartburn and Driving Performance

Condition: GERD
Intervention: Drug: esomeprazole 40 mg
Sponsors: Digestive & Liver Disease Specialists; AstraZeneca
Recruiting - verified March 2010
Study of Undertreatment of Patients With Dyslipidemia in Bulgaria

Condition: Dyslipidemia
Intervention:
Sponsor: AstraZeneca
Recruiting - verified February 2010
Study to Assess MEDI -578 in Patients With Osteoarthritis (OA) of the Knee

Conditions: Osteoarthritis; Pain
Interventions: Drug: MEDI-578; Drug: Placebo for MEDI-578
Sponsors: AstraZeneca; MedImmune LLC
Recruiting - verified February 2010
This Study Will Investigate How Food and Age Effect the Way the Body Handles the AZD5069 Drug Given as a Oral Dose

Condition: Chronic Obstructive Pulmonary Disease
Intervention: Drug: AZD5069
Sponsors: AstraZeneca; Quintiles
Recruiting - verified March 2010
To Assess the Pharmacokinetics of AZD1656 and Its Metabolite in Type 2 Diabetes Mellitus Patients

Condition: Glucose Lowering
Intervention: Drug: AZD1656
Sponsor: AstraZeneca
Not yet recruiting - verified February 2010
Comparative Efficacy & Safety Study of D961H Versus Placebo for the Prevention of Gastric and Duodenal Ulcers With Low-dose Aspirin

Condition: Prevention
Interventions: Drug: D961H; Drug: Placebo
Sponsor: AstraZeneca
Recruiting - verified February 2010
A Study to to Assess the Effect of Dapagliflozin When Administered Once a Day Versus Twice a Day on Blood Glucose

Condition: Healthy Volunteers
Interventions: Drug: Dapagliflozin; Drug: Dapagliflozin
Sponsors: AstraZeneca; Bristol-Myers Squibb
Active, not recruiting - verified March 2010
Quetiapine XR in Schizophrenic Patients

Condition: Schizophrenia
Intervention: Drug: Quetiapine XR
Sponsors: Hannover Medical School; Hannover Clinical Trial Center GmbH; AstraZeneca
Recruiting - verified February 2010

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